{"id":"https://openalex.org/W2157764240","doi":null,"title":"Immune tolerance in hemophilia and treatment of hemophiliacs with an inhibitor.","display_name":"Immune tolerance in hemophilia and treatment of hemophiliacs with an inhibitor.","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2157764240","mag":"2157764240","pmid":"https://pubmed.ncbi.nlm.nih.gov/11255267"},"language":"en","primary_location":{"id":"pmid:11255267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11255267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Editorial"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111375509","display_name":"Guglielmo Mariani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Mariani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085290623","display_name":"Hans\u2010Hermann Brackmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H H Brackmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"86","issue":"3","first_page":"225","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophilia","display_name":"hemophilia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/immune-tolerance-induction","display_name":"immune tolerance induction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/factor-viii-inhibitors","display_name":"factor VIII inhibitors","score":0.6489999890327454},{"id":"https://openalex.org/keywords/inhibitor-treatment","display_name":"inhibitor treatment","score":0.6129999756813049},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.546999990940094},{"id":"https://openalex.org/keywords/joint-diseases","display_name":"joint diseases","score":0.8389999866485596},{"id":"https://openalex.org/keywords/high-titer-inhibitors","display_name":"high-titer inhibitors","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8264845609664917},{"id":"https://openalex.org/C2779526002","wikidata":"https://www.wikidata.org/wiki/Q1642040","display_name":"Hemarthrosis","level":2,"score":0.5806348919868469},{"id":"https://openalex.org/C2779146052","wikidata":"https://www.wikidata.org/wiki/Q708176","display_name":"Arthropathy","level":4,"score":0.4869895875453949},{"id":"https://openalex.org/C2778385053","wikidata":"https://www.wikidata.org/wiki/Q134003","display_name":"Haemophilia","level":2,"score":0.4685039818286896},{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.4548524022102356},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41544508934020996},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39902788400650024},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34917962551116943},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3197336196899414},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26431167125701904},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1007811427116394},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.05261516571044922},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007518","descriptor_name":"Isoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11255267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11255267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Editorial"},{"id":"pmh:oai:doaj.org/article:b83b50bd20714358a849605519a51669","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b83b50bd20714358a849605519a51669","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 86, Iss 3 (2001)","raw_type":"article"},{"id":"mag:2157764240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11255267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W109308927","https://openalex.org/W134074767","https://openalex.org/W148295968","https://openalex.org/W175264726","https://openalex.org/W645174011","https://openalex.org/W1487084354","https://openalex.org/W1588659566","https://openalex.org/W1801228818","https://openalex.org/W1839760847","https://openalex.org/W1942870285","https://openalex.org/W1975528602","https://openalex.org/W1978519692","https://openalex.org/W1988846258","https://openalex.org/W1994517706","https://openalex.org/W1996631085","https://openalex.org/W2005011625","https://openalex.org/W2010347101","https://openalex.org/W2011891951","https://openalex.org/W2024397909","https://openalex.org/W2024996514","https://openalex.org/W2026854040","https://openalex.org/W2036877355","https://openalex.org/W2050193680","https://openalex.org/W2050245606","https://openalex.org/W2056634959","https://openalex.org/W2067202614","https://openalex.org/W2083788869","https://openalex.org/W2089745978","https://openalex.org/W2089865394","https://openalex.org/W2096309023","https://openalex.org/W2128684337","https://openalex.org/W2155710930","https://openalex.org/W2166031247","https://openalex.org/W2170341515","https://openalex.org/W2332645155","https://openalex.org/W2401045994","https://openalex.org/W2410730751","https://openalex.org/W2412307082","https://openalex.org/W2415751972","https://openalex.org/W2418283309","https://openalex.org/W2441696068","https://openalex.org/W2470482979","https://openalex.org/W2477939303","https://openalex.org/W2508519367","https://openalex.org/W2515040497","https://openalex.org/W2529382946","https://openalex.org/W2991710020"],"related_works":["https://openalex.org/W2059328460","https://openalex.org/W947457007","https://openalex.org/W4237835873","https://openalex.org/W2325837299","https://openalex.org/W4301895071","https://openalex.org/W2013821178","https://openalex.org/W628087876","https://openalex.org/W2066861413","https://openalex.org/W1642559060","https://openalex.org/W4220801080"],"abstract_inverted_index":{"The":[0,25],"appearance":[1],"of":[2,14,27,43,47],"inhibitors":[3],"in":[4],"hemophilia":[5,15,48],"is":[6,39],"now":[7],"considered":[8],"by":[9],"far":[10],"the":[11,44],"severest":[12],"problem":[13],"treatment,":[16],"being":[17],"associated":[18],"with":[19],"increased":[20],"morbidity":[21],"if":[22,31],"not":[23],"mortality.":[24],"presence":[26],"an":[28],"inhibitor,":[29],"especially":[30],"high-titer,":[32],"leads":[33],"to":[34,41,54],"a":[35],"clinical":[36],"situation":[37],"which":[38],"comparable":[40],"that":[42],"early":[45],"years":[46],"treatment":[49],"when":[50],"bleedings":[51],"were":[52],"difficult":[53],"treat":[55],"and":[56],"arthropathy":[57],"rapidly":[58],"progressed":[59],"towards":[60],"dis":[61]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}