{"id":"https://openalex.org/W2158604176","doi":"https://doi.org/10.1517/13543776.2012.682571","title":"Androgen receptor antagonists: a patent review (2008 \u2013 2011)","display_name":"Androgen receptor antagonists: a patent review (2008 \u2013 2011)","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W2158604176","doi":"https://doi.org/10.1517/13543776.2012.682571","mag":"2158604176","pmid":"https://pubmed.ncbi.nlm.nih.gov/22583332"},"language":"en","primary_location":{"id":"doi:10.1517/13543776.2012.682571","doi":"https://doi.org/10.1517/13543776.2012.682571","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543776.2012.682571","pdf_url":null,"source":{"id":"https://openalex.org/S3784663","display_name":"Expert Opinion on Therapeutic Patents","issn_l":"1354-3776","issn":["1354-3776","1744-7674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Patents","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065375417","display_name":"Michael L. Mohler","orcid":"https://orcid.org/0000-0002-1609-6524","observed_orcids":["https://orcid.org/0000-0002-1609-6524"]},"institutions":[{"id":"https://openalex.org/I188703185","display_name":"GTx (United States)","ror":"https://ror.org/0400j3f74","country_code":"US","type":"company","lineage":["https://openalex.org/I188703185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L Mohler","raw_affiliation_strings":["Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, TN 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I188703185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047984092","display_name":"Christopher Charles Coss","orcid":"https://orcid.org/0000-0002-8184-9190","observed_orcids":["https://orcid.org/0000-0002-8184-9190"]},"institutions":[{"id":"https://openalex.org/I188703185","display_name":"GTx (United States)","ror":"https://ror.org/0400j3f74","country_code":"US","type":"company","lineage":["https://openalex.org/I188703185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher C Coss","raw_affiliation_strings":["Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, TN 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I188703185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017977887","display_name":"C. B. Duke","orcid":"https://orcid.org/0000-0003-4649-7246","observed_orcids":["https://orcid.org/0000-0003-4649-7246"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles B Duke","raw_affiliation_strings":["University of Tennessee Health Science Center, Pharmaceutical Sciences Department, 302 Johnson Bldg, Memphis TN, 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tennessee Health Science Center, Pharmaceutical Sciences Department, 302 Johnson Bldg, Memphis TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014948881","display_name":"Shivaputra A. Patil","orcid":"https://orcid.org/0000-0001-6959-524X","observed_orcids":["https://orcid.org/0000-0001-6959-524X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivaputra A Patil","raw_affiliation_strings":["University of Tennessee Health Science Center, Pharmaceutical Sciences Department, 327 Johnson Bldg, Memphis TN, 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tennessee Health Science Center, Pharmaceutical Sciences Department, 327 Johnson Bldg, Memphis TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016676195","display_name":"Duane D. Miller","orcid":"https://orcid.org/0000-0002-6093-0985","observed_orcids":["https://orcid.org/0000-0002-6093-0985"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duane D Miller","raw_affiliation_strings":["University of Tennessee Health Science Center, Pharmaceutical Sciences Department, 435 Pharmacy Bldg, Memphis TN, 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tennessee Health Science Center, Pharmaceutical Sciences Department, 435 Pharmacy Bldg, Memphis TN, 38163, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002243266","display_name":"James T. Dalton","orcid":"https://orcid.org/0000-0002-3915-7326","observed_orcids":["https://orcid.org/0000-0002-3915-7326"]},"institutions":[{"id":"https://openalex.org/I188703185","display_name":"GTx (United States)","ror":"https://ror.org/0400j3f74","country_code":"US","type":"company","lineage":["https://openalex.org/I188703185"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T Dalton","raw_affiliation_strings":["Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, TN 38163, USA +1 901 507 8604; +1 901 844 8078; jdalton@gtxinc.com","+1 901 844 8078","Preclinical Research and Development, GTx, Inc.,\n3 North Dunlap Street, Memphis, TN 38163, USA +1 901 507 8604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Research and Development, GTx, Inc., 3 North Dunlap Street, Memphis, TN 38163, USA +1 901 