{"id":"https://openalex.org/W2158317161","doi":"https://doi.org/10.1128/mcb.5.10.2705","title":"X Chromosome Reactivation in Mouse Embryonal Carcinoma Cells","display_name":"X Chromosome Reactivation in Mouse Embryonal Carcinoma Cells","publication_year":1985,"publication_date":"1985-10-01","ids":{"openalex":"https://openalex.org/W2158317161","doi":"https://doi.org/10.1128/mcb.5.10.2705","mag":"2158317161","pmid":"https://pubmed.ncbi.nlm.nih.gov/2426574","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/367008"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.5.10.2705","doi":"https://doi.org/10.1128/mcb.5.10.2705","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.5.10.2705","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC367008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068701513","display_name":"Gary D. Paterno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D Paterno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019592349","display_name":"Chaker N. Adra","orcid":"https://orcid.org/0000-0002-4132-4621","observed_orcids":["https://orcid.org/0000-0002-4132-4621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C N Adra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108532003","display_name":"M W McBurney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M W McBurney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8152,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.86237432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"10","first_page":"2705","last_page":"2712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.04619999974966049,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.984000027179718},{"id":"https://openalex.org/keywords/x-chromosome-reactivation","display_name":"X chromosome reactivation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/embryonal-carcinoma-cells","display_name":"embryonal carcinoma cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/hypoxanthine-phosphoribosyltransferase","display_name":"hypoxanthine phosphoribosyltransferase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/x-linked-gene-expression","display_name":"X-linked gene expression","score":0.7860000133514404},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8281017541885376},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7050378918647766},{"id":"https://openalex.org/C78179603","wikidata":"https://www.wikidata.org/wiki/Q14864606","display_name":"Hypoxanthine-guanine phosphoribosyltransferase","level":4,"score":0.6336358785629272},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5675497055053711},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.42226383090019226},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4116172790527344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3686942458152771},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.335340678691864},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.32821375131607056},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1687624752521515}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004303","descriptor_name":"Dosage Compensation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007041","descriptor_name":"Hypoxanthine Phosphoribosyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013724","descriptor_name":"Teratoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013724","descriptor_name":"Teratoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014960","descriptor_name":"X Chromosome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.5.10.2705","doi":"https://doi.org/10.1128/mcb.5.10.2705","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.5.10.2705","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.5.10.2705-2712.1985","doi":"https://doi.org/10.1128/mcb.5.10.2705-2712.1985","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.5.10.2705-2712.1985","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:233745","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC367008","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:367008","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/367008","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:2426574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2426574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:233745","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC367008","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W193699753","https://openalex.org/W1445927788","https://openalex.org/W1528346173","https://openalex.org/W1544424898","https://openalex.org/W1969883059","https://openalex.org/W1972528263","https://openalex.org/W1972941987","https://openalex.org/W1976291082","https://openalex.org/W1983119583","https://openalex.org/W1995339904","https://openalex.org/W2001855651","https://openalex.org/W2009701813","https://openalex.org/W2014281089","https://openalex.org/W2020138426","https://openalex.org/W2022686144","https://openalex.org/W2027815400","https://openalex.org/W2031131841","https://openalex.org/W2036303296","https://openalex.org/W2040430744","https://openalex.org/W2051001991","https://openalex.org/W2051406511","https://openalex.org/W2053248329","https://openalex.org/W2055025630","https://openalex.org/W2058475255","https://openalex.org/W2074159514","https://openalex.org/W2074534353","https://openalex.org/W2076979909","https://openalex.org/W2083740379","https://openalex.org/W2083786053","https://openalex.org/W2087737282","https://openalex.org/W2088223280","https://openalex.org/W2089457844","https://openalex.org/W2091001503","https://openalex.org/W2093896423","https://openalex.org/W2095040506","https://openalex.org/W2102824799","https://openalex.org/W2120594831","https://openalex.org/W2129599465","https://openalex.org/W2145750252","https://openalex.org/W2158343596","https://openalex.org/W2160177445","https://openalex.org/W2343724130","https://openalex.org/W3024125022"],"related_works":["https://openalex.org/W2022374290","https://openalex.org/W2021824129","https://openalex.org/W1969883059","https://openalex.org/W1983119583","https://openalex.org/W1989992091","https://openalex.org/W1868307671","https://openalex.org/W4251432605","https://openalex.org/W2084612750","https://openalex.org/W2151199739","https://openalex.org/W1972941987"],"abstract_inverted_index":{"The":[0],"embryonal":[1],"carcinoma":[2],"cell":[3,20],"line,":[4],"C86S1,":[5],"carries":[6],"two":[7,99],"X":[8,100,115,137,147,169],"chromosomes,":[9],"one":[10,176],"of":[11,18,35,43,63,66,81,89,132,144,168,183,195],"which":[12,32,94,102,110],"replicates":[13],"late":[14],"during":[15],"S":[16,106],"phase":[17],"the":[19,36,56,78,113,130,135,142,145,157,166],"cycle":[21],"and":[22,68,76,139],"appears":[23],"to":[24,85,87,120,163],"be":[25,173],"genetically":[26],"inactive.":[27],"C86S1A1":[28,44,108,154],"is":[29],"a":[30,174,179,189],"mutant":[31],"lacks":[33],"activity":[34],"X-encoded":[37],"enzyme,":[38],"hypoxanthine":[39],"phosphoribosyltransferase":[40],"(HPRT).":[41],"Treatment":[42],"cells":[45,62,93,109,155,158],"with":[46],"DNA-demethylating":[47],"agents,":[48],"such":[49,150],"as":[50,178,188],"5-azacytidine":[51],"(5AC),":[52],"resulted":[53],"in":[54,59,83,104,129,141,153],"(i)":[55],"transient":[57],"expression":[58,80],"almost":[60],"all":[61],"elevated":[64],"levels":[65],"HPRT":[67,82,97],"three":[69],"other":[70,193],"enzymes":[71],"encoded":[72],"by":[73],"X-linked":[74],"genes":[75,133],"(ii)":[77],"stable":[79],"up":[84],"5":[86],"20%":[88],"surviving":[90],"cells.":[91],"Most":[92],"stably":[95],"expressed":[96],"had":[98,111],"chromosomes":[101],"replicated":[103],"early":[105],"phase.":[107],"lost":[112],"inactive":[114,136],"chromosome":[116,138,170],"did":[117],"not":[118],"respond":[119],"5AC.":[121,164],"These":[122],"results":[123,128],"suggest":[124],"that":[125],"DNA":[126,185],"demethylation":[127],"reactivation":[131,143,151],"on":[134],"perhaps":[140],"entire":[146],"chromosome.":[148],"No":[149],"occurred":[152],"when":[156],"were":[159],"differentiated":[160],"before":[161],"exposure":[162],"Thus,":[165],"process":[167],"inactivation":[171],"may":[172],"sequential":[175],"involving,":[177],"first":[180],"step,":[181,191],"methylation":[182],"certain":[184],"sequences":[186],"and,":[187],"second":[190],"some":[192],"mechanism(s)":[194],"transcriptional":[196],"repression.":[197]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}