{"id":"https://openalex.org/W2158917955","doi":null,"title":"The Impact of Conventional and Carbon Ion Irradiation on Metastatic Potential of Tumor Cells","display_name":"The Impact of Conventional and Carbon Ion Irradiation on Metastatic Potential of Tumor Cells","publication_year":2014,"publication_date":"2014-10-18","ids":{"openalex":"https://openalex.org/W2158917955","mag":"2158917955"},"language":"en","primary_location":{"id":"mag:2158917955","doi":null,"is_oa":false,"landing_page_url":"http://www.ghrnet.org/index.php/JT/article/download/873/982","pdf_url":null,"source":{"id":"https://openalex.org/S2764864537","display_name":"Journal of Tumor","issn_l":"1819-6187","issn":["1819-6187","2410-7417"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Tumor","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090813567","display_name":"Mu-Tai Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mu-Tai Liu","raw_affiliation_strings":["Changhua Christian Medical Center, Chang Shan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changhua Christian Medical Center, Chang Shan Medical University","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102109989","display_name":"Tung-Hao Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tung-Hao Chang","raw_affiliation_strings":["Changhua Christian Medical Center, Chang Shan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changhua Christian Medical Center, Chang Shan Medical University","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080149007","display_name":"Mu\u2010Kuan Chen","orcid":"https://orcid.org/0000-0002-6242-1842","observed_orcids":["https://orcid.org/0000-0002-6242-1842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mu\u2010Kuan Chen","raw_affiliation_strings":["Chang Shan Medical University"],"raw_orcid":"https://orcid.org/0000-0002-6242-1842","affiliations":[{"raw_affiliation_string":"Chang Shan Medical University","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112836775","display_name":"Shou\u2010Jen Kuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shou\u2010Jen Kuo","raw_affiliation_strings":["Chang Shan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chang Shan Medical University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"9","first_page":"241","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.2865999937057495,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbon-ion-irradiation","display_name":"carbon ion irradiation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/heavy-ion-radiotherapy","display_name":"heavy ion radiotherapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/radiation-induced-metastasis","display_name":"radiation-induced metastasis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.656000018119812},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.6299999952316284},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.828000009059906},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8569999933242798},{"id":"https://openalex.org/keywords/integrin-alpha2beta1","display_name":"alpha2beta1 integrin","score":0.843999981880188},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9039999842643738},{"id":"https://openalex.org/keywords/vandetanib","display_name":"vandetanib","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8019999861717224},{"id":"https://openalex.org/keywords/patupilone","display_name":"patupilone","score":0.9679999947547913},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7383421659469604},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.6220217347145081},{"id":"https://openalex.org/C2780333294","wikidata":"https://www.wikidata.org/wiki/Q7914515","display_name":"Vandetanib","level":4,"score":0.621753990650177},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6141142249107361},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5867418646812439},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.548965573310852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5437288880348206},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.49277761578559875},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44039615988731384},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.43698686361312866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42970699071884155},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.26128876209259033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2581201493740082},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25071871280670166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23027223348617554},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1414015293121338},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.09737071394920349},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2158917955","doi":null,"is_oa":false,"landing_page_url":"http://www.ghrnet.org/index.php/JT/article/download/873/982","pdf_url":null,"source":{"id":"https://openalex.org/S2764864537","display_name":"Journal of