{"id":"https://openalex.org/W2157790730","doi":null,"title":"Ultraviolet B and blue light - induced phototoxic effects on retinal pigment epithelium using in vitro assays","display_name":"Ultraviolet B and blue light - induced phototoxic effects on retinal pigment epithelium using in vitro assays","publication_year":2008,"publication_date":"2008-09-12","ids":{"openalex":"https://openalex.org/W2157790730","mag":"2157790730"},"language":"en","primary_location":{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/3973","doi":null,"is_oa":false,"landing_page_url":"https://uwspace.uwaterloo.ca/bitstreams/24941256-5855-4074-9234-169251925ba5/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076781309","display_name":"Hyun-Yi Youn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hyun-Yi Youn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076781309"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13869","display_name":"Ocular and Laser Science Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13869","display_name":"Ocular and Laser Science Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uv-b-radiation","display_name":"UV-B radiation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/blue-light","display_name":"blue light","score":0.9739999771118164},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9190000295639038},{"id":"https://openalex.org/keywords/phototoxicity","display_name":"phototoxicity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.8489999771118164},{"id":"https://openalex.org/keywords/arpe-19-cells","display_name":"ARPE-19 cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/intraocular-lens-materials","display_name":"intraocular lens materials","score":0.8149999976158142},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/in-vitro-toxicity-testing","display_name":"in vitro toxicity testing","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.7843459844589233},{"id":"https://openalex.org/C20639190","wikidata":"https://www.wikidata.org/wiki/Q2088972","display_name":"Phototoxicity","level":3,"score":0.7577744126319885},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6477929949760437},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5618074536323547},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5461451411247253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48090648651123047},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4711274802684784},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46251431107521057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41459745168685913},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35428428649902344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34059399366378784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1731628179550171},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.05791211128234863}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uwspace.uwaterloo.ca:10012/3973","doi":null,"is_oa":false,"landing_page_url":"https://uwspace.uwaterloo.ca/bitstreams/24941256-5855-4074-9234-169251925ba5/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306401661","display_name":"UWSpace (University of Waterloo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I151746483","host_organization_name":"University of Waterloo","host_organization_lineage":["https://openalex.org/I151746483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},{"id":"mag:2157790730","doi":null,"is_oa":false,"landing_page_url":"https://uwspace.uwaterloo.ca/bitstream/10012/3973/1/Thesis-Youn-Revised.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":187,"referenced_works":["https://openalex.org/W16671151","https://openalex.org/W66023759","https://openalex.org/W99534246","https://openalex.org/W110197551","https://openalex.org/W121477089","https://openalex.org/W169563596","https://openalex.org/W193934658","https://openalex.org/W197021737","https://openalex.org/W572849208","https://openalex.org/W1521877864","https://openalex.org/W1526091749","https://openalex.org/W1531307769","https://openalex.org/W1535602988","https://openalex.org/W1541631182","https://openalex.org/W1550247880","https://openalex.org/W1554332217","https://openalex.org/W1558645663","https://openalex.org/W1565530759","https://openalex.org/W1576741560","https://openalex.org/W1594562213","https://openalex.org/W1596688170","https://openalex.org/W1602152439","https://openalex.org/W1712412471","https://openalex.org/W1883306593","https://openalex.org/W1896820448","https://openalex.org/W1953475802","https://openalex.org/W1963591622","https://openalex.org/W1965884923","https://openalex.org/W1967064274","https://openalex.org/W1971349034","https://openalex.org/W1971718844","https://openalex.org/W1971877137","