{"id":"https://openalex.org/W2158567574","doi":"https://doi.org/10.2217/nnm.12.14","title":"Prostate-Targeted Biodegradable Nanoparticles Loaded with Androgen Receptor Silencing Constructs Eradicate Xenograft Tumors in Mice","display_name":"Prostate-Targeted Biodegradable Nanoparticles Loaded with Androgen Receptor Silencing Constructs Eradicate Xenograft Tumors in Mice","publication_year":2012,"publication_date":"2012-05-14","ids":{"openalex":"https://openalex.org/W2158567574","doi":"https://doi.org/10.2217/nnm.12.14","mag":"2158567574","pmid":"https://pubmed.ncbi.nlm.nih.gov/22583574","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3448843"},"language":"en","primary_location":{"id":"doi:10.2217/nnm.12.14","doi":"https://doi.org/10.2217/nnm.12.14","is_oa":false,"landing_page_url":"https://doi.org/10.2217/nnm.12.14","pdf_url":null,"source":{"id":"https://openalex.org/S4210216406","display_name":"Nanomedicine","issn_l":"1743-5889","issn":["1743-5889","1748-6963"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3448843","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101846977","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0003-3261-5774","observed_orcids":["https://orcid.org/0000-0003-3261-5774"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jun Yang","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","Department of Urology, Tongji Hospital, Huazhong University of Science &amp; Technology, Wuhan430030, China","Department of Urology, The University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Urology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan 430030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Urology, Tongji Hospital, Huazhong University of Science &amp; Technology, Wuhan430030, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Urology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan 430030, China","institution_ids":["https://openalex.org/I4210128618","https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103279289","display_name":"Sheng\u2010Xue Xie","orcid":"https://orcid.org/0000-0003-3873-5064","observed_orcids":["https://orcid.org/0000-0003-3873-5064"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheng-Xue Xie","raw_affiliation_strings":["Departments of Pharmaceutical Chemistry &amp; Chemical &amp; Petroleum Engineering, The University of Kansas, Lawrence, KS66045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmaceutical Chemistry &amp; Chemical &amp; Petroleum Engineering, The University of Kansas, Lawrence, KS66045, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073216349","display_name":"Yiling Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiling Huang","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","Departments of Pathology &amp; Pharmacology, Three George University School of Medicine, Yichang443000, China","Department of Urology, The University of Kansas Medical Center, Kansas City, KS 66160, USADepartments of Pathology & Pharmacology, Three George University School of Medicine, Yichang 443000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pathology &amp; Pharmacology, Three George University School of Medicine, Yichang443000, China","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS 66160, USADepartments of Pathology & Pharmacology, Three George University School of Medicine, Yichang 443000, China","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Min Ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Ling","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422746","display_name":"Jihong Liu","orcid":"https://orcid.org/0000-0001-9711-2428","observed_orcids":["https://orcid.org/0000-0001-9711-2428"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jihong Liu","raw_affiliation_strings":["Department of Urology, Tongji Hospital, Huazhong University of Science &amp; Technology, Wuhan430030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tongji Hospital, Huazhong University of Science &amp; Technology, Wuhan430030, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017064687","display_name":"Yali Ran","orcid":"https://orcid.org/0000-0003-1871-7264","observed_orcids":["https://orcid.org/0000-0003-1871-7264"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yali Ran","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038551527","display_name":"Yanlin Wang","orcid":"https://orcid.org/0000-0002-5660-7704","observed_orcids":["https://orcid.org/0000-0002-5660-7704","https://orcid.org/0000-0001-7423-6815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanlin Wang","raw_affiliation_strings":["Departments of Pathology &amp; Pharmacology, Three George University School of Medicine, Yichang443000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology &amp; Pharmacology, Three George University School