{"id":"https://openalex.org/W2158989840","doi":"https://doi.org/10.1074/jbc.m112.442285","title":"The Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in Oligomerization","display_name":"The Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in Oligomerization","publication_year":2013,"publication_date":"2013-01-24","ids":{"openalex":"https://openalex.org/W2158989840","doi":"https://doi.org/10.1074/jbc.m112.442285","mag":"2158989840","pmid":"https://pubmed.ncbi.nlm.nih.gov/23344952","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3605634"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.442285","doi":"https://doi.org/10.1074/jbc.m112.442285","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.442285","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m112.442285","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028585720","display_name":"Christopher A. G. S\u00f6derberg","orcid":"https://orcid.org/0000-0002-0850-2676","observed_orcids":["https://orcid.org/0000-0002-0850-2676"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christopher A.G. S\u00f6derberg","raw_affiliation_strings":["Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000496754","display_name":"S. S. Rajan","orcid":"https://orcid.org/0000-0003-4453-3936","observed_orcids":["https://orcid.org/0000-0003-4453-3936"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sreekanth Rajan","raw_affiliation_strings":["Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040738906","display_name":"Alexander V. Shkumatov","orcid":"https://orcid.org/0000-0001-7281-9291","observed_orcids":["https://orcid.org/0000-0001-7281-9291"]},"institutions":[{"id":"https://openalex.org/I2801876189","display_name":"Deutsches Elektronen-Synchrotron DESY","ror":"https://ror.org/01js2sh04","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801876189"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander V. Shkumatov","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL), Hamburg Unit c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), Hamburg Unit c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany","institution_ids":["https://openalex.org/I2801876189","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016287902","display_name":"Oleksandr Gakh","orcid":"https://orcid.org/0000-0003-3708-1118","observed_orcids":["https://orcid.org/0000-0003-3708-1118"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleksandr Gakh","raw_affiliation_strings":["Departments of Pediatric and Adolescent Medicine and Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatric and Adolescent Medicine and Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Susanne Schaefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Susanne Schaefer","raw_affiliation_strings":["Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007858388","display_name":"Eva-Christina Ahlgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eva-Christina Ahlgren","raw_affiliation_strings":["Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081712139","display_name":"Dmitri I. Svergun","orcid":"https://orcid.org/0000-0003-0830-5696","observed_orcids":["https://orcid.org/0000-0003-0830-5696"]},"institutions":[{"id":"https://openalex.org/I2801876189","display_name":"Deutsches Elektronen-Synchrotron DESY","ror":"https://ror.org/01js2sh04","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801876189"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dmitri I. Svergun","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL), Hamburg Unit c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), Hamburg Unit c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany","institution_ids":["https://openalex.org/I2801876189","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065330135","display_name":"Grazia Isaya","orcid":"https://orcid.org/0000-0002-3459-8595","observed_orcids":["https://orcid.org/0000-0002-3459-8595"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Grazia Isaya","raw_affiliation_strings":["Departments of Pediatric and Adolescent Medicine and Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905. Electronic address: isaya@mayo.edu","Departments of Pediatric and Adolescent Medicine and Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatric and Adolescent Medicine and Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905. Electronic address: isaya@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Departments of Pediatric and Adolescent Medicine and Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078557226","display_name":"Salam Al\u2010Karadaghi","orcid":"https://orcid.org/0000-0001-8608-0635","observed_orcids":["https://orcid.org/0000-0001-8608-0635"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Salam Al-Karadaghi","raw_affiliation_strings":["Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden. Electronic address: salam.al-karadaghi@biochemistry.lu.se","Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden. Electronic address: salam.al-karadaghi@biochemistry.lu.se","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Center for Molecular Protein Science, Institute for Chemistry and Chemical Engineering, Lund University, P. O. Box 