{"id":"https://openalex.org/W2158095584","doi":"https://doi.org/10.1128/jvi.02422-06","title":"West Nile Virus-Induced Neuroinflammation: Glial Infection and Capsid Protein-Mediated Neurovirulence","display_name":"West Nile Virus-Induced Neuroinflammation: Glial Infection and Capsid Protein-Mediated Neurovirulence","publication_year":2007,"publication_date":"2007-08-02","ids":{"openalex":"https://openalex.org/W2158095584","doi":"https://doi.org/10.1128/jvi.02422-06","mag":"2158095584","pmid":"https://pubmed.ncbi.nlm.nih.gov/17670819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2045515"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.02422-06","doi":"https://doi.org/10.1128/jvi.02422-06","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02422-06","pdf_url":"https://jvi.asm.org/content/jvi/81/20/10933.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/81/20/10933.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074081305","display_name":"Guido van Marle","orcid":"https://orcid.org/0000-0002-5148-6229","observed_orcids":["https://orcid.org/0000-0002-5148-6229"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Guido van Marle","raw_affiliation_strings":["Departments of Microbiology and Infectious Diseases","Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta T6G 2S2, Canada","Departments of Microbiology and Infectious Diseases 1 and Clinical Neurosciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology and Infectious Diseases","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta T6G 2S2, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Departments of Microbiology and Infectious Diseases 1 and Clinical Neurosciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039875122","display_name":"Joseph Mathew Antony","orcid":"https://orcid.org/0000-0002-5700-7719","observed_orcids":["https://orcid.org/0000-0002-5700-7719"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joseph Antony","raw_affiliation_strings":["Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada","Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059157414","display_name":"Heather Ostermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Heather Ostermann","raw_affiliation_strings":["Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059000453","display_name":"Christopher P. Dunham","orcid":"https://orcid.org/0000-0002-6244-0584","observed_orcids":["https://orcid.org/0000-0002-6244-0584"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christopher Dunham","raw_affiliation_strings":["Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada","Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111505332","display_name":"Tracey A. Hunt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tracey Hunt","raw_affiliation_strings":["Departments of Cell Biology","Medical Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Medical Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054445737","display_name":"WILLIAM C. HALLIDAY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"William Halliday","raw_affiliation_strings":["Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada","; and Departments of Cell Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"; and Departments of Cell Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055404426","display_name":"Ferdinand G. Maingat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ferdinand Maingat","raw_affiliation_strings":["Medicine, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070477531","display_name":"Matt D. Urbanowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matt D. Urbanowski","raw_affiliation_strings":["Departments of Cell Biology","Medical Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Medical Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030893419","display_name":"Tom C. Hobman","orcid":"https://orcid.org/0000-0002-5744-3545","observed_orcids":["https://orcid.org/0000-0002-5744-3545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom Hobman","raw_affiliation_strings":["Departments of Cell Biology","Medical Microbiology and Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell Biology","institution_ids":[]},{"raw_affiliation_string":"Medical Microbiology and Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015877227","display_name":"James Peeling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James Peeling","raw_affiliation_strings":["Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038583170","display_name":"Christopher Power","orcid":"https://orcid.org/0000-0002-5131-9711","observed_orcids":["https://orcid.org/0000-0002-5131-9711"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christopher Power","raw_affiliation_strings":["Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada","Departments of Microbiology and Infectious Diseases","Medical Microbiology and Immunology","Medicine, University of Alberta, Edmonton, Alberta, Canada","Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada","and Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Departments of Microbiology and Infectious