of Medicine, Yichang443000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113835930","display_name":"James Brantley Thrasher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Brantley Thrasher","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103278951","display_name":"Cory J. Berkland","orcid":"https://orcid.org/0000-0002-7164-7886","observed_orcids":["https://orcid.org/0000-0002-7164-7886"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cory Berkland","raw_affiliation_strings":["Departments of Pharmaceutical Chemistry &amp; Chemical &amp; Petroleum Engineering, The University of Kansas, Lawrence, KS66045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmaceutical Chemistry &amp; Chemical &amp; Petroleum Engineering, The University of Kansas, Lawrence, KS66045, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084681260","display_name":"Benyi Li","orcid":"https://orcid.org/0000-0001-6242-5117","observed_orcids":["https://orcid.org/0000-0001-6242-5117"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Benyi Li","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","Departments of Pathology &amp; Pharmacology, Three George University School of Medicine, Yichang443000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center, Kansas City, KS66160, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Departments of Pathology &amp; Pharmacology, Three George University School of Medicine, Yichang443000, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084681260"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":null,"apc_paid":null,"fwci":2.3118,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.89102821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"9","first_page":"1297","last_page":"1309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.09830000251531601,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.6060000061988831},{"id":"https://openalex.org/keywords/biodegradable-nanoparticles","display_name":"biodegradable nanoparticles","score":0.9620000123977661},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.847000002861023},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.8669999837875366},{"id":"https://openalex.org/keywords/xenograft-tumor-regression","display_name":"xenograft tumor regression","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.6710000038146973},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.6890000104904175},{"id":"https://openalex.org/keywords/lapc4-cells","display_name":"LAPC4 cells","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.744861364364624},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7350688576698303},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6914178133010864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5524455904960632},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4546213746070862},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34220802783966064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2985612750053406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2788075804710388},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1882752776145935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05785128474235535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.2217/nnm.12.14","doi":"https://doi.org/10.2217/nnm.12.14","is_oa":false,"landing_page_url":"https://doi.org/10.2217/nnm.12.14","pdf_url":null,"source":{"id":"https://openalex.org/S4210216406","display_name":"Nanomedicine","issn_l":"1743-5889","issn":["1743-5889","1748-6963"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine","raw_type":"journal-article"},{"id":"pmid:22583574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22583574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2449151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3448843","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3448843","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3448843","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nanomedicine (Lond)","raw_type":"Text"},{"id":"pmh:oai:kuscholarworks.ku.edu:1808/24597","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1808/24597","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2449151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3448843","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1754526367","display_name":null,"funder_award_id":"AR054035","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2465488096","display_name":"Mechanisms by which Nanoparticle Agglomerates Enhance Aerosol Performance","funder_award_id":"0966614","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7782657537","display_name":"Nanoparticle targeting of ICAM-1 as a potential treatment for Rheumatoid