{"id":"https://openalex.org/W2158316645","doi":"https://doi.org/10.1093/hmg/ddh267","title":"Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells","display_name":"Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells","publication_year":2004,"publication_date":"2004-08-18","ids":{"openalex":"https://openalex.org/W2158316645","doi":"https://doi.org/10.1093/hmg/ddh267","mag":"2158316645","pmid":"https://pubmed.ncbi.nlm.nih.gov/15317755"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddh267","doi":"https://doi.org/10.1093/hmg/ddh267","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/ddh267","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34614972","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102827068","display_name":"Olga Kolesnikova","orcid":"https://orcid.org/0000-0002-8765-5207","observed_orcids":["https://orcid.org/0000-0002-8765-5207","https://orcid.org/0000-0002-4776-0926"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Olga A. Kolesnikova","raw_affiliation_strings":["CNRS-FRE 2375, Institute of Physiology and Biological Chemistry, Universit\u00e9 Louis Pasteur, 21 Ren\u00e9 Descartes, 67084 Strasbourg, France","GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS-FRE 2375, Institute of Physiology and Biological Chemistry, Universit\u00e9 Louis Pasteur, 21 Ren\u00e9 Descartes, 67084 Strasbourg, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)","institution_ids":["https://openalex.org/I4210148000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012326573","display_name":"Nina Entelis","orcid":"https://orcid.org/0000-0002-7915-5528","observed_orcids":["https://orcid.org/0000-0002-7915-5528"]},"institutions":[{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nina S. Entelis","raw_affiliation_strings":["GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)","institution_ids":["https://openalex.org/I4210148000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050755217","display_name":"Clarisse Jacquin-Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Clarisse Jacquin-Becker","raw_affiliation_strings":["GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)","institution_ids":["https://openalex.org/I4210148000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028326723","display_name":"Francine Goltzen\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francine Goltzene","raw_affiliation_strings":["GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)","institution_ids":["https://openalex.org/I4210148000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024032202","display_name":"Zofia M. Chrzanowska\u2010Lightowlers","orcid":"https://orcid.org/0000-0002-0045-3152","observed_orcids":["https://orcid.org/0000-0002-0045-3152","https://orcid.org/0000-0002-0587-9937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zofia M. Chrzanowska-Lightowlers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003252797","display_name":"Robert Neil Lightowlers","orcid":"https://orcid.org/0000-0002-0587-9937","observed_orcids":["https://orcid.org/0000-0002-0587-9937"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert N. Lightowlers","raw_affiliation_strings":["Mitochondrial Research Group, School of Neurology (Framlington Place, Newcastle upon Tyne, NH2 4HH - United Kingdom)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitochondrial Research Group, School of Neurology (Framlington Place, Newcastle upon Tyne, NH2 4HH - United Kingdom)","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109223079","display_name":"Robert Pierre Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Robert P. Martin","raw_affiliation_strings":["GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)","institution_ids":["https://openalex.org/I4210148000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048639809","display_name":"Ivan Tarassov","orcid":"https://orcid.org/0000-0001-8763-6703","observed_orcids":["https://orcid.org/0000-0001-8763-6703"]},"institutions":[{"id":"https://openalex.org/I4210148000","display_name":"G\u00e9n\u00e9tique Mol\u00e9culaire G\u00e9nomique Microbiologie","ror":"https://ror.org/05n4nmn13","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210148000","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ivan Tarassov","raw_affiliation_strings":["GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GMGM - G\u00e9n\u00e9tique mol\u00e9culaire, g\u00e9nomique, microbiologie (28 Rue Goethe 67083 STRASBOURG CEDEX - France)","institution_ids":["https://openalex.org/I4210148000"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102827068"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210148000"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.4399,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.89663663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"13","issue":"20","first_page":"2519","last_page":"2534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/merrf-syndrome","display_name":"MERRF