{"id":"https://openalex.org/W2158564298","doi":"https://doi.org/10.1080/00365529850171486","title":"Glucagon-Like Peptide-2 Inhibits Centrally Induced Antral Motility in Pigs","display_name":"Glucagon-Like Peptide-2 Inhibits Centrally Induced Antral Motility in Pigs","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2158564298","doi":"https://doi.org/10.1080/00365529850171486","mag":"2158564298","pmid":"https://pubmed.ncbi.nlm.nih.gov/9754730"},"language":"en","primary_location":{"id":"doi:10.1080/00365529850171486","doi":"https://doi.org/10.1080/00365529850171486","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365529850171486","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2158564298"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020351592","display_name":"Morten W\u00f8jdemann","orcid":"https://orcid.org/0000-0002-1319-0187","observed_orcids":["https://orcid.org/0000-0002-1319-0187"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"M. W\u00d8JDEMANN, A. WETTERGREN, B. HAR","raw_affiliation_strings":["Dept. of Surgical Gastroenterology, Rigshospitalet, The National University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgical Gastroenterology, Rigshospitalet, The National University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020351592"],"corresponding_institution_ids":["https://openalex.org/I2802709434"],"apc_list":null,"apc_paid":null,"fwci":10.0643,"has_fulltext":false,"cited_by_count":208,"citation_normalized_percentile":{"value":0.98474524,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"33","issue":"8","first_page":"828","last_page":"832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.2476000040769577,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.08699999749660492,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-2","display_name":"glucagon-like peptide-2","score":1.0},{"id":"https://openalex.org/keywords/antral-motility","display_name":"antral motility","score":0.8309999704360962},{"id":"https://openalex.org/keywords/enterogastrone","display_name":"enterogastrone","score":0.7630000114440918},{"id":"https://openalex.org/keywords/insulin-induced-hypoglycemia","display_name":"insulin-induced hypoglycemia","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ileal-brake","display_name":"ileal brake","score":0.7099999785423279},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.6620000004768372},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.6759999990463257},{"id":"https://openalex.org/keywords/intestinal-l-cells","display_name":"intestinal L cells","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2780768396","wikidata":"https://www.wikidata.org/wiki/Q66310097","display_name":"Proglucagon","level":5,"score":0.8449941277503967},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.7961287498474121},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7447647452354431},{"id":"https://openalex.org/C131253125","wikidata":"https://www.wikidata.org/wiki/Q609361","display_name":"Antrum","level":3,"score":0.7421778440475464},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.730762243270874},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6782453060150146},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5153409838676453},{"id":"https://openalex.org/C2781219945","wikidata":"https://www.wikidata.org/wiki/Q5572288","display_name":"Glucagon-like peptide-2","level":3,"score":0.5108137130737305},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.486592173576355},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.48628032207489014},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.4733593165874481},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.428911417722702},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.41168150305747986},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4074876606464386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.380450963973999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37256696820259094},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2201521396636963},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.18049746751785278},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.14201074838638306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08078140020370483},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.07419627904891968},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.048874080181121826}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005746","descriptor_name":"Gastric Emptying","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005768","descriptor_name":"Gastrointestinal Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005768","descriptor_name":"Gastrointestinal Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019518","descriptor_name":"Postprandial Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053767","descriptor_name":"Glucagon-Like Peptide 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/00365529850171486","doi":"https://doi.org/10.1080/00365529850171486","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365529850171486","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:9754730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9754730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/d2ce1010-74c9-11db-bee9-02004c4f4f50","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/d2ce1010-74c9-11db-bee9-02004c4f4f50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wojdemann, M, Wettergren, A, Hartmann, B & Holst, J J 1998, 'Glucagon-like peptide-2 inhibits centrally induced antral motility in pigs', Scandinavian Journal of Gastroenterology, no. 33, pp. 828-832.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1494795869","https://openalex.org/W1570425797","https://openalex.org/W1637070219","https://openalex.org/W1752824908","https://openalex.org/W1966512269","https://openalex.org/W1991210323","https://openalex.org/W2003141714","https://openalex.org/W2007879964","https://openalex.org/W2013395086","https://openalex.org/W2035284219","https://openalex.org/W2061274996","https://openalex.org/W2066729454","https://openalex.org/W2087063469","https://openalex.org/W2091381344","https://openalex.org/W2143752451","https://openalex.org/W2161966085","https://openalex.org/W2521892745","https://openalex.org/W2593260189","https://openalex.org/W4233330545"],"related_works":["https://openalex.org/W1993903158","https://openalex.org/W2156955992","https://openalex.org/W2119670027","https://openalex.org/W2048151708","https://openalex.org/W2022080162","https://openalex.org/W2129546109","https://openalex.org/W7132890738","https://openalex.org/W2097325055","https://openalex.org/W2769448074","https://openalex.org/W1590886519"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glucagon-like":[1],"peptide-2":[2],"is":[3,12],"formed":[4],"from":[5,89],"proglucagon":[6],"in":[7,15,25,87,100,133],"the":[8,18,44,50,78,95,111,145,155,165],"intestinal":[9,156],"L-cells":[10],"and":[11,72,108,113],"secreted":[13],"postprandially":[14],"parallel":[16],"with":[17,62],"insulinotropic":[19],"hormone":[20],"GLP-1":[21],"(glucagon-like":[22],"peptide-1),":[23],"which":[24],"addition":[26],"acts":[27,54],"to":[28,69,77,80,91,102],"inhibit":[29],"gastric":[30],"motility":[31,99,146],"(enterogastrone":[32],"effect)":[33],"by":[34,150],"inhibiting":[35],"central":[36],"parasympathetic":[37],"outflow.":[38],"GLP-2":[39,53,83,121,135],"has":[40],"no":[41],"effect":[42],"on":[43],"endocrine":[45],"pancreas.":[46],"We":[47],"here":[48],"tested":[49],"hypothesis":[51],"that":[52],"as":[55,161],"an":[56],"enterogastrone.":[57],"METHODS:":[58],"Fourteen":[59],"anesthetized":[60],"pigs":[61],"their":[63],"splanchnic":[64],"nerves":[65],"cut":[66],"were":[67,75],"subjected":[68],"insulin":[70],"hypoglycemia,":[71],"force":[73],"transducers":[74],"sutured":[76],"antrum":[79],"record":[81],"motility.":[82,128],"was":[84,148],"infused":[85],"intravenously":[86],"doses":[88],"1":[90],"6":[92],"pmol/kg/min":[93],"after":[94],"onset":[96],"of":[97,115,120,137,154,164],"antral":[98,116,127],"response":[101],"hypoglycemia.":[103],"RESULTS:":[104],"Insulin":[105],"hypoglycemia":[106],"invariably":[107],"greatly":[109],"increased":[110],"frequency":[112],"amplitude":[114],"phasic":[117],"contractions.":[118],"Infusions":[119],"dose":[122],"dependently":[123],"(1-6":[124],"pmol/kg/min)":[125],"inhibited":[126,149],"At":[129],"2":[130],"pmol/kg/min,":[131],"resulting":[132],"plasma":[134],"concentrations":[136],"102.5+/-19":[138],"pmol/l":[139],"(normal":[140],"postprandial":[141],"range,":[142],"30-82":[143],"pmol/l),":[144],"index":[147],"91%+/-14%.":[151],"CONCLUSIONS:":[152],"Both":[153],"glucagon-like":[157],"peptides":[158],"may":[159],"operate":[160],"hormonal":[162],"transmitters":[163],"ileal":[166],"brake":[167],"effect.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}