507 8604; +1 901 844 8078; jdalton@gtxinc.com","institution_ids":["https://openalex.org/I188703185"]},{"raw_affiliation_string":"+1 901 844 8078","institution_ids":[]},{"raw_affiliation_string":"Preclinical Research and Development, GTx, Inc.,\n3 North Dunlap Street, Memphis, TN 38163, USA +1 901 507 8604","institution_ids":["https://openalex.org/I188703185"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7612,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.5980198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"5","first_page":"541","last_page":"565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":1.0},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/competitive-antagonists","display_name":"competitive antagonists","score":0.7590000033378601},{"id":"https://openalex.org/keywords/noncompetitive-antagonists","display_name":"noncompetitive antagonists","score":0.8640000224113464},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.7179999947547913},{"id":"https://openalex.org/keywords/patent-landscape","display_name":"patent landscape","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7210221290588379},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5560012459754944},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4475024938583374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42559054493904114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3958556056022644},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2161647081375122},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21514227986335754},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12140977382659912}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007880","descriptor_name":"Legislation, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010330","descriptor_name":"Patents as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/13543776.2012.682571","doi":"https://doi.org/10.1517/13543776.2012.682571","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543776.2012.682571","pdf_url":null,"source":{"id":"https://openalex.org/S3784663","display_name":"Expert Opinion on Therapeutic Patents","issn_l":"1354-3776","issn":["1354-3776","1744-7674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Patents","raw_type":"journal-article"},{"id":"pmid:22583332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22583332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic patents","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W154571260","https://openalex.org/W157846566","https://openalex.org/W1508200717","https://openalex.org/W1524696217","https://openalex.org/W1533238941","https://openalex.org/W1543020615","https://openalex.org/W1546185806","https://openalex.org/W1550530127","https://openalex.org/W1551778018","https://openalex.org/W1559159566","https://openalex.org/W1562818834","https://openalex.org/W1568509428","https://openalex.org/W1577676192","https://openalex.org/W1578641183","https://openalex.org/W1583943366","https://openalex.org/W1591942474","https://openalex.org/W1658584202","https://openalex.org/W1753538888","https://openalex.org/W1762886014","https://openalex.org/W1866962481","https://openalex.org/W1964443835","https://openalex.org/W1966114716","https://openalex.org/W1970586482","https://openalex.org/W1974810481","https://openalex.org/W1976003215","https://openalex.org/W1976983409","https://openalex.org/W1979959257","https://openalex.org/W1983131802","https://openalex.org/W1986385964","https://openalex.org/W1987439849","https://openalex.org/W1988467765","https://openalex.org/W1990287298","https://openalex.org/W1993554231","https://openalex.org/W2002791165","https://openalex.org/W2003955264","https://openalex.org/W2004635842","https://openalex.org/W2004636807","https://openalex.org/W2005140082","https://openalex.org/W2005302422","https://openalex.org/W2005374212","https://openalex.org/W2009532504","https://openalex.org/W2013138600","https://openalex.org/W2013809140","https://openalex.org/W2013896822","https://openalex.org/W2014284922","https://openalex.org/W2019311111","https://openalex.org/W2023018072","https://openalex.org/W2024558899","https://openalex.org/W2026268878","https://openalex.org/W2027602941","https://openalex.org/W2029105107","https://openalex.org/W2030086348","https://openalex.org/W2030759538","https://openalex.org/W2035087312","https://openalex.org/W2036441940","https://openalex.org/W2037932659","https://openalex.org/W2038114355","https://openalex.org/W2039410885","https://openalex.org/W2041623560","https://openalex.org/W2044203168","https://openalex.org/W2045158420","https://openalex.org/W2047064944","https://openalex.org/W2048523515","https://openalex.org/W2049454233","https://openalex.org/W2051