Tumor","issn_l":"1819-6187","issn":["1819-6187","2410-7417"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Tumor","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1965902856","https://openalex.org/W1986286728","https://openalex.org/W1987807963","https://openalex.org/W1989649622","https://openalex.org/W1990424719","https://openalex.org/W1994843494","https://openalex.org/W1997766443","https://openalex.org/W2001171563","https://openalex.org/W2001683140","https://openalex.org/W2002986828","https://openalex.org/W2003736915","https://openalex.org/W2005334224","https://openalex.org/W2011942823","https://openalex.org/W2016613877","https://openalex.org/W2021274795","https://openalex.org/W2022796808","https://openalex.org/W2029023103","https://openalex.org/W2030575063","https://openalex.org/W2034017959","https://openalex.org/W2036460370","https://openalex.org/W2039769899","https://openalex.org/W2056977288","https://openalex.org/W2057291878","https://openalex.org/W2073464610","https://openalex.org/W2078816010","https://openalex.org/W2079029353","https://openalex.org/W2082390885","https://openalex.org/W2087196957","https://openalex.org/W2100975996","https://openalex.org/W2102540838","https://openalex.org/W2105804718","https://openalex.org/W2114007536","https://openalex.org/W2115835968","https://openalex.org/W2118485237","https://openalex.org/W2122656686","https://openalex.org/W2135278755","https://openalex.org/W2142411152","https://openalex.org/W2144273675","https://openalex.org/W2146322233","https://openalex.org/W2146629016","https://openalex.org/W2147000598","https://openalex.org/W2158049887","https://openalex.org/W2165796043","https://openalex.org/W2166223410","https://openalex.org/W2166676532","https://openalex.org/W2168910780","https://openalex.org/W2170062661","https://openalex.org/W2172227881"],"related_works":["https://openalex.org/W7004866384","https://openalex.org/W7144771552","https://openalex.org/W2094001485","https://openalex.org/W2884333358","https://openalex.org/W2156480607","https://openalex.org/W2158049887","https://openalex.org/W7144397437","https://openalex.org/W2159889625","https://openalex.org/W2016613877","https://openalex.org/W7203687380"],"abstract_inverted_index":{"AIM:":[0],"There":[1],"are":[2],"clinical":[3],"and":[4,45,210,247,321,339,352,361,372,480],"experimental":[5],"studies":[6,407],"indicating":[7],"that":[8,62,410],"ionizing":[9,219,252,276,315,411,423],"radiation":[10,236,253,316,412],"might":[11,222,237,254,270,295,323,426],"promote":[12,414],"metastatic":[13,22,34,50,396,474],"processes":[14],"of":[15,20,24,36,42,227,244,257,263,265,300,304,327,331,398,431,450,452],"malignant":[16,454],"tumors.":[17],"The":[18,180,213,261,329,418],"mechanism":[19],"radiation-induced":[21,220,239,319,424],"potential":[23,35,397],"cancer":[25,37,259,399],"remains":[26],"substantially":[27],"elusive.":[28],"Carbon":[29,355],"ion":[30,205,356,482],"irradiation":[31,357,387,435,483],"may":[32,388,436],"suppress":[33,238,255,271],"cells.":[38,260],"A":[39],"detailed":[40],"understanding":[41],"the":[43,197,218,224,272,282,297,325,366,380,422,428,448,468],"mechanisms":[44,471],"molecular":[46,470],"pathways":[47],"activated":[48],"in":[49,54,189,249,347,370,379,443,457,473],"progression":[51,475],"is":[52,484],"crucial":[53],"identifying":[55],"new":[56],"treatment":[57,225,298,429],"options":[58],"for":[59,187,447],"anticancer":[60],"therapy":[61,279,442],"target":[63,318],"metastasis.":[64,417],"MATERIALS":[177],"AND":[178],"METHODS:":[179],"systematic":[181],"review":[182],"was":[183],"conducted":[184],"by":[185,275],"searching":[186],"keywords":[188],"Pubmed":[190],"(January":[191],"2000":[192],"-":[193],"May":[194],"2014)":[195],"using":[196],"search":[198],"terms:":[199],"\u2018photon":[200],"irradiation\u2019,":[201,203,206],"\u2018particle":[202],"\u2018carbon":[204],"\u2018migration\u2019,":[207],"\u2018invasion\u2019,":[208],"\u2018angiogenesis\u2019":[209],"\u2018metastasis\u2019.":[211],"RESULTS:":[212],"following":[214],"strategies":[215,419],"to":[216,291,317,420,439,459,466],"counteract":[217,421],"metastasis":[221,425,451],"improve":[223,296,324,427],"result":[226],"photon":[228,301,403,432,441,479],"irradiation.":[229,302,404,433],"Combining":[230,303],"PI3K/Akt":[231],"inhibitors":[232,285],"LY294002":[233],"with":[234,251,268,281,314,333,478],"ioninzing":[235],"MMP-9":[240],"mRNA":[241],"expression.":[242],"Inhibitors":[243],"integrin":[245],"\u03b12\u03b21":[246],"EGFR":[248],"combination":[250,262,330],"invasiveness":[256,273],"lung":[258],"inhibition":[264],"NF-\u03baB/\u03b21-integrin":[266],"signaling":[267],"radiotherapy":[269,332],"induced":[274],"radiation.":[277],"Radiation":[278],"combined":[280],"tyrosine":[283],"kinase":[284],"(TKI)":[286],"vandetanib":[287],"(anti-EGFR":[288],"plus":[289],"anti-VEGFR)":[290],"inhibit":[292],"glioblastoma":[293],"growth":[294,336,341],"results":[299,430],"matrix":[305],"metalloproteinase":[306],"inhibitor":[307],"Metastat":[308],"or":[309],"microtubule":[310],"stabilizing":[311],"agent":[312],"Patupilone":[313],"invasion":[320,415],"angiogenesis":[322],"efficacy":[326],"radiotherapy.":[328],"vascular":[334],"endothelial":[335],"factor":[337,342],"(VEGF)":[338],"platelet-derived":[340],"(PDGF)":[343],"antiangiogenic":[344],"agents":[345],"resulted":[346],"reduced":[348],"cell":[349],"proliferation,":[350],"migration":[351],"tube":[353],"formation.":[354],"provides":[358],"both":[359],"physical":[360,461],"biological":[362,376],"advantages,":[363],"such":[364,391],"as":[365,392],"inverted":[367],"dose-depth":[368],"pro\ufb01le":[369],"tissue":[371],"an":[373],"increased":[374],"relative":[375],"effectiveness":[377],"(RBE)":[378],"tumor":[381,455],"region.":[382],"In":[383],"addition,":[384],"carbon":[385,481],"beam":[386],"have":[389,408],"advantages":[390],"inhibitory":[393],"effects":[394,446],"on":[395],"cells,":[400],"distinct":[401],"from":[402],"CONCLUSIONS:":[405],"Many":[406],"demonstrated":[409],"can":[413],"and/or":[416],"Heavy-ion":[434],"be":[437],"superior":[438],"conventional":[440],"its":[444,460],"possible":[445],"prevention":[449],"irradiated":[453],"cells":[456],"addition":[458],"dose":[462],"distribution.":[463],"Further":[464],"investigation":[465],"elucidate":[467],"intricate":[469],"involved":[472],"specifically":[476],"associated":[477],"warranted.":[485]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