Diseases","institution_ids":[]},{"raw_affiliation_string":"Medical Microbiology and Immunology","institution_ids":[]},{"raw_affiliation_string":"Medicine, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Departments of Pharmacology and Therapeutics and Radiology, University of Manitoba, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"and Medicine,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9691,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.94806642,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"81","issue":"20","first_page":"10933","last_page":"10949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.179299995303154,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/west-nile-virus","display_name":"West Nile virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neurovirulence","display_name":"neurovirulence","score":0.656000018119812},{"id":"https://openalex.org/keywords/capsid-protein","display_name":"capsid protein","score":0.9279999732971191},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9900000095367432},{"id":"https://openalex.org/keywords/oasis","display_name":"OASIS","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"indoleamine 2,3-dioxygenase","score":0.8309999704360962},{"id":"https://openalex.org/keywords/sindbis-virus-vector","display_name":"Sindbis virus vector","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.6119999885559082},{"id":"https://openalex.org/keywords/west-nile-encephalitis","display_name":"West Nile encephalitis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/neurobehavioral-changes","display_name":"neurobehavioral abnormalities","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8352681994438171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8063796758651733},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7140285968780518},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.6059898734092712},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.49015817046165466},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.4755370616912842},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4491167962551117},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41225606203079224},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4018186926841736},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3763321340084076},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19012051820755005},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16667181253433228},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14622455835342407}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014901","descriptor_name":"West Nile Fever","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014902","descriptor_name":"West Nile virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D020078","descriptor_name":"Neurogenic Inflammation","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.02422-06","doi":"https://doi.org/10.1128/jvi.02422-06","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02422-06","pdf_url":"https://jvi.asm.org/content/jvi/81/20/10933.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:17670819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17670819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2045515","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2045515/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.5373","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.5373","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/81/20/10933.full.pdf","raw_type":"text"},{"id":"mag:2588965869","doi":null,"is_oa":false,"landing_page_url":"https://jvi.asm.org/content/early/2007/08/01/JVI.02422-06.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1128/jvi.02422-06","doi":"https://doi.org/10.1128/jvi.02422-06","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02422-06","pdf_url":"https://jvi.asm.org/content/jvi/81/20/10933.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320321767","display_name":"Alberta Heritage Foundation for Medical Research","ror":"https://ror.org/0160cpw27"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158095584.pdf","grobid_xml":"https://content.openalex.org/works/W2158095584.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W174726270","https://openalex.org/W1567194265","https://openalex.org/W1590810109","https://openalex.org/W1595473373","https://openalex.org/W1605308668","https://openalex.org/W1675705467","https://openalex.org/W1897775719","https://openalex.org/W1966719975","https://openalex.org/W1969587116","https://openalex.org/W1969673444","https://openalex.org/W1976744165","https://openalex.org/W1988811280","https://openalex.org/W1989981838","https://openalex.org/W1995254193","https://openalex.org/W1996547434","https://openalex.org/W1996598909","https://openalex.org/W2001142746","https://openalex.org/W2004680936","https://openalex.org/W2006173437","https://openalex.org/W2007163774","https://openalex.org/W2018685714","https://openalex.org/W2033573754","https://openalex.org/W2037012882","https://openalex.org/W2042466557","https://openalex.org/W2043