{"id":"https://openalex.org/W2158667695","doi":"https://doi.org/10.1136/jclinpath-2012-201194","title":"EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples","display_name":"EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples","publication_year":2012,"publication_date":"2012-11-21","ids":{"openalex":"https://openalex.org/W2158667695","doi":"https://doi.org/10.1136/jclinpath-2012-201194","mag":"2158667695","pmid":"https://pubmed.ncbi.nlm.nih.gov/23172555","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3582044"},"language":"en","primary_location":{"id":"doi:10.1136/jclinpath-2012-201194","doi":"https://doi.org/10.1136/jclinpath-2012-201194","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jclinpath-2012-201194","pdf_url":"https://jcp.bmj.com/content/jclinpath/66/2/79.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jcp.bmj.com/content/jclinpath/66/2/79.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065310394","display_name":"Gillian Ellison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gillian Ellison","raw_affiliation_strings":["AstraZeneca, Macclesfield, Alderley Park, UK","AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Macclesfield, Alderley Park, UK","institution_ids":["https://openalex.org/I105036370"]},{"raw_affiliation_string":"AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113748653","display_name":"Guanshan Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guanshan Zhu","raw_affiliation_strings":["AstraZeneca R&D, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059752563","display_name":"Alexandros Moulis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandros Moulis","raw_affiliation_strings":["AstraZeneca SA Hellas, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca SA Hellas, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025920692","display_name":"Simon Patrick Dearden","orcid":"https://orcid.org/0000-0002-4485-9760","observed_orcids":["https://orcid.org/0000-0002-4485-9760"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Dearden","raw_affiliation_strings":["AstraZeneca, Macclesfield, Alderley Park, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Macclesfield, Alderley Park, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042329520","display_name":"Georgina Speake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Georgina Speake","raw_affiliation_strings":["AstraZeneca, Macclesfield, Alderley Park, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Macclesfield, Alderley Park, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112903852","display_name":"Rose McCormack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rose McCormack","raw_affiliation_strings":["AstraZeneca, Macclesfield, Alderley Park, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Macclesfield, Alderley Park, UK","institution_ids":["https://openalex.org/I105036370"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065310394"],"corresponding_institution_ids":["https://openalex.org/I105036370"],"apc_list":null,"apc_paid":null,"fwci":4.0859,"has_fulltext":true,"cited_by_count":304,"citation_normalized_percentile":{"value":0.9734139,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"66","issue":"2","first_page":"79","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutation-testing","display_name":"EGFR mutation testing","score":0.9860000014305115},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9449999928474426},{"id":"https://openalex.org/keywords/fine-needle-aspirate","display_name":"fine needle aspirate","score":0.6359999775886536},{"id":"https://openalex.org/keywords/pleural-effusion","display_name":"pleural effusion","score":0.9430000185966492},{"id":"https://openalex.org/keywords/uncommon-egfr-mutations","display_name":"uncommon EGFR mutations","score":0.734000027179718},{"id":"https://openalex.org/keywords/direct-dna-sequencing","display_name":"direct DNA sequencing","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.63514244556427},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.6345112323760986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5981655120849609},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5816428661346436},{"id":"https://openalex.org/C163565370","wikidata":"https://www.wikidata.org/wiki/Q4308623","display_name":"Mutation testing","level":4,"score":0.5605728626251221},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5151723623275757},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48069673776626587},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.44238218665122986},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4192076623439789},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39083635807037354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25516223907470703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23541414737701416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20008134841918945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11088022589683533}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003581","descriptor_name":"Cytodiagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010996","descriptor_name":"Pleural Effusion","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010996","descriptor_name":"Pleural Effusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010996","descriptor_name":"Pleural Effusion","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013048","descriptor_name":"Specimen Handling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042282","descriptor_name":"Microdissection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/jclinpath-2012-201194","doi":"https://doi.org/10.1136/jclinpath-2012-201194","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jclinpath-2012-201194","pdf_url":"https://jcp.bmj.com/content/jclinpath/66/2/79.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2586757","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3582044","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3582044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3582044","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Pathol","raw_type":"Text"},{"id":"pmid:23172555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23172555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/jclinpath-2012-201194","doi":"https://doi.org/10.1136/jclinpath-2012-201194","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jclinpath-2012-201194","pdf_url":"https://jcp.bmj.com/content/jclinpath/66/2/79.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158667695.pdf","grobid_xml":"https://content.openalex.org/works/W2158667695.