{"id":"https://openalex.org/W2158451809","doi":"https://doi.org/10.1093/ofid/ofv131.117","title":"Developing a Biomarker-Driven Algorithm to Improve Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) Study","display_name":"Developing a Biomarker-Driven Algorithm to Improve Antibiotic Use in the Pediatric Intensive Care Unit: The Optimizing Antibiotic Strategies in Sepsis (OASIS) Study","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2158451809","doi":"https://doi.org/10.1093/ofid/ofv131.117","mag":"2158451809"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofv131.117","doi":"https://doi.org/10.1093/ofid/ofv131.117","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv131.117","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofv131.117","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031607533","display_name":"Kevin J. Downes","orcid":"https://orcid.org/0000-0001-5015-8146","observed_orcids":["https://orcid.org/0000-0001-5015-8146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Downes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048932268","display_name":"Scott L. Weiss","orcid":"https://orcid.org/0000-0002-7040-3281","observed_orcids":["https://orcid.org/0000-0002-7040-3281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019887163","display_name":"Sarah B. Klieger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah B. Klieger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088663182","display_name":"Julie C. Fitzgerald","orcid":"https://orcid.org/0000-0001-9936-9569","observed_orcids":["https://orcid.org/0000-0001-9936-9569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Fitzgerald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003140166","display_name":"Fran Balamuth","orcid":"https://orcid.org/0000-0003-3709-7160","observed_orcids":["https://orcid.org/0000-0003-3709-7160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran Balamuth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103181368","display_name":"Sherri E. Kubis","orcid":"https://orcid.org/0000-0003-4688-0050","observed_orcids":["https://orcid.org/0000-0003-4688-0050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sherri Kubis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021230105","display_name":"Pam Tolomeo","orcid":"https://orcid.org/0000-0001-5594-8884","observed_orcids":["https://orcid.org/0000-0001-5594-8884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pam Tolomeo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024575747","display_name":"Warren B. Bilker","orcid":"https://orcid.org/0000-0002-2704-7525","observed_orcids":["https://orcid.org/0000-0002-2704-7525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Warren Bilker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030639018","display_name":"Xiaoyan Han","orcid":"https://orcid.org/0009-0004-8881-4523","observed_orcids":["https://orcid.org/0009-0004-8881-4523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyan Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000083246","display_name":"Irving Nachamkin","orcid":"https://orcid.org/0000-0003-4811-9716","observed_orcids":["https://orcid.org/0000-0003-4811-9716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irving Nachamkin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003448475","display_name":"Charles Garrigan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Garrigan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080136539","display_name":"Jennifer Han","orcid":"https://orcid.org/0000-0003-4744-8067","observed_orcids":["https://orcid.org/0000-0003-4744-8067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090134158","display_name":"Ebbing Lautenbach","orcid":"https://orcid.org/0000-0003-4772-2409","observed_orcids":["https://orcid.org/0000-0003-4772-2409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ebbing Lautenbach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046201088","display_name":"Jeffrey S. Gerber","orcid":"https://orcid.org/0000-0002-3076-3186","observed_orcids":["https://orcid.org/0000-0002-3076-3186"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey S. Gerber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030055621","display_name":"Susan E Coffin","orcid":"https://orcid.org/0000-0001-9566-5600","observed_orcids":["https://orcid.org/0000-0001-9566-5600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Coffin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.09421864,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"2","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-stewardship","display_name":"antibiotic stewardship","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pediatric-intensive-care","display_name":"pediatric intensive care","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/systemic-inflammatory-response-syndrome","display_name":"systemic inflammatory response syndrome","score":0.9509999752044678},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5989999771118164},{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9150000214576721},{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bacterial-infection-diagnosis","display_name":"bacterial infection diagnosis","score":0.6510000228881836},{"id":"https://openalex.org/keywords/overuse-of-antibiotics","display_name":"antibiotic overuse","score":0.5720000267028809},{"id":"https://openalex.org/keywords/clinical-decision-algorithm","display_name":"clinical decision algorithm","score":0.5920000076293945},{"id":"https://openalex.org/keywords/critically-ill-children","display_name":"critically ill children","score":0.7730000019073486},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.5099999904632568},{"id":"https://openalex.org/keywords/bacterial-bloodstream-infection","display_name":"bacterial