{"id":"https://openalex.org/W2158964347","doi":"https://doi.org/10.1074/jbc.273.41.26755","title":"ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase","display_name":"ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2158964347","doi":"https://doi.org/10.1074/jbc.273.41.26755","mag":"2158964347","pmid":"https://pubmed.ncbi.nlm.nih.gov/9756919"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.41.26755","doi":"https://doi.org/10.1074/jbc.273.41.26755","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.41.26755","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.273.41.26755","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019349365","display_name":"Sylvaine Cases","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvaine Cases","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110402422","display_name":"Sabine Novak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabine Novak","raw_affiliation_strings":["Cardiovascular Research Institute, San Francisco, California 94141","Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, San Francisco, California 94141","institution_ids":[]},{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111797751","display_name":"Yao-Wu Zheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yao-Wu Zheng","raw_affiliation_strings":["Cardiovascular Research Institute, San Francisco, California 94141"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, San Francisco, California 94141","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Heather M. Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather M. Myers","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025976292","display_name":"Steven R. Lear","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Lear","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco, California 94141","Veterans Administration Medical Center, San Francisco, California 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California 94141","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Veterans Administration Medical Center, San Francisco, California 94121","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113543464","display_name":"Eric Sande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Sande","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018185033","display_name":"Carrie L. Welch","orcid":"https://orcid.org/0000-0003-3521-4458","observed_orcids":["https://orcid.org/0000-0003-3521-4458"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie B. Welch","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Department of Medicine, and Molecular Biology Institute, University of California, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Department of Medicine, and Molecular Biology Institute, University of California, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024741961","display_name":"Aldons Jake Lusis","orcid":"https://orcid.org/0000-0001-9013-0228","observed_orcids":["https://orcid.org/0000-0001-9013-0228"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aldons J. Lusis","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Department of Medicine, and Molecular Biology Institute, University of California, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Department of Medicine, and Molecular Biology Institute, University of California, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057809374","display_name":"Thomas A. Spencer","orcid":"https://orcid.org/0000-0001-5736-0582","observed_orcids":["https://orcid.org/0000-0001-5736-0582"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Spencer","raw_affiliation_strings":["Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109888970","display_name":"Brian R. Krause","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian R. Krause","raw_affiliation_strings":["Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111858331","display_name":"Sandra K. Erickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra K. Erickson","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco, California 94141","Veterans Administration Medical Center, San Francisco, California 94121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California 94141","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Veterans Administration Medical Center, San Francisco, California 94121","institution_ids":["https://openalex.org/I1315708478"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083674919","display_name":"Robert V. Farese","orcid":"https://orcid.org/0000-0001-8103-2239","observed_orcids":["https://orcid.org/0000-0001-8103-2239"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert V. Farese","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco, California 94141","Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California 94141","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141","institution_ids":["https://openalex.org/I1321430492"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083674919"],"corresponding_institution_ids":["https://openalex.org/I1321430492","https://openalex.org/I180670191"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":11.0265,"has_fulltext":false,"cited_by_count":389,"citation_normalized_percentile":{"value":0.99569378,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"273","issue":"41","first_page":"26755","last_page":"26764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyl-coa-cholesterol-acyltransferase","display_name":"acyl-CoA:cholesterol acyltransferase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cholesterol-esterification","display_name":"cholesterol esterification","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cholesteryl-ester-synthesis","display_name":"cholesteryl ester synthesis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/acat1","display_name":"ACAT1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/acat-inhibitors","display_name":"ACAT inhibitors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/tissue-expression","display_name":"tissue expression","score":0.5019999742507935},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7070000171661377},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/chromosome-15","display_name":"chromosome 15","score":0.746999979019165},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.7080000042915344},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/intestinal-cholesterol-absorption","display_name":"intestinal cholesterol absorption","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.9384355545043945},{"id":"https://openalex.org/C2779685201","wikidata":"https://www.wikidata.org/wiki/Q2699537","display_name":"Acyl-CoA","level":3,"score":0.7389618754386902},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6484704613685608},{"id":"https://openalex.org/C89673097","wikidata":"https://www.wikidata.org/wiki/Q14907373","display_name":"Cholesterol 7 