{"id":"https://openalex.org/W2158899331","doi":"https://doi.org/10.1007/s11064-014-1251-0","title":"The Odyssey of a Young Gene: Structure\u2013Function Studies in Human Glutamate Dehydrogenases Reveal Evolutionary-Acquired Complex Allosteric Regulation Mechanisms","display_name":"The Odyssey of a Young Gene: Structure\u2013Function Studies in Human Glutamate Dehydrogenases Reveal Evolutionary-Acquired Complex Allosteric Regulation Mechanisms","publication_year":2014,"publication_date":"2014-02-10","ids":{"openalex":"https://openalex.org/W2158899331","doi":"https://doi.org/10.1007/s11064-014-1251-0","mag":"2158899331","pmid":"https://pubmed.ncbi.nlm.nih.gov/24515454"},"language":"en","primary_location":{"id":"doi:10.1007/s11064-014-1251-0","doi":"https://doi.org/10.1007/s11064-014-1251-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11064-014-1251-0","pdf_url":null,"source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040448710","display_name":"Ioannis V. Zaganas","orcid":"https://orcid.org/0000-0002-0774-5772","observed_orcids":["https://orcid.org/0000-0002-0774-5772"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Ioannis V. Zaganas","raw_affiliation_strings":["Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece, johnzag@med.uoc.gr","Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece, johnzag@med.uoc.gr","institution_ids":["https://openalex.org/I142617266"]},{"raw_affiliation_string":"Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004503378","display_name":"Konstantinos Kanavouras","orcid":"https://orcid.org/0000-0003-4655-9523","observed_orcids":["https://orcid.org/0000-0003-4655-9523"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Kanavouras","raw_affiliation_strings":["Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000995719","display_name":"Nikolas Borompokas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolas Borompokas","raw_affiliation_strings":["Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089923913","display_name":"Giovanna Arianoglou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Giovanna Arianoglou","raw_affiliation_strings":["Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087332358","display_name":"Christina Dimovasili","orcid":"https://orcid.org/0000-0003-1364-6161","observed_orcids":["https://orcid.org/0000-0003-1364-6161"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christina Dimovasili","raw_affiliation_strings":["Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077811761","display_name":"Helen Latsoudis","orcid":"https://orcid.org/0000-0002-7857-4448","observed_orcids":["https://orcid.org/0000-0002-7857-4448"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Helen Latsoudis","raw_affiliation_strings":["Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086180613","display_name":"Metaxia Vlassi","orcid":"https://orcid.org/0000-0003-0931-2660","observed_orcids":["https://orcid.org/0000-0003-0931-2660"]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]},{"id":"https://openalex.org/I4387153668","display_name":"Institute of Biosciences & Applications","ror":"https://ror.org/00rhzk043","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044","https://openalex.org/I4387153668"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Metaxia Vlassi","raw_affiliation_strings":["Institute of Biosciences and Applications, National Center for Scientific Research \u201cDemokritos\u201d, 15310, Ag. Paraskevi, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biosciences and Applications, National Center for Scientific Research \u201cDemokritos\u201d, 15310, Ag. Paraskevi, Athens, Greece","institution_ids":["https://openalex.org/I203474044","https://openalex.org/I4387153668"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005381448","display_name":"Vasileios C. Mastorodemos","orcid":"https://orcid.org/0000-0002-7397-2930","observed_orcids":["https://orcid.org/0000-0002-7397-2930"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasileios Mastorodemos","raw_affiliation_strings":["Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Laboratory, Medical School, University of Crete, Voutes, 71003, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040448710"],"corresponding_institution_ids":["https://openalex.org/I142617266"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.2276,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.12285012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"39","issue":"3","first_page":"471","last_page":"486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-dehydrogenase","display_name":"glutamate dehydrogenase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glud1","display_name":"GLUD1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gdh2","display_name":"GDH2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/glud2","display_name":"GluD2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.6759999990463257},{"id":"https://openalex.org/keywords/retrotransposition","display_name":"retrotransposition","score":0.8149999976158142},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.4480000138282776},{"id":"https://openalex.org/keywords/gtp-inhibition","display_name":"GTP