{"id":"https://openalex.org/W2158016264","doi":"https://doi.org/10.3748/wjg.v11.i38.6003","title":"A haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease","display_name":"A haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2158016264","doi":"https://doi.org/10.3748/wjg.v11.i38.6003","mag":"2158016264","pmid":"https://pubmed.ncbi.nlm.nih.gov/16273614","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4436724"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v11.i38.6003","doi":"https://doi.org/10.3748/wjg.v11.i38.6003","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v11.i38.6003","pdf_url":"https://www.wjgnet.com/1007-9327/full/v11/i38/6003.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v11/i38/6003.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017595704","display_name":"David G. Cox","orcid":"https://orcid.org/0000-0003-2047-4687","observed_orcids":["https://orcid.org/0000-0003-2047-4687"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]},{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["DE","FR","NL","US"],"is_corresponding":true,"raw_author_name":"David G Cox","raw_affiliation_strings":["Genome Analysis Team (GAN), International Agency for Research on Cancer, 150 cours Albert Thomas, F-69372 Lyon Cedex 08, France","-de-Mesquita, Department of Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands","ELSEVIER PO Box 2345, Beijing 100023, China","Federico Canzian, International Agency for Research on Cancer, Lyon, France","German Cancer Research Center, Heidelberg, Germany)","Harvard School of Public Health, Boston, MA, USA)","International Agency for Research on Cancer, Lyon, France (Current address: Molecular Epidemiology,","Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands","Laboratory of Immunogenetics and Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands","Laboratory of Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands","PhD, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Analysis Team (GAN), International Agency for Research on Cancer, 150 cours Albert Thomas, F-69372 Lyon Cedex 08, France","institution_ids":["https://openalex.org/I42237331"]},{"raw_affiliation_string":"-de-Mesquita, Department of Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]},{"raw_affiliation_string":"ELSEVIER PO Box 2345, Beijing 100023, China","institution_ids":[]},{"raw_affiliation_string":"Federico Canzian, International Agency for Research on Cancer, Lyon, France","institution_ids":["https://openalex.org/I42237331"]},{"raw_affiliation_string":"German Cancer Research Center, Heidelberg, Germany)","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Harvard School of Public Health, Boston, MA, USA)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"International Agency for Research on Cancer, Lyon, France (Current address: Molecular Epidemiology,","institution_ids":["https://openalex.org/I42237331"]},{"raw_affiliation_string":"Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Laboratory of Immunogenetics and Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Laboratory of Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"PhD, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5017595704"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I17937529","https://openalex.org/I3018483916","https://openalex.org/I4210104433","https://openalex.org/I42237331","https://openalex.org/I911458345"],"apc_list":null,"apc_paid":null,"fwci":1.0798,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.77213755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"38","first_page":"6003","last_page":"6003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7329999804496765},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8730000257492065},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6800000071525574},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7402299046516418},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.73496413230896},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6444556713104248},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6188065409660339},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.5904529094696045},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5531305074691772},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5508225560188293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4831392467021942},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4569159150123596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4213855564594269},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42079344391822815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4205036163330078},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4091622233390808},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31496673822402954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2602625787258148},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12982740998268127},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":13,"locations":[{"id":"doi:10.3748/wjg.v11.i38.6003","doi":"https://doi.org/10.3748/wjg.v11.i38.6003","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v11.i38.6003","pdf_url":"https://www.wjgnet.com/1007-9327/full/v11/i38/6003.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4436724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4436724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmid:16273614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16273614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/603fa634-07d6-40b3-85fb-bc3481e6dbd4","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/603fa634-07d6-40b3-85fb-bc3481e6dbd4","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cox, D G, Crusius, J B A, Peeters, P H, Bueno-de-Mesquita, H B, Pena, A S & Canzian, F 2005, 'Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease', World Journal of Gastroenterology, vol. 11, no. 38, pp. 6003-6008. https://doi.org/10.3748/wjg.v11.i38.6003","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.ubvu.vu.nl:1871/22814","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1871/22814","pdf_url":null,"source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"11","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:dspace.library.uu.nl:1874/11527","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/11527","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/10e38a7d-42e9-4a95-a468-900d896420af","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/files/111823732/188685","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cox, D G, Crusius, J B A, Peeters, P H, Bueno-de-Mesquita, H B, Pena, A S & Canzian, F 2005, 'Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease', World journal of gastroenterology, vol. 11, no. 38, pp. 6003-6008. https://doi.org/10.3748/wjg.v11.i38.6003","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:rivm.openrepository.com:10029/640932","doi":null,"is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/640932","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/066b78e1-19dd-41a5-af71-82aec034b0d1","doi":null,"is_oa":false,"landing_page_url":"https://www.rug.nl/research/portal/en/publications/a-haplotype-of-prostaglandin-synthase-2cyclooxygenase-2-is-involved-in-the-susceptibility-to-inflammatory-bowel-disease(066b78e1-19dd-41a5-af71-82aec034b0d1).