{"id":"https://openalex.org/W2158310399","doi":null,"title":"Are we missing the target? Cancer stem cells and drug resistance in non-small cell lung cancer.","display_name":"Are we missing the target? Cancer stem cells and drug resistance in non-small cell lung cancer.","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W2158310399","mag":"2158310399","pmid":"https://pubmed.ncbi.nlm.nih.gov/22990107"},"language":"en","primary_location":{"id":"pmid:22990107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22990107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genomics & proteomics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019113386","display_name":"Sandra Gottschling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandra Gottschling","raw_affiliation_strings":["Department of Thoracic Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany. sandra.gottschling@thoraxklinik-heidelberg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany. sandra.gottschling@thoraxklinik-heidelberg.de","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016216382","display_name":"Philipp Albert Schnabel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp A Schnabel","raw_affiliation_strings":["2 Institute of Pathology, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Institute of Pathology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024585720","display_name":"Felix J.F. Herth","orcid":"https://orcid.org/0000-0002-7638-2506","observed_orcids":["https://orcid.org/0000-0002-7638-2506"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix J F Herth","raw_affiliation_strings":["3 Department of Pneumology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Department of Pneumology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079261820","display_name":"Esther Herpel","orcid":"https://orcid.org/0000-0002-0110-9257","observed_orcids":["https://orcid.org/0000-0002-0110-9257"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Esther Herpel","raw_affiliation_strings":["2 Institute of Pathology, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Institute of Pathology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":4.7452,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.9613984,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"5","first_page":"275","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.996999979019165},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/resistance-mechanisms","display_name":"resistance mechanisms","score":0.6650000214576721},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.8428196907043457},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7958860397338867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6742308139801025},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.599262535572052},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5586416125297546},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5528589487075806},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5386236906051636},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5207476615905762},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5169407725334167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.454860657453537},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43700820207595825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42287978529930115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1873210370540619},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071916","descriptor_name":"AC133 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22990107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22990107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genomics & proteomics","raw_type":"Journal Article"},{"id":"mag:2158310399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22990107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W239251301","https://openalex.org/W1568323318","https://openalex.org/W1807201070","https://openalex.org/W1858316002","https://openalex.org/W1873996393","https://openalex.org/W1965406763","https://openalex.org/W1971106777","https://openalex.org/W1971745560","https://openalex.org/W1972152785","https://openalex.org/W1974059924","https://openalex.org/W1977799184","https://openalex.org/W1983357205","https://openalex.org/W1985100212","https://openalex.org/W1989645169","https://openalex.org/W1993598681","https://openalex.org/W1994599132","https://openalex.org/W1998534168","https://openalex.org/W2004718750","https://openalex.org/W2008188840","https://openalex.org/W2009031936","https://openalex.org/W2012087132","https://openalex.org/W2013614359","https://openalex.org/W2018591615","https://openalex.org/W2020339825","https://openalex.org/W2021349501","https://openalex.org/W2022881840","https://openalex.org/W2028804710","https://openalex.org/W2028871210","https://openalex.org/W2030196256","https://openalex.org/W2033427329","https://openalex.org/W2034461318","https://openalex.org/W2034946640","https://openalex.org/W2035813402","https://openalex.org/W2041752578","https://openalex.org/W2043844361","https://openalex.org/W2045476312","https://openalex.org/W2045729702","https://openalex.org/W2046152312","https://openalex.org/W2052687680","https://openalex.org/W2057449864","https://openalex.org/W2062891843","https://openalex.org/W2068229142","https://openalex.org/W2071541060","https://openalex.org/W2072693879","https://openalex.org/W2074630546","https://openalex.org/W2074730941","https://openalex.org/W2084996794","https://openalex.org/W2085709433","https://openalex.org/W2095050803","https://openalex.org/W2095618958","https://openalex.org/W2096289704","https://openalex.org/W2096986950","https://openalex.org/W2100049008","https://openalex.org/W2102085111","https://openalex.org/W2104098330","https://openalex.org/W2104830962","https://openalex.org/W2105202429","https://openalex.org/W2105902643","https://openalex.org/W2106356990","https://openalex.org/W2106391833","https://openalex.org/W2108035852","https://openalex.org/W2111016379","https://openalex.org/W2112986981","https://openalex.org/W2119165414","https://openalex.org/W2119835285","https://openalex.org/W2120656656","https://openalex.org/W2129336819","https://openalex.org/W2134538612","https://openalex.org/W2135035591","https://openalex.org/W2138919514","https://openalex.org/W2146260605","https://openalex.org/W2146701605","https://openalex.org/W2146949185","https://openalex.org/W2157779601","https://openalex.org/W2158063043","https://openalex.org/W2159500738","https://openalex.org/W2159757693","https://openalex.org/W2163798887","https://openalex.org/W2164543086","https://openalex.org/W2166089777","https://openalex.org/W2168168277","https://openalex.org/W2317790843"],"related_works":["https://openalex.org/W2214517872","https://openalex.org/W2055579579","https://openalex.org/W4214638690","https://openalex.org/W2981950059","https://openalex.org/W2148156211","https://openalex.org/W2354110090","https://openalex.org/W2256043817","https://openalex.org/W4386619892","https://openalex.org/W2255361441","https://openalex.org/W2809990610"],"abstract_inverted_index":{"Non-small":[0],"cell":[1],"lung":[2,72,114],"cancer":[3,52,69,115],"(NSCLC)":[4],"is":[5],"the":[6,19,43,79,108],"leading":[7],"cause":[8],"of":[9,21,36,67,94,103,107,111],"cancer-related":[10],"death":[11],"in":[12,60,84,113,127],"Western":[13],"countries.":[14],"Despite":[15],"novel":[16],"molecular":[17],"therapies,":[18],"majority":[20],"patients":[22],"with":[23],"advanced":[24],"or":[25],"metastatic":[26],"disease":[27],"show":[28],"rapid":[29],"progression":[30],"and":[31,65,88,96,99,123],"a":[32,57],"median":[33],"survival":[34,125],"time":[35],"not":[37],"more":[38],"than":[39],"18":[40],"months.":[41],"In":[42,74],"last":[44],"decade,":[45],"there":[46],"has":[47],"been":[48],"increasing":[49],"evidence":[50,80],"that":[51],"stem":[53,82],"cells":[54,83],"(CSC)":[55],"play":[56],"pivotal":[58],"role":[59],"drug":[61],"resistance,":[62],"tumour":[63],"regeneration":[64],"metastasis":[66],"various":[68],"entities":[70],"including":[71],"cancer.":[73],"this":[75,128],"review,":[76],"we":[77],"discuss":[78],"for":[81,101],"NSCLC,":[85],"their":[86,91],"predictive":[87],"prognostic":[89],"significance,":[90],"specific":[92,109],"mechanisms":[93],"resistance":[95],"potential":[97],"targets":[98],"strategies":[100],"eradication":[102],"these":[104],"cells.":[105],"Consideration":[106],"properties":[110],"CSC":[112],"therapy":[116],"might":[117],"substantially":[118],"contribute":[119],"to":[120],"increased":[121],"response":[122],"prolonged":[124],"rates":[126],"disease.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
