{"id":"https://openalex.org/W2158902902","doi":null,"title":"Expression and function of Suppressor of zeste 12 in Drosophila melanogaster","display_name":"Expression and function of Suppressor of zeste 12 in Drosophila melanogaster","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2158902902","mag":"2158902902"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-18483","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18483","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002392039","display_name":"Sa Chen","orcid":"https://orcid.org/0009-0007-9541-7691","observed_orcids":["https://orcid.org/0009-0007-9541-7691"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sa Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002392039"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycomb-group-proteins","display_name":"Polycomb group proteins","score":0.7919999957084656},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/enhancer-of-zeste","display_name":"Enhancer of zeste","score":0.8130000233650208},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.9049999713897705},{"id":"https://openalex.org/keywords/polytene-chromosomes","display_name":"polytene chromosomes","score":0.828000009059906},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6679999828338623},{"id":"https://openalex.org/keywords/neuronal-development","display_name":"neuronal development","score":0.6899999976158142},{"id":"https://openalex.org/keywords/wing-imaginal-disc","display_name":"wing imaginal disc","score":0.6600000262260437},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.817696213722229},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6060891151428223},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5664844512939453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.554902970790863},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5351171493530273},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5151873826980591},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4742162227630615},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4658105671405792},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.45371565222740173},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.43147796392440796},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1647493839263916},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-18483","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18483","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2158902902","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:159903/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-18483","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18483","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":211,"referenced_works":["https://openalex.org/W319494764","https://openalex.org/W607004233","https://openalex.org/W1497151945","https://openalex.org/W1497941038","https://openalex.org/W1500148822","https://openalex.org/W1506481199","https://openalex.org/W1520098172","https://openalex.org/W1530362142","https://openalex.org/W1534977145","https://openalex.org/W1571013355","https://openalex.org/W1574290520","https://openalex.org/W1605425036","https://openalex.org/W1656315914","https://openalex.org/W1669374546","https://openalex.org/W1832030339","https://openalex.org/W1845773031","https://openalex.org/W1891332773","https://openalex.org/W1914441096","https://openalex.org/W1964010516","https://openalex.org/W1966156883","https://openalex.org/W1968369914","https://openalex.org/W1968407066","https://openalex.org/W1968670742","https://openalex.org/W1969851123","https://openalex.org/W1970569685","https://openalex.org/W1970709003","https://openalex.org/W1971708895","https://openalex.org/W1973837846","https://openalex.org/W1975859486","https://openalex.org/W1977032812","https://openalex.org/W1977711073","https://openalex.org/W1977836335","https://openalex.org/W1978139037","https://openalex.org/W1979157667","https://openalex.org/W1980132133","https://openalex.org/W1980483123","https://openalex.org/W1982409009","https://openalex.org/W1982791788","https://openalex.org/W1983224905","https://openalex.org/W1984678352","https://openalex.org/W1985361814","https://openalex.org/W1986801877","https://openalex.org/W1987521119","https://openalex.org/W1991995900","https://openalex.org/W1992324957","https://openalex.org/W1992662525","https://openalex.org/W1994333872","https://openalex.org/W1995070143","https://openalex.org/W1997663843","https://openalex.org/W1999002996","https://openalex.org/W1999181734","https://openalex.org/W1999406663","https://openalex.org/W1999952815","https://openalex.org/W2000507520","https://openalex.org/W2001029086","https://openalex.org/W2001858515","https://openalex.org/W2004286348","https://openalex.org/W2004499293","https://openalex.org/W2004608668","https://openalex.org/W2005723902","https://openalex.org/W2006788765","https://openalex.org/W2007576401","https://openalex.org/W2007684630","https://openalex.org/W2008735740","https://openalex.org/W2008922065","https://openalex.org/W2008992619","https://openalex.org/W2011192730","https://openalex.org/W2012992456","https://openalex.org/W2014039677","https