{"id":"https://openalex.org/W2158555665","doi":"https://doi.org/10.1124/dmd.113.050955","title":"Hydroxylation of CYP11A1-Derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1","display_name":"Hydroxylation of CYP11A1-Derived Products of Vitamin D3 Metabolism by Human and Mouse CYP27B1","publication_year":2013,"publication_date":"2013-03-02","ids":{"openalex":"https://openalex.org/W2158555665","doi":"https://doi.org/10.1124/dmd.113.050955","mag":"2158555665","pmid":"https://pubmed.ncbi.nlm.nih.gov/23454830","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3629803"},"language":"en","primary_location":{"id":"doi:10.1124/dmd.113.050955","doi":"https://doi.org/10.1124/dmd.113.050955","is_oa":true,"landing_page_url":"https://doi.org/10.1124/dmd.113.050955","pdf_url":"https://dmd.aspetjournals.org/content/dmd/41/5/1112.full.pdf","source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://dmd.aspetjournals.org/content/dmd/41/5/1112.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029285544","display_name":"Edith K. Y. Tang","orcid":"https://orcid.org/0000-0002-6266-6874","observed_orcids":["https://orcid.org/0000-0002-6266-6874"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Edith K.Y. Tang","raw_affiliation_strings":["School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia","Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038622036","display_name":"Jianjun Chen","orcid":"https://orcid.org/0000-0002-6439-5123","observed_orcids":["https://orcid.org/0000-0002-6439-5123"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Jianjun Chen","raw_affiliation_strings":["School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I177877127"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090109773","display_name":"Zorica Janjetovi\u0107","orcid":"https://orcid.org/0000-0001-6108-2212","observed_orcids":["https://orcid.org/0000-0001-6108-2212"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Zorica Janjetovic","raw_affiliation_strings":["School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I177877127"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039870157","display_name":"Elaine W. Tieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Elaine W. Tieu","raw_affiliation_strings":["School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I177877127"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050860545","display_name":"Andrzej T. Slominski","orcid":"https://orcid.org/0000-0001-8963-3995","observed_orcids":["https://orcid.org/0000-0001-8963-3995"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Andrzej T. Slominski","raw_affiliation_strings":["School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I177877127"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I177877127"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058359268","display_name":"Robert Charles Tuckey","orcid":"https://orcid.org/0000-0002-5022-4729","observed_orcids":["https://orcid.org/0000-0002-5022-4729"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Robert C. Tuckey","raw_affiliation_strings":["School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.); and Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I177877127"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy (J.C., W.L.), and Department of Pathology and Laboratory Medicine (Z.J., A.T.S.) and Department of Medicine (A.T.S.), University of Tennessee Health Science Center, Memphis, Tennessee","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia (E.K.Y.T., E.W.T., R.C.T.)","institution_ids":["https://openalex.org/I177877127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.4628,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.93268743,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"5","first_page":"1112","last_page":"1124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp11a1","display_name":"CYP11A1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cyp27b1","display_name":"CYP27B1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vitamin-d3-metabolism","display_name":"vitamin D3 metabolism","score":0.9179999828338623},{"id":"https://openalex.org/keywords/secosteroids","display_name":"secosteroids","score":0.8320000171661377},{"id":"https://openalex.org/keywords/1alpha-hydroxylation","display_name":"1\u03b1-hydroxylation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d3","display_name":"25-hydroxyvitamin D3","score":0.8130000233650208},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.4620000123977661},{"id":"https://openalex.org/keywords/colony-formation-inhibition","display_name":"colony formation inhibition","score":0.6869999766349792},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C76743606","wikidata":"https://www.wikidata.org/wiki/Q21110757","display_name":"CYP24A1","level":4,"score":0.7711058855056763},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.680108904838562},{"id":"https://openalex.org/C7309524","wikidata":"https://www.wikidata.org/wiki/Q14905630","display_name":"CYP27A1","level":3,"score":0.5804140567779541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5548025965690613},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5523093342781067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.481748104095459},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4787023365497589},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4679245948791504},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.44281792640686035},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.43149203062057495},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.41982728242874146},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4097239673137665},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3979208171367645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3284760117530823},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.30042439699172974},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2132965326309204},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11090916395187378},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.09702807664871216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002786","descriptor_name":"Cholesterol