{"id":"https://openalex.org/W2158286268","doi":"https://doi.org/10.1371/journal.pgen.1003638","title":"Cited1 Deficiency Suppresses Intestinal Tumorigenesis","display_name":"Cited1 Deficiency Suppresses Intestinal Tumorigenesis","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2158286268","doi":"https://doi.org/10.1371/journal.pgen.1003638","mag":"2158286268","pmid":"https://pubmed.ncbi.nlm.nih.gov/23935526","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3731217"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1003638","doi":"https://doi.org/10.1371/journal.pgen.1003638","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1003638","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003638&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003638&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050391127","display_name":"Val\u00e9rie S. M\u00e9niel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie M\u00e9niel","raw_affiliation_strings":["School of Biological Sciences, Cardiff University, Cardiff, Wales, UK","School of Biological Sciences, Cardiff University, Cardiff, Wales, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Cardiff University, Cardiff, Wales, UK","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"School of Biological Sciences, Cardiff University, Cardiff, Wales, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101715421","display_name":"Fei Song","orcid":"https://orcid.org/0000-0002-3286-8782","observed_orcids":["https://orcid.org/0000-0002-3286-8782"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Fei Song","raw_affiliation_strings":["Department of Gastroenterology, Institute of Translational Medicine, The Henry Wellcome Laboratory, University of Liverpool, England, United Kingdom","Institute of Physiology, Justus-Liebig University Giessen, Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Institute of Translational Medicine, The Henry Wellcome Laboratory, University of Liverpool, England, United Kingdom","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Institute of Physiology, Justus-Liebig University Giessen, Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067834126","display_name":"Toby James Phesse","orcid":"https://orcid.org/0000-0001-9568-4916","observed_orcids":["https://orcid.org/0000-0001-9568-4916"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Toby Phesse","raw_affiliation_strings":["Cell Signaling and Cell Death, Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling and Cell Death, Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035431425","display_name":"Madeleine A. Young","orcid":"https://orcid.org/0000-0002-1487-0694","observed_orcids":["https://orcid.org/0000-0002-1487-0694"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Madeleine Young","raw_affiliation_strings":["School of Biological Sciences, Cardiff University, Cardiff, Wales, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Cardiff University, Cardiff, Wales, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009014368","display_name":"Oliver Poetz","orcid":"https://orcid.org/0000-0002-1189-9547","observed_orcids":["https://orcid.org/0000-0002-1189-9547"]},"institutions":[{"id":"https://openalex.org/I4210111828","display_name":"Natural and Medical Sciences Institute","ror":"https://ror.org/01th1p123","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210111828"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Poetz","raw_affiliation_strings":["Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany","institution_ids":["https://openalex.org/I4210111828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046528312","display_name":"Lee Parry","orcid":"https://orcid.org/0000-0002-4467-9196","observed_orcids":["https://orcid.org/0000-0002-4467-9196"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lee Parry","raw_affiliation_strings":["School of Biological Sciences, Cardiff University, Cardiff, Wales, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Cardiff University, Cardiff, Wales, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102094664","display_name":"John R. Jenkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John R. Jenkins","raw_affiliation_strings":["Department of Gastroenterology, Institute of Translational Medicine, The Henry Wellcome Laboratory, University of Liverpool, England, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Institute of Translational Medicine, The Henry Wellcome Laboratory, University of Liverpool, England, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110837446","display_name":"Geraint T. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geraint T. Williams","raw_affiliation_strings":["School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Cardiff University, Heath Park, Cardiff, Wales, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024781173","display_name":"Sally L. Dunwoodie","orcid":"https://orcid.org/0000-0002-2069-7349","observed_orcids":["https://orcid.org/0000-0002-2069-7349"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sally L. Dunwoodie","raw_affiliation_strings":["Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales, Australia","Faculty of Medicine, University of New South Wales, Kensington, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I19514445"]},{"raw_affiliation_string":"Faculty of Medicine, University of New South Wales, Kensington, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049110134","display_name":"Alastair