{"id":"https://openalex.org/W2157694367","doi":"https://doi.org/10.1093/infdis/jiv300","title":"Inhibition of Heat-Stable Toxin\u2013Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors","display_name":"Inhibition of Heat-Stable Toxin\u2013Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors","publication_year":2015,"publication_date":"2015-05-21","ids":{"openalex":"https://openalex.org/W2157694367","doi":"https://doi.org/10.1093/infdis/jiv300","mag":"2157694367","pmid":"https://pubmed.ncbi.nlm.nih.gov/25999056"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiv300","doi":"https://doi.org/10.1093/infdis/jiv300","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv300","pdf_url":"https://academic.oup.com/jid/article-pdf/212/11/1806/17409671/jiv300.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jid/article-pdf/212/11/1806/17409671/jiv300.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023055657","display_name":"Marcel J. C. Bijvelds","orcid":"https://orcid.org/0000-0003-0814-188X","observed_orcids":["https://orcid.org/0000-0003-0814-188X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marcel J. C. Bijvelds","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113784901","display_name":"Michaela Loos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Michaela Loos","raw_affiliation_strings":["Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009902878","display_name":"Inez Bronsveld","orcid":"https://orcid.org/0000-0001-8877-645X","observed_orcids":["https://orcid.org/0000-0001-8877-645X"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Inez Bronsveld","raw_affiliation_strings":["Department of Pulmonology, University Medical Center Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology, University Medical Center Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103720086","display_name":"Ann Hellemans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Hellemans","raw_affiliation_strings":["Shire-Movetis NV, Turnhout"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shire-Movetis NV, Turnhout","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029469694","display_name":"Jean\u2010Pierre Bongartz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Bongartz","raw_affiliation_strings":["Janssen Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067876230","display_name":"Luc Ver Donck","orcid":"https://orcid.org/0000-0003-1666-3274","observed_orcids":["https://orcid.org/0000-0003-1666-3274"]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Luc Ver Donck","raw_affiliation_strings":["Janssen Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035453859","display_name":"Eric Cox","orcid":"https://orcid.org/0000-0003-4281-2990","observed_orcids":["https://orcid.org/0000-0003-4281-2990"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eric Cox","raw_affiliation_strings":["Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052613378","display_name":"Hugo R. de Jonge","orcid":"https://orcid.org/0000-0003-2777-4084","observed_orcids":["https://orcid.org/0000-0003-2777-4084","https://orcid.org/0000-0001-7596-7433"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hugo R. de Jonge","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108588247","display_name":"Jan A.J. Schuurkes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan A. J. Schuurkes","raw_affiliation_strings":["Shire-Movetis NV, Turnhout"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shire-Movetis NV, Turnhout","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054405489","display_name":"Joris H. De Maeyer","orcid":"https://orcid.org/0000-0002-3574-6158","observed_orcids":["https://orcid.org/0000-0002-3574-6158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joris H. De Maeyer","raw_affiliation_strings":["Shire-Movetis NV, Turnhout"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shire-Movetis NV, Turnhout","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023055657"],"corresponding_institution_ids":["https://openalex.org/I2801952686"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":{"value":4763,"currency":"USD","value_usd":4763},"fwci":2.7477,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.8945098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"212","issue":"11","first_page":"1806","last_page":"1815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0786999985575676,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-stable-enterotoxin","display_name":"heat-stable enterotoxin","score":0.800000011920929},{"id":"https://openalex.org/keywords/sta","display_name":"STa","score":0.7699999809265137},{"id":"https://openalex.org/keywords/enterotoxigenic-escherichia-coli","display_name":"enterotoxigenic Escherichia coli","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.6000000238418579},{"id":"https://openalex.org/keywords/anion-secretion","display_name":"anion secretion","score":0.6439999938011169},{"id":"https://openalex.org/keywords/intestinal-secretion","display_name":"intestinal secretion","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator","display_name":"cystic fibrosis transmembrane conductance regulator","score":0.9629999995231628},{"id":"https://openalex.org/keywords/piperidinone-derivatives","display_name":"piperidinone derivatives","score":0.6100000143051147},{"id":"https://openalex.org/keywords/infectious-diarrhea","display_name":"infectious diarrhea","score":0.5320000052452087},{"id":"https://openalex.org/keywords/enterotoxemia","display_name":"enterotoxemia","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C13121076","wikidata":"https://www.wikidata.org/wiki/Q1552797","display_name":"Guanylate cyclase 2C","level":4,"score":0.6960963606834412},{"id":"https://openalex.org/C96178990","wikidata":"https://www.wikidata.org/wiki/Q4819046","display_name":"Heat-stable enterotoxin","level":5,"score":0.6872377991676331},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.6737239360809326},{"id":"https://openalex.org/C2777871010","wikidata":"https://www.wikidata.org/wiki/Q265214","display_name":"Enterotoxigenic Escherichia