{"id":"https://openalex.org/W2157705605","doi":"https://doi.org/10.3892/or.15.4.861","title":"Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: Analysis of immunological parameters","display_name":"Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: Analysis of immunological parameters","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2157705605","doi":"https://doi.org/10.3892/or.15.4.861","mag":"2157705605","pmid":"https://pubmed.ncbi.nlm.nih.gov/16525672"},"language":"en","primary_location":{"id":"doi:10.3892/or.15.4.861","doi":"https://doi.org/10.3892/or.15.4.861","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.15.4.861","pdf_url":"https://www.spandidos-publications.com/10.3892/or.15.4.861/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spandidos-publications.com/10.3892/or.15.4.861/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084699233","display_name":"Susumu Ohwada","orcid":"https://orcid.org/0000-0002-9872-7560","observed_orcids":["https://orcid.org/0000-0002-9872-7560"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Susumu Ohwada","raw_affiliation_strings":["Department of Surgery, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan. sohwada@med.gunma-u.ac.jp","Department of Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-Machi, Maebashi 371-8511, Gunma, Japan","Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan. sohwada@med.gunma-u.ac.jp","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Department of Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-Machi, Maebashi 371-8511, Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024661044","display_name":"Tetsushi Ogawa","orcid":"https://orcid.org/0000-0002-1994-8286","observed_orcids":["https://orcid.org/0000-0002-1994-8286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsushi Ogawa","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034810437","display_name":"Fujio Makita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fujio Makita","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111664571","display_name":"Yoshifumi Tanahashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshifumi Tanahashi","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048908132","display_name":"Toshihiro Ohya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshihiro Ohya","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017823254","display_name":"Naoki Tomizawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Tomizawa","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshihiro Satoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiro Satoh","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105462958","display_name":"Isao Kobayashi","orcid":"https://orcid.org/0000-0002-3908-4681","observed_orcids":["https://orcid.org/0000-0002-3908-4681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isao Kobayashi","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024069449","display_name":"Masaru Izumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaru Izumi","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101095","display_name":"Izumi Takeyoshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Izumi Takeyoshi","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010643575","display_name":"\u90a6\u5f18 \u6d5c\u7530","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunihiro Hamada","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055288802","display_name":"S Minaguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigeyuki Minaguchi","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasushi Togo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasushi Togo","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056782627","display_name":"Toshihiko Tago","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tago Toshihiko","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toru Koyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Koyama","raw_affiliation_strings":["Department of Surgery , Gunma University , Graduate School of Medicine , 3-39-15 Showa- Machi , Maebashi , Gunma 371-8511 , Japan","Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery , Gunma University , Graduate School of Medicine , 3-39-15 Showa- Machi , Maebashi , Gunma 371-8511 , Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017564042","display_name":"Masashi Kamio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masashi Kamio","raw_affiliation_strings":["Gunma Oncology Study Group,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gunma Oncology Study Group,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084699233"],"corresponding_institution_ids":["https://openalex.org/I165735259"],"apc_list":null,"apc_paid":null,"fwci":0.508,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.63667709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"4","first_page":"861","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.2653999924659729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.2653999924659729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.1868000030517578,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psk","display_name":"PSK","score":0.828000009059906},{"id":"https://openalex.org/keywords/tegafur-uracil","display_name":"tegafur-uracil","score":0.9789999723434448},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/stage-ii-iii-colorectal-cancer","display_name":"stage II and III colorectal cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8309999704360962},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.48399999737739563},{"id":"https://openalex.org/keywords/immunosuppressive-acidic-protein","display_name":"immunosuppressive acidic protein","score":0.9150000214576721},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7419999837875366},{"id":"https://openalex.org/keywords/regional-metastases","display_name":"regional