inhibition","score":0.6940000057220459},{"id":"https://openalex.org/keywords/estrogen-sensitivity","display_name":"estrogen sensitivity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/heat-lability","display_name":"heat lability","score":0.6700000166893005},{"id":"https://openalex.org/keywords/adp-activation","display_name":"ADP stimulation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/leucine","display_name":"leucine","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8343477249145508},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.70893394947052},{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.6220262050628662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4961183965206146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4812176525592804},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4673970341682434},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3947615921497345},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36284419894218445},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.3604912757873535},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35489365458488464},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31776607036590576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.220956951379776},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0979672372341156}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11064-014-1251-0","doi":"https://doi.org/10.1007/s11064-014-1251-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11064-014-1251-0","pdf_url":null,"source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},{"id":"pmid:24515454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24515454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W3595601","https://openalex.org/W109284476","https://openalex.org/W1488582389","https://openalex.org/W1520094144","https://openalex.org/W1530697014","https://openalex.org/W1557188560","https://openalex.org/W1583479632","https://openalex.org/W1945838488","https://openalex.org/W1963894699","https://openalex.org/W1967002251","https://openalex.org/W1968086812","https://openalex.org/W1971719161","https://openalex.org/W1972362927","https://openalex.org/W1973175579","https://openalex.org/W1978738775","https://openalex.org/W1981868452","https://openalex.org/W1985083001","https://openalex.org/W1987430808","https://openalex.org/W1990213356","https://openalex.org/W1991883105","https://openalex.org/W1992215991","https://openalex.org/W1995240857","https://openalex.org/W1995287413","https://openalex.org/W1996503280","https://openalex.org/W1998348821","https://openalex.org/W1999389160","https://openalex.org/W2001167195","https://openalex.org/W2001306008","https://openalex.org/W2002005260","https://openalex.org/W2008398516","https://openalex.org/W2011348009","https://openalex.org/W2011859165","https://openalex.org/W2014618899","https://openalex.org/W2016463583","https://openalex.org/W2023110509","https://openalex.org/W2025478209","https://openalex.org/W2029766561","https://openalex.org/W2042422091","https://openalex.org/W2044950847","https://openalex.org/W2045074917","https://openalex.org/W2046916908","https://openalex.org/W2053573985","https://openalex.org/W2054017160","https://openalex.org/W2054053875","https://openalex.org/W2054711070","https://openalex.org/W2057315336","https://openalex.org/W2062289824","https://openalex.org/W2068301872","https://openalex.org/W2071279619","https://openalex.org/W2072722739","https://openalex.org/W2073614544","https://openalex.org/W2080349528","https://openalex.org/W2080937133","https://openalex.org/W2084480094","https://openalex.org/W2084578352","https://openalex.org/W2088141578","https://openalex.org/W2090796300","https://openalex.org/W2092895145","https://openalex.org/W2093625559","https://openalex.org/W2094569176","https://openalex.org/W2095021929","https://openalex.org/W2095127846","https://openalex.org/W2096962761","https://openalex.org/W2098227908","https://openalex.org/W2111230820","https://openalex.org/W2123715446","https://openalex.org/W2134294998","https://openalex.org/W2137015675","https://openalex.org/W2150297520","https://openalex.org/W2152622208","https://openalex.org/W2159122349","https://openalex.org/W2163309432","https://openalex.org/W2235776350","https://openalex.org/W2253685784","https://openalex.org/W2322041353","https://openalex.org/W2342082898","https://openalex.org/W2440082204","https://openalex.org/W2468755002","https://openalex.org/W4231627353","https://openalex.org/W4233604467"],"related_works":["https://openalex.org/W1968086812","https://openalex.org/W2002168701","https://openalex.org/W4231627353","https://openalex.org/W1530697014","https://openalex.org/W2078821377","https://openalex.org/W1967002251","https://openalex.org/W2586404693","https://openalex.org/W1980450633","https://openalex.org/W1971719161","https://openalex.org/W2092895145"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}