{"id":"https://openalex.org/W2157755166","doi":"https://doi.org/10.11606/t.5.2010.tde-24082010-171621","title":"An\u00e1lise de polimorfismos do gene que codifica a prote\u00edna B do surfactante: compara\u00e7\u00e3o entre rec\u00e9m-nascidos pr\u00e9-termo com e sem s\u00edndrome do desconforto respirat\u00f3rio","display_name":"An\u00e1lise de polimorfismos do gene que codifica a prote\u00edna B do surfactante: compara\u00e7\u00e3o entre rec\u00e9m-nascidos pr\u00e9-termo com e sem s\u00edndrome do desconforto respirat\u00f3rio","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2157755166","doi":"https://doi.org/10.11606/t.5.2010.tde-24082010-171621","mag":"2157755166"},"language":"pt","primary_location":{"id":"doi:10.11606/t.5.2010.tde-24082010-171621","doi":"https://doi.org/10.11606/t.5.2010.tde-24082010-171621","is_oa":false,"landing_page_url":"https://doi.org/10.11606/t.5.2010.tde-24082010-171621","pdf_url":null,"source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/5/5141/tde-24082010-171621/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082747801","display_name":"Priscila Pinheiro Ribeiro Lyra","orcid":"https://orcid.org/0000-0002-0300-4993","observed_orcids":["https://orcid.org/0000-0002-0300-4993"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Priscila Pinheiro Ribeiro Lyra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082747801"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11586","display_name":"Congenital Diaphragmatic Hernia Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surfactant-protein-b","display_name":"surfactant protein B","score":0.8930000066757202},{"id":"https://openalex.org/keywords/respiratory-distress-syndrome","display_name":"respiratory distress syndrome","score":0.984000027179718},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.9330000281333923},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.628000020980835},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7620000243186951},{"id":"https://openalex.org/keywords/genotype-frequency","display_name":"genotype frequency","score":0.32899999618530273},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.546999990940094},{"id":"https://openalex.org/keywords/racial-differences","display_name":"racial differences","score":0.8100000023841858},{"id":"https://openalex.org/keywords/restriction-fragment-length-polymorphism","display_name":"restriction fragment length polymorphism","score":0.5720000267028809},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.31700000166893005},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.45215675234794617},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.13233309984207153}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.11606/t.5.2010.tde-24082010-171621","doi":"https://doi.org/10.11606/t.5.2010.tde-24082010-171621","is_oa":false,"landing_page_url":"https://doi.org/10.11606/t.5.2010.tde-24082010-171621","pdf_url":null,"source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},{"id":"pmh:oai:americanae.aecid.es:2259646","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.usp.br/teses/disponiveis/5/5141/tde-24082010-171621/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:teses.usp.br:tde-24082010-171621","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.11606/T.5.2010.tde-24082010-171621","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:2259646","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.usp.br/teses/disponiveis/5/5141/tde-24082010-171621/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W53510