{"id":"https://openalex.org/W2158235229","doi":"https://doi.org/10.1016/0016-5085(87)90454-9","title":"Cyclosporine treatment of autoimmune chronic active hepatitis","display_name":"Cyclosporine treatment of autoimmune chronic active hepatitis","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W2158235229","doi":"https://doi.org/10.1016/0016-5085(87)90454-9","mag":"2158235229","pmid":"https://pubmed.ncbi.nlm.nih.gov/2887482"},"language":"en","primary_location":{"id":"doi:10.1016/0016-5085(87)90454-9","doi":"https://doi.org/10.1016/0016-5085(87)90454-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0016-5085(87)90454-9","pdf_url":"https://doi.org/10.1016/0016-5085(87)90454-9","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/0016-5085(87)90454-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006726610","display_name":"Jeffrey S. Hyams","orcid":"https://orcid.org/0000-0002-9769-236X","observed_orcids":["https://orcid.org/0000-0002-9769-236X"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Hyams","raw_affiliation_strings":["Deuartment of Pediatrics, Hartford Hospital, Hartford, Connecticut; and","Divi-sion of Pediatric Gastroenterology and Nutrition, Hartford Hospi-tal, Hartford, Connecticut 06115","University of Connecticut Hekh Center, Farmington, Connecticut _"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deuartment of Pediatrics, Hartford Hospital, Hartford, Connecticut; and","institution_ids":["https://openalex.org/I1302163369"]},{"raw_affiliation_string":"Divi-sion of Pediatric Gastroenterology and Nutrition, Hartford Hospi-tal, Hartford, Connecticut 06115","institution_ids":["https://openalex.org/I1302163369"]},{"raw_affiliation_string":"University of Connecticut Hekh Center, Farmington, Connecticut _","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037734477","display_name":"Mark C. Ballow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Ballow","raw_affiliation_strings":["Deuartment of Pediatrics, Hartford Hospital, Hartford, Connecticut; and","University of Connecticut Hekh Center, Farmington, Connecticut _","Divi-sion of Pediatric Gastroenterology and Nutrition, Hartford Hospi-tal, Hartford, Connecticut 06115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deuartment of Pediatrics, Hartford Hospital, Hartford, Connecticut; and","institution_ids":["https://openalex.org/I1302163369"]},{"raw_affiliation_string":"University of Connecticut Hekh Center, Farmington, Connecticut _","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"Divi-sion of Pediatric Gastroenterology and Nutrition, Hartford Hospi-tal, Hartford, Connecticut 06115","institution_ids":["https://openalex.org/I1302163369"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114115426","display_name":"Alan M. Leichtner","orcid":"https://orcid.org/0000-0003-4634-6632","observed_orcids":["https://orcid.org/0000-0003-4634-6632"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]},{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan M. Leichtner","raw_affiliation_strings":["Deuartment of Pediatrics, Hartford Hospital, Hartford, Connecticut; and","University of Connecticut Hekh Center, Farmington, Connecticut _","Divi-sion of Pediatric Gastroenterology and Nutrition, Hartford Hospi-tal, Hartford, Connecticut 06115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deuartment of Pediatrics, Hartford Hospital, Hartford, Connecticut; and","institution_ids":["https://openalex.org/I1302163369"]},{"raw_affiliation_string":"University of Connecticut Hekh Center, Farmington, Connecticut _","institution_ids":["https://openalex.org/I140172145","https://openalex.org/I75929689"]},{"raw_affiliation_string":"Divi-sion of Pediatric Gastroenterology and Nutrition, Hartford Hospi-tal, Hartford, Connecticut 06115","institution_ids":["https://openalex.org/I1302163369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":3.1686,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.91150693,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"93","issue":"4","first_page":"890","last_page":"893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pediatric-liver-disease","display_name":"pediatric liver disease","score":0.6949999928474426},{"id":"https://openalex.org/keywords/aminotransferase-levels","display_name":"aminotransferase levels","score":0.8709999918937683},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.906000018119812},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.640999972820282},{"id":"https://openalex.org/keywords/growth-failure","display_name":"growth failure","score":0.9359999895095825},{"id":"https://openalex.org/keywords/catch-up-growth","display_name":"catch-up growth","score":0.8619999885559082},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8456010818481445},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.7420799732208252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6630481481552124},{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.6546040773391724},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6415374875068665},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.550280749797821},{"id":"https://openalex.org/C2779528694","wikidata":"https://www.wikidata.org/wiki/Q367700","display_name":"Ciclosporin","level":3,"score":0.5485790371894836},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5423397421836853},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5074631571769714},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.4429362714290619},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3749181032180786},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3569193482398987},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.07257527112960815},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000637","descriptor_name":"Transaminases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006521","descriptor_name":"Hepatitis, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006521","descriptor_name":"Hepatitis, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0016-5085(87)90454-9","doi":"https://doi.org/10.1016/0016-5085(87)90454-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0016-5085(87)90454-9","pdf_url":"https://doi.org/10.1016/0016-5085(87)90454-9","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:2887482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2887482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1016/0016-5085(87)90454-9","doi":"https://doi.org/10.1016/0016-5085(87)90454-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0016-5085(87)90454-9","pdf_url":"https://doi.org/10.1016/0016-5085(87)90454-9","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8799999952316284,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158235229.pdf","grobid_xml":"https://content.openalex.org/works/W2158235229.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1530475382","https://openalex.org/W1904573026","https://openalex.org/W1970192183","https://openalex.org/W1977287087","https://openalex.org/W1995616322","https://openalex.org/W2018625187","https://openalex.org/W2044529181","https://openalex.org/W2060958447","https://openalex.org/W2080385360","https://openalex.org/W2150631622","https://openalex.org/W2162627130","https://openalex.org/W2165883700","https://openalex.org/W2341774156","https://openalex.org/W2415980267","https://openalex.org/W4297752219"],"related_works":["https://openalex.org/W2126493213","https://openalex.org/W2137507272","https://openalex.org/W2044176473","https://openalex.org/W2415980267","https://openalex.org/W4240799802","https://openalex.org/W2080236843","https://openalex.org/W2789161103","https://openalex.org/W2017729523","https://openalex.org/W1502319745","https://openalex.org/W2004500475"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}