{"id":"https://openalex.org/W2158967285","doi":"https://doi.org/10.1146/annurev-micro-091313-103537","title":"The Peculiarities and Paradoxes of Plasmodium Heme Metabolism","display_name":"The Peculiarities and Paradoxes of Plasmodium Heme Metabolism","publication_year":2014,"publication_date":"2014-06-27","ids":{"openalex":"https://openalex.org/W2158967285","doi":"https://doi.org/10.1146/annurev-micro-091313-103537","mag":"2158967285","pmid":"https://pubmed.ncbi.nlm.nih.gov/25002093"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-micro-091313-103537","doi":"https://doi.org/10.1146/annurev-micro-091313-103537","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-micro-091313-103537","pdf_url":null,"source":{"id":"https://openalex.org/S82779230","display_name":"Annual Review of Microbiology","issn_l":"0066-4227","issn":["0066-4227","1545-3251"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063744332","display_name":"Paul A. Sigala","orcid":"https://orcid.org/0000-0002-3464-3042","observed_orcids":["https://orcid.org/0000-0002-3464-3042"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Sigala","raw_affiliation_strings":["Departments of Medicine and Molecular Microbiology and the Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Molecular Microbiology and the Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110;,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029982946","display_name":"Daniel E. Goldberg","orcid":"https://orcid.org/0000-0003-3529-8399","observed_orcids":["https://orcid.org/0000-0003-3529-8399"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E. Goldberg","raw_affiliation_strings":["Departments of Medicine and Molecular Microbiology and the Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Molecular Microbiology and the Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110;,","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.62,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.82830056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"68","issue":"1","first_page":"259","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium","display_name":"Plasmodium","score":0.9829999804496765},{"id":"https://openalex.org/keywords/heme-metabolism","display_name":"heme metabolism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hemozoin","display_name":"hemozoin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.6079999804496765},{"id":"https://openalex.org/keywords/digestive-vacuole","display_name":"digestive vacuole","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hemoglobin-degradation","display_name":"hemoglobin degradation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/electron-transport","display_name":"electron transport","score":0.6650000214576721},{"id":"https://openalex.org/keywords/antimalarial-drug-targets","display_name":"antimalarial drug targets","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.9398473501205444},{"id":"https://openalex.org/C2776028358","wikidata":"https://www.wikidata.org/wiki/Q3144960","display_name":"Hemozoin","level":4,"score":0.8777092695236206},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.6752141714096069},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5620095729827881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5617966651916504},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.54967200756073},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5077289342880249},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.4995136260986328},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.49240219593048096},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.43547338247299194},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4111180305480957},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.372169554233551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3515271544456482},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.13548746705055237},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10350075364112854},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.101724773645401},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D010961","descriptor_name":"Plasmodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev-micro-091313-103537","doi":"https://doi.org/10.1146/annurev-micro-091313-103537","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-micro-091313-103537","pdf_url":null,"source":{"id":"https://openalex.org/S82779230","display_name":"Annual Review of Microbiology","issn_l":"0066-4227","issn":["0066-4227","1545-3251"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Microbiology","raw_type":"journal-article"},{"id":"pmid:25002093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25002093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W30387893","https://openalex.org/W1493715460","https://openalex.org/W1512031035","https://openalex.org/W1551787983","https://openalex.org/W1963603371","https://openalex.org/W1963775811","https://openalex.org/W1964184807","https://openalex.org/W1965834391","https://openalex.org/W1975398334","https://openalex.org/W1976977157","https://openalex.org/W1977153934","https://openalex.org/W1978653284","https://openalex.org/W1979821380","https://openalex.org/W1980079347","https://openalex.org/W1980141830","https://openalex.org/W1987793605","https://openalex.org/W1988000537","https://openalex.org/W1990392794","https://openalex.org/W1990713801","https://openalex.org/W1990814829","https://openalex.org/W1991946877","https://openalex.org/W1993798031","https://openalex.org/W1994184498","https://openalex.org/W1994787682","https://openalex.org/W1994913181","https://openalex.org/W1996070288","https://openalex.org/W1997554053","https://openalex.org/W2001455540","https://openalex.org/W2002249679","https://openalex.org/W2002258545","https://openalex.org/W2002897