{"id":"https://openalex.org/W2158698293","doi":"https://doi.org/10.1523/jneurosci.2243-10.2011","title":"Deletion of ERK1 and ERK2 in the CNS Causes Cortical Abnormalities and Neonatal Lethality:Erk1Deficiency Enhances the Impairment of Neurogenesis inErk2-Deficient Mice","display_name":"Deletion of ERK1 and ERK2 in the CNS Causes Cortical Abnormalities and Neonatal Lethality:Erk1Deficiency Enhances the Impairment of Neurogenesis inErk2-Deficient Mice","publication_year":2011,"publication_date":"2011-01-19","ids":{"openalex":"https://openalex.org/W2158698293","doi":"https://doi.org/10.1523/jneurosci.2243-10.2011","mag":"2158698293","pmid":"https://pubmed.ncbi.nlm.nih.gov/21248139","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6632941"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2243-10.2011","doi":"https://doi.org/10.1523/jneurosci.2243-10.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2243-10.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/3/1149.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/31/3/1149.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078310718","display_name":"Yasushi Satoh","orcid":"https://orcid.org/0000-0002-0527-6319","observed_orcids":["https://orcid.org/0000-0002-0527-6319"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Satoh","raw_affiliation_strings":["Department of Anesthesiology, National Defense Medical College, Tokorozawa 359-8513, Japan. ys@ndmc.ac.jp","(University of Kyoto, Kyoto, Japan)","Department of Anesthesiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan","Departments of 1 Anesthesiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Defense Medical College, Tokorozawa 359-8513, Japan. ys@ndmc.ac.jp","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]},{"raw_affiliation_string":"(University of Kyoto, Kyoto, Japan)","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Anesthesiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]},{"raw_affiliation_string":"Departments of 1 Anesthesiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011766068","display_name":"Yasushi Kobayashi","orcid":"https://orcid.org/0000-0001-5072-5040","observed_orcids":["https://orcid.org/0000-0001-5072-5040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasushi Kobayashi","raw_affiliation_strings":["Departments of 1 Anesthesiology , Anatomy and Neurobiology , and","Anatomy and Neurobiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Anesthesiology , Anatomy and Neurobiology , and","institution_ids":[]},{"raw_affiliation_string":"Anatomy and Neurobiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109244941","display_name":"Atsuya Takeuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuya Takeuchi","raw_affiliation_strings":["Ophthalmology, National Defense Medical College, Tokorozawa 359-8513, Japan, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, National Defense Medical College, Tokorozawa 359-8513, Japan, and","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083085617","display_name":"Gilles Pag\u00e8s","orcid":"https://orcid.org/0000-0002-8466-5610","observed_orcids":["https://orcid.org/0000-0002-8466-5610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilles Pag\u00e8s","raw_affiliation_strings":["Institute of Developmental Biology and Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Developmental Biology and Cancer","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091254505","display_name":"Jacques Pouyss\u00e9gur","orcid":"https://orcid.org/0000-0003-2779-6902","observed_orcids":["https://orcid.org/0000-0003-2779-6902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacques Pouyss\u00e9gur","raw_affiliation_strings":["Institute of Developmental Biology and Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Developmental Biology and Cancer","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Tomiei Kazama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomiei Kazama","raw_affiliation_strings":["(University of Kyoto, Kyoto, Japan)","Department of Anesthesiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan","Departments of 1 Anesthesiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(University of Kyoto, Kyoto, Japan)","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Anesthesiology, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]},{"raw_affiliation_string":"Departments of 1 Anesthesiology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1277,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.875343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"3","first_page":"1149","last_page":"1155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk1","display_name":"ERK1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/erk2","display_name":"ERK2","score":1.0},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase","display_name":"extracellular signal-regulated kinase","score":0.8579999804496765},{"id":"https://openalex.org/keywords/double-knockout-mice","display_name":"double knockout mice","score":0.7269999980926514},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.5929999947547913},{"id":"https://openalex.org/keywords/neonatal-lethality","display_name":"neonatal lethality","score":0.875},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.9760000109672546},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.8650000095367432},{"id":"https://openalex.org/keywords/ventricular-zone","display_name":"ventricular zone","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neuronal-morphology","display_name":"neuronal morphology","score":0.6439999938011169},{"id":"https://openalex.org/keywords/compensatory-function","display_name":"compensatory