387126","https://openalex.org/W2047045353","https://openalex.org/W2049675290","https://openalex.org/W2056952714","https://openalex.org/W2063193694","https://openalex.org/W2071107608","https://openalex.org/W2072425436","https://openalex.org/W2074413041","https://openalex.org/W2076206556","https://openalex.org/W2077968305","https://openalex.org/W2078241292","https://openalex.org/W2083395969","https://openalex.org/W2084603039","https://openalex.org/W2084705620","https://openalex.org/W2086937330","https://openalex.org/W2087606023","https://openalex.org/W2093627269","https://openalex.org/W2095980699","https://openalex.org/W2097088780","https://openalex.org/W2105414274","https://openalex.org/W2106056357","https://openalex.org/W2111374555","https://openalex.org/W2120771396","https://openalex.org/W2121749546","https://openalex.org/W2125863122","https://openalex.org/W2132214317","https://openalex.org/W2140630012","https://openalex.org/W2141711957","https://openalex.org/W2142448578","https://openalex.org/W2142913420","https://openalex.org/W2143529823","https://openalex.org/W2143694457","https://openalex.org/W2144034260","https://openalex.org/W2144555452","https://openalex.org/W2147012515","https://openalex.org/W2147100664","https://openalex.org/W2147217990","https://openalex.org/W2153776211","https://openalex.org/W2160590732","https://openalex.org/W2163207471","https://openalex.org/W2164781680","https://openalex.org/W2168646690","https://openalex.org/W2169590081","https://openalex.org/W2400280092"],"related_works":["https://openalex.org/W2588965869","https://openalex.org/W4417498787","https://openalex.org/W2142448578","https://openalex.org/W2128660481","https://openalex.org/W7098492943","https://openalex.org/W7099122537","https://openalex.org/W3082264962","https://openalex.org/W2983065389","https://openalex.org/W2103964958","https://openalex.org/W171848939"],"abstract_inverted_index":{"West":[0],"Nile":[1],"virus":[2],"(WNV)":[3],"infection":[4,49,78,139],"causes":[5],"neurological":[6,273],"disease":[7],"at":[8],"all":[9],"levels":[10],"of":[11,31,50,66,79,85,95,129,168,189,202,206,216,237,271],"the":[12,22,28,96,169,187,214,235,238,252,258,262,269],"neural":[13,68],"axis,":[14],"accompanied":[15],"by":[16,60,124,136,177,192,248],"neuroinflammation":[17,42,209,267],"and":[18,43,53,82,90,146,175,186,200,218,231,266],"neuronal":[19,164,184],"loss,":[20],"although":[21],"underlying":[23],"mechanisms":[24],"remain":[25],"uncertain.":[26],"Given":[27],"substantial":[29],"activation":[30],"neuroinflammatory":[32],"pathways":[33],"observed":[34],"in":[35,58,113,133,148,173,210,234,251,268],"WNV":[36,48,61,73,77,138,263],"infection,":[37],"we":[38],"hypothesized":[39],"that":[40],"WNV-mediated":[41],"cell":[44],"death":[45,185],"occurred":[46],"through":[47],"both":[51,80],"glia":[52,134,176],"neurons,":[54],"which":[55,162,245],"was":[56,111,246],"driven":[57],"part":[59],"capsid":[62,171,264],"protein":[63,172,265],"expression.":[64],"Analysis":[65],"autopsied":[67],"tissues":[69],"from":[70],"humans":[71],"with":[72,92,196,213],"encephalomyelitis":[74],"(WNVE)":[75],"revealed":[76],"neurons":[81,149,174],"glia.":[83],"Upregulation":[84],"proinflammatory":[86,131,197],"genes,":[87],"CXCL10,":[88],"interleukin-1beta,":[89],"indolamine-2',3'-deoxygenase":[91],"concurrent":[93],"suppression":[94,201],"protective":[97],"astrocyte-specific":[98],"endoplasmic":[99,141],"reticulum":[100,142],"stress":[101,143],"sensor":[102],"gene,":[103],"OASIS":[104,220],"(for":[105],"old":[106],"astrocyte":[107],"specifically":[108],"induced":[109,208],"substance),":[110],"evident":[112],"WNVE":[114],"patients":[115],"compared":[116,222,242],"to":[117,223,243],"non-WNVE":[118],"controls.":[119,224],"These":[120,255],"findings":[121],"were":[122],"supported":[123],"increased":[125],"ex":[126],"vivo":[127],"expression":[128,167],"these":[130],"genes":[132],"infected":[135,193],"WNV-NY99.":[137],"caused":[140,163,183],"gene":[144,198],"induction":[145,199,215],"apoptosis":[147],"but":[150],"did":[151],"not":[152],"affect":[153],"glial":[154],"viability.":[155],"WNV-infected":[156],"astrocytic":[157],"cells":[158],"secreted":[159],"cytotoxic":[160],"factors,":[161],"apoptosis.":[165],"The":[166],"WNV-NY99":[170],"a":[178],"Sindbis":[179],"virus-derived":[180],"vector":[181],"(SINrep5-WNVc)":[182],"release":[188],"neurotoxic":[190],"factors":[191],"astrocytes,":[194],"coupled":[195],"OASIS.":[203],"Striatal":[204],"implantation":[205,240],"SINrep5-WNV(C)":[207],"rats,":[211],"together":[212],"CXCL10":[217],"diminished":[219],"expression,":[221],"Moreover,":[225],"magnetic":[226],"resonance":[227],"neuroimaging":[228],"showed":[229],"edema":[230],"tissue":[232],"injury":[233],"vicinity":[236],"SINrep5-WNVc":[239],"site":[241],"controls,":[244],"complemented":[247],"neurobehavioral":[249],"abnormalities":[250],"SINrep5-WNVc-implanted":[253],"animals.":[254],"studies":[256],"underscore":[257],"important":[259],"interactions":[260],"between":[261],"pathogenesis":[270],"WNV-induced":[272],"disorders.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
