{"id":"https://openalex.org/W2158163786","doi":null,"title":"Translational control during viral infection, investigating the role of severe acute respiratory syndrome non-structural protein 1 and enterovirus 71 internal ribosome entry site.","display_name":"Translational control during viral infection, investigating the role of severe acute respiratory syndrome non-structural protein 1 and enterovirus 71 internal ribosome entry site.","publication_year":2015,"publication_date":"2015-01-30","ids":{"openalex":"https://openalex.org/W2158163786","mag":"2158163786"},"language":"en","primary_location":{"id":"pmh:oai:epubs.surrey.ac.uk:807087","doi":null,"is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/807087/7/Author_Deposit_Agreement.docx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025826172","display_name":"Melvin M. Leteane","orcid":"https://orcid.org/0000-0002-6680-1121","observed_orcids":["https://orcid.org/0000-0002-6680-1121"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melvin Leteane","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6680-1121","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025826172"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/viral-translation","display_name":"viral protein synthesis","score":0.5249999761581421},{"id":"https://openalex.org/keywords/translation-initiation-factors","display_name":"translation initiation factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/eif4a","display_name":"eIF4A","score":0.8809999823570251},{"id":"https://openalex.org/keywords/eif4e","display_name":"eIF4E","score":0.9800000190734863},{"id":"https://openalex.org/keywords/eif4g","display_name":"eIF4G","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fbp2","display_name":"FBP2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7480000257492065},{"id":"https://openalex.org/keywords/rna-secondary-structure","display_name":"RNA secondary structure","score":0.8560000061988831},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.9303926229476929},{"id":"https://openalex.org/C2776054693","wikidata":"https://www.wikidata.org/wiki/Q5323186","display_name":"EIF4G","level":5,"score":0.8719319105148315},{"id":"https://openalex.org/C161295673","wikidata":"https://www.wikidata.org/wiki/Q5408696","display_name":"EIF4E","level":5,"score":0.8023970127105713},{"id":"https://openalex.org/C97154109","wikidata":"https://www.wikidata.org/wiki/Q906570","display_name":"Eukaryotic initiation factor","level":5,"score":0.7202669978141785},{"id":"https://openalex.org/C62493599","wikidata":"https://www.wikidata.org/wiki/Q424137","display_name":"Initiation factor","level":5,"score":0.6894016265869141},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.6149665713310242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.602261483669281},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.5522869229316711},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5248658657073975},{"id":"https://openalex.org/C33277056","wikidata":"https://www.wikidata.org/wiki/Q17916089","display_name":"Eukaryotic translation initiation factor 4 gamma","level":5,"score":0.4621961712837219},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4449446499347687},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.4441414177417755},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4433867037296295},{"id":"https://openalex.org/C99348085","wikidata":"https://www.wikidata.org/wiki/Q5323174","display_name":"eIF4A","level":5,"score":0.43793898820877075},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42192769050598145},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4011717736721039},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3688836097717285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3165827989578247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27485668659210205}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:epubs.surrey.ac.uk:807087","doi":null,"is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/807087/7/Author_Deposit_Agreement.docx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2158163786","doi":null,"is_oa":false,"landing_page_url":"https://epubs.surrey.ac.uk/807087/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":290,"referenced_works":["https://openalex.org/W69657478","https://openalex.org/W72940490","https://openalex.org/W85890770","https://openalex.org/W86541428","https://openalex.org/W101566136","https://openalex.org/W120142365","https://openalex.org