874241","https://openalex.org/W2066570340","https://openalex.org/W2067438553","https://openalex.org/W2077946302","https://openalex.org/W2079320970","https://openalex.org/W2080722341","https://openalex.org/W2083926838","https://openalex.org/W2084637523","https://openalex.org/W2086400515","https://openalex.org/W2087109466","https://openalex.org/W2088228692","https://openalex.org/W2088456447","https://openalex.org/W2091104967","https://openalex.org/W2092714565","https://openalex.org/W2095240081","https://openalex.org/W2102239047","https://openalex.org/W2102620699","https://openalex.org/W2108552422","https://openalex.org/W2108955823","https://openalex.org/W2109541969","https://openalex.org/W2114941442","https://openalex.org/W2118238803","https://openalex.org/W2118906905","https://openalex.org/W2119504728","https://openalex.org/W2128840922","https://openalex.org/W2131059659","https://openalex.org/W2136160453","https://openalex.org/W2138684882","https://openalex.org/W2142184845","https://openalex.org/W2142614941","https://openalex.org/W2144492823","https://openalex.org/W2146319242","https://openalex.org/W2147988255","https://openalex.org/W2148349025","https://openalex.org/W2149131962","https://openalex.org/W2155368234","https://openalex.org/W2156816941","https://openalex.org/W2158600871","https://openalex.org/W2160084272","https://openalex.org/W2161123101","https://openalex.org/W2163278630","https://openalex.org/W2164092182","https://openalex.org/W2165782799","https://openalex.org/W2170311200","https://openalex.org/W2171434323","https://openalex.org/W2189633225","https://openalex.org/W2208343753","https://openalex.org/W2265857716","https://openalex.org/W2326357482","https://openalex.org/W2340799873","https://openalex.org/W2419174552","https://openalex.org/W2435382281","https://openalex.org/W2580776060","https://openalex.org/W2734491081","https://openalex.org/W2736395683","https://openalex.org/W2850465016","https://openalex.org/W3193354671"],"related_works":["https://openalex.org/W2320292895","https://openalex.org/W2900742550","https://openalex.org/W30124836","https://openalex.org/W2152046394","https://openalex.org/W2091098941","https://openalex.org/W1926009117","https://openalex.org/W1932077478","https://openalex.org/W2023109070","https://openalex.org/W1530978709","https://openalex.org/W2107759665"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Androgen":[1],"receptor":[2],"(AR)":[3],"antagonists":[4,65,116,163],"are":[5,124,127],"predominantly":[6],"used":[7],"as":[8,105,135,178],"chemical":[9],"castration":[10],"to":[11,33,42],"treat":[12],"prostate":[13,25],"cancer":[14,26],"(i.e.,":[15],"in":[16,55,97,157],"conjunction":[17],"with":[18],"androgen":[19],"deprivation":[20],"therapy":[21],"(ADT)).":[22],"Unfortunately,":[23],"castration-resistant":[24],"(CRPC)":[27],"typically":[28],"develops":[29],"that":[30],"is":[31],"refractory":[32],"targeted":[34],"therapy.":[35],"Insights":[36],"into":[37],"CRPC":[38],"biology":[39],"have":[40,164],"led":[41],"the":[43,100,131],"emergence":[44],"of":[45,60,71,168,176,179],"a":[46,53,69,106,143,149],"promising":[47,107],"clinical":[48,170,174],"candidate":[49],"MDV3100":[50],"(1)":[51],"and":[52,87,122,155],"resurgence":[54],"this":[56],"field.":[57],"A":[58],"pipeline":[59],"preclinical":[61],"competitive":[62,150],"(C-terminally":[63],"directed)":[64],"was":[66],"discovered":[67],"using":[68],"variety":[70],"innovative":[72],"screening":[73,132],"paradigms.":[74],"Some":[75],"inhibit":[76],"nuclear":[77],"translocation,":[78],"selectively":[79],"downregulate":[80],"or":[81],"degrade":[82],"AR":[83,90,94,115],"(SARD),":[84],"antagonize":[85,93],"wild-type":[86],"escape":[88],"mutant":[89],"(pan-antagonists)":[91],"and/or":[92],"target":[95,109],"organs":[96],"vivo.":[98],"Separately,":[99],"N-terminal":[101],"domain":[102],"has":[103],"emerged":[104],"novel":[108],"for":[110,147],"noncompetitive":[111],"antagonists.":[112],"AREAS":[113],"COVERED:":[114],"whose":[117],"patents":[118],"published":[119],"between":[120],"2008":[121],"2011":[123],"reviewed.":[125],"Antagonists":[126],"organized":[128],"based":[129],"on":[130],"paradigm":[133],"reported":[134],"discussed":[136],"above.":[137],"EXPERT":[138],"OPINION:":[139],"Novel":[140],"mechanisms":[141],"provide":[142],"more":[144],"informed":[145],"basis":[146],"selecting":[148],"antagonist;":[151],"however,":[152],"high":[153],"potency":[154],"favorable":[156],"vivo":[158],"properties":[159],"remain":[160],"paramount.":[161],"Noncompetitive":[162],"theoretical":[165],"advantages":[166],"suggestive":[167],"improved":[169],"efficacy,":[171],"but":[172],"no":[173],"proof":[175],"concept":[177],"yet.":[180]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