124, SE-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065330135","https://openalex.org/A5078557226"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I187531555"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4375,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.79048365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"288","issue":"12","first_page":"8156","last_page":"8167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frataxin","display_name":"frataxin","score":1.0},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.8579999804496765},{"id":"https://openalex.org/keywords/iron-chaperone","display_name":"iron chaperone","score":0.8529999852180481},{"id":"https://openalex.org/keywords/iron-storage","display_name":"iron storage","score":0.43700000643730164},{"id":"https://openalex.org/keywords/iron-sulfur-cluster-assembly","display_name":"iron-sulfur cluster assembly","score":0.7020000219345093},{"id":"https://openalex.org/keywords/yfh1","display_name":"Yfh1","score":0.7369999885559082},{"id":"https://openalex.org/keywords/protein-solution-structure","display_name":"protein solution structure","score":0.5659999847412109},{"id":"https://openalex.org/keywords/iron-binding","display_name":"iron binding","score":0.4880000054836273},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mitochondrial-iron-metabolism","display_name":"mitochondrial iron metabolism","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2779314966","wikidata":"https://www.wikidata.org/wiki/Q409999","display_name":"Frataxin","level":4,"score":0.9793577194213867},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.8934087157249451},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.726257860660553},{"id":"https://openalex.org/C189754071","wikidata":"https://www.wikidata.org/wiki/Q7291972","display_name":"Random hexamer","level":2,"score":0.6703113913536072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6359665989875793},{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.5747780203819275},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.5647627115249634},{"id":"https://openalex.org/C2779369046","wikidata":"https://www.wikidata.org/wiki/Q6072234","display_name":"Iron-binding proteins","level":3,"score":0.5071060657501221},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4566565752029419},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.45429790019989014},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.42639437317848206},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4010290503501892},{"id":"https://openalex.org/C200886947","wikidata":"https://www.wikidata.org/wiki/Q342083","display_name":"Aconitase","level":3,"score":0.3779444098472595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3589784801006317},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.34759530425071716},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.1841246783733368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18119767308235168},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09711810946464539},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000096923","descriptor_name":"Frataxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D033862","descriptor_name":"Iron-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033862","descriptor_name":"Iron-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053838","descriptor_name":"Scattering, Small Angle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1074/jbc.m112.442285","doi":"https://doi.org/10.1074/jbc.m112.442285","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.442285","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2940071","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3605634","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3605634","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3605634","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:23344952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23344952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:bib-pubdb1.desy.de:148379","doi":null,"is_oa":false,"landing_page_url":"https://bib-pubdb1.desy.de/record/148379","pdf_url":null,"source":{"id":"https://openalex.org/S4377196278","display_name":"Desy Publications Database (Deutsches Elektronen-Synchrotron DESY)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801876189","host_organization_name":"Deutsches Elektronen-Synchrotron DESY","host_organization_lineage":["https://openalex.org/I2801876189"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of biological chemistry 288, 8156 (2013). doi:10.1074/jbc.M112.442285","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lup.lub.lu.se:1f5078cc-84f1-4eb4-ba7e-b8f375d7fdc2","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/3438417","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1083-351X","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2188405319","doi":null,"is_oa":false,"landing_page_url":"https://www.jbc.org/content/288/12/8156.