/W136234913","https://openalex.org/W645770732","https://openalex.org/W1480005431","https://openalex.org/W1490158396","https://openalex.org/W1513981950","https://openalex.org/W1544561280","https://openalex.org/W1545528913","https://openalex.org/W1559631147","https://openalex.org/W1600974081","https://openalex.org/W1666195836","https://openalex.org/W1684819408","https://openalex.org/W1758820812","https://openalex.org/W1869889838","https://openalex.org/W1892009258","https://openalex.org/W1902706292","https://openalex.org/W1930219409","https://openalex.org/W1938755197","https://openalex.org/W1963611256","https://openalex.org/W1965280032","https://openalex.org/W1965319639","https://openalex.org/W1965447234","https://openalex.org/W1965514223","https://openalex.org/W1966303376","https://openalex.org/W1968786460","https://openalex.org/W1969003683","https://openalex.org/W1969264016","https://openalex.org/W1969588503","https://openalex.org/W1969841753","https://openalex.org/W1970561614","https://openalex.org/W1970743470","https://openalex.org/W1970949525","https://openalex.org/W1971046207","https://openalex.org/W1971140237","https://openalex.org/W1971739920","https://openalex.org/W1972533328","https://openalex.org/W1974408803","https://openalex.org/W1974431355","https://openalex.org/W1975520452","https://openalex.org/W1975959718","https://openalex.org/W1976006940","https://openalex.org/W1976098622","https://openalex.org/W1976367392","https://openalex.org/W1977955723","https://openalex.org/W1977964738","https://openalex.org/W1979168172","https://openalex.org/W1979191846","https://openalex.org/W1981014117","https://openalex.org/W1982319128","https://openalex.org/W1983381811","https://openalex.org/W1984092826","https://openalex.org/W1984902027","https://openalex.org/W1984956585","https://openalex.org/W1987104397","https://openalex.org/W1988595481","https://openalex.org/W1989328535","https://openalex.org/W1991192984","https://openalex.org/W1991256205","https://openalex.org/W1991321216","https://openalex.org/W1991999080","https://openalex.org/W1992509320","https://openalex.org/W1992920740","https://openalex.org/W1993577573","https://openalex.org/W1993777187","https://openalex.org/W1993964516","https://openalex.org/W1993969571","https://openalex.org/W1994709797","https://openalex.org/W1995329701","https://openalex.org/W1995403172","https://openalex.org/W1997324386","https://openalex.org/W1997754945","https://openalex.org/W1999090224","https://openalex.org/W1999719904","https://openalex.org/W1999787047","https://openalex.org/W2002220847","https://openalex.org/W2003230246","https://openalex.org/W2004030503","https://openalex.org/W2004143350","https://openalex.org/W2006299881","https://openalex.org/W2007541286","https://openalex.org/W2008410413","https://openalex.org/W2008414809","https://openalex.org/W2008776451","https://openalex.org/W2009269401","https://openalex.org/W2010232164","https://openalex.org/W2011847293","https://openalex.org/W2012660749","https://openalex.org/W2013771316","https://openalex.org/W2015532290","https://openalex.org/W2015974098","https://openalex.org/W2017356464","https://openalex.org/W2019031253","https://openalex.org/W2020721543","https://openalex.org/W2023590131","https://openalex.org/W2024062560","https://openalex.org/W2024756093","https://openalex.org/W2025170735","https://openalex.org/W2025518316","https://openalex.org/W2025595745","https://openalex.org/W2026422822","https://openalex.org/W2027291842","https://openalex.org/W2030632564","https://openalex.org/W2032206556","https://openalex.org/W2034760423","https://openalex.org/W2034987463","https://openalex.org/W2036412199","https://openalex.org/W2036693329","https://openalex.org/W2036806075","https://openalex.org/W2037313242","https://openalex.org/W2038487518","https://openalex.org/W2039461665","https://openalex.org/W2041122594","https://openalex.org/W2044113516","https://openalex.org/W2046153984","https://openalex.org/W2048651813","https://openalex.org/W2048731469","https://openalex.org/W2049814812","https://openalex.org/W2052805423","https://openalex.org/W2053186308","https://openalex.org/W2054347908","https://openalex.org/W2055866850","https://openalex.org/W2056525941","https://openalex.org/W2056748259","https://openalex.org/W2057906496","https://openalex.org/W2058278479","https://openalex.org/W2058426472","https://openalex.org/W2058780476","https://openalex.org/W2059617809","https://openalex.org/W2061356817","https://openalex.org/W2061384728","https://openalex