{"id":"https://openalex.org/W21587001","doi":null,"title":"Epigenetics of human asthma and allergy: promises to keep.","display_name":"Epigenetics of human asthma and allergy: promises to keep.","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W21587001","mag":"21587001","pmid":"https://pubmed.ncbi.nlm.nih.gov/24053700"},"language":"en","primary_location":{"id":"pmid:24053700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24053700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of allergy and immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080384279","display_name":"Avery DeVries","orcid":"https://orcid.org/0000-0001-7274-8403","observed_orcids":["https://orcid.org/0000-0001-7274-8403"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4388891792","display_name":"BIO5 Institute","ror":"https://ror.org/023drta67","country_code":"US","type":"facility","lineage":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avery Devries","raw_affiliation_strings":["Functional Genomics Laboratory, Arizona Respiratory Center; Arizona Center for the Biology of Complex Diseases; Department of Cellular and Molecular Medicine; and The Bio5 Institute, University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics Laboratory, Arizona Respiratory Center; Arizona Center for the Biology of Complex Diseases; Department of Cellular and Molecular Medicine; and The Bio5 Institute, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055148239","display_name":"Donata Vercelli","orcid":"https://orcid.org/0000-0001-5276-8976","observed_orcids":["https://orcid.org/0000-0001-5276-8976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donata Vercelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0377,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93852793,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"3","first_page":"183","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8217999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.17399999499320984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7789999842643738},{"id":"https://openalex.org/keywords/allergy","display_name":"allergy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":1.0},{"id":"https://openalex.org/keywords/candidate-gene-studies","display_name":"candidate gene association","score":0.9660000205039978},{"id":"https://openalex.org/keywords/environmental-contaminants","display_name":"environmental pollutants","score":0.7289999723434448},{"id":"https://openalex.org/keywords/allergic-disease-pathogenesis","display_name":"allergic disease pathogenesis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/disease-endotypes","display_name":"disease endotypes","score":0.9470000267028809},{"id":"https://openalex.org/keywords/epigenetic-networks","display_name":"epigenetic networks","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.9208859205245972},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.743903398513794},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5689393281936646},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.5477166175842285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5468152165412903},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5135210156440735},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.480116605758667},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.46195435523986816},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41904258728027344},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41803669929504395},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4132366478443146},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32986125349998474},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27024298906326294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.258466899394989},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17271649837493896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:24053700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24053700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of allergy and immunology","raw_type":"Journal Article"},{"id":"mag:21587001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24053700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G899749199","display_name":"Epigenetic predicators of asthma in