{"id":"https://openalex.org/W2158648217","doi":null,"title":"Selected markers of endothelial dysfunction in women with polycystic ovary syndrome.","display_name":"Selected markers of endothelial dysfunction in women with polycystic ovary syndrome.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2158648217","mag":"2158648217","pmid":"https://pubmed.ncbi.nlm.nih.gov/21717407"},"language":"en","primary_location":{"id":"pmid:21717407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21717407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endokrynologia Polska","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078343737","display_name":"Wanda Fo\u0142tyn","orcid":"https://orcid.org/0000-0002-1453-5087","observed_orcids":["https://orcid.org/0000-0002-1453-5087"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wanda Foltyn","raw_affiliation_strings":["Division of Endocrinology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. wandafoltyn@poczta.onet.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. wandafoltyn@poczta.onet.pl","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039986027","display_name":"Janusz Strzelczyk","orcid":"https://orcid.org/0000-0003-3438-9512","observed_orcids":["https://orcid.org/0000-0003-3438-9512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janusz Strzelczyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108229067","display_name":"Bogan Marek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bogan Marek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053698057","display_name":"Dariusz Kajdaniuk","orcid":"https://orcid.org/0000-0002-5577-800X","observed_orcids":["https://orcid.org/0000-0002-5577-800X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dariusz Kajdaniuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033144279","display_name":"Lucyna Siemi\u0144\u015bka","orcid":"https://orcid.org/0000-0003-4579-2382","observed_orcids":["https://orcid.org/0000-0003-4579-2382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucyna Siemi\u0144ska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011780241","display_name":"Anna Zemczak","orcid":"https://orcid.org/0000-0001-6314-2661","observed_orcids":["https://orcid.org/0000-0001-6314-2661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Zemczak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083238229","display_name":"Jolanta Blicharz-Dorniak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolanta Blicharz-Dorniak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003314722","display_name":"Beata Kos\u2010Kud\u0142a","orcid":"https://orcid.org/0000-0003-3755-1722","observed_orcids":["https://orcid.org/0000-0003-3755-1722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beata Kos-Kud\u0142a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5037,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.7944655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"3","first_page":"243","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":1.0},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":1.0},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8579999804496765},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.460999995470047},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.5389999747276306},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8437207937240601},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.8160951137542725},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.7689279317855835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.72807776927948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7201663255691528},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.6766501665115356},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5820563435554504},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5359625816345215},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.46526315808296204},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4465913474559784},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4326328635215759},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4203818440437317},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.12642917037010193}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019040","descriptor_name":"E-Selectin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21717407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21717407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endokrynologia Polska","raw_type":"Comparative