.org/W2061764129","https://openalex.org/W2062264009","https://openalex.org/W2062887711","https://openalex.org/W2063343111","https://openalex.org/W2064447948","https://openalex.org/W2065305397","https://openalex.org/W2065553421","https://openalex.org/W2066536058","https://openalex.org/W2067181050","https://openalex.org/W2068070201","https://openalex.org/W2068446924","https://openalex.org/W2068881880","https://openalex.org/W2068921257","https://openalex.org/W2071249470","https://openalex.org/W2072141763","https://openalex.org/W2072946951","https://openalex.org/W2073051449","https://openalex.org/W2075301798","https://openalex.org/W2075351796","https://openalex.org/W2078138301","https://openalex.org/W2078472264","https://openalex.org/W2078532165","https://openalex.org/W2079983210","https://openalex.org/W2080190754","https://openalex.org/W2081053429","https://openalex.org/W2081309601","https://openalex.org/W2081458703","https://openalex.org/W2081495506","https://openalex.org/W2081666563","https://openalex.org/W2081997160","https://openalex.org/W2082129486","https://openalex.org/W2082881669","https://openalex.org/W2083468489","https://openalex.org/W2084054547","https://openalex.org/W2085899914","https://openalex.org/W2086079901","https://openalex.org/W2087107399","https://openalex.org/W2087693580","https://openalex.org/W2088656743","https://openalex.org/W2088788596","https://openalex.org/W2089198803","https://openalex.org/W2090266461","https://openalex.org/W2091091730","https://openalex.org/W2091668708","https://openalex.org/W2092581586","https://openalex.org/W2095582889","https://openalex.org/W2095748631","https://openalex.org/W2095897227","https://openalex.org/W2096296961","https://openalex.org/W2098852876","https://openalex.org/W2099136664","https://openalex.org/W2100124939","https://openalex.org/W2100593398","https://openalex.org/W2102032642","https://openalex.org/W2104548316","https://openalex.org/W2104730869","https://openalex.org/W2104947461","https://openalex.org/W2105554008","https://openalex.org/W2105637133","https://openalex.org/W2106854623","https://openalex.org/W2108785757","https://openalex.org/W2109009498","https://openalex.org/W2109941922","https://openalex.org/W2111183040","https://openalex.org/W2111412754","https://openalex.org/W2111478644","https://openalex.org/W2111668132","https://openalex.org/W2112459919","https://openalex.org/W2113368761","https://openalex.org/W2113508801","https://openalex.org/W2114859361","https://openalex.org/W2116569365","https://openalex.org/W2119896177","https://openalex.org/W2120974004","https://openalex.org/W2121596680","https://openalex.org/W2123742352","https://openalex.org/W2123909876","https://openalex.org/W2124371255","https://openalex.org/W2125633274","https://openalex.org/W2125722640","https://openalex.org/W2125908595","https://openalex.org/W2126073956","https://openalex.org/W2126428749","https://openalex.org/W2127062009","https://openalex.org/W2127340570","https://openalex.org/W2131632095","https://openalex.org/W2131988685","https://openalex.org/W2132202407","https://openalex.org/W2132245233","https://openalex.org/W2133856510","https://openalex.org/W2134092129","https://openalex.org/W2134159081","https://openalex.org/W2135158492","https://openalex.org/W2135513925","https://openalex.org/W2137032962","https://openalex.org/W2137259955","https://openalex.org/W2137300354","https://openalex.org/W2138970689","https://openalex.org/W2139498893","https://openalex.org/W2139919363","https://openalex.org/W2140526135","https://openalex.org/W2140734584","https://openalex.org/W2141157874","https://openalex.org/W2141301273","https://openalex.org/W2141571283","https://openalex.org/W2141838466","https://openalex.org/W2141877163","https://openalex.org/W2142082526","https://openalex.org/W2142612221","https://openalex.org/W2142986041","https://openalex.org/W2144024988","https://openalex.org/W2145502099","https://openalex.org/W2146339805","https://openalex.org/W2147509381","https://openalex.org/W2149474451","https://openalex.org/W2149676146","https://openalex.org/W2149794276","https://openalex.org/W2150135205","https://openalex.org/W2151596277","https://openalex.org/W2153439063","https://openalex.org/W2153465289","https://openalex.org/W2154128645","https://openalex.org/W2154551219","https://openalex.org/W2154664055","https://openalex.org/W2155441706","https://openalex.org/W2155639426","https://openalex.org/W2156039975","https://openalex.org/W2156095183","https://openalex.org/W2156868505","https://openalex.org/W2157497892","https://openalex.org/W2157980687","https://openalex.org/W2158215881","https://openalex.org/W2158497767","https://openalex.org/W2159673867","https://openalex.org/W2160079255","https://openalex.org/W2162504855","https://openalex.org/W2162784534","https://openalex.org/W2162794587","https://openalex.org/W2163714351","https://openalex.org/W2164272554","https://openalex.org/W2166567740","https://openalex.org/W2166867592","https://openalex.org/W2167080692","https://openalex.org/W2169198329","https://openalex.org/W2170625826","https://openalex.org/W2171726839","https://openalex.org/W2236522101","https://openalex.org/W2287048591","https://openalex.org/W2315475605","https://openalex.org/W2397221660","https://openalex.org/W2463755683","https://openalex.org/W2595920264","https://openalex.org/W2764433274","https://openalex.org/W2916336743","https://openalex.org/W7075694256"],"related_works":["https://openalex.org/W2068881880","https://openalex.org/W2102837703","https://openalex.org/W2534914451","https://openalex.org/W2112512495","https://openalex.org/W1766348969","https://openalex.org/W2916842228","https://openalex.org/W1974963408","https://openalex.org/W4206639713","https://openalex.org/W1977964738","https://openalex.org/W7098385109"],"abstract_inverted_index":{"Translation":[0],"of":[1,16,24,41,58,71,83,100,109,135,157,168,175,183,193,203,210,214,234,250,260,268,273],"mRNA":[2],"into":[3],"protein":[4,141,160,170,176],"represents":[5],"the":[6,10,14,17,50,67,84,98,107,133,155,166,191,201,232,257,261,266],"final":[7],"step":[8],"in":[9,37,65,75,150,161,253],"gene-expression":[11],"pathway,":[12],"driving":[13],"formation":[15,267],"proteome":[18],"from":[19],"genomic":[20],"information.":[21],"The":[22],"regulation":[23,99,163],"this":[25,151],"process":[26],"is":[27,31,46],"a":[28,38,93,180,207,269],"mechanism":[29],"that":[30,105],"used":[32,247],"to":[33,230,255],"modulate":[34],"gene":[35,59],"expression":[36],"wide":[39,181,208],"range":[40,182,209],"biological":[42],"situations.":[43],"Protein":[44],"synthesis":[45],"principally":[47],"regulated":[48],"at":[49],"initiation":[51,87,102,110,115,238],"stage,":[52],"allowing":[53],"for":[54,96],"rapid,":[55],"reversible":[56],"control":[57,126],"expression.":[60],"Progress":[61],"over":[62],"recent":[63],"years":[64],"determining":[66],"structures":[68],"and":[69,74,116,143,217,243],"activities":[70],"regulatory":[72],"factors,":[73],"mapping":[76],"their":[77,219],"interactions,":[78],"have":[79,91],"advanced":[80],"our":[81],"understanding":[82],"complex":[85],"translation":[86,101,162],"process.":[88,152],"These":[89],"developments":[90],"provided":[92],"solid":[94],"foundation":[95],"studying":[97],"by":[103],"mechanisms":[104],"include":[106],"modulation":[108],"factor":[111],"activity,":[112],"internal":[113],"ribosome":[114],"through":[117],"sequence-specific":[118],"RNA-binding":[119],"proteins.":[120,198],"This":[121,227],"thesis":[122],"focused":[123],"on":[124],"translational":[125],"during":[127],"viral":[128],"infection,":[129],"where":[130],"we":[131,164,185,205,246],"investigated":[132],"role":[134,202],"Severe":[136],"Acute":[137],"Respiratory":[138],"Syndrome":[139],"non-structural":[140],"1":[142],"Enterovirus":[144],"71":[145],"Internal":[146],"Ribosome":[147],"Entry":[148],"Site":[149],"\\nTo":[153],"establish":[154,256],"function":[156],"SARS":[158],"NSP1":[159,169,194],"attempted":[165],"identification":[167],"partners":[171],"using":[172,224],"several":[173],"types":[174],"affinity":[177],"chromatography.":[178],"Using":[179],"approaches,":[184],"could":[186],"not":[187],"detect":[188],"nor":[189],"confirm":[190],"association":[192],"with":[195,221,237],"any":[196],"cellular":[197],"To":[199],"dissect":[200],"FBP2,":[204],"engineered":[206],"recombinant":[211],"FBP2":[212],"proteins":[213],"different":[215],"lengths":[216],"analysed":[218],"interactions":[220],"IRES":[222,236],"elements":[223],"biochemical":[225],"techniques.":[226],"allowed":[228],"us":[229],"characterize":[231],"interaction":[233],"EV71":[235],"factors":[239],"eIF4A,":[240],"eIF4E,":[241],"eIF4G":[242],"FBP2.":[244],"Finally,":[245],"chemical":[248],"probing":[249],"RNA":[251,271],"structure":[252,259],"solution":[254],"secondary":[258],"BiP":[262],"IRES.":[263],"We":[264],"identified":[265],"structured":[270],"scaffold":[272],"220":[274],"nucleotides":[275],"comprising":[276],"3":[277],"major":[278],"domains.":[279]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}