{"id":"https://openalex.org/W2158693836","doi":"https://doi.org/10.1128/jvi.75.23.11408-11416.2001","title":"NF-\u03baBcis-Acting Motifs of the Human Immunodeficiency Virus (HIV) Long Terminal Repeat Regulate HIV Transcription in Human Macrophages","display_name":"NF-\u03baBcis-Acting Motifs of the Human Immunodeficiency Virus (HIV) Long Terminal Repeat Regulate HIV Transcription in Human Macrophages","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2158693836","doi":"https://doi.org/10.1128/jvi.75.23.11408-11416.2001","mag":"2158693836","pmid":"https://pubmed.ncbi.nlm.nih.gov/11689622","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/114727"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.75.23.11408-11416.2001","doi":"https://doi.org/10.1128/jvi.75.23.11408-11416.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.75.23.11408-11416.2001","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114727","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009763979","display_name":"Susana Asin","orcid":"https://orcid.org/0000-0001-7976-000X","observed_orcids":["https://orcid.org/0000-0001-7976-000X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susana Asin","raw_affiliation_strings":["<!--label omitted: 1-->Department of Immunology1 and","Department of Immunology1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Immunology1 and","institution_ids":[]},{"raw_affiliation_string":"Department of Immunology1 and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037719445","display_name":"Gary D. Bren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary D. Bren","raw_affiliation_strings":["<!--label omitted: 1-->Department of Immunology1 and","Department of Immunology1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Immunology1 and","institution_ids":[]},{"raw_affiliation_string":"Department of Immunology1 and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007441721","display_name":"Eva M. Carmona","orcid":"https://orcid.org/0000-0001-9852-8396","observed_orcids":["https://orcid.org/0000-0001-9852-8396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva M. Carmona","raw_affiliation_strings":["<!--label omitted: 1-->Department of Immunology1 and","Department of Immunology1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Immunology1 and","institution_ids":[]},{"raw_affiliation_string":"Department of Immunology1 and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113457161","display_name":"Nancie J. Solan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancie J. Solan","raw_affiliation_strings":["<!--label omitted: 1-->Department of Immunology1 and","Department of Immunology1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Immunology1 and","institution_ids":[]},{"raw_affiliation_string":"Department of Immunology1 and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111834025","display_name":"Carlos V. Pay\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos V. Paya","raw_affiliation_strings":["<!--label omitted: 1-->Department of Immunology1 and","<!--label omitted: 2-->Divisions of Infectious Diseases2 and","<!--label omitted: 3-->Experimental Pathology,3 Mayo Clinic, Rochester, Minnesota 55905","Department of Immunology1 and","Divisions of Infectious Diseases2 and","Experimental Pathology,3 Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Department of Immunology1 and","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 2-->Divisions of Infectious Diseases2 and","institution_ids":[]},{"raw_affiliation_string":"<!--label omitted: 3-->Experimental Pathology,3 Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Immunology1 and","institution_ids":[]},{"raw_affiliation_string":"Divisions of Infectious Diseases2 and","institution_ids":[]},{"raw_affiliation_string":"Experimental Pathology,3 Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.33,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.49429793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"75","issue":"23","first_page":"11408","last_page":"11416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hiv-long-terminal-repeat","display_name":"HIV long terminal repeat","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hiv-transcription","display_name":"HIV transcription","score":0.9860000014305115},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7609999775886536},{"id":"https://openalex.org/keywords/relb","display_name":"RelB","score":0.7889999747276306},{"id":"https://openalex.org/keywords/rela","display_name":"RelA","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hiv-latency","display_name":"HIV latency","score":0.46299999952316284},{"id":"https://openalex.org/keywords/monocytic-cells","display_name":"monocytic cells","score":0.6869999766349792},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.6930000185966492},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hiv-reactivation","display_name":"HIV reactivation","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2777453290","wikidata":"https://www.wikidata.org/wiki/Q18031090","display_name":"RELB","level":5,"score":0.915925145149231},{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.9024423956871033},{"id":"https://openalex.org/C2910020833","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"HIV Long Terminal Repeat","level":5,"score":0.8702035546302795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8383426070213318},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.681853175163269},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.6763138771057129},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5266915559768677},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5245892405509949},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45083582401275635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.444553941488266},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4193049371242523},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.41168588399887085},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.40375030040740967},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3822475075721741},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3594781160354614},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20653310418128967},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15535444021224976},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14920830726623535},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12636330723762512},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.75.23.11408-11416.2001","doi":"https://doi.org/10.1128/jvi.75.23.11408-11416.