{"id":"https://openalex.org/W2158010031","doi":"https://doi.org/10.1128/iai.00225-09","title":"Decreased Expression of Colonic Slc26a3 and Carbonic Anhydrase IV as a Cause of Fatal Infectious Diarrhea in Mice","display_name":"Decreased Expression of Colonic Slc26a3 and Carbonic Anhydrase IV as a Cause of Fatal Infectious Diarrhea in Mice","publication_year":2009,"publication_date":"2009-06-23","ids":{"openalex":"https://openalex.org/W2158010031","doi":"https://doi.org/10.1128/iai.00225-09","mag":"2158010031","pmid":"https://pubmed.ncbi.nlm.nih.gov/19546193","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738044"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00225-09","doi":"https://doi.org/10.1128/iai.00225-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00225-09","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738044","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004750753","display_name":"Diana Borenshtein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diana Borenshtein","raw_affiliation_strings":["Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060749096","display_name":"Katherine Ann Schlieper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A. Schlieper","raw_affiliation_strings":["Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676416","display_name":"Barry H. Rickman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry H. Rickman","raw_affiliation_strings":["Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066250149","display_name":"Jeannie M. Chapman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210095449","display_name":"MUSC Hollings Cancer Center","ror":"https://ror.org/00w52vt71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeannie M. Chapman","raw_affiliation_strings":["Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29403","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088120266","display_name":"Clifford W. Schweinfest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210095449","display_name":"MUSC Hollings Cancer Center","ror":"https://ror.org/00w52vt71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford W. Schweinfest","raw_affiliation_strings":["Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29403","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024428264","display_name":"James G. Fox","orcid":"https://orcid.org/0000-0001-9307-6116","observed_orcids":["https://orcid.org/0000-0001-9307-6116"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G. Fox","raw_affiliation_strings":["Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084039634","display_name":"David B. Schauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Schauer","raw_affiliation_strings":["Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004750753"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":2.8746,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.89919852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"77","issue":"9","first_page":"3639","last_page":"3650"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/citrobacter-rodentium","display_name":"Citrobacter rodentium","score":0.9179999828338623},{"id":"https://openalex.org/keywords/slc26a3","display_name":"SLC26A3","score":0.8790000081062317},{"id":"https://openalex.org/keywords/carbonic-anhydrase-iv","display_name":"carbonic anhydrase IV","score":0.996999979019165},{"id":"https://openalex.org/keywords/infectious-diarrhea","display_name":"infectious diarrhea","score":0.6000000238418579},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.4429999887943268},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.6809999942779541},{"id":"https://openalex.org/keywords/fvb-mice","display_name":"FVB mice","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypochloremia","display_name":"hypochloremia","score":0.9120000004768372},{"id":"https://openalex.org/keywords/electrolyte-loss","display_name":"electrolyte loss","score":0.6729999780654907},{"id":"https://openalex.org/keywords/intestinal-ion-transport","display_name":"intestinal ion transport","score":0.7160000205039978},{"id":"https://openalex.org/keywords/fluid-therapy","display_name":"fluid therapy","score":0.6050000190734863},{"id":"https://openalex.org/keywords/mouse-strain-susceptibility","display_name":"mouse strain susceptibility","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C2910319489","wikidata":"https://www.wikidata.org/wiki/Q16975761","display_name":"Citrobacter rodentium","level":3,"score":0.739115834236145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7010409235954285},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.665109395980835},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5410327911376953},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.44870367646217346},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.41721513867378235},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3900730311870575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24084466695785522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15310510993003845},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.14917650818824768},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10697939991950989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076988","descriptor_name":"Sulfate Transporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004756","descriptor_name":"Enterobacteriaceae Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004756","descriptor_name":"Enterobacteriaceae Infections","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004756","descriptor_name":"Enterobacteriaceae Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017920","descriptor_name":"Antiporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017920","descriptor_name":"Antiporters","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018988","descriptor_name":"Bacterial Translocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030741","descriptor_name":"Carbonic Anhydrase IV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030741","descriptor_name":"Carbonic