://openalex.org/W2015261079","https://openalex.org/W2015416439","https://openalex.org/W2016518060","https://openalex.org/W2017840637","https://openalex.org/W2017920584","https://openalex.org/W2020767030","https://openalex.org/W2021399061","https://openalex.org/W2021510847","https://openalex.org/W2022936129","https://openalex.org/W2025833890","https://openalex.org/W2026501344","https://openalex.org/W2032736838","https://openalex.org/W2033102369","https://openalex.org/W2033890654","https://openalex.org/W2034032029","https://openalex.org/W2036874847","https://openalex.org/W2036927238","https://openalex.org/W2037541952","https://openalex.org/W2039162046","https://openalex.org/W2041165979","https://openalex.org/W2042487483","https://openalex.org/W2042514308","https://openalex.org/W2042949617","https://openalex.org/W2044012809","https://openalex.org/W2044561872","https://openalex.org/W2047143392","https://openalex.org/W2048670128","https://openalex.org/W2050014967","https://openalex.org/W2050735681","https://openalex.org/W2051166632","https://openalex.org/W2051167924","https://openalex.org/W2051406511","https://openalex.org/W2052087397","https://openalex.org/W2052816402","https://openalex.org/W2053317015","https://openalex.org/W2053421436","https://openalex.org/W2053616835","https://openalex.org/W2054616775","https://openalex.org/W2054621094","https://openalex.org/W2054643318","https://openalex.org/W2054938702","https://openalex.org/W2055773750","https://openalex.org/W2058203910","https://openalex.org/W2058386953","https://openalex.org/W2060336856","https://openalex.org/W2060875411","https://openalex.org/W2062420791","https://openalex.org/W2063682537","https://openalex.org/W2066170392","https://openalex.org/W2068157186","https://openalex.org/W2068468911","https://openalex.org/W2070399051","https://openalex.org/W2070758108","https://openalex.org/W2071784672","https://openalex.org/W2073157961","https://openalex.org/W2073712512","https://openalex.org/W2073869073","https://openalex.org/W2076572271","https://openalex.org/W2077249217","https://openalex.org/W2078362264","https://openalex.org/W2079739354","https://openalex.org/W2080585376","https://openalex.org/W2080933801","https://openalex.org/W2085932408","https://openalex.org/W2086958019","https://openalex.org/W2087172939","https://openalex.org/W2087819910","https://openalex.org/W2088170764","https://openalex.org/W2090632681","https://openalex.org/W2091330219","https://openalex.org/W2092476087","https://openalex.org/W2093181692","https://openalex.org/W2096149908","https://openalex.org/W2098332052","https://openalex.org/W2098848421","https://openalex.org/W2100325414","https://openalex.org/W2102143993","https://openalex.org/W2102207018","https://openalex.org/W2102901123","https://openalex.org/W2103419911","https://openalex.org/W2104268529","https://openalex.org/W2107833239","https://openalex.org/W2108625845","https://openalex.org/W2110894784","https://openalex.org/W2112441454","https://openalex.org/W2114641334","https://openalex.org/W2114762637","https://openalex.org/W2117344426","https://openalex.org/W2118083063","https://openalex.org/W2119938322","https://openalex.org/W2121302715","https://openalex.org/W2123623304","https://openalex.org/W2123829095","https://openalex.org/W2124035206","https://openalex.org/W2127614175","https://openalex.org/W2128343787","https://openalex.org/W2128540730","https://openalex.org/W2128624858","https://openalex.org/W2128962905","https://openalex.org/W2128963466","https://openalex.org/W2129208603","https://openalex.org/W2129523993","https://openalex.org/W2129695504","https://openalex.org/W2131185365","https://openalex.org/W2132880451","https://openalex.org/W2133400477","https://openalex.org/W2133987610","https://openalex.org/W2135241884","https://openalex.org/W2136742557","https://openalex.org/W2136779909","https://openalex.org/W2137001129","https://openalex.org/W2139295688","https://openalex.org/W2139610636","https://openalex.org/W2140463144","https://openalex.org/W2141452262","https://openalex.org/W2143230895","https://openalex.org/W2148121673","https://openalex.org/W2148282966","https://openalex.org/W2149548305","https://openalex.org/W2151477426","https://openalex.org/W2153397085","https://openalex.org/W2153537891","https://openalex.org/W2154284135","https://openalex.org/W2155563035","https://openalex.org/W2156137186","https://openalex.org/W2158610627","https://openalex.org/W2159211726","https://openalex.org/W2162316859","https://openalex.org/W2163665787","https://openalex.org/W2163771097","https://openalex.org/W2164819701","https://openalex.org/W2164850035","https://openalex.org/W2168687126","https://openalex.org/W2169640176","https://openalex.org/W2170716343","https://openalex.org/W2170964470","https://openalex.org/W2171125622","https://openalex.org/W2172298521","https://openalex.org/W2181877403","https://openalex.org/W2186155771","https://openalex.org/W2188543379","https://openalex.org/W2420554259"],"related_works":["https://openalex.org/W607004233","https://openalex.org/W231801086","https://openalex.org/W318041170","https://openalex.org/W2068468911","https://openalex.org/W154771165","https://openalex.org/W291029733","https