J.M. Watson","orcid":"https://orcid.org/0000-0003-3326-0426","observed_orcids":["https://orcid.org/0000-0003-3326-0426"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]},{"id":"https://openalex.org/I2799300731","display_name":"Norwich Research Park","ror":"https://ror.org/0062dz060","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799300731"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alastair Watson","raw_affiliation_strings":["Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom","institution_ids":["https://openalex.org/I1118541","https://openalex.org/I2799300731"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001013132","display_name":"Alan Richard Clarke","orcid":"https://orcid.org/0000-0002-4281-426X","observed_orcids":["https://orcid.org/0000-0002-4281-426X"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan R. Clarke","raw_affiliation_strings":["School of Biological Sciences, Cardiff University, Cardiff, Wales, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Cardiff University, Cardiff, Wales, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5049110134"],"corresponding_institution_ids":["https://openalex.org/I1118541","https://openalex.org/I2799300731"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":0.6049,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.60044848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"8","first_page":"e1003638","last_page":"e1003638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cited1","display_name":"CITED1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intestinal-tumorigenesis","display_name":"intestinal tumorigenesis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.6859999895095825},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.6909999847412109},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9279999732971191},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.843999981880188},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.7739999890327454},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5600000023841858},{"id":"https://openalex.org/keywords/intestinal-stem-cells","display_name":"intestinal stem cells","score":0.699999988079071},{"id":"https://openalex.org/keywords/adenoma-formation","display_name":"adenoma formation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.7129999995231628},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8040000200271606},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.882556676864624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7755770683288574},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6436489224433899},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5952965617179871},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5785504579544067},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49505773186683655},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4596426486968994},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41956669092178345},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.4104447066783905},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39574316143989563},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2710948586463928},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20235911011695862},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19706588983535767},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17870309948921204},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17270898818969727}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pgen.1003638","doi":"https://doi.org/10.1371/journal.pgen.1003638","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1003638","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003638&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2731359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3731217","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23935526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23935526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3731217","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3731217/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:52653","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/52653/1/Meniel%202013.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/52653/1/Meniel%202013.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.789.6622","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.789.6622","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c3/f9/pgen.1003638.PMC3731217.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5bd420bdc4d04018827e6e78d3fdaffb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5bd420bdc4d04018827e6e78d3fdaffb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 9, Iss 8, p e1003638 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/761878","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Cited1_Deficiency_Suppresses_Intestinal_Tumorigenesis/761878","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ueaeprints.uea.ac.uk:48956","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/48956/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1003638","doi":"https://doi.org/10.1371/journal.pgen.1003638","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1003638","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003638&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3965118808","display_name":null,"funder_award_id":"RCBMA7613","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5620567772","display_name":null,"funder_award_id":"15937","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6391090246","display_name":"Uncoupled Research Fellowship","funder_award_id":"514900","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320061","display_name":"North West Cancer Research","ror":"https://ror.org/025qv0671"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158286268.pdf","grobid_xml":"https://content.openalex.org/works/W2158286268.