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.75.23.11408-11416.2001","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:114727","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:11689622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11689622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:114727","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/114727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8689388633","display_name":"HIV AND NF-KB INTERACTIONS IN MONOCYTES","funder_award_id":"R01AI036076","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320333988","display_name":"Roche Diagnostics","ror":null},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1494346716","https://openalex.org/W1502937057","https://openalex.org/W1507020270","https://openalex.org/W1573228341","https://openalex.org/W1605613258","https://openalex.org/W1613477799","https://openalex.org/W1776728769","https://openalex.org/W1907736549","https://openalex.org/W1940240994","https://openalex.org/W1966429830","https://openalex.org/W1990028169","https://openalex.org/W1993243592","https://openalex.org/W2010081701","https://openalex.org/W2016839140","https://openalex.org/W2019508559","https://openalex.org/W2024588681","https://openalex.org/W2030692398","https://openalex.org/W2036890038","https://openalex.org/W2041136290","https://openalex.org/W2042161153","https://openalex.org/W2042832398","https://openalex.org/W2048963024","https://openalex.org/W2061286251","https://openalex.org/W2066121768","https://openalex.org/W2070837106","https://openalex.org/W2070854699","https://openalex.org/W2078883220","https://openalex.org/W2080606789","https://openalex.org/W2088358220","https://openalex.org/W2088493593","https://openalex.org/W2089307417","https://openalex.org/W2098105597","https://openalex.org/W2102274109","https://openalex.org/W2102966709","https://openalex.org/W2109486527","https://openalex.org/W2109669557","https://openalex.org/W2116014786","https://openalex.org/W2129242841","https://openalex.org/W2139018692","https://openalex.org/W2139250164","https://openalex.org/W2145656711","https://openalex.org/W2147921405","https://openalex.org/W2166595456","https://openalex.org/W2166781237","https://openalex.org/W2169164673","https://openalex.org/W2342508582","https://openalex.org/W4240845107","https://openalex.org/W4300503127"],"related_works":["https://openalex.org/W2169164673","https://openalex.org/W2088358220","https://openalex.org/W2043541788","https://openalex.org/W1998694210","https://openalex.org/W2010081701","https://openalex.org/W2418142320","https://openalex.org/W3120282064","https://openalex.org/W1246629475","https://openalex.org/W2355399568","https://openalex.org/W2042648555"],"abstract_inverted_index":{"The":[0],"role":[1,23,50],"of":[2,7,37,55,62,82,87,123,130,142,146,165,173,183,194,214],"NF-kappaB":[3,56,59,88,124,147,167,192,215],"in":[4,14,24,28,70,74,92,110,135,148,170,200,204,218,222],"the":[5,49,52,58,63,83,93,111,131,136,143,166,171,180,190,195,210],"reactivation":[6],"human":[8,29,75,149,205],"immunodeficiency":[9],"virus":[10],"(HIV)":[11],"from":[12],"latency":[13],"CD4":[15],"T":[16],"lymphocytes":[17],"is":[18,39,107,138,216],"well":[19,41],"documented.":[20],"However,":[21],"its":[22],"driving":[25],"HIV":[26,64,72,103,126,161,176,184,196,202,220],"transcription":[27,73,203,221],"macrophages,":[30],"which":[31,117],"contain":[32],"a":[33,119,156],"constitutive":[34,53,84,120,144,211],"nuclear":[35,85,121,212],"pool":[36,54,86,122,145,213],"NF-kappaB,":[38],"less":[40],"understood.":[42],"In":[43],"this":[44],"study":[45],"we":[46],"have":[47],"investigated":[48],"that":[51,109,189,209],"and":[57,78,90,207],"cis-acting":[60,133,168,191],"motifs":[61,193],"long":[65],"terminal":[66],"repeat":[67],"(LTR)":[68],"play":[69],"regulating":[71,219],"monocytic":[76,113],"cells":[77],"primary":[79],"macrophages.":[80],"Inhibition":[81],"(RelA":[89],"RelB)":[91],"promonocytic":[94],"U937":[95],"cell":[96,114],"line":[97,115],"using":[98],"dominant-negative":[99,157],"IkappaBalpha":[100,158],"significantly":[101],"decreases":[102],"replication.":[104],"Moreover,":[105],"it":[106],"demonstrated":[108],"differentiated":[112],"THP1,":[116],"contains":[118],"(RelB),an":[125],"provirus":[127,177],"containing":[128],"mutations":[129],"kappaB":[132],"sites":[134,169],"LTR":[137,172,197],"transcriptionally":[139],"impaired.":[140],"Reduction":[141],"macrophages":[150,206],"by":[151],"an":[152,174],"adenovirus":[153],"vector":[154],"expressing":[155],"also":[159],"reduces":[160],"transcription.":[162,185],"Lastly,":[163],"mutation":[164],"R5":[175],"completely":[178],"abrogates":[179],"first":[181],"cycle":[182],"These":[186],"studies":[187],"indicate":[188],"are":[198],"critical":[199],"initiating":[201],"suggest":[208],"important":[217],"these":[223],"cells.":[224]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}