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W143155629","https://openalex.org/W1539990701","https://openalex.org/W1887901281","https://openalex.org/W1924626340","https://openalex.org/W1931438814","https://openalex.org/W1967394241","https://openalex.org/W1969014470","https://openalex.org/W1969525589","https://openalex.org/W1969800769","https://openalex.org/W1970738520","https://openalex.org/W1973312323","https://openalex.org/W1978756198","https://openalex.org/W1981989535","https://openalex.org/W1987497394","https://openalex.org/W1988110408","https://openalex.org/W1991481804","https://openalex.org/W1993427909","https://openalex.org/W1997575097","https://openalex.org/W1997860952","https://openalex.org/W2005593667","https://openalex.org/W2008013090","https://openalex.org/W2013733453","https://openalex.org/W2016136864","https://openalex.org/W2019640857","https://openalex.org/W2023338738","https://openalex.org/W2026948951","https://openalex.org/W2030488226","https://openalex.org/W2030883899","https://openalex.org/W2033780390","https://openalex.org/W2036189924","https://openalex.org/W2036792965","https://openalex.org/W2040761461","https://openalex.org/W2041738335","https://openalex.org/W2043696829","https://openalex.org/W2044166187","https://openalex.org/W2048293465","https://openalex.org/W2053325414","https://openalex.org/W2055923085","https://openalex.org/W2065480386","https://openalex.org/W2065521652","https://openalex.org/W2075897605","https://openalex.org/W2076415245","https://openalex.org/W2077437377","https://openalex.org/W2077858174","https://openalex.org/W2078618371","https://openalex.org/W2079294958","https://openalex.org/W2083829591","https://openalex.org/W2086425302","https://openalex.org/W2087058708","https://openalex.org/W2092950092","https://openalex.org/W2093450371","https://openalex.org/W2093917120","https://openalex.org/W2098379595","https://openalex.org/W2098410220","https://openalex.org/W2098707628","https://openalex.org/W2102726935","https://openalex.org/W2103388071","https://openalex.org/W2103803613","https://openalex.org/W2104374250","https://openalex.org/W2109361793","https://openalex.org/W2111662961","https://openalex.org/W2112096254","https://openalex.org/W2113687561","https://openalex.org/W2119366998","https://openalex.org/W2123372966","https://openalex.org/W2129360604","https://openalex.org/W2130601380","https://openalex.org/W2130849650","https://openalex.org/W2131036723","https://openalex.org/W2131831783","https://openalex.org/W2131962884","https://openalex.org/W2132157071","https://openalex.org/W2135595269","https://openalex.org/W2137729785","https://openalex.org/W2138312420","https://openalex.org/W2139236349","https://openalex.org/W2141575819","https://openalex.org/W2147017515","https://openalex.org/W2154662831","https://openalex.org/W2156713238","https://openalex.org/W2160982674","https://openalex.org/W2161821474","https://openalex.org/W2163195607","https://openalex.org/W2166084034","https://openalex.org/W2167010023","https://openalex.org/W2169215908","https://openalex.org/W2169592600","https://openalex.org/W2170442437","https://openalex.org/W2171981784","https://openalex.org/W2313088519","https://openalex.org/W2318366936","https://openalex.org/W6679645986"],"related_works":["https://openalex.org/W7097801157","https://openalex.org/W2131589647","https://openalex.org/W2108726676","https://openalex.org/W2315509387","https://openalex.org/W2046550496","https://openalex.org/W2080317021","https://openalex.org/W2466194316","https://openalex.org/W2082743794","https://openalex.org/W2320288478","https://openalex.org/W2907260205"],"abstract_inverted_index":{"AIMS:":[0],"Activating":[1],"mutations":[2,32,180],"in":[3,23,33,40,52,76,100],"the":[4,41,71,89,115,134,223],"gene":[5],"encoding":[6],"epidermal":[7],"growth":[8],"factor":[9],"receptor":[10],"(EGFR)":[11],"can":[12,193],"confer":[13],"sensitivity":[14],"to":[15,78,114,167,197,219,231],"EGFR":[16,34,49,83,96,119,137,199,227],"tyrosine":[17],"kinase":[18],"inhibitors":[19],"such":[20],"as":[21,111],"gefitinib":[22],"patients":[24,53,101],"with":[25,54,102],"advanced":[26],"non-small-cell":[27],"lung":[28,55,103],"cancer.":[29,104],"Testing":[30],"for":[31,48,82,92,118,222,239],"is":[35,181],"therefore":[36],"an":[37],"important":[38],"step":[39],"treatment-decision":[42],"pathway.":[43],"We":[44,66,87],"reviewed":[45],"reported":[46],"methods":[47,99,107,130,145,206,213],"mutation":[50,84,97,120,143,200,240],"testing":[51,98,144,205,212,241],"cancer,":[56],"initially":[57],"focusing":[58],"on":[59,70,95],"studies":[60,93],"involving":[61],"standard":[62,117],"tumour":[63,243],"tissue":[64,244],"samples.":[65,160],"also":[67,172],"evaluated":[68],"data":[69],"use":[72,162],"of":[73,126,141,158,163,176,225],"cytology":[74,234],"samples":[75,185,235,245],"order":[77],"determine":[79,198],"their":[80],"suitability":[81],"analysis.":[85],"METHODS:":[86],"searched":[88],"MEDLINE":[90],"database":[91],"reporting":[94],"RESULTS:":[105],"Various":[106],"have":[108],"been":[109],"investigated":[110],"potential":[112],"alternatives":[113,238],"historical":[116],"testing,":[121],"direct":[122,220],"DNA":[123],"sequencing.":[124],"Many":[125],"these":[127],"are":[128,207,236,246],"targeted":[129,142],"that":[131,174,203],"specifically":[132],"detect":[133],"most":[135],"common":[136,226],"mutations.":[138,228],"The":[139,161],"development":[140],"and":[146,155,190],"commercially":[147],"available":[148],"test":[149],"kits":[150],"has":[151,171],"enabled":[152],"sensitive,":[153],"rapid":[154],"robust":[156],"analysis":[157],"clinical":[159],"screening":[164],"methods,":[165],"subsequent":[166],"sample":[168],"micro":[169],"dissection,":[170],"ensured":[173],"identification":[175],"more":[177,216],"rare,":[178],"uncommon":[179],"now":[182],"feasible.":[183],"Cytology":[184],"including":[186],"fine":[187],"needle":[188],"aspirate":[189],"pleural":[191],"effusion":[192],"be":[194],"used":[195],"successfully":[196],"status":[201],"provided":[202],"sensitive":[204,217],"employed.":[208],"CONCLUSIONS:":[209],"Several":[210],"different":[211],"offer":[214],"a":[215],"alternative":[218],"sequencing":[221],"detection":[224],"Evidence":[229],"published":[230],"date":[232],"suggests":[233],"viable":[237],"when":[242],"not":[247],"available.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":38},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":39},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":26}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}