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.442285","doi":"https://doi.org/10.1074/jbc.m112.442285","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.442285","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7597708529","display_name":"New Determinants of mtDNA Integrity in Yeast and Heart","funder_award_id":"R01AG015709","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W263234349","https://openalex.org/W1577212167","https://openalex.org/W1604284211","https://openalex.org/W1967350387","https://openalex.org/W1977013265","https://openalex.org/W1977038370","https://openalex.org/W1982126789","https://openalex.org/W1984104940","https://openalex.org/W1984218254","https://openalex.org/W1985093325","https://openalex.org/W1986581289","https://openalex.org/W1989255793","https://openalex.org/W1991166915","https://openalex.org/W1991357892","https://openalex.org/W1994839139","https://openalex.org/W1998500812","https://openalex.org/W2004049878","https://openalex.org/W2007804411","https://openalex.org/W2014020549","https://openalex.org/W2015291802","https://openalex.org/W2021579813","https://openalex.org/W2022541418","https://openalex.org/W2024138709","https://openalex.org/W2027903172","https://openalex.org/W2029582401","https://openalex.org/W2030356875","https://openalex.org/W2031873349","https://openalex.org/W2034986522","https://openalex.org/W2035503835","https://openalex.org/W2044720698","https://openalex.org/W2050091361","https://openalex.org/W2050254511","https://openalex.org/W2058276214","https://openalex.org/W2062094479","https://openalex.org/W2064250654","https://openalex.org/W2066088601","https://openalex.org/W2072654958","https://openalex.org/W2074981631","https://openalex.org/W2075817699","https://openalex.org/W2076403457","https://openalex.org/W2077687448","https://openalex.org/W2080731376","https://openalex.org/W2082351355","https://openalex.org/W2088038616","https://openalex.org/W2091848369","https://openalex.org/W2094754882","https://openalex.org/W2095217602","https://openalex.org/W2096032513","https://openalex.org/W2102144538","https://openalex.org/W2105822562","https://openalex.org/W2109745203","https://openalex.org/W2114622716","https://openalex.org/W2115953418","https://openalex.org/W2120039680","https://openalex.org/W2124026197","https://openalex.org/W2124983865","https://openalex.org/W2125078806","https://openalex.org/W2137015675","https://openalex.org/W2146149050","https://openalex.org/W2148047088","https://openalex.org/W2154254146","https://openalex.org/W2158155007","https://openalex.org/W2159509177","https://openalex.org/W2163221921","https://openalex.org/W2163341755","https://openalex.org/W2164361934","https://openalex.org/W2168176110","https://openalex.org/W2168201480","https://openalex.org/W2169150541","https://openalex.org/W2171678792","https://openalex.org/W2172203290","https://openalex.org/W2180229411","https://openalex.org/W2201713963","https://openalex.org/W2590763898","https://openalex.org/W2607732975","https://openalex.org/W4247088117","https://openalex.org/W4248872320","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2188405319","https://openalex.org/W818085375","https://openalex.org/W2754071562","https://openalex.org/W1977013265","https://openalex.org/W2009265061","https://openalex.org/W2021579813","https://openalex.org/W2094754882","https://openalex.org/W7095686462","https://openalex.org/W2064250654","https://openalex.org/W2318653168"],"abstract_inverted_index":{"The":[0,95,113,216],"role":[1],"of":[2,40,43,61,69,81,140,150,180,195,207,213,221,225,231,243],"the":[3,28,38,41,58,62,66,83,101,126,136,151,156,160,168,176,192,208,222,232,235,241],"mitochondrial":[4],"protein":[5,152],"frataxin":[6,44,172,181,226],"in":[7,93,97,155],"iron":[8,12,123,177],"storage":[9],"and":[10,20,46,53,72,174,182,240],"detoxification,":[11],"delivery":[13],"to":[14,89,132],"iron-sulfur":[15],"cluster":[16],"biosynthesis,":[17,19],"heme":[18],"aconitase":[21],"repair":[22],"has":[23],"been":[24],"extensively":[25],"studied":[26],"during":[27,65,246],"last":[29],"decade.":[30],"However,":[31],"still":[32,145],"no":[33],"general":[34],"consensus":[35],"exists":[36],"on":[37],"details":[39],"mechanism":[42],"function":[45,179,227],"oligomerization.":[47],"Here,":[48],"using":[49],"small-angle":[50],"x-ray":[51,54,114],"scattering":[52],"crystallography,":[55],"we":[56],"describe":[57],"solution":[59],"structure":[60,116,242],"oligomers":[63,107,198,244],"formed":[64,245],"iron-dependent":[67,142],"assembly":[68,102,173,193],"yeast":[70],"(Yfh1)":[71],"Escherichia":[73],"coli":[74,190],"(CyaY)":[75],"frataxin.":[76],"At":[77],"an":[78,205],"iron-to-protein":[79,111,162],"ratio":[80,163],"2,":[82],"initially":[84],"monomeric":[85,157],"Yfh1":[86],"is":[87,153,199],"converted":[88],"a":[90,200],"trimeric":[91],"form":[92],"solution.":[94],"trimer":[96],"turn":[98],"serves":[99],"as":[100],"unit":[103,194],"for":[104],"higher":[105,110,196],"order":[106,197],"induced":[108],"at":[109,125,159],"ratios.":[112],"crystallographic":[115],"obtained":[117],"from":[118],"iron-soaked":[119],"crystals":[120],"demonstrates":[121,166],"that":[122,167,219],"binds":[124],"trimer-trimer":[127],"interaction":[128],"sites,":[129],"presumably":[130,175],"contributing":[131],"oligomer":[133],"stabilization.":[134],"For":[135,188],"ferroxidation-deficient":[137],"D79A/D82A":[138],"variant":[139],"Yfh1,":[141],"oligomerization":[143],"may":[144],"take":[146],"place,":[147],"although":[148],">50%":[149],"found":[154],"state":[158],"highest":[161],"used.":[164],"This":[165],"ferroxidation":[169,236],"reaction":[170],"controls":[171],"chaperone":[178],"its":[183],"interactions":[184],"with":[185],"target":[186],"proteins.":[187],"E.":[189],"CyaY,":[191],"tetramer,":[201],"which":[202],"could":[203],"be":[204],"effect":[206],"much":[209],"shorter":[210],"N-terminal":[211],"region":[212],"this":[214],"protein.":[215],"results":[217],"show":[218],"understanding":[220],"mechanistic":[223],"features":[224],"requires":[228],"detailed":[229],"knowledge":[230],"interplay":[233],"between":[234],"reaction,":[237],"iron-induced":[238],"oligomerization,":[239],"assembly.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}