{"id":"https://openalex.org/W2158176433","doi":"https://doi.org/10.2337/diabetes.52.11.2689","title":"Recombinant Fabs of Human Monoclonal Antibodies Specific to the Middle Epitope of GAD65 Inhibit Type 1 Diabetes\u2013Specific GAD65Abs","display_name":"Recombinant Fabs of Human Monoclonal Antibodies Specific to the Middle Epitope of GAD65 Inhibit Type 1 Diabetes\u2013Specific GAD65Abs","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2158176433","doi":"https://doi.org/10.2337/diabetes.52.11.2689","mag":"2158176433","pmid":"https://pubmed.ncbi.nlm.nih.gov/14578287"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.52.11.2689","doi":"https://doi.org/10.2337/diabetes.52.11.2689","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.52.11.2689","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/52/11/2689/372937/db1103002689.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/52/11/2689/372937/db1103002689.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030709033","display_name":"Carolyn J. Padoa","orcid":"https://orcid.org/0000-0001-5154-3943","observed_orcids":["https://orcid.org/0000-0001-5154-3943"]},"institutions":[{"id":"https://openalex.org/I107920810","display_name":"National Health Laboratory Service","ror":"https://ror.org/00znvbk37","country_code":"ZA","type":"government","lineage":["https://openalex.org/I107920810"]},{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US","ZA"],"is_corresponding":false,"raw_author_name":"Carolyn J. Padoa","raw_affiliation_strings":["Department of Chemical Pathology, University of the Witwatersrand & National Health Laboratory Services, Johannesburg, South Africa","Department of Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, University of the Witwatersrand & National Health Laboratory Services, Johannesburg, South Africa","institution_ids":["https://openalex.org/I107920810","https://openalex.org/I192619145"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110817121","display_name":"Jasvinder Paul Banga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Paul Banga","raw_affiliation_strings":["Division of Medicine, Guy\u2019s, Kings and St. Thomas\u2019 School of Medicine, London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine, Guy\u2019s, Kings and St. Thomas\u2019 School of Medicine, London, U.K","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060731771","display_name":"Anne\u2010Marie Madec","orcid":"https://orcid.org/0000-0002-5072-8572","observed_orcids":["https://orcid.org/0000-0002-5072-8572"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Marie Madec","raw_affiliation_strings":["Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Laennec Faculty of Medicine, University of Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Laennec Faculty of Medicine, University of Lyon, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I203339264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112199463","display_name":"MANFRED ZIEGLER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145262","display_name":"Institute for Diabetes Gerhardt Katsch","ror":"https://ror.org/05d854h51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210145262"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Ziegler","raw_affiliation_strings":["Institute of Diabetes \u201cGerhardt Katsch,\u201d Karlsburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Diabetes \u201cGerhardt Katsch,\u201d Karlsburg, Germany","institution_ids":["https://openalex.org/I4210145262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011573488","display_name":"Michael Schlosser","orcid":"https://orcid.org/0000-0001-8173-6578","observed_orcids":["https://orcid.org/0000-0001-8173-6578"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schlosser","raw_affiliation_strings":["Institute of Pathophysiology, Ernst Moritz Arndt University of Greifswald, Karlsburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathophysiology, Ernst Moritz Arndt University of Greifswald, Karlsburg, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081200857","display_name":"Eva \u00d6rtqvist","orcid":"https://orcid.org/0000-0002-6924-704X","observed_orcids":["https://orcid.org/0000-0002-6924-704X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eva Ortqvist","raw_affiliation_strings":["Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070458733","display_name":"Ingrid  Skelton Kockum","orcid":"https://orcid.org/0000-0002-0867-4726","observed_orcids":["https://orcid.org/0000-0002-0867-4726"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ingrid Kockum","raw_affiliation_strings":["Department of Molecular Medicine, Clinical Genetics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Clinical Genetics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005436471","display_name":"Jerry P. Palmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Palmer","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085215443","display_name":"Olov Rolandsson","orcid":"https://orcid.org/0000-0002-1341-6828","observed_orcids":["https://orcid.org/0000-0002-1341-6828"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olov Rolandsson","raw_affiliation_strings":["Department of Public Health and Clinical Medicine, Umea\u030a University, Umea\u030a, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Clinical Medicine, Umea\u030a University, Umea\u030a, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077890446","display_name":"Katherine A. Binder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A. Binder","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033948327","display_name":"Jefferson Foote","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jefferson Foote","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dong Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Luo","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036401896","display_name":"Christiane S. Hampe","orcid":"https://orcid.org/0000-0001-9111-6671","observed_orcids":["https://orcid.org/0000-0001-9111-6671"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christiane S. Hampe","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1707,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.92042573,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"52","issue":"11","first_page":"2689","last_page":"2695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gad65-autoantibodies","display_name":"GAD65 antibodies","score":0.9010000228881836},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9399999976158142},{"id":"https://openalex.org/keywords/conformational-epitopes","display_name":"conformational epitopes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/first-degree-relatives","display_name":"first-degree relatives","score":0.8519999980926514},{"id":"https://openalex.org/keywords/disease-specific-autoantibodies","display_name":"disease-specific autoantibodies","score":0.7329999804496765},{"id":"https://openalex.org/keywords/competitive-radioimmunoassay","display_name":"competitive radioimmunoassay","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9418027997016907},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7417611479759216},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7147489786148071},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6211105585098267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5902953743934631},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5784151554107666},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5711110234260559},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5709944367408752},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5063959360122681},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.481960266828537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48050105571746826},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.464809775352478},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4592639207839966},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4373641908168793},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.4310990273952484},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42165204882621765},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.419388085603714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2427942454814911},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15346699953079224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06140202283859253}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005968","descriptor_name":"Glutamate Decarboxylase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diabetes.52.11.2689","doi":"https://doi.org/10.2337/diabetes.52.11.2689","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.52.11.2689","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/52/11/2689/372937/db1103002689.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:14578287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14578287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/d64f98ce-d350-4ed3-873c-9afb22f4a580","doi":null,"is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=10744229400&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Padoa, C J, Banga, J P, Madec, A M, Ziegler, M, Schlosser, M, Ortqvist, E, Kockum, I, Palmer, J, Rolandsson, O, Binder, K A, Foote, J, Luo, D & Hampe, C S 2003, 'Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs', Diabetes, vol. 52, no. 11, pp. 2689 - 2695. https://doi.org/10.2337/diabetes.52.11.2689","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.2337/diabetes.52.11.2689","doi":"https://doi.org/10.2337/diabetes.52.11.2689","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.52.11.2689","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/52/11/2689/372937/db1103002689.