function","score":0.5080000162124634},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.8007384538650513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6524925231933594},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.6374388337135315},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.6078504920005798},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5865568518638611},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5702240467071533},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5066388249397278},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4849141240119934},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45159053802490234},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4070145785808563},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3829089105129242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35582542419433594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20593303442001343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20180276036262512},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1353183090686798}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003337","descriptor_name":"Corpus Callosum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D061085","descriptor_name":"Agenesis of Corpus Callosum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.2243-10.2011","doi":"https://doi.org/10.1523/jneurosci.2243-10.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2243-10.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/3/1149.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6632941","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6632941","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:21248139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21248139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00559427v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00559427","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroscience, 2011, 31 (3), pp.1149-55. &#x27E8;10.1523/JNEUROSCI.2243-10.2011&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2243-10.2011","doi":"https://doi.org/10.1523/jneurosci.2243-10.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2243-10.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/3/1149.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158698293.pdf","grobid_xml":"https://content.openalex.org/works/W2158698293.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1963970654","https://openalex.org/W1967400782","https://openalex.org/W1973642840","https://openalex.org/W1976385326","https://openalex.org/W1977472414","https://openalex.org/W2029022867","https://openalex.org/W2033223846","https://openalex.org/W2035079756","https://openalex.org/W2035422545","https://openalex.org/W2036450246","https://openalex.org/W2063584052","https://openalex.org/W2063620761","https://openalex.org/W2084480427","https://openalex.org/W2093712120","https://openalex.org/W2093767388","https://openalex.org/W2126642279","https://openalex.org/W2146407472","https://openalex.org/W2171234592","https://openalex.org/W2791952348"],"related_works":["https://openalex.org/W1968676329","https://openalex.org/W2035079756","https://openalex.org/W1608081470","https://openalex.org/W3149213576","https://openalex.org/W2165890492","https://openalex.org/W2012944967","https://openalex.org/W7096129831","https://openalex.org/W4385066912","https://openalex.org/W2146153583","https://openalex.org/W2146407472"],"abstract_inverted_index":{"Intracellular":[0],"signaling":[1],"through":[2],"extracellular":[3],"signal-regulated":[4],"kinase":[5],"(ERK)":[6],"is":[7],"important":[8],"in":[9,13,78,126,163,170,180],"regulating":[10],"cellular":[11,195],"functions":[12],"a":[14,26,184],"variety":[15],"of":[16,85,91,96,149],"tissues":[17],"including":[18],"the":[19,46,79,89,150,171],"CNS.":[20],"Although":[21,100],"ERK1":[22],"and":[23,31,42,87,139,146,160],"ERK2":[24],"have":[25,66],"very":[27],"similar":[28],"substrate":[29],"profile":[30],"amino":[32],"acid":[33],"sequences,":[34],"there":[35],"are":[36,55],"strikingly":[37],"different":[38],"phenotypes":[39,90],"between":[40],"Erk1-":[41],"Erk2-deficient":[43,98],"mice.":[44,99],"Thus,":[45],"question":[47],"arose":[48],"as":[49],"to":[50,197],"whether":[51,64],"these":[52,92],"two":[53],"proteins":[54],"functional":[56],"homologs":[57],"that":[58,190],"compensate":[59],"for":[60,76,110],"each":[61],"other,":[62],"or":[63],"they":[65,108,122],"distinct":[67],"functions.":[68],"Here,":[69],"we":[70,101],"generated":[71],"double":[72,104,151,172],"knock-out":[73,105,152,173],"mice":[74,93],"deficient":[75],"Erk2":[77,181],"CNS,":[80],"with":[81,94,136,176],"ubiquitous":[82],"homozygous":[83],"deletion":[84],"Erk1,":[86],"compared":[88,175],"those":[95],"monogenic":[97],"did":[102,154],"obtain":[103],"newborn":[106],"pups,":[107],"survived":[109],"not":[111,155],">1":[112],"d.":[113],"These":[114,187],"pups":[115,153,174],"appeared":[116],"normal":[117],"just":[118],"after":[119,132],"parturition.":[120],"However,":[121],"had":[123],"no":[124],"milk":[125],"their":[127],"stomachs":[128],"even":[129],"6-7":[130],"h":[131],"birth.":[133],"Intracerebral":[134],"hemorrhages":[135],"varying":[137],"location":[138],"severity":[140],"were":[141,167],"observed.":[142],"The":[143],"ventricular":[144],"zones":[145],"corpus":[147],"callosum":[148],"develop":[156],"adequately.":[157],"Neuronal":[158],"size":[159],"nuclear":[161],"morphology":[162],"some":[164],"brain":[165,200],"regions":[166],"markedly":[168],"aberrant":[169],"controls,":[177],"while":[178],"deficiency":[179],"only":[182],"caused":[183],"mild":[185],"phenotype.":[186],"results":[188],"suggest":[189],"total":[191],"ERK1/2":[192],"activity":[193],"governs":[194],"behaviors":[196],"ensure":[198],"proper":[199],"development.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