alpha-hydroxylase","level":3,"score":0.6354464888572693},{"id":"https://openalex.org/C2910079589","wikidata":"https://www.wikidata.org/wiki/Q2609152","display_name":"Acyltransferases","level":4,"score":0.6137557625770569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5379498600959778},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5191642045974731},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5154374837875366},{"id":"https://openalex.org/C110459506","wikidata":"https://www.wikidata.org/wiki/Q7318217","display_name":"Reverse cholesterol transport","level":4,"score":0.5024285316467285},{"id":"https://openalex.org/C2776448209","wikidata":"https://www.wikidata.org/wiki/Q415555","display_name":"Cholesteryl ester","level":4,"score":0.4525834321975708},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34025245904922485},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3287745714187622},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.23734697699546814},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.14346542954444885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016367","descriptor_name":"Baculoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018411","descriptor_name":"Spodoptera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.41.26755","doi":"https://doi.org/10.1074/jbc.273.41.26755","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.41.26755","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9756919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9756919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.41.26755","doi":"https://doi.org/10.1074/jbc.273.41.26755","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.41.26755","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1880246782","display_name":"OXYSTEROL REGULATION OF CHOLESTEROL METABOLISM","funder_award_id":"R01HL052069","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G488389715","display_name":null,"funder_award_id":"HL-42488","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6536301463","display_name":"Investigation of ACAT Functions Using Knockout","funder_award_id":"R01HL057170","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W644717607","https://openalex.org/W1490548175","https://openalex.org/W1499573413","https://openalex.org/W1500619872","https://openalex.org/W1552571969","https://openalex.org/W1567966142","https://openalex.org/W1587455807","https://openalex.org/W1762207328","https://openalex.org/W1772398232","https://openalex.org/W1823018609","https://openalex.org/W1830912132","https://openalex.org/W1898264975","https://openalex.org/W1903300978","https://openalex.org/W1954198545","https://openalex.org/W1964278353","https://openalex.org/W1965394772","https://openalex.org/W1969326283","https://openalex.org/W1977828235","https://openalex.org/W1982641958","https://openalex.org/W1983130452","https://openalex.org/W1989024478","https://openalex.org/W1994050381","https://openalex.org/W1994166619","https://openalex.org/W1996168740","https://openalex.org/W1997167574","https://openalex.org/W2010266390","https://openalex.org/W2011101734","https://openalex.org/W2012431524","https://openalex.org/W2016375553","https://openalex.org/W2018917785","https://openalex.org/W2022923134","https://openalex.org/W2028123717","https://openalex.org/W2030046033","https://openalex.org/W2040492211","https://openalex.org/W2045902945","https://openalex.org/W2046478229","https://openalex.org/W2052985926","https://openalex.org/W2055240842","https://openalex.org/W2058820558","https://openalex.org/W2066674794","https://openalex.org/W2068345120","https://openalex.org/W2078406520","https://openalex.org/W2098919692","https://openalex.org/W2102589304","https://openalex.org/W2124760389","https://openalex.org/W2135007868","https://openalex.org/W2144230929","https://openalex.org/W2146409387","https://openalex.org/W2160040803","https://openalex.org/W2162458714","https://openalex.org/W2162459202","https://openalex.org/W2169502881","https://openalex.org/W2248897797","https://openalex.org/W2342920521","https://openalex.org/W2345318649","https://openalex.org/W2402730912","https://openalex.org/W2415979451","https://openalex.org/W3004782929"],"related_works":["https://openalex.org/W2977531087","https://openalex.org/W1979830788","https://openalex.org/W2022923134","https://openalex.org/W2006831721","https://openalex.org/W2020585666","https://openalex.org/W2169792817","https://openalex.org/W1954198545","https://openalex.org/W2362032512","https://openalex.org/W143007151","https://openalex.org/W2063960234"],"abstract_inverted_index":{"The":[0,206,227],"synthesis":[1],"of":[2,15,54,106,118,132,144,148,151,169,182,231,241],"cholesterol":[3,17,34,133,201,225],"esters":[4],"by":[5],"acyl-CoA:cholesterol":[6],"acyltransferase":[7],"(ACAT,":[8],"EC":[9],"2.3.1.26)":[10],"is":[11,23,75,93],"an":[12,111],"important":[13,27,76],"component":[14],"cellular":[16],"homeostasis.":[18],"Cholesterol":[19,153],"ester":[20],"formation":[21,43],"also":[22,140],"hypothesized":[24],"to":[25,96,200,212,237],"be":[26],"in":[28,44,68,77,116,123,166,188,203,215,244],"several":[29,170],"physiologic":[30],"processes,":[31],"including":[32],"intestinal":[33],"absorption,":[35],"hepatic":[36],"lipoprotein":[37],"production,":[38],"and":[39,51,70,80,138,158,191,229],"macrophage":[40],"foam":[41],"cell":[42,124],"atherosclerotic":[45],"lesions.":[46],"Mouse":[47],"tissue":[48],"expression":[49,117],"studies":[50],"the":[52,55,97,142,145,167,195,239],"disruption":[53],"mouse":[56,78,100,189,207],"ACAT":[57,66,88,101,175,242],"gene":[58,209],"(Acact)":[59],"have":[60],"indicated":[61],"that":[62,72,92,126,174,197],"more":[63],"than":[64],"one":[65],"exists":[67],"mammals":[69],"specifically":[71],"another":[73],"enzyme":[74],"liver":[79,190],"intestine.":[81],"We":[82],"now":[83],"describe":[84],"a":[85,119,149,216,219],"second":[86],"mammalian":[87,245],"enzyme,":[89],"designated":[90,103],"ACAT-2,":[91],"44%":[94],"identical":[95],"first":[98],"cloned":[99],"(henceforth":[102],"ACAT-1).":[104],"Infection":[105],"H5":[107],"insect":[108],"cells":[109],"with":[110,129],"ACAT-2":[112,139,159,184,198,208,232],"recombinant":[113],"baculovirus":[114],"resulted":[115],"approximately":[120],"46-kDa":[121],"protein":[122],"membranes":[125],"was":[127,185],"associated":[128],"high":[130],"levels":[131],"esterification":[134,143,154,202],"activity.":[135],"Both":[136],"ACAT-1":[137,157],"catalyzed":[141],"3beta-hydroxyl":[146],"group":[147],"variety":[150],"oxysterols.":[152],"activities":[155],"for":[156],"exhibited":[160],"different":[161],"IC50":[162],"values":[163],"when":[164],"assayed":[165],"presence":[168],"ACAT-specific":[171],"inhibitors,":[172],"demonstrating":[173],"inhibitors":[176],"can":[177],"selectively":[178],"target":[179],"specific":[180],"forms":[181],"ACAT.":[183],"expressed":[186],"primarily":[187],"small":[192],"intestine,":[193],"supporting":[194],"hypothesis":[196],"contributes":[199],"these":[204],"tissues.":[205],"(Acact2)":[210],"maps":[211],"chromosome":[213],"15":[214],"region":[217],"containing":[218],"quantitative":[220],"trait":[221],"locus":[222],"influencing":[223],"plasma":[224],"levels.":[226],"identification":[228],"cloning":[230],"will":[233],"facilitate":[234],"molecular":[235],"approaches":[236],"understanding":[238],"role":[240],"enzymes":[243],"biology.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
