{"id":"https://openalex.org/W2158477462","doi":null,"title":"Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.","display_name":"Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2158477462","mag":"2158477462","pmid":"https://pubmed.ncbi.nlm.nih.gov/10815920"},"language":"en","primary_location":{"id":"pmid:10815920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086486880","display_name":"Dorit Goren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"D Goren","raw_affiliation_strings":["Sharet Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharet Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066659326","display_name":"Aviva T. Horowitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A T Horowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011898524","display_name":"Dina Tzemach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Tzemach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042520916","display_name":"Mark Tarshish","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tarshish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042245871","display_name":"Samuel Zalipsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Zalipsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060158935","display_name":"Alberto Gabiz\u00f3n","orcid":"https://orcid.org/0000-0003-1332-1164","observed_orcids":["https://orcid.org/0000-0003-1332-1164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Gabizon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8406,"has_fulltext":false,"cited_by_count":401,"citation_normalized_percentile":{"value":0.98210784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"6","issue":"5","first_page":"1949","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/folate-targeted-liposomes","display_name":"folate-targeted liposomes","score":0.9629999995231628},{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9290000200271606},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.902999997138977},{"id":"https://openalex.org/keywords/drug-efflux-pumps","display_name":"drug efflux pumps","score":0.7559999823570251},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nuclear-drug-delivery","display_name":"nuclear drug delivery","score":0.7450000047683716},{"id":"https://openalex.org/keywords/liposome-internalization","display_name":"liposome internalization","score":0.6759999990463257},{"id":"https://openalex.org/keywords/liposome-aggregation","display_name":"liposome aggregation","score":0.4099999964237213},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5860000252723694},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6600000262260437},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7720934152603149},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6650006175041199},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.517231285572052},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48517972230911255},{"id":"https://openalex.org/C2778589691","wikidata":"https://www.wikidata.org/wiki/Q3429577","display_name":"Rhodamine 123","level":4,"score":0.4671551585197449},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.46414318680763245},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4555453360080719},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4502621293067932},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.43068790435791016},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40425270795822144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39759528636932373},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36062031984329224},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.2972913980484009},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2964121699333191},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29342031478881836},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13986128568649292},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058973","descriptor_name":"Folate