Study"},{"id":"mag:2158648217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21717407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W17203237","https://openalex.org/W1871865728","https://openalex.org/W1963628647","https://openalex.org/W1975142697","https://openalex.org/W1977006005","https://openalex.org/W1991154936","https://openalex.org/W1992673626","https://openalex.org/W2009654724","https://openalex.org/W2017528217","https://openalex.org/W2028121321","https://openalex.org/W2051219879","https://openalex.org/W2052504098","https://openalex.org/W2053731484","https://openalex.org/W2057023689","https://openalex.org/W2066044812","https://openalex.org/W2074957886","https://openalex.org/W2078156869","https://openalex.org/W2080859883","https://openalex.org/W2096773810","https://openalex.org/W2100211815","https://openalex.org/W2107781166","https://openalex.org/W2114577467","https://openalex.org/W2118743055","https://openalex.org/W2122027543","https://openalex.org/W2123709459","https://openalex.org/W2137570167","https://openalex.org/W2137710668","https://openalex.org/W2139915659","https://openalex.org/W2144997397","https://openalex.org/W2148804426","https://openalex.org/W2152097518","https://openalex.org/W2294856982"],"related_works":["https://openalex.org/W3029193277","https://openalex.org/W2935923757","https://openalex.org/W2113385698","https://openalex.org/W7129076140","https://openalex.org/W1976453819","https://openalex.org/W2078374488","https://openalex.org/W1969666778","https://openalex.org/W2099195181","https://openalex.org/W275410586","https://openalex.org/W2114577467"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,39,95,109,142],"increased":[2],"incidence":[3],"of":[4,21,29,33,41,49,53,73,99,111,139,147,254,267,281],"cardiovascular":[5],"disease":[6],"in":[7,25,65,92,170,230,240,251,272,278,292],"women":[8,67,102,274],"with":[9,80,205],"polycystic":[10],"ovary":[11],"syndrome":[12],"(PCOS)":[13],"has":[14],"prompted":[15],"researchers":[16],"to":[17,45],"look":[18],"for":[19,104],"indicators":[20],"early":[22],"atherosclerotic":[23],"changes":[24],"these":[26,132],"patients.":[27,282],"One":[28],"the":[30,47,93,128,252],"earliest":[31],"stages":[32],"atherogenesis":[34],"is":[35],"endothelial":[36,54,276,290],"cell":[37],"dysfunction.":[38],"aim":[40],"this":[42,279],"study":[43,143],"was":[44,179,218,236],"assess":[46],"levels":[48,110,146,200,226,242,253,266],"selected":[50],"plasma":[51],"markers":[52],"injury":[55],"[E-selectin,":[56],"endothelin-1":[57],"(ET-1)":[58],"and":[59,69,106,121,123,165,184,193,210,223,248,259,269,284],"von":[60],"Willebrand":[61],"Factor":[62],"antigen":[63],"(vWF:Ag)]":[64],"PCOS":[66,81,129,171,231,273],"before":[68],"after":[70,136],"six":[71,137],"months":[72,138],"treatment.":[74,140],"MATERIAL":[75],"AND":[76],"METHODS:":[77],"32":[78],"patients":[79,172],"aged":[82],"18-36":[83],"years":[84],"(mean":[85],"age":[86,105],"25.16":[87],"\u00b1":[88],"5.80)":[89],"were":[90,125,134],"included":[91],"study.":[94],"control":[96],"group":[97,280],"consisted":[98],"20":[100],"healthy":[101,174],"matched":[103],"body":[107],"mass.":[108],"ET-1,":[112],"vWF:Ag,":[113],"E-selectin,":[114],"fasting":[115],"glucose,":[116],"insulin,":[117],"total":[118,224],"cholesterol,":[119],"HDL":[120,255],"LDL-cholesterol":[122],"triglycerides":[124,189,211,260],"assessed.":[126],"In":[127],"group,":[130],"all":[131],"tests":[133],"repeated":[135],"RESULTS:":[141],"showed":[144,201],"higher":[145],"vWF:Ag":[148,199,268],"(p":[149,154,158,162,167,186,190,196,207,212,227,245,256,261],"=":[150,155,159,163,168,187,191,197,208,213,228,246,257,262],"0.043),":[151],"E":[152,182,270],"selectin":[153,183,271],"0.028),":[156],"insulin":[157],"0.044),":[160],"glucose":[161,185,206],"0.036)":[164],"LDL":[166],"0.006)":[169],"versus":[173],"women.":[175,232],"A":[176,215],"positive":[177,203,216],"correlation":[178,204,217],"demonstrated":[180],"between":[181,221],"0.0001),":[188],"0.014)":[192],"uric":[194],"acid":[195],"0.008).":[198],"a":[202,237],"0.04)":[209],"0.036).":[214],"also":[219],"found":[220],"ET-1":[222],"cholesterol":[225],"0.012)":[229],"After":[233],"treatment,":[234],"there":[235],"significant":[238,287],"reduction":[239],"E-selectin":[241],"from":[243],"baseline":[244],"0.002)":[247],"an":[249],"increase":[250],"0.0002)":[258],"0.033).":[263],"CONCLUSIONS:":[264],"Elevated":[265],"suggest":[275],"dysfunction":[277],"Glucose":[283],"triglyceride":[285],"are":[286],"factors":[288],"affecting":[289],"function":[291],"PCOS.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}