syndrome","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.8090000152587891},{"id":"https://openalex.org/keywords/trna-lys","display_name":"tRNALys","score":0.5559999942779541},{"id":"https://openalex.org/keywords/a8344g-mutation","display_name":"A8344G mutation","score":0.890999972820282},{"id":"https://openalex.org/keywords/mitochondrial-translation","display_name":"mitochondrial translation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8270000219345093},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7120000123977661},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8784670829772949},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.8245949745178223},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7988607883453369},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6088196039199829},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.5451074242591858},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.5268096923828125},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4719974994659424},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4470604360103607},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43668070435523987},{"id":"https://openalex.org/C151994961","wikidata":"https://www.wikidata.org/wiki/Q715263","display_name":"Human mitochondrial genetics","level":4,"score":0.4289873242378235},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3629319667816162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3294212222099304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.223233163356781},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.10376578569412231}],"mesh":[{"descriptor_ui":"D000926","descriptor_name":"Anticodon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012357","descriptor_name":"RNA, Transfer, Lys","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012357","descriptor_name":"RNA, Transfer, Lys","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012357","descriptor_name":"RNA, Transfer, Lys","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017243","descriptor_name":"MERRF Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017243","descriptor_name":"MERRF Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034443","descriptor_name":"RNA Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/hmg/ddh267","doi":"https://doi.org/10.1093/hmg/ddh267","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/ddh267","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:15317755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15317755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.543.6766","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.543.6766","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://hmg.oxfordjournals.org/content/early/2004/08/18/hmg.ddh267.full.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00153771v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00153771","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Molecular Genetics, 2004, 13 (20), pp.2519-34. ⟨10.1093/hmg/ddh267⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:hmg:13/20/2519","doi":null,"is_oa":false,"landing_page_url":"http://hmg.oxfordjournals.org/cgi/content/short/13/20/2519","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"doi:10.25405/ncl.34614972","doi":"https://doi.org/10.25405/ncl.34614972","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34614972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34614972.v1","doi":"https://doi.org/10.25405/ncl.34614972.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34614972.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34614972","doi":"https://doi.org/10.25405/ncl.34614972","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34614972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W25928582","https://openalex.org/W136513817","https://openalex.org/W152670902","https://openalex.org/W320699853","https://openalex.org/W350047312","https://openalex.org/W1484307555","https://openalex.org/W1518241034","https://openalex.org/W1528770098","https://openalex.org/W1532431885","https://openalex.org/W1560824582","https://openalex.org/W1900912241","https://openalex.org/W1908757304","https://openalex.org/W1970345057","https://openalex.org/W1973104019","https://openalex.org/W1973382928","https://openalex.org/W1977382850","https://openalex.org/W1978476989","https://openalex.org/W1978814343","https://openalex.org/W1979422233","https://openalex.org/W1979951442","https://openalex.org/W1982944995","https://openalex.org/W1986739001","https://openalex.org/W1989011586","https://openalex.org/W1997007031","https://openalex.org/W2002123956","https://openalex.org/W2003574027","https://openalex.org/W2003990799","https://openalex.org/W2012102114","https://openalex.org/W2022100522","https://openalex.org/W2035294162","https://openalex.org/W2039733809","https://openalex.org/W2040118814","https://openalex.org/W2041628676","https://openalex.org/W2043779724","https://openalex.org/W2044494908","https://openalex.org/W2045576314","https://openalex.org/W2046989527","https://openalex.org/W2049599303","https://openalex.org/W2051649294","https://openalex.org/W2063873651","https://openalex.org/W2064896769","https://openalex.org/W2066250257","https://openalex.org/W2067393357","https://openalex.org/W2067974742","https://openalex.org/W2075705708","https://openalex.org/W2078528695","https://openalex.org/W2079506707","https://openalex.org/W2091487052","https://openalex.org/W2091879751","https://openalex.org/W2104018711","https://openalex.org/W2108508097","https://openalex.org/W2109374618","https://openalex.org/W2114355757","https://openalex.org/W2123896834","https://openalex.org/W2128903118","https://openalex.org/W2130872480","https://openalex.org/W2135506329","https://openalex.org/W2135776849","https://openalex.org/W2153544052","https://openalex.org/W2158305445","https://openalex.org/W2162288115","https://openalex.org/W2334559647","https://openalex.org/W2462855682","https://openalex.org/W2493590780","https://openalex.org/W2615749116","https://openalex.org/W2989345970","https://openalex.org/W4254119740"],"related_works":["https://openalex.org/W2041628676","https://openalex.org/W7095584805","https://openalex.org/W2735372301","https://openalex.org/W24876115","https://openalex.org/W2136861527","https://openalex.org/W4327544791","https://openalex.org/W2048875992","https://openalex.org/W2594741141","https://openalex.org/W2996452096","https://openalex.org/W436265596"],"abstract_inverted_index":{"Mitochondrial":[0],"DNA":[1],"(mtDNA)":[2],"mutations":[3],"are":[4,110,117,121],"an":[5],"important":[6],"cause":[7,31],"of":[8,52,141,149,161,174,185,197,229],"human":[9,70,91,103,108,233],"disease":[10],"for":[11,223,241],"which":[12,29],"there":[13],"is":[14,143,215],"no":[15],"efficient":[16],"treatment.":[17],"Our":[18],"aim":[19],"was":[20],"to":[21,123,192,217,247],"determine":[22],"whether":[23],"the":[24,32,49,137,154,167,181,186,198,208,218,224,227,239,243],"A8344G":[25],"mitochondrial":[26,126,150,158,168],"tRNA(Lys)":[27],"mutation,":[28,139],"can":[30,86],"MERRF":[33,138],"(myoclonic":[34],"epilepsy":[35],"with":[36,177,250],"ragged-red":[37],"fibers)":[38],"syndrome,":[39],"could":[40],"be":[41,87],"complemented":[42],"by":[43,145,153,201],"targeting":[44],"tRNAs":[45,75,116,200,231],"into":[46,55,89,113],"mitochondria":[47,56,71,234],"from":[48],"cytosol.":[50],"Import":[51,173],"small":[53,202],"RNAs":[54],"has":[57],"been":[58],"demonstrated":[59,80],"in":[60,76,101,106,125,133,180,232,235],"many":[61],"organisms,":[62],"including":[63],"protozoans,":[64],"plants,":[65],"fungi":[66],"and":[67,105,120,132,170,237],"animals.":[68],"Although":[69],"do":[72],"not":[73,190],"import":[74,140,245],"vivo,":[77],"we":[78],"previously":[79],"that":[81,96,212],"some":[82],"yeast":[83,97],"tRNA":[84],"derivatives":[85,99],"imported":[88,112,230],"isolated":[90],"mitochondria.":[92,114],"We":[93],"show":[94],"here":[95],"tRNALys":[98,142,176],"expressed":[100],"immortalized":[102],"cells":[104,131],"primary":[107],"fibroblasts":[109,135],"partially":[111],"Imported":[115],"correctly":[118],"aminoacylated":[119],"able":[122],"participate":[124],"translation.":[127],"In":[128],"transmitochondrial":[129],"cybrid":[130],"patient-derived":[134],"bearing":[136],"accompanied":[144],"a":[146,175,178],"partial":[147],"rescue":[148,214],"functions":[151],"affected":[152],"mutation":[155,179],"such":[156],"as":[157],"translation,":[159],"activity":[160],"respiratory":[162],"complexes,":[163],"electrochemical":[164],"potential":[165,240],"across":[166],"membrane":[169],"respiration":[171],"rate.":[172],"anticodon":[182],"preventing":[183],"recognition":[184],"lysine":[187],"codons":[188],"does":[189],"lead":[191],"any":[193],"rescue,":[194,210],"whereas":[195],"downregulation":[196],"transgenic":[199],"interfering":[203],"RNA":[204,244],"(siRNA)":[205],"transiently":[206],"abolishes":[207],"functional":[209],"showing":[211],"this":[213],"due":[216],"import.":[219],"These":[220],"findings":[221],"prove":[222],"first":[225],"time":[226],"functionality":[228],"vivo":[236],"highlight":[238],"exploiting":[242],"pathway":[246],"treat":[248],"patients":[249],"mtDNA":[251],"diseases.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}