971","https://openalex.org/W107992251","https://openalex.org/W1884476348","https://openalex.org/W1963785722","https://openalex.org/W1970047669","https://openalex.org/W1974977343","https://openalex.org/W1975721704","https://openalex.org/W1982877581","https://openalex.org/W1989320161","https://openalex.org/W1990402565","https://openalex.org/W2002859881","https://openalex.org/W2007087386","https://openalex.org/W2008512736","https://openalex.org/W2010175471","https://openalex.org/W2019094071","https://openalex.org/W2020236767","https://openalex.org/W2020986301","https://openalex.org/W2021321934","https://openalex.org/W2044571502","https://openalex.org/W2054933658","https://openalex.org/W2056567933","https://openalex.org/W2070739144","https://openalex.org/W2081589751","https://openalex.org/W2093118781","https://openalex.org/W2093314252","https://openalex.org/W2102229646","https://openalex.org/W2105567835","https://openalex.org/W2116046790","https://openalex.org/W2125940921","https://openalex.org/W2128551817","https://openalex.org/W2131817432","https://openalex.org/W2140190085","https://openalex.org/W2141134109","https://openalex.org/W2147034448","https://openalex.org/W2153409356","https://openalex.org/W2158290723","https://openalex.org/W2158337570","https://openalex.org/W2159477646","https://openalex.org/W2161157806","https://openalex.org/W2179225990","https://openalex.org/W2331089332","https://openalex.org/W2335075431","https://openalex.org/W2416170092","https://openalex.org/W3016611452","https://openalex.org/W3102457749"],"related_works":["https://openalex.org/W7120884616","https://openalex.org/W7120761152","https://openalex.org/W6979860563","https://openalex.org/W1581392272","https://openalex.org/W2158290723","https://openalex.org/W2020005960","https://openalex.org/W4229082486","https://openalex.org/W1968595768","https://openalex.org/W2369463372","https://openalex.org/W1530173273"],"abstract_inverted_index":{"A":[0,34,53,443],"s\u00edndrome":[1,470,504],"do":[2,37,45,63,81,88,244,250,307,313,395,445,448,454,461,471,505],"desconforto":[3,472,506],"respirat\u00f3rio":[4,473,507],"(SDR)":[5],"\u00e9":[6,40],"causada":[7],"pela":[8],"defici\u00eancia":[9],"transit\u00f3ria":[10],"de":[11,21,55,79,92,156,192,216,220,264,270,280,290,327,333,343,349,357,371,432,478],"surfactante":[12,38,46,89,462],"pulmonar":[13,51],"em":[14,59,197,474,508],"rec\u00e9m-nascidos":[15,475,509],"(RN)":[16],"prematuros":[17],"nos":[18],"primeiros":[19],"dias":[20,145,288],"vida.":[22],"Estudos":[23],"sugerem":[24],"que":[25,83,304,375,382,391,456],"a":[26,77,85,158,214,272,276,283,335,338,352,364,376,380,386,406,458],"etiologia":[27],"da":[28,68,188,199,209,255,259,317,322,388,469,476],"SDR":[29,132,151,297],"seja":[30],"multifatorial":[31],"e":[32,47,57,97,109,118,121,140,143,146,178,201,247,262,275,286,293,310,325,390,440,491],"multig\u00eanica.":[33],"prote\u00edna":[35,86,459],"B":[36,87,460],"(SP-B)":[39],"fundamental":[41],"para":[42,48,362,385,405,466],"o":[43,392,467],"metabolismo":[44],"uma":[49],"fun\u00e7\u00e3o":[50],"normal.":[52],"presen\u00e7a":[54,444],"polimorfismos":[56,80,104,184,426,481],"muta\u00e7\u00f5es":[58],"genes":[60],"dos":[61,190,211,424],"componentes":[62],"surfactante,":[64],"particularmente":[65],"no":[66,90,125,166,171,175,180,483,488,493,497],"gene":[67,82,455,499],"SP-B,":[69],"parece":[70],"estar":[71],"associada":[72],"\u00e0":[73,438,503],"SDR.":[74,119],"Objetivos:":[75],"Determinar":[76],"freq\u00fc\u00eancia":[78],"codifica":[84,457],"DNA":[91,193],"rec\u00e9m":[93],"nascidos":[94],"pr\u