https://openalex.org/W1972369793","https://openalex.org/W1974178637","https://openalex.org/W1974593679","https://openalex.org/W1974642362","https://openalex.org/W1974719727","https://openalex.org/W1974980101","https://openalex.org/W1981324076","https://openalex.org/W1982628663","https://openalex.org/W1982973742","https://openalex.org/W1986568749","https://openalex.org/W1987669878","https://openalex.org/W1989089629","https://openalex.org/W1989130934","https://openalex.org/W1990761289","https://openalex.org/W1992338727","https://openalex.org/W1993075522","https://openalex.org/W1994341055","https://openalex.org/W1997173699","https://openalex.org/W1998043586","https://openalex.org/W1998174286","https://openalex.org/W1998393168","https://openalex.org/W1998425495","https://openalex.org/W1999383714","https://openalex.org/W2000057971","https://openalex.org/W2000605323","https://openalex.org/W2000776456","https://openalex.org/W2002849044","https://openalex.org/W2003098197","https://openalex.org/W2003268613","https://openalex.org/W2004457671","https://openalex.org/W2005150915","https://openalex.org/W2005722654","https://openalex.org/W2007663481","https://openalex.org/W2009417067","https://openalex.org/W2009874603","https://openalex.org/W2011395714","https://openalex.org/W2013895647","https://openalex.org/W2015461541","https://openalex.org/W2016200686","https://openalex.org/W2016528601","https://openalex.org/W2017414430","https://openalex.org/W2018777623","https://openalex.org/W2019378578","https://openalex.org/W2020756204","https://openalex.org/W2022186270","https://openalex.org/W2024112605","https://openalex.org/W2024605446","https://openalex.org/W2026127186","https://openalex.org/W2026735889","https://openalex.org/W2027716003","https://openalex.org/W2028605911","https://openalex.org/W2032836423","https://openalex.org/W2035106127","https://openalex.org/W2035923470","https://openalex.org/W2039276913","https://openalex.org/W2039619219","https://openalex.org/W2040756966","https://openalex.org/W2041061895","https://openalex.org/W2041365012","https://openalex.org/W2042162229","https://openalex.org/W2042529841","https://openalex.org/W2043234752","https://openalex.org/W2043701287","https://openalex.org/W2044333041","https://openalex.org/W2045738364","https://openalex.org/W2045775784","https://openalex.org/W2045906508","https://openalex.org/W2046275014","https://openalex.org/W2046346685","https://openalex.org/W2048270119","https://openalex.org/W2049339881","https://openalex.org/W2051474575","https://openalex.org/W2051747007","https://openalex.org/W2052274401","https://openalex.org/W2053534803","https://openalex.org/W2054863662","https://openalex.org/W2055859594","https://openalex.org/W2055962869","https://openalex.org/W2060651470","https://openalex.org/W2063312096","https://openalex.org/W2066357681","https://openalex.org/W2068045732","https://openalex.org/W2069176933","https://openalex.org/W2069735998","https://openalex.org/W2070592244","https://openalex.org/W2070614604","https://openalex.org/W2071385002","https://openalex.org/W2071520151","https://openalex.org/W2071657421","https://openalex.org/W2071756113","https://openalex.org/W2072882448","https://openalex.org/W2075551125","https://openalex.org/W2075602499","https://openalex.org/W2076961896","https://openalex.org/W2077043144","https://openalex.org/W2077462696","https://openalex.org/W2079659679","https://openalex.org/W2079854314","https://openalex.org/W2080122674","https://openalex.org/W2080514724","https://openalex.org/W2081163107","https://openalex.org/W2082532338","https://openalex.org/W2082589157","https://openalex.org/W2084685164","https://openalex.org/W2086340841","https://openalex.org/W2086790354","https://openalex.org/W2087018054","https://openalex.org/W2094696997","https://openalex.org/W2098201185","https://openalex.org/W2099890622","https://openalex.org/W2099942774","https://openalex.org/W2101895611","https://openalex.org/W2102160935","https://openalex.org/W2102310386","https://openalex.org/W2102408077","https://openalex.org/W2103696198","https://openalex.org/W2106850981","https://openalex.org/W2107782131","https://openalex.org/W2108300681","https://openalex.org/W2109241448","https://openalex.org/W2111735005","https://openalex.org/W2111823557","https://openalex.org/W2115961256","https://openalex.org/W2119738981","https://openalex.org/W2123832535","https://openalex.org/W2125324546","https://openalex.org/W2129609456","https://openalex.org/W2131606575","https://openalex.org/W2135851757","https://openalex.org/W2136359299","https://openalex.org/W2136501493","https://openalex.org/W2137531664","https://openalex.org/W2138099801","https://openalex.org/W2138751275","https://openalex.org/W2139710149","https://openalex.org/W2144839999