{"id":"https://openalex.org/W2158288461","doi":"https://doi.org/10.1210/jc.2004-1921","title":"Recombinant Methionyl Human Leptin Administration to Achieve High Physiologic or Pharmacologic Leptin Levels Does Not Alter Circulating Inflammatory Marker Levels in Humans with Leptin Sufficiency or Excess","display_name":"Recombinant Methionyl Human Leptin Administration to Achieve High Physiologic or Pharmacologic Leptin Levels Does Not Alter Circulating Inflammatory Marker Levels in Humans with Leptin Sufficiency or Excess","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W2158288461","doi":"https://doi.org/10.1210/jc.2004-1921","mag":"2158288461","pmid":"https://pubmed.ncbi.nlm.nih.gov/15613407"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2004-1921","doi":"https://doi.org/10.1210/jc.2004-1921","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2004-1921","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034166604","display_name":"Jean Lin Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean L. Chan","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004145848","display_name":"John William Bullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Bullen","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032827184","display_name":"Violeta Stoyneva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Violeta Stoyneva","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041247266","display_name":"Alex M. DePaoli","orcid":"https://orcid.org/0000-0001-6365-6099","observed_orcids":["https://orcid.org/0000-0001-6365-6099"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex M. DePaoli","raw_affiliation_strings":["Amgen, Inc. (A.M.D.), Thousand Oaks, California 91320"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen, Inc. (A.M.D.), Thousand Oaks, California 91320","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089852008","display_name":"Carol Addy","orcid":"https://orcid.org/0000-0003-1028-2649","observed_orcids":["https://orcid.org/0000-0003-1028-2649"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Addy","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005766189","display_name":"Christos Socrates Mantzoros","orcid":"https://orcid.org/0000-0003-3755-8158","observed_orcids":["https://orcid.org/0000-0003-3755-8158"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christos S. Mantzoros","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism (J.L.C., J.B., V.S., C.A., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005766189"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.3305,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94595311,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"90","issue":"3","first_page":"1618","last_page":"1624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperleptinemia","display_name":"hyperleptinemia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.640999972820282},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7680000066757202},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7269999980926514},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8560000061988831},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/soluble-intercellular-adhesion-molecule-1","display_name":"soluble intercellular adhesion molecule-1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9359999895095825},{"id":"https://openalex.org/keywords/leptin-therapy","display_name":"leptin therapy","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9224711656570435},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8316326141357422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7372469902038574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7044846415519714},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6533485651016235},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5088546276092529},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.48721784353256226},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3089870810508728}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2004-1921","doi":"https://doi.org/10.1210/jc.2004-1921","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2004-1921","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:15613407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15613407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G146493050","display_name":null,"funder_award_id":"R0-158785","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G2872377240","display_name":"General Clinical Research Center","funder_award_id":"M01RR001032","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G820896236","display_name":"Leptin in