Anhydrase IV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044082","descriptor_name":"Citrobacter rodentium","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.00225-09","doi":"https://doi.org/10.1128/iai.00225-09","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00225-09","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1875778","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738044","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2738044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738044","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:19546193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19546193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1875778","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738044","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3909382221","display_name":"MIT Center for Environmental Health Sciences","funder_award_id":"P30ES002109","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4012495672","display_name":"Training Grant in Environmental Toxicology","funder_award_id":"T32ES007020","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7234316914","display_name":"Endogenous Nitrite Carcinogenesis in Man","funder_award_id":"P01CA026731","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W127605655","https://openalex.org/W644335729","https://openalex.org/W1512935654","https://openalex.org/W1548282994","https://openalex.org/W1573547148","https://openalex.org/W1607470432","https://openalex.org/W1752465711","https://openalex.org/W1942135952","https://openalex.org/W1970587817","https://openalex.org/W1977420289","https://openalex.org/W1985374970","https://openalex.org/W1987985249","https://openalex.org/W1993257138","https://openalex.org/W1999281277","https://openalex.org/W2008979188","https://openalex.org/W2011973633","https://openalex.org/W2012401588","https://openalex.org/W2015884194","https://openalex.org/W2016045507","https://openalex.org/W2026828260","https://openalex.org/W2035893433","https://openalex.org/W2044552965","https://openalex.org/W2047922146","https://openalex.org/W2054977175","https://openalex.org/W2065231269","https://openalex.org/W2074747290","https://openalex.org/W2078872477","https://openalex.org/W2084763423","https://openalex.org/W2088721135","https://openalex.org/W2091349763","https://openalex.org/W2098086549","https://openalex.org/W2098212461","https://openalex.org/W2104328367","https://openalex.org/W2106038477","https://openalex.org/W2108254388","https://openalex.org/W2112111992","https://openalex.org/W2115830594","https://openalex.org/W2120110704","https://openalex.org/W2122034180","https://openalex.org/W2123297106","https://openalex.org/W2124446505","https://openalex.org/W2125590017","https://openalex.org/W2127907894","https://openalex.org/W2132092571","https://openalex.org/W2134508859","https://openalex.org/W2137803034","https://openalex.org/W2138377790","https://openalex.org/W2142636789","https://openalex.org/W2144603992","https://openalex.org/W2144924831","https://openalex.org/W2145446900","https://openalex.org/W2151712359","https://openalex.org/W2153724086","https://openalex.org/W2165039491","https://openalex.org/W2169361032","https://openalex.org/W2405406971","https://openalex.org/W2485912879","https://openalex.org/W4206096918"],"related_works":["https://openalex.org/W2098212461","https://openalex.org/W7036647514","https://openalex.org/W2169361032","https://openalex.org/W1971740873","https://openalex.org/W2017991098","https://openalex.org/W2941480066","https://openalex.org/W2890050465","https://openalex.org/W2981117779","https://openalex.org/W2113737673","https://openalex.org/W1876321204"],"abstract_inverted_index":{"Citrobacter":[0],"rodentium":[1,53,91],"causes":[2],"epithelial":[3],"hyperplasia":[4],"and":[5,7,15,33,60,71,76,98,113,119,127,137,142,153,171,181,190],"colitis":[6],"is":[8],"used":[9],"as":[10,164],"a":[11,108,198],"model":[12],"for":[13,87,201],"enteropathogenic":[14],"enterohemorrhagic":[16],"Escherichia":[17],"coli":[18],"infections.":[19],"Little":[20],"or":[21],"no":[22],"mortality":[23,150],"develops":[24],"in":[25,56,58,94,106,125,131,151,177,185],"most":[26],"inbred":[27,73],"strains":[28,64,74,96],"of":[29,39,78,89,111,123,167,169,204],"mice,":[30,183],"but":[31],"C3H":[32,182],"FVB/N":[34,61,99,154],"mice":[35,70,139,155],"exhibit":[36],"fatal":[37],"outcomes":[38,88],"infection.":[40,92,145],"Here":[41],"we":[42],"test":[43],"the":[44,144,202],"hypothesis":[45],"that":[46],"decreased":[47,165],"intestinal":[48,132,174],"transport":[49,176],"activity":[50],"during":[51],"C.":[52,90,178],"infection":[54],"results":[55],"fatality":[57],"C3H/HeOu":[59,97,152],"mice.":[62],"Susceptible":[63],"were":[65,140],"compared":[66],"to":[67,72],"resistant":[68,141],"C57BL/6":[69,138],"SWR":[75],"SJL":[77],"Swiss":[79],"origin,":[80],"which":[81],"have":[82],"not":[83],"been":[84],"previously":[85],"characterized":[86],"Mortality":[93],"susceptible":[95],"was":[100],"associated":[101],"with":[102],"significant":[103],"fluid":[104],"loss":[105],"feces,":[107],"remarkable":[109],"downregulation":[110],"Slc26a3":[112,170],"carbonic":[114],"anhydrase":[115],"IV":[116],"(CAIV)":[117],"message":[118],"protein":[120],"expression,":[121],"retention":[122],"chloride":[124,133,193],"stool,":[126],"hypochloremia,":[128],"suggesting":[129],"defects":[130],"absorption.":[134],"SWR,":[135],"SJL,":[136],"survived":[143],"Fluid":[146],"therapy":[147],"fully":[148],"prevented":[149],"without":[156],"affecting":[157],"clinical":[158],"disease.":[159],"Common":[160],"pathogenic":[161],"mechanisms,":[162],"such":[163],"levels":[166],"expression":[168],"CAIV,":[172],"affect":[173],"ion":[175],"rodentium-infected":[179],"FVB":[180],"resulting":[184],"profound":[186],"electrolyte":[187],"loss,":[188],"dehydration,":[189],"mortality.":[191],"Intestinal":[192],"absorption":[194],"pathways":[195],"are":[196],"likely":[197],"potential":[199],"target":[200],"treatment":[203],"infectious":[205],"diarrhea.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}