bloodstream infection","score":0.5130000114440918},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.8859999775886536},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.5509999990463257},{"id":"https://openalex.org/keywords/immunocompromised-children","display_name":"immunocompromised children","score":0.5239999890327454},{"id":"https://openalex.org/keywords/oasis","display_name":"OASIS","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8783687353134155},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6543917059898376},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6365620493888855},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.595546543598175},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5715928673744202},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5391095280647278},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.37344348430633545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21519142389297485},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10138621926307678},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08943724632263184},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ofid/ofv131.117","doi":"https://doi.org/10.1093/ofid/ofv131.117","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv131.117","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofv131.117","doi":"https://doi.org/10.1093/ofid/ofv131.117","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv131.117","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2346076419","https://openalex.org/W2900932496","https://openalex.org/W2291006937","https://openalex.org/W3133835092","https://openalex.org/W3173225464","https://openalex.org/W7161770171","https://openalex.org/W2329369124","https://openalex.org/W2311166776","https://openalex.org/W4229336432","https://openalex.org/W7135624987"],"abstract_inverted_index":{"Background.":[0],"Biomarkers":[1],"that":[2],"identify":[3,328],"children":[4,26,40,222,331],"at":[5,29,93,248,287,317,334],"low":[6,30,335],"risk":[7,336],"for":[8,32,107,168,298],"bacterial":[9,33,146,169,178,224,242,257,302,311,338],"infection":[10,229,258,339],"may":[11,347],"reduce":[12],"unnecessary":[13,355],"antibiotic":[14,356],"use.":[15,357],"We":[16,55,148],"sought":[17],"to":[18,22,45,52,117,161,353],"derive":[19],"an":[20],"algorithm":[21,352],"classify":[23,118],"critically":[24,329],"ill":[25,330],"with":[27,41,77,223,241,301,332,343],"SIRS":[28,43,333],"likelihood":[31],"infection.":[34,147,170],"Methods.":[35],"Prospective":[36],"cohort":[37],"study":[38],"of":[39,60,68,96,153,262,266,293,323,337],"new-onset":[42],"admitted":[44],"a":[46,66,291,349],"pediatric":[47],"ICU":[48],"from":[49],"January":[50],"2012":[51],"March":[53],"2014.":[54],"enrolled":[56],"patients":[57,240,300,305],"upon":[58],"initiation/expansion":[59],"antibiotics":[61,137],"(time":[62],"0)":[63],"and":[64,88,102,112,157,185,191,199,209,217,276,325],"measured":[65],"panel":[67],"8":[69],"serum":[70],"biomarkers":[71,131],"daily":[72],"over":[73],"72":[74],"hours.":[75,319],"Patients":[76,255],"immune":[78],"compromise,":[79],"neutropenia,":[80],"or":[81,125,227,245],"without":[82,145,256],"blood":[83],"cultures":[84],"were":[85,91,105,115,139,197,219],"excluded.":[86],"Bacterial":[87],"viral":[89,226,244],"testing":[90],"performed":[92],"the":[94,97,133,163],"discretion":[95],"clinical":[98,103],"team.":[99],"Microbiology,":[100],"imaging,":[101],"data":[104],"reviewed":[106],"48":[108,318],"hours":[109,144,250],"after":[110],"enrollment":[111],"CDC":[113],"definitions":[114],"used":[116],"infections":[119,247,312],"as":[120,141,307],"proven/probable":[121],"bacterial,":[122],"laboratory-confirmed":[123],"viral,":[124,190],"no":[126,194,228,246],"infection;":[127,195],"Kruskal-Wallis":[128],"tests":[129],"compared":[130],"among":[132],"3":[134,183],"groups.":[135],"Excess":[136],"(abx)":[138],"calculated":[140],"use":[142],">48":[143],"tested":[149],"various":[150],"cut":[151],"points":[152],"C-reactive":[154],"protein":[155],"(CRP)":[156],"procalcitonin":[158],"(PCT)":[159],"combinations":[160],"maximize":[162],"negative":[164],"predictive":[165],"value":[166],"(NPV)":[167],"Results.":[171],"Of":[172,273],"87":[173],"patients,":[174],"24":[175,188,210],"(28%)":[176],"had":[177,189,193,290,309],"(11":[179],"pneumonia,":[180],"4":[181],"BSI,":[182],"sinusitis,":[184],"6":[186],"other),":[187],"39":[192],"38":[196],"female":[198],"median":[200],"age":[201],"was":[202,237],"4.2":[203],"years":[204],"(IQR":[205],"1.0\u201312.4).":[206],"At":[207],"0":[208,249,289],"hours,":[211],"tissue":[212],"plasminogen":[213],"activator":[214],"(TPA),":[215],"PCT":[216,284,326],"CRP":[218,280,324],"higher":[220,238],"in":[221,239,341],"vesus":[225],"(P":[230,251],"<":[231],".05;":[232],"figure).":[233,254],"Serum":[234],"amyloid":[235],"A":[236],"versus":[243],"=":[252],".01;":[253],"received":[259],"153":[260],"days":[261],"excess":[263,271],"abx":[264],"(55%":[265],"all":[267,274],"abx,":[268],"mean:":[269],"2.4":[270],"days/patient).":[272],"biomarker":[275],"time":[277,288],"point":[278],"combinations,":[279],"<4":[281],"mg/dL":[282],"plus":[283],"<1":[285],"ng/mL":[286],"NPV":[292],"0.89":[294],"(95%":[295],"CI,":[296],"0.77\u20131.01)":[297],"identifying":[299],"infections.":[303],"All":[304,359],"misclassified":[306],"\u201clow-risk\u201d":[308],"identifiable":[310],"on":[313],"standard":[314,344],"diagnostic":[315,345],"evaluation":[316],"Conclusion.":[320],"Early":[321],"measurement":[322],"can":[327],"and,":[340],"combination":[342],"tests,":[346],"augment":[348],"clinically":[350],"useful":[351],"decrease":[354],"Disclosures.":[358],"authors:":[360],"No":[361],"reported":[362],"disclosures.":[363]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}