Side-Chain Cleavage Enzyme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015090","descriptor_name":"25-Hydroxyvitamin D3 1-alpha-Hydroxylase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015090","descriptor_name":"25-Hydroxyvitamin D3 1-alpha-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1124/dmd.113.050955","doi":"https://doi.org/10.1124/dmd.113.050955","is_oa":true,"landing_page_url":"https://doi.org/10.1124/dmd.113.050955","pdf_url":"https://dmd.aspetjournals.org/content/dmd/41/5/1112.full.pdf","source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2980736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3629803","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3629803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3629803","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metab Dispos","raw_type":"Text"},{"id":"pmid:23454830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23454830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.852.7431","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.852.7431","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dmd.aspetjournals.org/content/early/2013/03/01/dmd.113.050955.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.864.1139","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.864.1139","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dmd.aspetjournals.org/content/41/5/1112.full.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:publications/6f4596a3-3561-4f02-b65f-9a4ed65b31a8","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/6f4596a3-3561-4f02-b65f-9a4ed65b31a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tang, E K Y, Chen, J, Janjetovic, Z, Tieu, E, S\u0142omi\u0144ski, A T, Li, W & Tuckey, R 2013, 'Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and Mouse CYP27B1', Drug Metabolism and Disposition, vol. 41, no. 5, pp. 1112-1124. https://doi.org/10.1124/dmd.113.050955","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1124/dmd.113.050955","doi":"https://doi.org/10.1124/dmd.113.050955","is_oa":true,"landing_page_url":"https://doi.org/10.1124/dmd.113.050955","pdf_url":"https://dmd.aspetjournals.org/content/dmd/41/5/1112.full.pdf","source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4806036218","display_name":"Novel Biosynthethic Pathway for Secosteroids and the Skin","funder_award_id":"R01AR052190","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6503107640","display_name":"Acquisition of a Q-TOF Mass Spectrometer","funder_award_id":"1s10od010678-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7434347083","display_name":"Acquisition of a 400MHz Solution NMR System with an Autosampler","funder_award_id":"S10RR026377","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158555665.pdf","grobid_xml":"https://content.openalex.org/works/W2158555665.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W39472367","https://openalex.org/W158926978","https://openalex.org/W1495372639","https://openalex.org/W1517355139","https://openalex.org/W1540236839","https://openalex.org/W1887054657","https://openalex.org/W1951469402","https://openalex.org/W1972743589","https://openalex.org/W1973216325","https://openalex.org/W1973857698","https://openalex.org/W1977426683","https://openalex.org/W1995138037","https://openalex.org/W2000227232","https://openalex.org/W2005879837","https://openalex.org/W2006784527","https://openalex.org/W2011216582","https://openalex.org/W2018517476","https://openalex.org/W2019568275","https://openalex.org/W2020048876","https://openalex.org/W2028177638","https://openalex.org/W2028202048","https://openalex.org/W2028613340","https://openalex.org/W2028875889","https://openalex.org/W2040722453","https://openalex.org/W2042977757","https://openalex.org/W2043534208","https://openalex.org/W2046143181","https://openalex.org/W2057354512","https://openalex.org/W2064114293","https://openalex.org/W2066368067","https://openalex.org/W2071882832","https://openalex.org/W2076615170","https://openalex.org/W2078693171","https://openalex.org/W2083444816","https://openalex.org/W2108296645","https://openalex.org/W2113779902","https://openalex.org/W2118228269","https://openalex.org/W2121341879","https://openalex.org/W2122456263","https://openalex.org/W2124070987","https://openalex.org/W2125720142","https://openalex.org/W2127898028","https://openalex.org/W2135017544","https://openalex.org/W2144520265","https://openalex.org/W2153488515","https://openalex.org/W2154250040","https://openalex.org/W2157471721","https://openalex.org/W2165780256","https://openalex.org/W2166262263","https://openalex.org/W2909976415","https://openalex.org/W6683969728"],"related_works":["https://openalex.org/W1976466424","https://openalex.org/W4388317459","https://openalex.org/W3177531250","https://openalex.org/W2157471721","https://openalex.org/W2407105187","https://openalex.org/W2073924296","https://openalex.org/W1994942125","https://openalex.org/W2000227232","https://openalex.org/W2071882832","https://openalex.org/W7095122534"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