00e9-termo":[95,149,238],"com":[96,133,150,152,218],"sem":[98,131,239],"SDR,":[99,373],"comparar":[100],"as":[101,422],"freq\u00fc\u00eancias":[102,423],"desses":[103],"entre":[105,115,137,421,428],"os":[106,429],"dois":[107],"grupos":[108,431],"avaliar":[110,363],"se":[111],"existe":[112],"alguma":[113],"rela\u00e7\u00e3o":[114],"sexo,":[116],"ra\u00e7a":[117,256,260,318,323,439],"Casu\u00edstica":[120],"M\u00e9todos:":[122],"Foram":[123,161],"inclu\u00eddos":[124],"estudo":[126],"151":[127],"RNPT,":[128,302],"sendo":[129,241,303],"79":[130,236],"idades":[134,153],"gestacionais":[135,154],"variando":[136,155],"29":[138,281],"semanas":[139,142,282,285,292,345,351],"35":[141,159,284,353],"6":[144,294],"72":[147,301],"RN":[148,237],"26":[157,350],"semanas.":[160,354],"analisados":[162],"quatro":[163],"polimorfismos:":[164],"A/C":[165,482],"nucleot\u00eddeo":[167,172,176,181,484,489,494],"-":[168,415,485],"18;":[169],"C/T":[170,487],"1580;":[173],"A/G":[174,397,450],"9306":[177,400,453],"G/C":[179,492],"8714.":[182],"Os":[183,204,480],"foram":[185,206,418],"determinados":[186],"atrav\u00e9s":[187,208],"amplifica\u00e7\u00e3o":[189],"segmentos":[191],"gen\u00f4mico":[194],"por":[195,235,300],"rea\u00e7\u00e3o":[196],"cadeia":[198],"polimerase":[200],"posterior":[202],"genotipagem.":[203],"gen\u00f3tipos":[205],"definidos":[207],"an\u00e1lise":[210],"produtos":[212],"obtidos":[213],"partir":[215],"rea\u00e7\u00f5es":[217],"enzimas":[219],"restri\u00e7\u00e3o":[221],"[PCR-based":[222],"converted":[223],"restriction":[224],"fragment":[225],"length":[226],"polymorphism":[227],"(cRFLP)].":[228],"Resultados:":[229],"O":[230,267,330,355],"grupo":[231,296],"Controle":[232],"foi":[233,298,342,379,401,463],"constitu\u00eddo":[234],"SDR;":[240],"42":[242],"(53,2%)":[243],"sexo":[245,251,308,314],"feminino":[246,309],"37":[248],"(46,8%)":[249],"masculino;":[252,315],"34":[253],"(43%)":[254,306],"negra,":[257,319],"16(20,3%)":[258],"branca":[261,324],"29(36,7)":[263],"indiv\u00edduos":[265,328],"pardos.":[266,329],"peso":[268,331],"variou":[269,279,332],"1170g":[271],"3260":[273],",":[274,346],"idade":[277,339,377],"gestacional":[278,340,378],"seis":[287],"(m\u00e9dia":[289],"33":[291],"dias).O":[295],"composto":[299],"31":[305],"41":[311],"(57%)":[312],"31(43%)":[316,326],"16":[320],"(14%)":[321],"614g":[334],"2.410g":[336],";":[337],"m\u00e9dia":[341],"32":[344],"tendo":[347],"variado":[348],"modelo":[356],"regress\u00e3o":[358],"log\u00edstica":[359],"m\u00faltipla,":[360],"utilizado":[361],"contribui\u00e7\u00e3o":[365],"das":[366],"diversas":[367],"vari\u00e1veis":[368],"na":[369,398,451,510],"probabilidade":[370],"ocorrer":[372],"demonstrou":[374],"vari\u00e1vel":[381],"mais":[383],"contribuiu":[384],"ocorr\u00eancia":[387],"patologia,":[389],"gen\u00f3tipo":[393,446],"AG":[394,447],"polimorfismo":[396,449],"posi\u00e7\u00e3o":[399,452],"um":[402],"fator":[403,464],"protetor":[404,465],"doen\u00e7a":[407],"nesta":[408],"popula\u00e7\u00e3o":[409],"(OR":[410],"0.1681;":[411],"IC":[412],"95%":[413],"0.0426":[414],"0.6629).":[416],"N\u00e3o":[417],"observadas":[419],"diferen\u00e7as":[420,436],"demais":[425],"avaliados":[427],"2":[430],"rec\u00e9m-nascidos,":[433],"bem":[434],"como":[435],"quanto":[437],"sexo.":[441],"Conclus\u00f5es:":[442],"desenvolvimento":[468],"cidade":[477],"Salvador-Bahia.":[479],"18,":[486],"1580,":[490],"8714":[495],"presentes":[496],"referido":[498],"n\u00e3o":[500],"estiveram":[501],"associados":[502],"amostra":[511],"estudada.":[512]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}