{"id":"https://openalex.org/W2158603877","doi":"https://doi.org/10.1172/jci115375","title":"Intra-islet insulin permits glucose to directly suppress pancreatic A cell function.","display_name":"Intra-islet insulin permits glucose to directly suppress pancreatic A cell function.","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W2158603877","doi":"https://doi.org/10.1172/jci115375","mag":"2158603877","pmid":"https://pubmed.ncbi.nlm.nih.gov/1679440","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/295460"},"language":"en","primary_location":{"id":"doi:10.1172/jci115375","doi":"https://doi.org/10.1172/jci115375","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115375","pdf_url":"http://www.jci.org/articles/view/115375/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/115375/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020555978","display_name":"Carla J. Greenbaum","orcid":"https://orcid.org/0000-0003-4451-9800","observed_orcids":["https://orcid.org/0000-0003-4451-9800"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C J Greenbaum","raw_affiliation_strings":["Veterans Medical Center, Seattle, WA 98108","Department ofMedicine, University of Washington, Seattle, Washington 98108","Veterans Affairs Medical Center, Medical Services ( 1 1), 1660 South Columbian Way, Seattle, WA 98108","Veterans Medical Center and the Division ofMetabolism, Endocrinology, and Nutrition,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Medical Center, Seattle, WA 98108","institution_ids":[]},{"raw_affiliation_string":"Department ofMedicine, University of Washington, Seattle, Washington 98108","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Medical Services ( 1 1), 1660 South Columbian Way, Seattle, WA 98108","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Veterans Medical Center and the Division ofMetabolism, Endocrinology, and Nutrition,","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034829692","display_name":"Peter Joseph Havel","orcid":"https://orcid.org/0000-0003-3652-8301","observed_orcids":["https://orcid.org/0000-0003-3652-8301"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P J Havel","raw_affiliation_strings":["Department ofMedicine, University of Washington, Seattle, Washington 98108","Veterans Medical Center and the Division ofMetabolism, Endocrinology, and Nutrition,","Veterans Affairs Medical Center, Medical Services ( 1 1), 1660 South Columbian Way, Seattle, WA 98108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedicine, University of Washington, Seattle, Washington 98108","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Veterans Medical Center and the Division ofMetabolism, Endocrinology, and Nutrition,","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Medical Services ( 1 1), 1660 South Columbian Way, Seattle, WA 98108","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035495914","display_name":"Gerald J. Taborsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G J Taborsky","raw_affiliation_strings":["Department ofMedicine, University of Washington, Seattle, Washington 98108","Veterans Medical Center and the Division ofMetabolism, Endocrinology, and Nutrition,","Veterans Affairs Medical Center, Medical Services ( 1 1), 1660 South Columbian Way, Seattle, WA 98108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedicine, University of Washington, Seattle, Washington 98108","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Veterans Medical Center and the Division ofMetabolism, Endocrinology, and Nutrition,","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Medical Services ( 1 1), 1660 South Columbian Way, Seattle, WA 98108","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069113394","display_name":"Leslie J. Klaff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L J Klaff","raw_affiliation_strings":["Department ofMedicine, University of Washington, Seattle, Washington 98108","Veterans Medical Center and the Division ofMetabolism, Endocrinology, and Nutrition,","Veterans Affairs Medical Center, Medical Services ( 1 1), 1660 South Columbian Way, Seattle, WA 98108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMedicine, University of Washington, Seattle, Washington 98108","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Veterans Medical Center and the Division ofMetabolism, Endocrinology, and Nutrition,","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Veterans Affairs Medical Center, Medical Services ( 1 1), 1660 South Columbian Way, Seattle, WA 98108","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.2731,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.56846594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"88","issue":"3","first_page":"767","last_page":"773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-suppression","display_name":"glucagon suppression","score":0.7649999856948853},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pancreatic-a-cells","display_name":"pancreatic A cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/glucose-infusion","display_name":"glucose infusion","score":0.49799999594688416},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.6510000228881836},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8962113857269287},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.873386025428772},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8668382167816162},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.8556745052337646},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7423492670059204},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.5474267601966858},{"id":"https://openalex.org/C144855686","wikidata":"https://www.wikidata.org/wiki/Q6042245","display_name":"Insulin