Receptors, GPI-Anchored","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10815920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2158477462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W153049307","https://openalex.org/W1560482245","https://openalex.org/W1953019510","https://openalex.org/W1980773456","https://openalex.org/W1988368614","https://openalex.org/W1990043592","https://openalex.org/W2003679416","https://openalex.org/W2004742967","https://openalex.org/W2013342651","https://openalex.org/W2035987019","https://openalex.org/W2036302880","https://openalex.org/W2036944284","https://openalex.org/W2042493999","https://openalex.org/W2046075094","https://openalex.org/W2056644518","https://openalex.org/W2062133534","https://openalex.org/W2063431146","https://openalex.org/W2065337815","https://openalex.org/W2068524399","https://openalex.org/W2077572218","https://openalex.org/W2084357980","https://openalex.org/W2105678378","https://openalex.org/W2143975668","https://openalex.org/W2146974131","https://openalex.org/W2148111514","https://openalex.org/W2154438514","https://openalex.org/W2157164941","https://openalex.org/W2167110945","https://openalex.org/W2407818163","https://openalex.org/W2409110531"],"related_works":["https://openalex.org/W1970829695","https://openalex.org/W2094781240","https://openalex.org/W2065337815","https://openalex.org/W2981612470","https://openalex.org/W2168321305","https://openalex.org/W1278072151","https://openalex.org/W2083852274","https://openalex.org/W2084329943","https://openalex.org/W2185580354","https://openalex.org/W2020126305"],"abstract_inverted_index":{"Folic":[0],"acid,":[1],"attached":[2],"to":[3,8,13,107,130,151,202,255],"polyethyleneglycol-derivatized,":[4],"distearoyl-phosphatidylethanolamine,":[5],"was":[6,98,163,174,227],"used":[7],"target":[9],"in":[10,66,74,104,143,155,193,204,208,210,217,252,276],"vitro":[11,156,205,253],"liposomes":[12,30,56,192],"folate":[14],"receptor":[15],"(FR)-overexpressing":[16],"tumor":[17,215,230],"cells.":[18,195],"Confocal":[19],"fluorescence":[20,52],"microscopic":[21],"observations":[22],"demonstrated":[23],"binding":[24],"and":[25,121,146,206,267],"subsequent":[26],"internalization":[27],"of":[28,86,94,109,118,126,137,168,179,242,259,272],"rhodamine-labeled":[29],"by":[31,43,100,128],"a":[32,91,221,269],"high":[33],"FR-expressing,":[34],"murine":[35],"lung":[36],"carcinoma":[37],"line":[38],"(M109-HiFR":[39],"cells),":[40],"with":[41,53,116,135,149,160,189],"inhibition":[42],"free":[44,110,152,180,233],"folic":[45],"acid.":[46],"Additional":[47],"experiments":[48,115],"tracking":[49],"doxorubicin":[50],"(DOX)":[51],"DOX-loaded,":[54],"folate-targeted":[55],"(FTLs)":[57],"indicate":[58],"that":[59,167,178,238],"liposomal":[60,88,243],"DOX":[61,89,120,127,181,226,244],"is":[62,236,250],"rapidly":[63],"internalized,":[64],"released":[65,245],"the":[67,75,77,169,183,190,239,247,256,263],"cytoplasmic":[68],"compartment,":[69],"and,":[70],"shortly":[71],"thereafter,":[72],"detected":[73],"nucleus,":[76],"entire":[78],"process":[79],"lasting":[80],"1-2":[81],"h.":[82],"FR-mediated":[83],"cell":[84],"uptake":[85,108],"targeted":[87,191],"into":[90],"multidrug-resistant":[92],"subline":[93],"M109-HiFR":[95],"cells":[96,132,145,199],"(M109R-HiFR)":[97],"unaffected":[99],"P-glycoprotein-mediated":[101],"drug":[102,141,186],"efflux,":[103],"sharp":[105],"contrast":[106],"DOX,":[111,260],"based":[112],"on":[113],"verapamil-blockade":[114],"quantitation":[117],"cell-associated":[119],"flow":[122],"cytometry":[123],"analysis.":[124],"Delivery":[125],"FTLs":[129,162],"M109R-HiFR":[131,194,198],"increased":[133],"continuously":[134],"time":[136,223,273],"exposure,":[138],"reaching":[139],"higher":[140,184],"concentrations":[142],"whole":[144],"nuclei":[147],"compared":[148],"exposure":[150],"DOX.":[153,234],"The":[154],"cytotoxic":[157],"activity":[158,241],"obtained":[159,188],"DOX-loaded":[161],"10-fold":[164],"greater":[165],"than":[166,232],"nontargeted":[170],"liposome":[171,264],"formulation,":[172],"but":[173],"not":[175],"improved":[176],"over":[177],"despite":[182],"cellular":[185,248],"levels":[187],"However,":[196],"if":[197],"were":[200],"exposed":[201],"drugs":[203],"tested":[207],"an":[209,275],"vivo":[211,277],"adoptive":[212],"assay":[213],"for":[214,279],"growth":[216],"syngeneic":[218],"mice":[219],"along":[220],"5-week":[222],"span,":[224],"FTL":[225],"significantly":[228],"more":[229],"inhibitory":[231],"It":[235],"suggested":[237],"biological":[240],"inside":[246],"compartment":[249],"reduced":[251],"due":[254],"aggregated":[257],"state":[258],"resulting":[261],"from":[262],"drug-loading":[265],"process,":[266],"requires":[268],"long":[270],"period":[271],"and/or":[274],"environment":[278],"full":[280],"expression.":[281]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}