{"id":"https://openalex.org/W2158397011","doi":"https://doi.org/10.1200/jco.2004.01.174","title":"Bicalutamide Monotherapy Versus Leuprolide Monotherapy for Prostate Cancer: Effects on Bone Mineral Density and Body Composition","display_name":"Bicalutamide Monotherapy Versus Leuprolide Monotherapy for Prostate Cancer: Effects on Bone Mineral Density and Body Composition","publication_year":2004,"publication_date":"2004-06-28","ids":{"openalex":"https://openalex.org/W2158397011","doi":"https://doi.org/10.1200/jco.2004.01.174","mag":"2158397011","pmid":"https://pubmed.ncbi.nlm.nih.gov/15226323"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.01.174","doi":"https://doi.org/10.1200/jco.2004.01.174","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.01.174","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105370289","display_name":"Matthew R. Smith","orcid":"https://orcid.org/0009-0005-5055-8672","observed_orcids":["https://orcid.org/0009-0005-5055-8672"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Smith","raw_affiliation_strings":["From the Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072479759","display_name":"Melissa Goode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Goode","raw_affiliation_strings":["From the Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062118116","display_name":"Anthony Laurence Zietman","orcid":"https://orcid.org/0000-0002-4005-8691","observed_orcids":["https://orcid.org/0000-0002-4005-8691"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony L. Zietman","raw_affiliation_strings":["From the Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035481632","display_name":"Francis J. McGovern","orcid":"https://orcid.org/0009-0004-8134-4952","observed_orcids":["https://orcid.org/0009-0004-8134-4952"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis J. McGovern","raw_affiliation_strings":["From the Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108713584","display_name":"H Lee","orcid":"https://orcid.org/0000-0002-3498-236X","observed_orcids":["https://orcid.org/0000-0002-3498-236X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hang Lee","raw_affiliation_strings":["From the Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013380382","display_name":"Joel S. Finkelstein","orcid":"https://orcid.org/0000-0003-4911-8870","observed_orcids":["https://orcid.org/0000-0003-4911-8870"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel S. Finkelstein","raw_affiliation_strings":["From the Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":4.6562,"has_fulltext":false,"cited_by_count":189,"citation_normalized_percentile":{"value":0.96268857,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"22","issue":"13","first_page":"2546","last_page":"2553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bicalutamide","display_name":"bicalutamide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/leuprolide-acetate","display_name":"leuprolide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7310000061988831},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.9909999966621399},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.8119999766349792},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gnrh-agonist","display_name":"GnRH agonist","score":0.9179999828338623},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6029999852180481},{"id":"https://openalex.org/keywords/breast-tenderness","display_name":"breast tenderness","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2780962315","wikidata":"https://www.wikidata.org/wiki/Q1988832","display_name":"Bicalutamide","level":5,"score":0.9179540872573853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8721596002578735},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.8662891387939453},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6808997392654419},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6656668186187744},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.5712740421295166},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.5414658784866333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4871244430541992},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4688625931739807},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.4255714416503906},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.41006237268447876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28392350673675537},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.2123766839504242},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.060824811458587646},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014105","descriptor_name":"Tosyl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016729","descriptor_name":"Leuprolide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016729","descriptor_name":"Leuprolide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.01.174","doi":"https://doi.org/10.1200/jco.2004.01.174","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.01.174","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:15226323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15226323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3641455109","display_name":null,"funder_award_id":"R21 