522","https://openalex.org/W2003590875","https://openalex.org/W2006156671","https://openalex.org/W2006250595","https://openalex.org/W2006620950","https://openalex.org/W2006754144","https://openalex.org/W2007972419","https://openalex.org/W2008186052","https://openalex.org/W2011048815","https://openalex.org/W2012758550","https://openalex.org/W2014387796","https://openalex.org/W2016657576","https://openalex.org/W2016950428","https://openalex.org/W2017094915","https://openalex.org/W2019673916","https://openalex.org/W2019851585","https://openalex.org/W2019995806","https://openalex.org/W2020755315","https://openalex.org/W2021650047","https://openalex.org/W2022857214","https://openalex.org/W2023633070","https://openalex.org/W2025605230","https://openalex.org/W2025706175","https://openalex.org/W2025765364","https://openalex.org/W2029665225","https://openalex.org/W2029888972","https://openalex.org/W2030750846","https://openalex.org/W2030803205","https://openalex.org/W2031257231","https://openalex.org/W2031292552","https://openalex.org/W2033702197","https://openalex.org/W2034636049","https://openalex.org/W2035062424","https://openalex.org/W2036181226","https://openalex.org/W2040765604","https://openalex.org/W2041036994","https://openalex.org/W2044909283","https://openalex.org/W2045091823","https://openalex.org/W2048160714","https://openalex.org/W2049237667","https://openalex.org/W2049368235","https://openalex.org/W2049803882","https://openalex.org/W2050052884","https://openalex.org/W2050175672","https://openalex.org/W2051447459","https://openalex.org/W2051989645","https://openalex.org/W2065314419","https://openalex.org/W2069228382","https://openalex.org/W2069360787","https://openalex.org/W2070136956","https://openalex.org/W2071219983","https://openalex.org/W2071534580","https://openalex.org/W2073586827","https://openalex.org/W2074082512","https://openalex.org/W2077159435","https://openalex.org/W2078353494","https://openalex.org/W2079968363","https://openalex.org/W2080412532","https://openalex.org/W2080661532","https://openalex.org/W2081078606","https://openalex.org/W2081828257","https://openalex.org/W2082992930","https://openalex.org/W2083280521","https://openalex.org/W2084340821","https://openalex.org/W2085162215","https://openalex.org/W2088123956","https://openalex.org/W2090632234","https://openalex.org/W2091524167","https://openalex.org/W2092604097","https://openalex.org/W2097992909","https://openalex.org/W2099136192","https://openalex.org/W2102170011","https://openalex.org/W2106198832","https://openalex.org/W2107919511","https://openalex.org/W2108523194","https://openalex.org/W2110343132","https://openalex.org/W2114296160","https://openalex.org/W2121356018","https://openalex.org/W2121913308","https://openalex.org/W2122247250","https://openalex.org/W2122838518","https://openalex.org/W2124634096","https://openalex.org/W2124773255","https://openalex.org/W2126361514","https://openalex.org/W2128378359","https://openalex.org/W2129248052","https://openalex.org/W2132673947","https://openalex.org/W2133664005","https://openalex.org/W2133972984","https://openalex.org/W2134213012","https://openalex.org/W2135155264","https://openalex.org/W2137713074","https://openalex.org/W2138488546","https://openalex.org/W2140473789","https://openalex.org/W2151694266","https://openalex.org/W2152471631","https://openalex.org/W2155625237","https://openalex.org/W2158040122","https://openalex.org/W2163331958","https://openalex.org/W2164038674","https://openalex.org/W2166369726","https://openalex.org/W2167970645","https://openalex.org/W2168855679","https://openalex.org/W2168989177","https://openalex.org/W2169952241","https://openalex.org/W2170133970","https://openalex.org/W2952826562","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2757850448","https://openalex.org/W91444433","https://openalex.org/W2013077627","https://openalex.org/W2080661532","https://openalex.org/W3006157380","https://openalex.org/W7095386779","https://openalex.org/W2507376633","https://openalex.org/W2084707771","https://openalex.org/W1980079347","https://openalex.org/W7135962261"],"abstract_inverted_index":{"For":[0],"over":[1],"a":[2,11,34,58,70],"century,":[3],"heme":[4,32,44,56,81,117,134],"metabolism":[5,135],"has":[6,75],"been":[7,76],"recognized":[8],"to":[9,63,78],"play":[10],"central":[12],"role":[13],"during":[14],"intraerythrocytic":[15],"infection":[16],"by":[17,121],"Plasmodium":[18,52,103],"parasites,":[19,122],"the":[20,40,80,99],"causative":[21],"agent":[22],"of":[23,29,36,98],"malaria.":[24],"Parasites":[25],"liberate":[26],"vast":[27],"quantities":[28],"potentially":[30],"cytotoxic":[31],"as":[33,48,57],"by-product":[35],"hemoglobin":[37],"catabolism":[38],"within":[39,136],"digestive":[41],"vacuole,":[42],"where":[43],"is":[45],"predominantly":[46],"sequestered":[47],"inert":[49],"crystalline":[50],"hemozoin.":[51],"spp.":[53],"also":[54],"utilize":[55],"metabolic":[59],"cofactor.":[60],"Despite":[61],"access":[62],"abundant":[64],"host-derived":[65],"heme,":[66,106],"parasites":[67,104],"paradoxically":[68],"maintain":[69],"biosynthetic":[71],"pathway.":[72],"This":[73],"pathway":[74],"assumed":[77],"produce":[79],"incorporated":[82],"into":[83],"mitochondrial":[84],"cytochromes":[85],"that":[86,111],"support":[87],"electron":[88],"transport.":[89],"In":[90],"this":[91],"review,":[92],"we":[93,107,124],"assess":[94],"our":[95],"current":[96],"understanding":[97,131],"love-hate":[100],"relationship":[101],"between":[102],"and":[105,119,123,128,132],"discuss":[108],"recent":[109],"studies":[110],"clarify":[112],"several":[113],"long-standing":[114],"riddles":[115],"about":[116],"production":[118],"utilization":[120],"consider":[125],"remaining":[126],"challenges":[127],"opportunities":[129],"for":[130],"targeting":[133],"parasites.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