Arthriti","funder_award_id":"R03AR054035","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306985","display_name":"Kansas Masonic Foundation","ror":"https://ror.org/018611e81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334221","display_name":"Cancer Center, University of Kansas","ror":"https://ror.org/00cj35179"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1533310838","https://openalex.org/W1964270561","https://openalex.org/W1965388918","https://openalex.org/W1965428790","https://openalex.org/W1968583232","https://openalex.org/W1977704448","https://openalex.org/W1981753743","https://openalex.org/W1985360090","https://openalex.org/W1987303550","https://openalex.org/W2003955264","https://openalex.org/W2005082473","https://openalex.org/W2007669532","https://openalex.org/W2011030869","https://openalex.org/W2015306991","https://openalex.org/W2019555018","https://openalex.org/W2038783205","https://openalex.org/W2045281082","https://openalex.org/W2046851174","https://openalex.org/W2047368765","https://openalex.org/W2056051091","https://openalex.org/W2064063123","https://openalex.org/W2074238907","https://openalex.org/W2081365151","https://openalex.org/W2082788526","https://openalex.org/W2082908153","https://openalex.org/W2088223764","https://openalex.org/W2093549201","https://openalex.org/W2095248480","https://openalex.org/W2107230180","https://openalex.org/W2115072986","https://openalex.org/W2119491276","https://openalex.org/W2120145250","https://openalex.org/W2129360146","https://openalex.org/W2144941480","https://openalex.org/W2148416479","https://openalex.org/W2149147994","https://openalex.org/W2149470160","https://openalex.org/W2150775704","https://openalex.org/W2158235081","https://openalex.org/W2158734599","https://openalex.org/W2163121767","https://openalex.org/W2163470211"],"related_works":["https://openalex.org/W2306329738","https://openalex.org/W2084891840","https://openalex.org/W2321482270","https://openalex.org/W2556873809","https://openalex.org/W2006714333","https://openalex.org/W2093549201","https://openalex.org/W2586136847","https://openalex.org/W4283835426","https://openalex.org/W2940827478","https://openalex.org/W4386423705"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prostate":[1],"cancer":[2,8,50,79,120,174],"is":[3],"the":[4,13,26,29,38,41,71,95,102,107,185],"major":[5],"cause":[6],"of":[7,28,40,106,129,140,161,184,220],"death":[9,56],"in":[10,25,48,131,144,152,155,168],"men":[11],"and":[12,57,94,135,179],"androgen":[14],"receptor":[15],"(AR)":[16],"has":[17],"been":[18],"shown":[19],"to":[20,53,69,77],"play":[21],"a":[22,45,66,90,224,229],"critical":[23],"role":[24],"progression":[27],"disease.":[30],"Our":[31],"previous":[32,199],"reports":[33],"showed":[34],"that":[35,217],"knocking":[36],"down":[37],"expression":[39],"AR":[42,73,96,141,147,163,186,221],"gene":[43,148],"using":[44,89,223],"siRNA-based":[46],"approach":[47,227],"prostate":[49,78,119,173,234],"cells":[51],"led":[52],"apoptotic":[54],"cell":[55,133,175],"xenograft":[58,169,206],"tumor":[59,190,207],"eradication.":[60],"In":[61],"this":[62],"study,":[63],"we":[64],"utilized":[65],"biodegradable":[67,85,225],"nanoparticle":[68,226],"deliver":[70],"therapeutic":[72,159],"shRNA":[74,97,142,222],"construct":[75],"specifically":[76],"cells.":[80],"MATERIALS":[81],"&":[82],"METHODS:":[83],"The":[84,104,138,158],"nanoparticles":[86,108,130,145,165],"were":[87,99,109],"fabricated":[88],"poly(dl-lactic-co-glycolic":[91],"acid)":[92],"polymer":[93],"constructs":[98],"loaded":[100],"inside":[101],"particles.":[103],"surface":[105],"then":[110],"conjugated":[111],"with":[112,171,198,210],"prostate-specific":[113],"membrane":[114],"antigen":[115],"aptamer":[116,202],"A10":[117,201],"for":[118,232],"cell-specific":[121],"targeting.":[122],"RESULTS:":[123],"A10-conjugation":[124],"largely":[125],"enhanced":[126,205],"cellular":[127],"uptake":[128],"both":[132],"culture-":[134],"xenograft-based":[136],"models.":[137],"efficacy":[139],"encapsulated":[143],"on":[146],"silencing":[149],"was":[150,166,192],"confirmed":[151],"PC-3/AR-derived":[153],"xenografts":[154],"nude":[156],"mice.":[157],"property":[160],"A10-conjugated":[162],"shRNA-loaded":[164,187],"evaluated":[167],"models":[170],"different":[172],"lines:":[176],"22RV1,":[177],"LAPC-4":[178],"LNCaP.":[180],"Upon":[181],"two":[182],"injections":[183],"nanoparticles,":[188],"rapid":[189],"regression":[191,208],"observed":[193],"over":[194],"2":[195],"weeks.":[196],"Consistent":[197],"reports,":[200],"conjugation":[203],"significantly":[204],"compared":[209],"nonconjugated":[211],"nanoparticles.":[212],"DISCUSSION:":[213],"These":[214],"data":[215],"demonstrated":[216],"tissue-specific":[218],"delivery":[219],"represents":[228],"novel":[230],"therapy":[231],"life-threatening":[233],"cancers.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