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Gastroenterology, 11(38), 6003 - 6008","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/11527","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/11527","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Gastroenterology, 11(38), 6003. WJG Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/11527","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/11527","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Gastroenterology, 11(38), 6003","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu2:oai:dare.ubvu.vu.nl:1871/22814","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/22814","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Gastroenterology, 11(38), 6003","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/603fa634-07d6-40b3-85fb-bc3481e6dbd4","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/603fa634-07d6-40b3-85fb-bc3481e6dbd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Journal of Gastroenterology, 11(38), 6003 - 6008. WJG Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3748/wjg.v11.i38.6003","doi":"https://doi.org/10.3748/wjg.v11.i38.6003","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v11.i38.6003","pdf_url":"https://www.wjgnet.com/1007-9327/full/v11/i38/6003.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320310728","display_name":"Centre International de Recherche sur le Cancer","ror":"https://ror.org/00v452281"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2158016264.pdf","grobid_xml":"https://content.openalex.org/works/W2158016264.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W121527128","https://openalex.org/W1485442945","https://openalex.org/W1563962170","https://openalex.org/W1642457845","https://openalex.org/W1670573097","https://openalex.org/W1980139315","https://openalex.org/W1994114406","https://openalex.org/W2001034838","https://openalex.org/W2011204584","https://openalex.org/W2015371826","https://openalex.org/W2018584013","https://openalex.org/W2026252313","https://openalex.org/W2044950842","https://openalex.org/W2046993758","https://openalex.org/W2050294746","https://openalex.org/W2051766001","https://openalex.org/W2062888745","https://openalex.org/W2065637841","https://openalex.org/W2074692515","https://openalex.org/W2077903648","https://openalex.org/W2082095075","https://openalex.org/W2095003217","https://openalex.org/W2095495874","https://openalex.org/W2096063169","https://openalex.org/W2110755408","https://openalex.org/W2115804583","https://openalex.org/W2123717662","https://openalex.org/W2130833596","https://openalex.org/W2133936908","https://openalex.org/W2136652614","https://openalex.org/W2137228574","https://openalex.org/W2150586689","https://openalex.org/W2152532561","https://openalex.org/W2162990291","https://openalex.org/W2399707149","https://openalex.org/W2416603259"],"related_works":["https://openalex.org/W3143885115","https://openalex.org/W2129503957","https://openalex.org/W2319772137","https://openalex.org/W7095595518","https://openalex.org/W2019054472","https://openalex.org/W2081405940","https://openalex.org/W2101316867","https://openalex.org/W1973767685","https://openalex.org/W2025642324","https://openalex.org/W7131982506"],"abstract_inverted_index":{"AIM:":[0],"Prostaglandin":[1],"G/H":[2],"synthase":[3],"2":[4],"(PTGS2":[5],"or":[6],"COX2)":[7],"is":[8,21,202],"one":[9],"of":[10,28,52,67,98,217,223],"the":[11,15,24,48,59,89,93,99,125,129,199,207,221],"key":[12],"factors":[13,73],"in":[14,23,198,206],"cellular":[16],"response":[17],"to":[18,45,220],"inflammation.":[19],"PTGS2":[20,68,100,218],"expressed":[22],"affected":[25],"intestinal":[26],"segments":[27],"patients":[29,208],"with":[30,83,141,156,171,187],"inflammatory":[31],"bowel":[32],"diseases":[33],"(IBD).":[34],"In":[35],"IBD":[36,56,84,188],"patients,":[37],"non-steroidal":[38],"anti-inflammatory":[39],"drugs,":[40],"which":[41],"have":[42,78],"been":[43],"shown":[44],"reduce":[46],"both":[47,181],"production":[49],"and":[50,57,85,128,168],"activity":[51],"PTGS2,":[53],"may":[54,70],"activate":[55],"aggravate":[58],"symptoms.":[60],"We":[61,77],"aimed":[62],"at":[63],"examining":[64],"genetic":[65],"variants":[66],"that":[69,214],"be":[71],"risk":[72],"for":[74,92],"IBD.":[75,224],"METHODS:":[76],"genotyped":[79],"291":[80],"individuals":[81],"diagnosed":[82],"367":[86],"controls":[87],"from":[88],"Dutch":[90],"population":[91],"five":[94],"most":[95],"frequent":[96],"polymorphisms":[97],"gene.":[101],"Clinical":[102],"data":[103,212],"were":[104],"collected":[105],"on":[106],"all":[107],"patients.":[108],"DNA":[109],"was":[110,117,137,153],"extracted":[111],"via":[112],"normal":[113],"laboratory":[114],"methods.":[115],"Genotyping":[116],"carried":[118],"out":[119],"using":[120],"multiplex":[121],"PCR":[122],"followed":[123,146],"by":[124,139,147],"Invader":[126],"Assay":[127],"5'":[130],"exonuclease":[131],"assay":[132],"(TaqMan).":[133],"New":[134],"polymorphism":[135],"screening":[136],"performed":[138],"pre-screening":[140],"denaturing":[142],"high-performance":[143],"liquid":[144],"chromatography,":[145],"fluorescent":[148],"sequencing.":[149],"RESULTS:":[150],"Allele":[151],"5209G":[152],"weakly":[154],"associated":[155],"Crohn's":[157],"disease":[158],"(odds":[159],"ratio":[160],"(OR)":[161],"1.63,":[162],"95%":[163],"confidence":[164],"interval":[165],"(CI)":[166],"1.03-2.57),":[167],"allele":[169],"8473T":[170],"ulcerative":[172],"colitis":[173],"(OR":[174,189],"1.50,":[175],"95%CI":[176,191],"1.00-2.27).":[177],"The":[178],"haplotype":[179,216],"including":[180],"alleles":[182],"showed":[183],"a":[184],"strong":[185],"association":[186],"13.15,":[190],"3.17-116.15).":[192],"This":[193],"haplotype,":[194],"while":[195],"rare":[196],"(-0.3%)":[197],"general":[200],"population,":[201],"found":[203],"more":[204],"frequently":[205],"(3.5%).":[209],"CONCLUSION:":[210],"Our":[211],"suggest":[213],"this":[215],"contributes":[219],"susceptibility":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}