{"id":"https://openalex.org/W2158990652","doi":"https://doi.org/10.1128/iai.56.7.1807-1813.1988","title":"Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin","display_name":"Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W2158990652","doi":"https://doi.org/10.1128/iai.56.7.1807-1813.1988","mag":"2158990652","pmid":"https://pubmed.ncbi.nlm.nih.gov/3384478","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/259481"},"language":"en","primary_location":{"id":"doi:10.1128/iai.56.7.1807-1813.1988","doi":"https://doi.org/10.1128/iai.56.7.1807-1813.1988","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.56.7.1807-1813.1988","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC259481","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010909919","display_name":"S F Little","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S F Little","raw_affiliation_strings":["U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701-5011"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701-5011","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109925952","display_name":"Stephen\u00a0H. Leppla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Leppla","raw_affiliation_strings":["U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701-5011"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701-5011","institution_ids":["https://openalex.org/I2801122164"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030907877","display_name":"Elsa M. Cora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Cora","raw_affiliation_strings":["U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701-5011"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701-5011","institution_ids":["https://openalex.org/I2801122164"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801122164"],"apc_list":null,"apc_paid":null,"fwci":1.1518,"has_fulltext":false,"cited_by_count":161,"citation_normalized_percentile":{"value":0.78710395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"56","issue":"7","first_page":"1807","last_page":"1813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protective-antigen","display_name":"protective antigen","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bacillus-anthracis","display_name":"Bacillus anthracis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/anthrax-toxin","display_name":"anthrax toxin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lethal-toxin","display_name":"lethal toxin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/edema-toxin","display_name":"edema toxin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antigenic-regions","display_name":"antigenic regions","score":0.7630000114440918},{"id":"https://openalex.org/keywords/antibody-affinity","display_name":"antibody affinity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/antibody-isotypes","display_name":"antibody isotypes","score":0.6320000290870667},{"id":"https://openalex.org/keywords/competitive-binding","display_name":"competitive binding","score":0.7350000143051147},{"id":"https://openalex.org/keywords/toxin-neutralization","display_name":"toxin neutralization","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C41810244","wikidata":"https://www.wikidata.org/wiki/Q1935986","display_name":"Anthrax toxin","level":5,"score":0.9529263973236084},{"id":"https://openalex.org/C2780239966","wikidata":"https://www.wikidata.org/wiki/Q614156","display_name":"Bacillus anthracis","level":3,"score":0.9304674863815308},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.8002809286117554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7730305194854736},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7389758229255676},{"id":"https://openalex.org/C2778723905","wikidata":"https://www.wikidata.org/wiki/Q408649","display_name":"Exotoxin","level":3,"score":0.7274105548858643},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.6808840036392212},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.587541937828064},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5703869462013245},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.416547954082489},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32656899094581604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2030988335609436},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.19416481256484985},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.12658217549324036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11520174145698547},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07187086343765259},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007525","descriptor_name":"Isoelectric Focusing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/iai.56.7.1807-1813.1988","doi":"https://doi.org/10.1128/iai.56.7.1807-1813.1988","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.56.7.1807-1813.1988","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:19004","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC259481","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:259481","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/259481","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:3384478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3384478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"pmh:ADA192855","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA192855","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},{"id":"mag:230796657","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a192855.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:19004","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC259481","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1508830093","https://openalex.org/W1536607091","https://openalex.org/W1572022498","https://openalex.org/W1586258598","https://openalex.org/W1588631953","https://openalex.org/W1765888134","https://openalex.org/W1842440437","https://openalex.org/W1853117060","https://openalex.org/W1864493807","https://openalex.org/W1895923479","https://openalex.org/W1901989107","https://openalex.org/W1917872578","https://openalex.org/W1951164890","https://openalex.org/W1965533737","https://openalex.org/W1974917488","https://openalex.org/W1997560169","https://openalex.org/W1999899180","https://openalex.org/W2011356981","https://openalex.org/W2031567515","https://openalex.org/W2040183090","https://openalex.org/W2064505443","https://openalex.org/W2070943463","https://openalex.org/W2076398951","https://openalex.org/W2105077075","https://openalex.org/W2137259085","https://openalex.org/W2139220679","https://openalex.org/W2147649244","https://openalex.org/W2151361725","https://openalex.org/W2251131472","https://openalex.org/W2345850446"],"related_works":["https://openalex.org/W230796657","https://openalex.org/W2125866523","https://openalex.org/W4229707846","https://openalex.org/W2101852933","https://openalex.org/W1994513272","https://openalex.org/W2001064571","https://openalex.org/W2166730758","https://openalex.org/W2032604903","https://openalex.org/W2001535873","https://openalex.org/W3004871855"],"abstract_inverted_index":{"Thirty-six":[0],"monoclonal":[1],"antibodies":[2,84],"to":[3,21,26,92,105],"the":[4,62,66,75,86,98],"protective":[5,41,90,103],"antigen":[6,42,91,104],"protein":[7],"of":[8,64,88,102,112],"Bacillus":[9],"anthracis":[10],"exotoxin":[11],"have":[12],"been":[13],"characterized":[14],"for":[15,55,110],"affinity,":[16],"antibody":[17],"subtype,":[18],"competitive":[19],"binding":[20,87,101],"antigenic":[22,36,58],"regions,":[23],"and":[24,29,52,60,74],"ability":[25],"neutralize":[27],"lethal":[28,67],"edema":[30,76],"toxin":[31,68,77],"activities.":[32],"At":[33],"least":[34],"23":[35],"regions":[37],"were":[38],"detected":[39],"on":[40],"by":[43],"a":[44,56],"blocking,":[45],"enzyme-linked":[46],"immunosorbent":[47],"assay.":[48],"Two":[49],"clones,":[50],"3B6":[51],"14B7,":[53],"competed":[54],"single":[57],"region":[59],"neutralized":[61],"activity":[63],"both":[65],"in":[69,78],"vivo":[70],"(Fisher":[71],"344":[72],"rat)":[73],"vitro":[79],"(CHO":[80],"cells).":[81],"These":[82],"two":[83],"blocked":[85],"125I-labeled":[89],"FRL-103":[93],"cells.":[94],"Our":[95],"results":[96],"support":[97],"proposal":[99],"that":[100],"cell":[106],"receptors":[107],"is":[108],"required":[109],"expression":[111],"toxicity.":[113]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