","https://openalex.org/W2147551208","https://openalex.org/W2152084367","https://openalex.org/W2152358794","https://openalex.org/W2154385453","https://openalex.org/W2159769286","https://openalex.org/W2159831982","https://openalex.org/W2160879248","https://openalex.org/W2161467354","https://openalex.org/W2162077332","https://openalex.org/W2166750139","https://openalex.org/W2167252811","https://openalex.org/W2170744683","https://openalex.org/W2178483454","https://openalex.org/W2290166085","https://openalex.org/W2394489928","https://openalex.org/W2408974827","https://openalex.org/W2411942113","https://openalex.org/W2422715985","https://openalex.org/W2616663633"],"related_works":["https://openalex.org/W7099538478","https://openalex.org/W1505980646","https://openalex.org/W1994341055","https://openalex.org/W2130748175","https://openalex.org/W2055962869","https://openalex.org/W2080811532","https://openalex.org/W1479788256","https://openalex.org/W4247322058","https://openalex.org/W2012832087","https://openalex.org/W2043149771"],"abstract_inverted_index":{"It":[0],"is":[1],"well":[2,232],"known":[3],"that":[4,247,311],"ultraviolet":[5],"(UV)":[6],"B":[7],"(280-315":[8],"nm)":[9,14],"and":[10,24,41,46,70,88,140,179,211,257,327,342,361,373,385],"blue":[11,137,153,204,307,315,330,343],"light":[12,138,154,308,316,331,344],"(400-500":[13],"radiation":[15,65,128,249,317,332,345],"can":[16,250,318,346],"produce":[17],"phototoxic":[18,348],"lesions":[19,158],"in":[20,57,66,73,89,98,112,141,185,191,200,223,228,262,292,362],"the":[21,25,31,79,108,111,126,150,160,220,244,253,270,351],"neural":[22],"retina":[23,161],"retinal":[26,48,83,104,352],"pigment":[27,49,84,353],"epithelium":[28,354],"(RPE).":[29],"In":[30,78,107,242],"first":[32],"section":[33],"of":[34,75,131,152,159,176,236,255,259,269,275,302,306,358],"this":[35,367],"thesis,":[36],"bovine":[37],"lens":[38,68,121,177],"cells":[39,52,87,178,181,238,261],"(epithelium":[40],"superficial":[42],"cortical":[43],"fibre":[44],"cell)":[45],"human":[47,82],"epithelial":[50,85],"(ARPE-19)":[51,86],"were":[53,92,144],"used":[54,93,118,145,365],"to":[55,95,124,146,165,167,294,322,350],"characterize":[56],"vitro":[58,90,99,113,142,201,363],"changes":[59],"following":[60],"oxidative":[61,359,384],"stress":[62],"with":[63,119],"UVB":[64,189,240,341],"ocular":[67],"optics":[69],"cellular":[71,288,335],"function":[72,382],"terms":[74],"mitochondrial":[76,174,186,209],"dynamics.":[77],"second":[80],"part,":[81],"bioassays":[91,364],"together":[94],"develop":[96],"an":[97,163,295],"approach":[100,114],"for":[101,156,208,218,366,379,390],"UV":[102,127,248,271,283],"radiation-induced":[103],"toxicology":[105],"research.":[106],"third":[109],"chapter,":[110],"developed":[115],"above":[116],"was":[117],"intraocular":[120],"(IOL)":[122],"materials":[123,279],"evaluate":[125],"blocking":[129,272,284],"efficiency":[130,273],"commercially":[132,276],"available":[133,277],"IOL\u2019s.":[134],"Lastly,":[135],"narrowband":[136],"irradiation":[139,190],"assays":[143,202],"determine":[147],"more":[148],"precisely":[149],"wavelengths":[151,305],"responsible":[155],"photochemical":[157],"as":[162,231,233,355],"effort":[164],"contribute":[166],"future":[168],"IOL":[169,278,296,392],"designs.":[170],"\\n\\tThe":[171],"results":[172,245,268,301],"from":[173,198],"dynamics":[175],"RPE":[180,237,260,323,381],"show":[182,225,246,280,310],"significant":[183,226,320],"decreases":[184,227],"movement":[187],"after":[188,239,383],"a":[192,263,356,371],"dose":[193,264],"dependent":[194,265],"manner.":[195,266],"Results":[196],"obtained":[197],"four":[199],"(Alamar":[203],"assay,":[205],"confocal":[206],"microscopy":[207],"distribution":[210],"nucleic":[212],"acids":[213],"damage,":[214],"phagocytotic":[215,234],"activity":[216,235],"assay)":[217],"evaluating":[219,380,391],"UVB-induced":[221],"damage":[222,289,321,336,349],"ARPE-19":[224],"cell":[229],"viability":[230],"radiation.":[241],"addition,":[243],"also":[251,389],"induce":[252],"degradation":[254],"DNA/RNA":[256],"mitochondria":[258],"The":[267,300],"test":[274],"very":[281],"effective":[282],"ability,":[285],"allowing":[286],"no":[287,334],"at":[290,337],"all,":[291],"comparison":[293],"uncovered":[297],"control":[298],"cell.":[299],"three":[303],"different":[304],"exposure":[309],"only":[312,378],"400":[313],"nm":[314,329],"cause":[319,333,347],"cells,":[324],"while":[325],"420":[326],"435.8":[328],"all.":[338],"\\n\\tIn":[339],"conclusion,":[340],"result":[357],"stress,":[360,387],"research":[368],"may":[369],"offer":[370],"sensitive,":[372],"meaningful":[374],"biomarker":[375],"approach,":[376],"not":[377],"chemical":[386],"but":[388],"effectiveness.":[393]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}