metastases","score":0.6019999980926514},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.6439999938011169},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6039304733276367},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.597509503364563},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.57545006275177},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5255894660949707},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.5232976078987122},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5206522345542908},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.48314163088798523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47189104557037354},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.44670921564102173},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4232545495033264},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37341850996017456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3360707759857178},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2632988691329956},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.11920008063316345},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018959","descriptor_name":"CD57 Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D039481","descriptor_name":"CD11b Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.15.4.861","doi":"https://doi.org/10.3892/or.15.4.861","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.15.4.861","pdf_url":"https://www.spandidos-publications.com/10.3892/or.15.4.861/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:16525672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16525672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.15.4.861","doi":"https://doi.org/10.3892/or.15.4.861","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.15.4.861","pdf_url":"https://www.spandidos-publications.com/10.3892/or.15.4.861/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157705605.pdf","grobid_xml":"https://content.openalex.org/works/W2157705605.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W109579298","https://openalex.org/W1532882724","https://openalex.org/W1780868497","https://openalex.org/W1945072268","https://openalex.org/W1946106924","https://openalex.org/W1974679399","https://openalex.org/W1979022060","https://openalex.org/W2000096016","https://openalex.org/W2011015194","https://openalex.org/W2035248336","https://openalex.org/W2046285045","https://openalex.org/W2055109849","https://openalex.org/W2075549113","https://openalex.org/W2076187678","https://openalex.org/W2086307329","https://openalex.org/W2088973294","https://openalex.org/W2098253706","https://openalex.org/W2100804133","https://openalex.org/W2127936077","https://openalex.org/W2137045685","https://openalex.org/W2144305464","https://openalex.org/W2146833023","https://openalex.org/W2221850846","https://openalex.org/W2313857605","https://openalex.org/W2401925634","https://openalex.org/W2402992683","https://openalex.org/W2416372319"],"related_works":["https://openalex.org/W2098253706","https://openalex.org/W2036500493","https://openalex.org/W2414376083","https://openalex.org/W2044615898","https://openalex.org/W2068766760","https://openalex.org/W2065072311","https://openalex.org/W2589215243","https://openalex.org/W7096154209","https://openalex.org/W2043238992","https://openalex.org/W2120327105"],"abstract_inverted_index":{"Protein-bound":[0],"polysaccharide":[1],"K":[2],"(PSK)":[3],"increased":[4,68],"the":[5,12,32,55,59,69,79,99,116,131,161,169,173],"5-year":[6,82,152],"disease-free":[7,33,83,153],"survival":[8,34,86,154],"rate":[9,87],"and":[10,24,38,67,84,108,125,187,212,229],"reduced":[11],"risk":[13],"of":[14,72,175,189,204],"recurrence":[15],"in":[16,49,54,115,130,215],"a":[17,44,148],"randomised,":[18],"controlled":[19],"study":[20],"for":[21,88],"stage":[22,216],"II":[23,217],"III":[25,219],"colorectal":[26,220],"cancer.":[27,221],"In":[28,134,168],"order":[29],"to":[30,160,184,198],"elucidate":[31],"benefits":[35],"with":[36,78,90,120,136],"PSK":[37,45,57,117,146,190,206,242],"what":[39],"immunological":[40,50],"markers":[41],"could":[42],"indicate":[43],"responder,":[46],"serial":[47],"changes":[48],"parameters":[51],"were":[52,102,201],"monitored":[53],"study.":[56],"decreased":[58],"mean":[60,70],"serum":[61,91,223],"immunosuppressive":[62],"acidic":[63],"protein":[64],"(IAP)":[65],"level,":[66],"population":[71,139,233],"natural":[73],"killer":[74],"(NK)":[75],"cells":[76],"compared":[77,119,159],"controls.":[80],"The":[81],"overall":[85],"patients":[89,135],"IAP":[92,224],"values":[93,225],"<or=500":[94,226],"microg":[95,227],"ml(-1),":[96],"which":[97],"represents":[98],"normal":[100],"value,":[101],"75.5%":[103],"(95%":[104,110,122,127],"CI:":[105,111,123,128,157,166,182,196],"66.8-84.2%;":[106],"p=0.016)":[107],"85.1%":[109],"77.9-92.3%;":[112],"p=0.032),":[113],"respectively,":[114],"group":[118,163],"57.5%":[121],"43.3-71.6%)":[124],"70.2%":[126],"57.1-83.3%)":[129],"control":[132,162],"group.":[133],"NK":[137,231],"cell":[138,232],">or=8%":[140,234],"at":[141,235],"3":[142,236],"months":[143,237],"after":[144,238],"surgery,":[145],"conferred":[147],"significantly":[149],"better":[150],"(p=0.038)":[151],"(86.7%;":[155],"95%":[156,165,181,195],"74.5-98.8%)":[158],"(60.0%;":[164],"29.6-90.4%).":[167],"proportional":[170],"hazards":[171],"model,":[172],"presence":[174],"regional":[176],"metastases":[177],"(relative":[178,192],"risk,":[179,193],"3.595;":[180],"1.518":[183],"8.518;":[185],"p=0.004)":[186],"omission":[188],"treatment":[191],"3.099;":[194],"1.202":[197],"7.990;":[199],"p=0.019)":[200],"significant":[202],"indicators":[203],"recurrence.":[205],"acts":[207],"as":[208],"an":[209,230],"immunomodulatory":[210],"activity":[211],"biochemical":[213],"modulator":[214],"or":[218],"Pre-operative":[222],"ml(-1)":[228],"surgery":[239],"are":[240],"possible":[241],"response":[243],"predictors.":[244]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