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G372127786","display_name":null,"funder_award_id":"DK 53004","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G411541712","display_name":null,"funder_award_id":"DK-26190","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5240651316","display_name":null,"funder_award_id":"DK-17047","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6216217890","display_name":"Islet Cell Membrane Antibodies in Diabetes","funder_award_id":"R01DK026190","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000881174","display_name":"Diabetes Research Center","funder_award_id":"P30DK017047","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158176433.pdf","grobid_xml":"https://content.openalex.org/works/W2158176433.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1484092314","https://openalex.org/W1535809378","https://openalex.org/W1680463210","https://openalex.org/W1781531090","https://openalex.org/W1963817400","https://openalex.org/W1968278124","https://openalex.org/W1982544710","https://openalex.org/W1986753195","https://openalex.org/W1987913280","https://openalex.org/W2006787271","https://openalex.org/W2013943197","https://openalex.org/W2016264613","https://openalex.org/W2024199579","https://openalex.org/W2028981905","https://openalex.org/W2029156207","https://openalex.org/W2033174513","https://openalex.org/W2041309682","https://openalex.org/W2052726638","https://openalex.org/W2059144476","https://openalex.org/W2064295609","https://openalex.org/W2071472322","https://openalex.org/W2084194744","https://openalex.org/W2089844019","https://openalex.org/W2090432138","https://openalex.org/W2092783189","https://openalex.org/W2096249455","https://openalex.org/W2109997219","https://openalex.org/W2114047926","https://openalex.org/W2122855951","https://openalex.org/W2126972494","https://openalex.org/W2142627742","https://openalex.org/W2167340154","https://openalex.org/W2168685099","https://openalex.org/W2171445832","https://openalex.org/W4234432884","https://openalex.org/W4244005547","https://openalex.org/W4245531498"],"related_works":["https://openalex.org/W7100087670","https://openalex.org/W2034787026","https://openalex.org/W2118680844","https://openalex.org/W4245531498","https://openalex.org/W2122855951","https://openalex.org/W2069585944","https://openalex.org/W2114692453","https://openalex.org/W2013634083","https://openalex.org/W2050578141","https://openalex.org/W1989320743"],"abstract_inverted_index":{"Autoantibodies":[0],"to":[1,56,67],"the":[2,16,20,24,64,146,187,202,205,224],"65-kDa":[3],"isoform":[4],"of":[5,19,26,48,145,163,169,176,226],"GAD":[6],"(GAD65Abs)":[7],"are":[8],"associated":[9,194],"with":[10,63,195],"type":[11,52,111,147,190,219],"1":[12,53,112,148,191,220],"diabetes":[13,122,192,221],"development,":[14],"but":[15],"conformational":[17,227],"nature":[18],"GAD65Ab":[21,70,228],"epitopes":[22],"complicates":[23],"evaluation":[25],"disease":[27,209],"risk.":[28],"Six":[29],"GAD65-specific":[30,212],"recombinant":[31],"Fabs":[32],"(rFabs)":[33],"were":[34,151],"cloned":[35],"from":[36,116],"monoclonal":[37],"antibodies":[38],"b96.11,":[39],"DP-C,":[40,157],"DP-A,":[41],"DPD,":[42],"144,":[43],"and":[44,101,135,143,156,161,167,172,174,197,200,222],"221-442.":[45],"The":[46,73,107],"binding":[47,71,75],"GAD65Abs":[49,199],"in":[50,110,118,123,217,223],"61":[51],"diabetic":[54,113,149],"patients":[55,114,126],"GAD65":[57],"was":[58,76],"analyzed":[59],"by":[60,79,153],"competitive":[61],"radioimmunoassays":[62],"six":[65],"rFabs":[66,213],"ascertain":[68],"disease-specific":[69],"specificities.":[72],"median":[74],"reduced":[77],"significantly":[78],"rFab":[80,154],"b96.11":[81,155],"(72%)":[82],"(P":[83,88,93,98,104,181],"<":[84,89,94,99,105,182],"0.0001),":[85,90,95,100],"DP-A":[86],"(84%)":[87,92],"DP-C":[91],"221-442":[96],"(79%)":[97],"DP-D":[102],"(80%)":[103],"0.0001).":[106,183],"competition":[108,180],"pattern":[109],"differed":[115],"that":[117,189,204],"GAD65Ab-positive":[119],"late":[120],"autoimmune":[121],"adults":[124],"(LADA)":[125],"(n":[127,132,138],"=":[128,133,139],"44),":[129],"first-degree":[130,170],"relatives":[131],"38),":[134],"healthy":[136,177],"individuals":[137,178],"14).":[140],"Whereas":[141],"87":[142],"72%":[144],"sera":[150],"competed":[152],"respectively,":[158],"only":[159],"34":[160],"26%":[162],"LADA":[164],"patients,":[165],"18":[166],"25%":[168],"relatives,":[171],"7":[173],"28%":[175],"showed":[179],"These":[184,211],"findings":[185],"support":[186],"view":[188],"is":[193,208],"disease-":[196],"epitope-specific":[198],"supports":[201],"notion":[203],"middle":[206],"epitope":[207],"associated.":[210],"should":[214],"prove":[215],"useful":[216],"predicting":[218],"study":[225],"epitopes.":[229]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}