CA10353-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5484229421","display_name":null,"funder_award_id":"RR-1066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6353989759","display_name":"Effects of androgens, estrogens, and PTH on bone","funder_award_id":"K24DK002759","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W207464390","https://openalex.org/W1606563840","https://openalex.org/W1814793649","https://openalex.org/W1968485175","https://openalex.org/W1968887826","https://openalex.org/W1970493821","https://openalex.org/W1974305754","https://openalex.org/W1974568933","https://openalex.org/W1976775669","https://openalex.org/W1980224053","https://openalex.org/W1984094265","https://openalex.org/W1985040614","https://openalex.org/W1988980726","https://openalex.org/W2005383842","https://openalex.org/W2005671531","https://openalex.org/W2010488726","https://openalex.org/W2023227918","https://openalex.org/W2024266959","https://openalex.org/W2026455376","https://openalex.org/W2038299154","https://openalex.org/W2054700953","https://openalex.org/W2054745440","https://openalex.org/W2055618001","https://openalex.org/W2058273161","https://openalex.org/W2062729355","https://openalex.org/W2066062971","https://openalex.org/W2066899660","https://openalex.org/W2080960491","https://openalex.org/W2082333541","https://openalex.org/W2082966382","https://openalex.org/W2085368059","https://openalex.org/W2089396531","https://openalex.org/W2103314990","https://openalex.org/W2113576333","https://openalex.org/W2117231350","https://openalex.org/W2123449568","https://openalex.org/W2139889229","https://openalex.org/W2143514874","https://openalex.org/W2144000500","https://openalex.org/W2163424852","https://openalex.org/W2228999161","https://openalex.org/W2299594662","https://openalex.org/W2326289669","https://openalex.org/W2885215127","https://openalex.org/W4234840545"],"related_works":["https://openalex.org/W2028542256","https://openalex.org/W1480772894","https://openalex.org/W2170480609","https://openalex.org/W3147415599","https://openalex.org/W1567509999","https://openalex.org/W2019530713","https://openalex.org/W1975366865","https://openalex.org/W4243159326","https://openalex.org/W1969767244","https://openalex.org/W2140757280"],"abstract_inverted_index":{"PURPOSE:":[0],"Gonadotropin-releasing":[1],"hormone":[2,256],"agonists":[3],"decrease":[4],"bone":[5,32,56,91,128,141,239],"mineral":[6,33,70,92,129,240],"density,":[7,241],"lean":[8,182],"mass,":[9,183],"and":[10,13,35,54,72,82,108,139,169,186,196,215,245],"muscle":[11,184,187],"size":[12],"increase":[14],"fat":[15,243],"mass":[16,159],"in":[17,104,114,127,165,174,181,201,206,221,226],"men":[18,50,232],"with":[19,51,233,253],"prostate":[20,52,234],"cancer.":[21],"Less":[22],"is":[23],"known":[24],"about":[25],"the":[26,95,105,115,132,143,166,175,192,202,207,222,227],"effects":[27,250],"of":[28,94,131,142,212],"bicalutamide":[29,63,116,176,203,223,236],"monotherapy":[30,237],"on":[31],"density":[34,71,93,130],"body":[36,73],"composition.":[37],"PATIENTS":[38],"AND":[39],"METHODS:":[40],"In":[41,231],"a":[42,254],"12-month,":[43],"open-label":[44],"study,":[45],"we":[46],"randomly":[47],"assigned":[48],"52":[49],"cancer":[53],"no":[55],"metastases":[57],"to":[58,120],"receive":[59],"either":[60],"leuprolide":[61,106,167,208,228],"or":[62,153],"(150":[64],"mg":[65],"by":[66,77,100,110,161,170],"mouth":[67],"daily).":[68],"Bone":[69],"composition":[74],"were":[75,189,198,218],"measured":[76],"dual":[78],"energy":[79],"x-ray":[80],"absorptiometry":[81],"quantitative":[83],"computed":[84],"tomography.":[85],"RESULTS:":[86],"Mean":[87,125],"(+/-":[88],"standard":[89],"error)":[90],"posterior-anterior":[96],"lumbar":[97,144],"spine":[98,145],"decreased":[99],"2.5%":[101],"+/-":[102,112,163,172],"0.5%":[103],"group":[107,117,168,177,204,224],"increased":[109,160],"2.5":[111],"0.5":[113],"from":[118],"baseline":[119],"12":[121],"months":[122],"(P":[123,151,178],"<.001).":[124],"changes":[126],"total":[133,135],"body,":[134],"hip,":[136],"femoral":[137],"neck,":[138],"trabecular":[140],"also":[146],"differed":[147],"significantly":[148],"between":[149,191],"groups":[150],"<":[152],"=.003":[154],"for":[155],"each":[156],"comparison).":[157],"Fat":[158],"11.1%":[162],"1.3%":[164],"6.4%":[171],"1.1%":[173],"=.01).":[179],"Changes":[180],"size,":[185],"strength":[188],"similar":[190],"groups.":[193],"Breast":[194],"tenderness":[195],"enlargement":[197],"more":[199],"common":[200,220],"than":[205,225,251],"group.":[209,229],"Fatigue,":[210],"loss":[211],"sexual":[213],"interest,":[214],"vasomotor":[216],"flushing":[217],"less":[219],"CONCLUSION:":[230],"cancer,":[235],"increases":[238],"lessens":[242],"accumulation,":[244],"has":[246],"fewer":[247],"bothersome":[248],"side":[249],"treatment":[252],"gonadotropin-releasing":[255],"agonist.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}