://openalex.org/W2119938322","https://openalex.org/W214710902","https://openalex.org/W319494764","https://openalex.org/W2551734375"],"abstract_inverted_index":{"The":[0,20,42,71,91,128,145,196,210,288,352,411],"development":[1],"of":[2,10,12,49,58,64,94,102,110,116,148,157,246,269,292,317,321,397,402,409,438,451,459],"animals":[3],"and":[4,26,56,104,206,216,257,310,399,425,447,472],"plants":[5,80],"needs":[6],"a":[7,28,47,249,258,266,314,337,358,362,406,415,448],"higher":[8],"order":[9],"regulation":[11],"gene":[13,29,54,72,355,404,416],"expression":[14,106,226],"to":[15,81,98,122,199,280,283,296,430],"maintain":[16],"proper":[17],"cell":[18,208,479],"state.":[19],"mechanisms":[21,458],"that":[22,163,233,334,370,382,400,414,426],"control":[23],"what,":[24],"when":[25,375,435],"where":[27],"should":[30,32],"(or":[31],"not)":[33],"be":[34,281,431],"expressed":[35],"are":[36,139,470],"essential":[37],"for":[38,52,285,305,340,364],"correct":[39],"organism":[40],"development.":[41,112,229,273],"Polycomb":[43,169],"group":[44],"(PcG)":[45],"is":[46,62,73,87,134,201,242,294,302,312,336,345,361,413,453,464],"family":[48],"genes":[50,348,469],"responsible":[51],"maintaining":[53],"silencing":[55,441],"Suppressor":[57],"zeste":[59],"12":[60],"(Su(z)12)":[61],"one":[63],"the":[65,69,84,100,131,140,158,168,175,189,243,277,297,383,456],"core":[66,315],"components":[67],"in":[68,76,136,150,254,262,271,308,323,328,423],"PcG.":[70],"highly":[74],"conserved":[75],"organisms":[77],"ranging":[78],"from":[79,219],"humans,":[82],"however,":[83],"specific":[85,125,190,251],"function":[86,101,268,344,377],"not":[88,179,373],"well":[89,181],"known.":[90],"main":[92,244],"tasks":[93],"this":[95,403],"thesis":[96],"was":[97,372,378],"investigate":[99],"Su(z)12":[103,120,149,164,197,213,301,322,335],"its":[105],"at":[107],"different":[108,212,225,237],"stages":[109],"Drosophila":[111],"In":[113,274],"polytene":[114,151],"chromosomes":[115,152],"larval":[117,255,260],"salivary":[118],"glands,":[119],"binds":[121],"about":[123,466],"90":[124],"euchromatic":[126],"sites.":[127],"binding":[129,146,176,198],"along":[130],"chromosome":[132],"arms":[133],"mostly":[135],"interbands,":[137],"which":[138],"most":[141],"DNA":[142],"de-condensed":[143],"regions.":[144],"sites":[147],"correlate":[153],"precisely":[154],"with":[155,182],"those":[156],"Enhancer-of-zeste":[159],"(E(z))":[160],"protein,":[161,385],"indicating":[162,333],"mainly":[165],"exists":[166],"within":[167],"Repressive":[170],"Complex":[171],"2":[172],"(PRC2).":[173],"However,":[174,300,367,462],"pattern":[177,253],"does":[178],"overlap":[180],"Histone":[183],"3":[184],"lysine":[185],"27":[186],"tri-methylations":[187],"(H3K27me3),":[188],"chromatin":[191,200],"mark":[192],"created":[193],"by":[194,387],"PRC2.":[195,318],"dynamically":[202],"regulated":[203],"during":[204,228],"mitotic":[205],"meiotic":[207],"division.":[209],"two":[211],"isoforms:":[214],"Su(z)12-A":[215,270],"Su(z)12-B":[217,240],"(resulting":[218],"alternative":[220],"RNA":[221],"splicing),":[222],"have":[223,236,418,429],"very":[224,443],"patterns":[227],"Functional":[230],"analyses":[231],"indicate":[232],"they":[234],"also":[235,303,392],"functions":[238],"he":[239],"form":[241],"mediator":[245],"silencing.":[247,341,366],"Furthermore,":[248],"neuron":[250,272],"localization":[252],"brain":[256],"giant":[259],"phenotype":[261],"transgenic":[263],"lines":[264],"reveal":[265],"potential":[267],"some":[275],"aspects":[276],"isoforms":[278],"seem":[279],"able":[282],"substitute":[284],"each":[286],"other.":[287],"histone":[289],"methyltransferase":[290],"activity":[291],"PRC2":[293,365,376],"due":[295],"E(z)":[298],"protein.":[299],"necessary":[304],"H3K27me3":[306,331],"methylation":[307],"vivo,":[309],"it":[311,371],"thus":[313],"component":[316],"Clonal":[319],"over-expression":[320],"imaginal":[324],"wing":[325],"discs":[326],"results":[327],"an":[329,395],"increased":[330],"activity,":[332],"limiting":[338],"factor":[339],"When":[342],"PcG":[343,389,440,460],"lost,":[346],"target":[347,363,390],"normally":[349],"become":[350],"de-repressed.":[351],"segment":[353],"polarity":[354],"engrailed,":[356],"encoding":[357],"transcription":[359],"factor,":[360],"we":[368],"found":[369],"activated":[374],"deleted.":[379],"We":[380],"show":[381],"Ultrabithorax":[384],"encoded":[386],"another":[388],"gene,":[391],"acts":[393],"as":[394],"inhibitor":[396],"engrailed":[398],"de-regulation":[401],"causes":[405],"continued":[407],"repression":[408],"engrailed.":[410],"conclusion":[412],"can":[417],"several":[419],"negative":[420],"regulators":[421],"working":[422],"parallel":[424],"secondary":[427],"effects":[428,437],"taken":[432],"into":[433],"consideration,":[434],"analyzing":[436],"mutants.":[439],"affects":[442],"many":[444],"cellular":[445],"processes":[446],"large":[449],"quantity":[450],"knowledge":[452],"gathered":[454],"on":[455],"overall":[457],"regulation.":[461],"little":[463],"known":[465],"how":[467,473],"individual":[468],"silenced":[471],"cells":[474],"\u201cremember\u201d":[475],"their":[476],"fate":[477],"through":[478],"generations.":[480]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}