oscillation","level":4,"score":0.4714423418045044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37895071506500244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3381112813949585}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000496","descriptor_name":"Alloxan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci115375","doi":"https://doi.org/10.1172/jci115375","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115375","pdf_url":"http://www.jci.org/articles/view/115375/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1313635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/295460","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:1679440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1679440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2sg4377x","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2sg4377x","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation, vol 88, iss 3","raw_type":"article"},{"id":"pmh:qt2sg4377x","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/2sg4377x","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Greenbaum, CJ; Havel, PJ; Taborsky, GJ; & Klaff, LJ. (1991). Intra-islet insulin permits glucose to directly suppress pancreatic A cell function.. The Journal of clinical investigation, 88(3), 767 - 773. doi: 10.1172/jci115375. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2sg4377x","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1172/jci115375","doi":"https://doi.org/10.1172/jci115375","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci115375","pdf_url":"http://www.jci.org/articles/view/115375/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G642268167","display_name":"Integration of Long- and Short-Term Control of Feeding","funder_award_id":"R01DK012829","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7551525971","display_name":"ISLET CELL SURFACE ANTIBODIES - B-CELL FUNCTION","funder_award_id":"F32DK008211","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000881174","display_name":"Diabetes Research Center","funder_award_id":"P30DK017047","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158603877.pdf","grobid_xml":"https://content.openalex.org/works/W2158603877.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W272235842","https://openalex.org/W1968863211","https://openalex.org/W1969581692","https://openalex.org/W1970459847","https://openalex.org/W1971286863","https://openalex.org/W1973457392","https://openalex.org/W1977225925","https://openalex.org/W1984541901","https://openalex.org/W1988170773","https://openalex.org/W1994115989","https://openalex.org/W1994280160","https://openalex.org/W1996874443","https://openalex.org/W1997046391","https://openalex.org/W2002848742","https://openalex.org/W2004808111","https://openalex.org/W2006094348","https://openalex.org/W2010821080","https://openalex.org/W2012360351","https://openalex.org/W2020464660","https://openalex.org/W2023712674","https://openalex.org/W2031662314","https://openalex.org/W2032076994","https://openalex.org/W2039242258","https://openalex.org/W2046096086","https://openalex.org/W2047529430","https://openalex.org/W2051877725","https://openalex.org/W2056862318","https://openalex.org/W2057601123","https://openalex.org/W2059027410","https://openalex.org/W2072084112","https://openalex.org/W2072850070","https://openalex.org/W2073625634","https://openalex.org/W2074180186","https://openalex.org/W2077934242","https://openalex.org/W2102348011","https://openalex.org/W2124602153","https://openalex.org/W2127112852","https://openalex.org/W2133327432","https://openalex.org/W2148012740","https://openalex.org/W2159459646","https://openalex.org/W2167805272","https://openalex.org/W2182512393","https://openalex.org/W2282945003","https://openalex.org/W2318264845","https://openalex.org/W4250756743"],"related_works":["https://openalex.org/W7099026654","https://openalex.org/W2023712674","https://openalex.org/W2010821080","https://openalex.org/W2057537453","https://openalex.org/W2073158702","https://openalex.org/W2104131411","https://openalex.org/W2021920528","https://openalex.org/W1970459847","https://openalex.org/W7213009823","https://openalex.org/W2047529430"],"abstract_inverted_index":{"Inhibition":[0],"of":[1,28,34,45,50,92,127,161,165,177],"pancreatic":[2,47],"glucagon":[3,35,85,108,128,162,181,194],"secretion":[4,195],"during":[5,170,199],"hyperglycemia":[6,178],"could":[7],"be":[8],"mediated":[9],"by":[10],"(a)":[11],"glucose,":[12],"(b)":[13],"insulin,":[14,66],"(c)":[15],"somatostatin,":[16],"or":[17,163],"(d)":[18],"glucose":[19,80,90,100,171,191],"in":[20,31,74,124,150],"conjunction":[21],"with":[22],"insulin.":[23],"To":[24],"determine":[25],"the":[26,32,42,46,58,125,142,146,175],"role":[27],"these":[29],"factors":[30],"mediation":[33,126],"suppression,":[36],"we":[37,134],"injected":[38],"alloxan":[39],"while":[40],"clamping":[41],"arterial":[43],"supply":[44],"splenic":[48],"lobe":[49,60,65,149],"dogs,":[51],"thus":[52],"inducing":[53],"insulin":[54,121,136,168,189],"deficiency":[55],"localized":[56],"to":[57,76,179,192],"ventral":[59],"and":[61,68,95,130,182,196],"avoiding":[62],"hyperglycemia.":[63,200],"Ventral":[64],"glucagon,":[67],"somatostatin":[69,96,115,131,198],"outputs":[70],"were":[71],"then":[72],"measured":[73],"response":[75],"a":[77,89],"stepped":[78],"IV":[79],"infusion.":[81],"In":[82,105],"control":[83],"dogs":[84,107],"suppression":[86,129,160],"occurred":[87],"at":[88,99,137],"level":[91],"150":[93],"mg/dl":[94],"output":[97,109,116],"increased":[98],"greater":[101],"than":[102],"250":[103],"mg/dl.":[104],"alloxan-treated":[106,152],"was":[110,122],"not":[111,158],"suppressed":[112],"nor":[113],"did":[114,157,173],"increase.":[117],"We":[118,185],"concluded":[119],"that":[120,144,187],"required":[123],"stimulation.":[132],"Subsequently,":[133],"infused":[135],"high":[138],"rates":[139],"directly":[140],"into":[141],"artery":[143],"supplied":[145],"beta":[147],"cell-deficient":[148],"six":[151],"dogs.":[153],"Insulin":[154],"infusion":[155],"alone":[156],"cause":[159],"stimulation":[164],"somatostatin;":[166],"however,":[167],"repletion":[169],"infusions":[172],"restore":[174],"ability":[176],"suppress":[180,193],"stimulate":[183,197],"somatostatin.":[184],"conclude":[186],"intra-islet":[188],"permits":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}