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1536067283","https://openalex.org/W1546952499","https://openalex.org/W1971697506","https://openalex.org/W1985904277","https://openalex.org/W1990823488","https://openalex.org/W1997018084","https://openalex.org/W2006419043","https://openalex.org/W2008956544","https://openalex.org/W2011623297","https://openalex.org/W2013469922","https://openalex.org/W2017632960","https://openalex.org/W2024554234","https://openalex.org/W2028550299","https://openalex.org/W2030762831","https://openalex.org/W2032989881","https://openalex.org/W2039542136","https://openalex.org/W2041970562","https://openalex.org/W2049524386","https://openalex.org/W2056127982","https://openalex.org/W2057830803","https://openalex.org/W2059861396","https://openalex.org/W2061260618","https://openalex.org/W2067526109","https://openalex.org/W2067911884","https://openalex.org/W2068738682","https://openalex.org/W2076246431","https://openalex.org/W2080506450","https://openalex.org/W2081098333","https://openalex.org/W2084780592","https://openalex.org/W2094059784","https://openalex.org/W2103597610","https://openalex.org/W2110065044","https://openalex.org/W2131261731","https://openalex.org/W2132780101","https://openalex.org/W2134359750","https://openalex.org/W2135715423","https://openalex.org/W2135900256","https://openalex.org/W2141145973","https://openalex.org/W2143259551","https://openalex.org/W2144796426","https://openalex.org/W2150719976","https://openalex.org/W2153561951","https://openalex.org/W2153583721","https://openalex.org/W2156435597","https://openalex.org/W2162200186","https://openalex.org/W2164683872","https://openalex.org/W2165087323","https://openalex.org/W2169962011","https://openalex.org/W2171974881","https://openalex.org/W2171996338","https://openalex.org/W2336968922","https://openalex.org/W7096329189"],"related_works":["https://openalex.org/W2171671536","https://openalex.org/W2171507631","https://openalex.org/W7099032303","https://openalex.org/W2134359750","https://openalex.org/W2021703422","https://openalex.org/W1978764437","https://openalex.org/W2055349636","https://openalex.org/W7100938789","https://openalex.org/W2135715423","https://openalex.org/W2099937870"],"abstract_inverted_index":{"Conditional":[0],"deletion":[1,117,170],"of":[2,25,39,58,89,109,118,129,132,150,159,164,171,182,186,191,216,258],"Apc":[3],"in":[4,20,29,79,93,123,208,255],"the":[5,37,56,71,110,133,176,180,256],"murine":[6,83],"intestine":[7],"alters":[8],"crypt-villus":[9],"architecture":[10],"and":[11,51,54,70,82,85,126,146,161,194,211,246,248],"function.":[12],"This":[13,222],"process":[14],"is":[15,32,77,227],"accompanied":[16],"by":[17,225],"multiple":[18,140],"changes":[19],"gene":[21],"expression,":[22],"including":[23,64,120,131,143,199,220],"upregulation":[24],"Cited1,":[26],"whose":[27],"role":[28],"colorectal":[30],"carcinogenesis":[31],"unknown.":[33],"Here":[34],"we":[35],"explore":[36],"relevance":[38],"Cited1":[40,46,59,76,90,103,153,173,187,203,226,233],"to":[41,98,189,234,238],"intestinal":[42,206],"tumorigenesis.":[43],"We":[44,73],"crossed":[45],"null":[47],"mice":[48,53,95,210],"with":[49,156,229,242],"Apc(Min/+)":[50,94,209],"AhCre(+)Apc(fl/fl)":[52],"determined":[55],"impact":[57],"deficiency":[60,88,104,154,185,204],"on":[61],"tumour":[62,65,253],"growth/initiation":[63],"multiplicity,":[66],"cell":[67,124,135,201],"proliferation,":[68],"apoptosis":[69],"transcriptome.":[72],"show":[74],"that":[75,86],"up-regulated":[78],"both":[80],"human":[81],"tumours,":[84],"constitutive":[87],"increases":[91],"survival":[92],"from":[96],"230.5":[97],"515":[99],"days.":[100],"However,":[101],"paradoxically,":[102],"accentuated":[105],"nearly":[106],"all":[107],"aspects":[108],"immediate":[111],"phenotype":[112,198],"4":[113],"days":[114],"after":[115],"conditional":[116],"Apc,":[119,172],"an":[121,195],"increase":[122],"death":[125],"enhanced":[127],"perturbation":[128],"differentiation,":[130],"stem":[134],"compartment.":[136],"Transcriptome":[137],"analysis":[138],"revealed":[139],"pathway":[141,178],"changes,":[142],"p53,":[144],"PI3K":[145],"Wnt.":[147,221],"The":[148],"activation":[149],"Wnt":[151,177,192,197,236],"through":[152],"correlated":[155],"increased":[157,162],"transcription":[158],"\u03b2-catenin":[160],"levels":[163],"dephosphorylated":[165],"\u03b2-catenin.":[166,183],"Hence,":[167],"immediately":[168],"following":[169],"normally":[174],"restrains":[175],"at":[179],"level":[181,240],"Thus":[184],"leads":[188],"hyper-activation":[190],"signaling":[193,218],"exaggerated":[196],"elevated":[200],"death.":[202],"decreases":[205],"tumourigenesis":[207],"impacts":[212],"upon":[213],"a":[214,230,239],"number":[215],"oncogenic":[217],"pathways,":[219],"restraint":[223],"imposed":[224],"consistent":[228],"requirement":[231],"for":[232,252],"constrain":[235],"activity":[237],"commensurate":[241],"optimal":[243],"adenoma":[244],"formation":[245],"maintenance,":[247],"provides":[249],"one":[250],"mechanism":[251],"repression":[254],"absence":[257],"Cited1.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}