neuroendocrine function","funder_award_id":"K23RR018860","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1590709474","https://openalex.org/W1855316965","https://openalex.org/W1974033843","https://openalex.org/W1974599416","https://openalex.org/W1978345359","https://openalex.org/W1992021850","https://openalex.org/W1992119116","https://openalex.org/W2007492870","https://openalex.org/W2008749530","https://openalex.org/W2008869160","https://openalex.org/W2019361383","https://openalex.org/W2023731005","https://openalex.org/W2027664697","https://openalex.org/W2033538734","https://openalex.org/W2046387295","https://openalex.org/W2048243155","https://openalex.org/W2049501468","https://openalex.org/W2051051060","https://openalex.org/W2058586322","https://openalex.org/W2061962106","https://openalex.org/W2063223047","https://openalex.org/W2065182009","https://openalex.org/W2078807483","https://openalex.org/W2084310603","https://openalex.org/W2088981742","https://openalex.org/W2098025594","https://openalex.org/W2101340193","https://openalex.org/W2101680331","https://openalex.org/W2113177621","https://openalex.org/W2136024338","https://openalex.org/W2143807844","https://openalex.org/W2153214557","https://openalex.org/W2158103150","https://openalex.org/W2160885977","https://openalex.org/W2165345254","https://openalex.org/W2166558587","https://openalex.org/W2167362639","https://openalex.org/W2329406962","https://openalex.org/W2334337188","https://openalex.org/W4233349015","https://openalex.org/W4238663920"],"related_works":["https://openalex.org/W2120252825","https://openalex.org/W2007492870","https://openalex.org/W4387216647","https://openalex.org/W2094641618","https://openalex.org/W2057788834","https://openalex.org/W2130200649","https://openalex.org/W7000929036","https://openalex.org/W7099676901","https://openalex.org/W2073550407","https://openalex.org/W2329406962"],"abstract_inverted_index":{"A":[0],"role":[1,236],"for":[2,193,237,253],"high":[3,36,122,148,200],"leptin":[4,32,94,110,142,202,238,244],"levels":[5,38,59,111,127,143],"in":[6,34,39,135,150,160,199,239,261],"the":[7,17,67,136,189,207,254],"proinflammatory":[8,240],"state":[9],"associated":[10,242],"with":[11,184,243],"obesity":[12,248],"has":[13],"been":[14,53,77],"proposed":[15],"on":[16],"basis":[18],"of":[19,29,62,69,90,116,128,191,259],"observational":[20],"studies,":[21],"but":[22],"a":[23,113],"recent":[24],"interventional":[25,48,86],"study":[26],"employing":[27],"administration":[28,89,190],"long-acting":[30],"pegylated":[31],"resulting":[33,198],"very":[35],"pharmacologic":[37,159,201],"obese":[40,102,161,182],"subjects":[41,104,183],"did":[42,166,204],"not":[43,51,75,167,205,232],"support":[44,233],"this":[45],"idea.":[46],"These":[47,229],"studies":[49,87],"have":[50,74,250],"yet":[52,76],"independently":[54],"confirmed,":[55],"however,":[56],"and":[57,60,101,131,153,224,249],"varying":[58],"duration":[61],"hyperleptinemia":[63],"as":[64,66,72,79,247],"well":[65],"presence":[68],"comorbidities":[70],"such":[71,246],"diabetes":[73,187],"investigated":[78],"potential":[80,255],"effect":[81],"modifiers.":[82],"We":[83],"performed":[84],"three":[85],"involving":[88],"recombinant":[91],"methionyl":[92],"human":[93],"(r-metHuLeptin)":[95],"to":[96,105,121,147,157],"lean,":[97],"otherwise":[98],"healthy":[99],"obese,":[100],"diabetic":[103],"investigate":[106],"whether":[107],"increasing":[108],"circulating":[109],"over":[112,163],"wide":[114],"spectrum":[115],"values":[117],"(from":[118],"low":[119,145,158],"physiologic":[120,146,149,156],"pharmacologic)":[123],"would":[124],"alter":[125,168],"serum":[126,169],"inflammatory":[129,214],"markers":[130],"other":[132],"cytokines":[133,212],"important":[134],"T":[137],"helper":[138],"cell":[139],"response.":[140],"Increasing":[141],"from":[144,154],"lean":[151],"men":[152,162],"higher":[155],"3":[164],"d":[165],"interferon-gamma,":[170],"IL-10,":[171,217],"TNF-alpha,":[172],"monocyte":[173,221],"chemoattractant":[174,222],"protein-1,":[175,223],"or":[176,195,210,213],"soluble":[177,225],"intercellular":[178,226],"adhesion":[179,227],"molecule-1.":[180,228],"In":[181],"type":[185],"2":[186],"mellitus,":[188],"r-metHuLeptin":[192,260],"4":[194],"16":[196],"wk,":[197],"levels,":[203],"activate":[206],"TNF-alpha":[208],"system":[209],"increase":[211],"markers,":[215],"including":[216],"IL-6,":[218],"C-reactive":[219],"protein,":[220],"findings":[230],"do":[231],"an":[234],"etiopathogenic":[235],"states":[241],"excess":[245],"direct":[251],"relevance":[252],"future":[256],"therapeutic":[257],"use":[258],"humans.":[262]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
