{"id":"https://openalex.org/W2157777451","doi":null,"title":"Treatment of gout and hyperuricemia, an update","display_name":"Treatment of gout and hyperuricemia, an update","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W2157777451","mag":"2157777451"},"language":"en","primary_location":{"id":"mag:2157777451","doi":null,"is_oa":false,"landing_page_url":"http://gouthyperuricemia.com/main.php?mod=tiny_mce4&func=readFile&path=/modules/adv_custom_page/0/GH_2014_vol1_iss1/GH_2014_vol1_iss1_01/GH_2014_vol1_iss1_01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102710491","display_name":"Naoyuki Kamatani","orcid":"https://orcid.org/0000-0002-7934-2462","observed_orcids":["https://orcid.org/0000-0002-7934-2462"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Naoyuki Kamatani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7934-2462","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102710491"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/acute-gouty-arthritis","display_name":"acute gouty arthritis","score":0.984000027179718},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.8539999723434448},{"id":"https://openalex.org/keywords/febuxostat","display_name":"febuxostat","score":0.9980000257492065},{"id":"https://openalex.org/keywords/xanthine-oxidase-inhibitors","display_name":"xanthine oxidase inhibitors","score":0.925000011920929},{"id":"https://openalex.org/keywords/uricosuric-drugs","display_name":"uricosuric drugs","score":0.8309999704360962},{"id":"https://openalex.org/keywords/slc22a12","display_name":"SLC22A12","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hla-b-58-01","display_name":"HLA-B*58:01","score":0.8309999704360962},{"id":"https://openalex.org/keywords/stevens-johnson-syndrome","display_name":"Stevens-Johnson syndrome","score":0.8650000095367432},{"id":"https://openalex.org/keywords/toxic-epidermal-necrolysis","display_name":"toxic epidermal necrolysis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tumor-lysis-syndrome","display_name":"tumor lysis syndrome","score":0.953000009059906},{"id":"https://openalex.org/keywords/rasburicase","display_name":"rasburicase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pegloticase","display_name":"pegloticase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-gout","display_name":"chronic gout","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.40700000524520874},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.9528968334197998},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.9385207295417786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9198132753372192},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.8880420923233032},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48651212453842163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48442891240119934},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3615421652793884},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.29028940200805664}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2157777451","doi":null,"is_oa":false,"landing_page_url":"http://gouthyperuricemia.com/main.php?mod=tiny_mce4&func=readFile&path=/modules/adv_custom_page/0/GH_2014_vol1_iss1/GH_2014_vol1_iss1_01/GH_2014_vol1_iss1_01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W68869269","https://openalex.org/W112609331","https://openalex.org/W1223429048","https://openalex.org/W1534146221","https://openalex.org/W1561987315","https://openalex.org/W1965135841","https://openalex.org/W1968290904","https://openalex.org/W1970809051","https://openalex.org/W1979308174","https://openalex.org/W2001666674","https://openalex.org/W2004364228","https://openalex.org/W2025125071","https://openalex.org/W2028179057","https://openalex.org/W2030062071","https://openalex.org/W2030072500","https://openalex.org/W2055631257","https://openalex.org/W2056818778","https://openalex.org/W2058739664","https://openalex.org/W2063161169","https://openalex.org/W2064732848","https://openalex.org/W2069478329","https://openalex.org/W2072083401","https://openalex.org/W2073496185","https://openalex.org/W2075505106","https://openalex.org/W2082279418","https://openalex.org/W2083508836","https://openalex.org/W2083739587","https://openalex.org/W2085340178","https://openalex.org/W2086138987","https://openalex.org/W2088913098","https://openalex.org/W2090573786","https://openalex.org/W2092415052","https://openalex.org/W2095026923","https://openalex.org/W2097592978","https://openalex.org/W2105092345","https://openalex.org/W2105450122","https://openalex.org/W2106983312","https://openalex.org/W2107419879","https://openalex.org/W2111255580","https://openalex.org/W2114104370","https://openalex.org/W2114365596","https://openalex.org/W2116477373","https://openalex.org/W2117518873","https://openalex.org/W2118685659","https://openalex.org/W2124881269","https://openalex.org/W2125730657","https://openalex.org/W2132895884","https://openalex.org/W2135099620","https://openalex.org/W2136456693","https://openalex.org/W2145066076","https://openalex.org/W2147452548","https://openalex.org/W2148364248","https://openalex.org/W2149786401","https://openalex.org/W2155080284","https://openalex.org/W2155931624","https://openalex.org/W2156131531","https://openalex.org/W2159835983","https://openalex.org/W2162235829","https://openalex.org/W2167491049","https://openalex.org/W2171446041","https://openalex.org/W2316561738","https://openalex.org/W2324138493"],"related_works":["https://openalex.org/W1992782747","https://openalex.org/W3215672376","https://openalex.org/W1996930866","https://openalex.org/W2111745910","https://openalex.org/W203907929","https://openalex.org/W2034938236","https://openalex.org/W4296481940","https://openalex.org/W2406111568","https://openalex.org/W2076678323","https://openalex.org/W2412439875"],"abstract_inverted_index":{"Acute":[0],"gouty":[1,41,113,150,236],"arthritis":[2,114,167],"(gouty":[3],"attack)":[4],"is":[5,17,43,55,126,141,187,195,203,227,262,274,336,350,357,363],"an":[6,148],"acute":[7,40,112,149,235],"inflammation":[8],"of":[9,26,28,36,39,51,77,92,100,109,147,157,176,201,211,223,229,234,240,245,251,292,311,320,377,391],"a":[10,56,80,85,121,134,198,257,371],"joint":[11],"or":[12,152,193,369,409],"joints.":[13],"Since":[14],"the":[15,29,34,37,49,52,75,90,98,101,107,144,155,158,166,174,209,249,293,309,318,334,367,375,389,412],"pain":[16,50],"often":[18,164],"severe,":[19],"though":[20],"transient,":[21],"it":[22,356],"decreases":[23],"QOL":[24,46],"(quality":[25],"life)":[27],"patient":[30],"very":[31,57],"much.":[32],"Therefore,":[33],"aim":[35],"treatment":[38,210,233,239,244,250],"attack":[42,151],"to":[44,64,103,255,343,360,415,419],"improve":[45],"by":[47,67,168,272,298,411],"relieving":[48],"patient.":[53],"Gout":[54],"old":[58],"disease":[59],"whose":[60],"description":[61],"goes":[62],"back":[63],"5":[65],"B.C.":[66],"Hippocrates":[68],"in":[69,94,143,253,284,290],"ancient":[70],"Greece.":[71],"Surprisingly,":[72],"he":[73],"described":[74],"effectiveness":[76,108],"colchicine":[78,110,125,131,177,202],"from":[79,120,218,382,398],"plant":[81],"Colchicum":[82],"autumnale":[83],"as":[84,185,359],"therapeutic":[86],"agent.":[87],"Colchicine":[88],"blocks":[89],"formation":[91],"microtubules":[93,291],"neutrophils":[95],"and":[96,213,225,242,267,301,313,316,329,384,393,404,418],"inhibits":[97],"migration":[99],"cells":[102],"inflammatory":[104],"lesions.":[105],"Although":[106,346],"for":[111,124,339,374,388],"has":[115],"long":[116],"been":[117,296,380,396],"obvious,":[118],"evidence":[119],"controlled":[122],"study":[123],"not":[127,204],"sufficient.":[128],"Typically":[129],"oral":[130],"given":[132],"at":[133,137,280],"dose":[135,200],"of,":[136],"most,":[138],"1.8":[139],"mg/d,":[140],"used":[142,196,338],"early":[145],"stage":[146],"even":[153],"before":[154],"initiation":[156],"pain.":[159],"Experienced":[160],"gout":[161,212,224,341,378,394,403],"patients":[162,417],"can":[163],"predict":[165],"some":[169,285],"local":[170],"feeling":[171],"(aura).":[172],"However,":[173],"administration":[175],"every":[178],"hour":[179],"until":[180],"adverse":[181],"events":[182],"occur,":[183],"such":[184],"diarrhea,":[186],"no":[188],"longer":[189],"recommended.":[190],"Either":[191],"NSAID":[192],"corticosteroid":[194],"when":[197],"small":[199],"sufficiently":[205],"Purpose:":[206],"To":[207],"update":[208],"hyperuricemia":[214,226,392,405],"based":[215],"on":[216],"papers":[217],"various":[219],"countries.":[220],"Findings:":[221],"Treatment":[222],"composed":[228],"three":[230],"segments":[231],"(a)":[232],"attack,":[237],"(b)":[238],"hyperuricemia,":[241,252],"(c)":[243],"associated":[246,276,352,365],"disorders.":[247],"For":[248,324],"addition":[254],"allopurinol,":[256],"xanthine":[258],"oxidase/dehydrogenase":[259],"inhibitor,":[260],"febuxostat":[261],"now":[263],"used.":[264],"Stevens-Johnson\u2019s":[265],"syndrome":[266],"toxic":[268],"epidermal":[269],"necrolysis":[270],"caused":[271],"allopurinol":[273],"strongly":[275],"with":[277,353,366,402],"HLA-B*5801":[278],"present":[279],"rather":[281],"high":[282],"frequencies":[283],"Asian":[286],"populations.":[287],"Many":[288],"transporters":[289],"kidney":[294],"have":[295,379,395],"identified":[297],"molecular":[299],"biology":[300],"GWAS":[302],"(genome-wide":[303],"association":[304],"study).":[305],"Uricosuric":[306],"drugs":[307],"inhibit":[308],"function":[310],"SLC22A12":[312],"other":[314,344],"transporters,":[315],"decrease":[317],"reabsorption":[319],"urate":[321,348,362],"into":[322],"blood.":[323],"tumor":[325],"lysis":[326],"syndrome,":[327],"rasburicase":[328],"pegloticase":[330],"are":[331],"used,":[332],"while":[333,386],"latter":[335],"also":[337],"chronic":[340],"refractory":[342],"treatments.":[345],"serum":[347],"concentration":[349],"positively":[351],"cardiovascular":[354],"death,":[355],"controversial":[358],"whether":[361],"directly":[364],"disorder":[368],"only":[370],"marker.":[372],"Guidelines":[373],"management":[376,390],"published":[381],"Europe":[383],"US,":[385],"guidelines":[387],"released":[397],"Japan.":[399],"Conclusion:":[400],"Patients":[401],"should":[406],"be":[407],"managed":[408],"treated":[410],"methods":[413],"suited":[414],"individual":[416],"their":[420],"conditions.":[421]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
