{"id":"https://openalex.org/W2157943401","doi":"https://doi.org/10.1161/01.res.77.6.1107","title":"Decreased Elastin Synthesis in Normal Development and in Long-term Aortic Organ and Cell Cultures Is Related to Rapid and Selective Destabilization of mRNA for Elastin","display_name":"Decreased Elastin Synthesis in Normal Development and in Long-term Aortic Organ and Cell Cultures Is Related to Rapid and Selective Destabilization of mRNA for Elastin","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2157943401","doi":"https://doi.org/10.1161/01.res.77.6.1107","mag":"2157943401","pmid":"https://pubmed.ncbi.nlm.nih.gov/7586222"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.77.6.1107","doi":"https://doi.org/10.1161/01.res.77.6.1107","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.77.6.1107","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D.J. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D.J. Johnson","raw_affiliation_strings":["From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","D.J. Johnson From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]},{"raw_affiliation_string":"D.J. Johnson From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008270331","display_name":"Paul Robson","orcid":"https://orcid.org/0000-0002-0191-3958","observed_orcids":["https://orcid.org/0000-0002-0191-3958"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P. Robson","raw_affiliation_strings":["From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","P. Robson From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]},{"raw_affiliation_string":"P. Robson From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060801340","display_name":"Yin Hew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yin Hew","raw_affiliation_strings":["From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","Yin Hew From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Yin Hew From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016794650","display_name":"Fred W. Keeley","orcid":"https://orcid.org/0000-0003-3319-2793","observed_orcids":["https://orcid.org/0000-0003-3319-2793"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F.W. Keeley","raw_affiliation_strings":["From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","F.W. Keeley From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]},{"raw_affiliation_string":"F.W. Keeley From the Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada, and the Departments of Biochemistry and Clinical Biochemistry, University of Toronto","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7075,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.68256361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"77","issue":"6","first_page":"1107","last_page":"1113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.3418000042438507,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.3418000042438507,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elastin-synthesis","display_name":"elastin synthesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mrna-destabilization","display_name":"mRNA destabilization","score":0.7900000214576721},{"id":"https://openalex.org/keywords/postnatal-growth","display_name":"postnatal growth","score":0.6890000104904175},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.39800000190734863},{"id":"https://openalex.org/keywords/transcription-inhibition","display_name":"transcription inhibition","score":0.5830000042915344},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.8539999723434448},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.9938438534736633},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.700068473815918},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.6388020515441895},{"id":"https://openalex.org/C28483552","wikidata":"https://www.wikidata.org/wiki/Q3634161","display_name":"Organ culture","level":3,"score":0.6050431132316589},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5934191942214966},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4460085332393646},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.43840712308883667},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.43439781665802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4217839241027832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4122703969478607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40502673387527466},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3783155381679535},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.35543638467788696},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30463308095932007},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.302485853433609},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21104931831359863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1418004035949707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07703226804733276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06290408968925476}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004004","descriptor_name":"Dichlororibofuranosylbenzimidazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.res.77.6.1107","doi":"https://doi.org/10.1161/01.res.77.6.1107","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.77.6.1107","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:7586222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7586222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W50541179","https://openalex.org/W68970436","https://openalex.org/W141288945","https://openalex.org/W187101362","https://openalex.org/W1502985975","https://openalex.org/W1513605181","https://openalex.org/W1536635467","https://openalex.org/W1537093485","https://openalex.org/W1543673067","https://openalex.org/W1588436096","https://openalex.org/W1608544454","https://openalex.org/W1963749563","https://openalex.org/W1964288360","https://openalex.org/W1971421846","https://openalex.org/W1973592220","https://openalex.org/W1985268990","https://openalex.org/W2007668542","https://openalex.org/W2007761497","https://openalex.org/W2013530991","https://openalex.org/W2015200204","https://openalex.org/W2016607156","https://openalex.org/W2017809525","https://openalex.org/W2019392009","https://openalex.org/W2025714049","https://openalex.org/W2026563924","https://openalex.org/W2034771809","https://openalex.org/W2038465187","https://openalex.org/W2043324515","https://openalex.org/W2055029438","https://openalex.org/W2064196833","https://openalex.org/W2066445704","https://openalex.org/W2072376171","https://openalex.org/W2079276351","https://openalex.org/W2080270540","https://openalex.org/W2093586592","https://openalex.org/W2117292138","https://openalex.org/W2119013939","https://openalex.org/W2122243862","https://openalex.org/W2125238692","https://openalex.org/W2150181161","https://openalex.org/W2162991824","https://openalex.org/W2283229976","https://openalex.org/W2405137466","https://openalex.org/W2407087799","https://openalex.org/W2414731660","https://openalex.org/W2471888606"],"related_works":["https://openalex.org/W2015200204","https://openalex.org/W1963749563","https://openalex.org/W1528492214","https://openalex.org/W1978534596","https://openalex.org/W1540191428","https://openalex.org/W2077270409","https://openalex.org/W101074761","https://openalex.org/W2471888606","https://openalex.org/W2018302068","https://openalex.org/W4312665580"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"shown":[3],"that":[4,43,171],"aortic":[5,50,108,150,186],"organ":[6,51],"cultures":[7,52],"from":[8,102,154],"1-":[9],"to":[10,87,110,162],"3-day-old":[11],"chickens":[12],"initially":[13],"mimic":[14],"the":[15,38,97,130,147,159,167,181],"high":[16],"levels":[17,67,77],"of":[18,28,35,46,68,78,93,99,121,132,134,149,173,185],"elastin":[19,47,56,79,122,151,187],"production":[20,45,184],"seen":[21],"in":[22,32,48,74,85,106,129,158,166,180,183],"vivo.":[23],"However,":[24],"more":[25],"prolonged":[26],"incubation":[27,115,128],"these":[29,49],"tissues":[30,109],"results":[31],"decreased":[33,44,64],"synthesis":[34],"elastin.":[36,71],"In":[37],"present":[39],"study,":[40],"we":[41],"demonstrate":[42],"is":[53,61,175],"selective":[54,91],"for":[55,70,95,116],"compared":[57],"with":[58,63],"collagen":[59],"and":[60,90,139,142],"correlated":[62],"steady":[65,75],"state":[66,76],"mRNA":[69,80,94,123,143,152,174],"These":[72],"decreases":[73,153],"are":[81],"due":[82],"at":[83],"least":[84],"part":[86],"a":[88],"rapid":[89],"destabilization":[92,172],"elastin,":[96],"half-life":[98,148],"which":[100],"falls":[101],"approximately":[103,111,155,163],"25":[104,156],"hours":[105,113,157,165],"fresh":[107],"15":[112],"after":[114],"only":[117],"8":[118],"hours.":[119],"Destabilization":[120],"can":[124],"be":[125],"prevented":[126],"by":[127],"presence":[131],"blockers":[133],"DNA":[135],"transcription":[136],"(5,6-dichlorobenzimidazole":[137],"riboside":[138],"actinomycin":[140],"D)":[141],"translation":[144],"(cycloheximide).":[145],"Furthermore,":[146],"1-day-old":[160],"chicken":[161],"7":[164],"8-week-old":[168],"chicken,":[169],"demonstrating":[170],"an":[176],"important":[177],"contributing":[178],"factor":[179],"decline":[182],"taking":[188],"place":[189],"during":[190],"normal":[191],"postnatal":[192],"growth.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}