neonates","funder_award_id":"RC1HL100800","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1594328627","https://openalex.org/W1747499909","https://openalex.org/W1965501136","https://openalex.org/W1965691847","https://openalex.org/W1967064280","https://openalex.org/W1971708895","https://openalex.org/W1979318039","https://openalex.org/W1980991473","https://openalex.org/W1981543052","https://openalex.org/W1982042604","https://openalex.org/W1982413607","https://openalex.org/W1983043354","https://openalex.org/W1983731581","https://openalex.org/W1985844966","https://openalex.org/W1988290255","https://openalex.org/W1995008831","https://openalex.org/W1996354856","https://openalex.org/W2004698615","https://openalex.org/W2006795503","https://openalex.org/W2007684630","https://openalex.org/W2008599922","https://openalex.org/W2011988545","https://openalex.org/W2017125863","https://openalex.org/W2019412393","https://openalex.org/W2022484411","https://openalex.org/W2045680696","https://openalex.org/W2067424864","https://openalex.org/W2073453074","https://openalex.org/W2074746593","https://openalex.org/W2078028724","https://openalex.org/W2080636110","https://openalex.org/W2081375496","https://openalex.org/W2089417246","https://openalex.org/W2099598799","https://openalex.org/W2101259235","https://openalex.org/W2123032740","https://openalex.org/W2136278733","https://openalex.org/W2138909489","https://openalex.org/W2140114724","https://openalex.org/W2141289961","https://openalex.org/W2142145773","https://openalex.org/W2148306389","https://openalex.org/W2154901013","https://openalex.org/W2155471840","https://openalex.org/W2159556553","https://openalex.org/W2165277651","https://openalex.org/W2167638767","https://openalex.org/W2170760459"],"related_works":["https://openalex.org/W2074959705","https://openalex.org/W2492947546","https://openalex.org/W2990644949","https://openalex.org/W6903064523","https://openalex.org/W3026625498","https://openalex.org/W1983283608","https://openalex.org/W2323726983","https://openalex.org/W4285218103","https://openalex.org/W4389288082","https://openalex.org/W2980898655"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,180],"interest":[2],"in":[3,65,78,94,135,145,157,166,177,196,200],"asthma":[4,31,48,158],"epigenetics":[5,32,49,174],"is":[6,175],"high":[7],"because":[8,138],"epigenetic":[9,127,218,226],"mechanisms":[10],"likely":[11,229],"contribute":[12],"to":[13,96,123,148,169,206],"the":[14,18,27,34,44,89,97,108,111,124,167,194,204,234],"environmental":[15,149,170],"origins":[16],"of":[17,30,88,99,102,110,139,182,191,217,238],"disease":[19,152,240,245],"and":[20,33,52,70,85,114,119,159,188,203,214,236,241],"its":[21,178],"phenotypic":[22],"variability.":[23],"This":[24],"review":[25],"presents":[26],"main":[28],"findings":[29],"challenges":[35,190,222],"that":[36],"still":[37,176],"delay":[38],"progress.":[39],"DATA":[40],"SOURCES:":[41],"We":[42,59],"examined":[43],"current":[45],"literature":[46,184],"on":[47,61,162],"(31":[50],"reviews":[51],"25":[53],"original":[54],"data":[55],"publications).":[56],"STUDY":[57],"SELECTIONS:":[58],"focused":[60,161],"DNA":[62,76,133,201],"methylation":[63,77,134],"studies":[64,73,82,131,156,227],"populations.":[66],"RESULTS:":[67],"Both":[68],"genome-wide":[69,192],"candidate":[71,163],"gene":[72,130],"have":[74,223],"explored":[75],"allergic":[79,239],"disease.":[80],"Genome-wide":[81],"ask":[83],"whether":[84],"which":[86],"regions":[87,104],"genome":[90],"are":[91],"differentially":[92],"methylated":[93],"relation":[95],"phenotype":[98,118,125],"interest.":[100],"Identification":[101],"such":[103],"provides":[105],"clues":[106],"about":[107,233],"identity":[109],"genes,":[112],"pathways":[113],"networks":[115,122],"underpinning":[116],"a":[117],"connects":[120],"these":[121,221],"through":[126],"mechanisms.":[128],"Candidate":[129],"examine":[132],"genes":[136,164],"chosen":[137],"their":[140],"known":[141],"or":[142,151],"hypothesized":[143],"role":[144],"immunity,":[146],"responses":[147],"stimuli":[150],"pathogenesis.":[153],"Most":[154],"existing":[155],"allergy":[160],"involved":[165],"response":[168],"pollutants.":[171],"CONCLUSION:":[172],"Asthma":[173],"infancy.":[179],"paucity":[181],"primary":[183],"originates":[185],"from":[186],"methodological":[187],"analytical":[189],"studies,":[193],"difficulties":[195],"interpreting":[197],"small":[198],"differences":[199],"methylation,":[202],"need":[205],"develop":[207],"robust":[208],"bioinformatic":[209],"tools":[210],"for":[211],"pathway,":[212],"network":[213],"system":[215],"analyses":[216],"data.":[219],"Once":[220],"been":[224],"overcome,":[225],"will":[228,242],"provide":[230],"important":[231],"insights":[232],"inception":[235],"pathogenesis":[237],"help":[243],"define":[244],"endotypes.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}