coli","level":5,"score":0.6718348264694214},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6499536037445068},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.58195960521698},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5643580555915833},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.5470602512359619},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5268726944923401},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4353676438331604},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4254003167152405},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.379213809967041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3550746738910675},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.32687026262283325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24788731336593628},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24407944083213806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21076470613479614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074261","descriptor_name":"Receptors, Enterotoxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018000","descriptor_name":"Receptors, Peptide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018000","descriptor_name":"Receptors, Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050705","descriptor_name":"Receptors, Guanylate Cyclase-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D050705","descriptor_name":"Receptors, Guanylate Cyclase-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054307","descriptor_name":"Enterotoxigenic Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1093/infdis/jiv300","doi":"https://doi.org/10.1093/infdis/jiv300","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv300","pdf_url":"https://academic.oup.com/jid/article-pdf/212/11/1806/17409671/jiv300.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:25999056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25999056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/a22e798b-80ca-4315-a295-7b0bc4c6a71e","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/a22e798b-80ca-4315-a295-7b0bc4c6a71e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bijvelds, M, Loos, M, Bronsveld, I, Hellemans, A, Bongartz, JP, Donck, LV, Cox, E, de Jonge, H, Schuurkes, JAJ & de Maeyer, JH 2015, 'Inhibition of Heat-Stable Toxin-Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors', Journal of Infectious Diseases, vol. 212, no. 11, pp. 1806-1815. https://doi.org/10.1093/infdis/jiv300","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/a22e798b-80ca-4315-a295-7b0bc4c6a71e","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/a22e798b-80ca-4315-a295-7b0bc4c6a71e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Infectious Diseases, 212(11), 1806 - 1815. Oxford University Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:archive.ugent.be:7067298","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1854/LU-7067298","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0022-1899","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/333741","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/333741","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/333741","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/333741","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Infectious Diseases, 212(11), 1806. Oxford University Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/333741","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/333741","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Infectious Diseases, 212(11), 1806","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/infdis/jiv300","doi":"https://doi.org/10.1093/infdis/jiv300","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv300","pdf_url":"https://academic.oup.com/jid/article-pdf/212/11/1806/17409671/jiv300.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321732","display_name":"Agentschap voor Innovatie door Wetenschap en Technologie","ror":"https://ror.org/01antkr91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157694367.pdf","grobid_xml":"https://content.openalex.org/works/W2157694367.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W143099781","https://openalex.org/W1543394229","https://openalex.org/W1549868451","https://openalex.org/W1569818199","https://openalex.org/W1589508442","https://openalex.org/W1601068357","https://openalex.org/W1959936864","https://openalex.org/W1976525815","https://openalex.org/W1978753843","https://openalex.org/W1983094993","https://openalex.org/W1985604430","https://openalex.org/W1990355822","https://openalex.org/W2013078897","https://openalex.org/W2016155421","https://openalex.org/W2021521740","https://openalex.org/W2027903939","https://openalex.org/W2028730278","https://openalex.org/W2035773315","https://openalex.org/W2038483247","https://openalex.org/W2042076829","https://openalex.org/W2046838884","https://openalex.org/W2054543034","https://openalex.org/W2054977175","https://openalex.org/W2055441085","https://openalex.org/W2069599181","https://openalex.org/W2080039779","https://openalex.org/W2080422730","https://openalex.org/W2084548757","https://openalex.org/W2087149725","https://openalex.org/W2105420306","https://openalex.org/W2114127069","https://openalex.org/W2120639350","https://openalex.org/W2133163062","https://openalex.org/W2142798158","https://openalex.org/W2146517647","https://openalex.org/W2160411670","https://openalex.org/W2164114364","https://openalex.org/W2269095518","https://openalex.org/W2294522417"],"related_works":["https://openalex.org/W3024042251","https://openalex.org/W7026441475","https://openalex.org/W2025158592","https://openalex.org/W1549868451","https://openalex.org/W2074449336","https://openalex.org/W2026504055","https://openalex.org/W4242247931","https://openalex.org/W2027903939","https://openalex.org/W1543394229","https://openalex.org/W2408762658"],"abstract_inverted_index":{"BACKGROUND:":[0],"Many":[1],"enterotoxigenic":[2],"Escherichia":[3],"coli":[4],"strains":[5],"produce":[6],"the":[7,15,40,69,80,205],"heat-stable":[8],"toxin,":[9],"STa,":[10],"which,":[11],"by":[12,58],"activation":[13,78],"of":[14,37,42,74,79,199,209],"intestinal":[16,98,110],"receptor-enzyme":[17],"guanylyl":[18],"cyclase":[19,60],"(GC)":[20],"C,":[21],"triggers":[22],"an":[23],"acute,":[24],"watery":[25],"diarrhea.":[26],"We":[27,193],"set":[28],"out":[29],"to":[30,120],"identify":[31],"GCC":[32,162,182,200],"inhibitors":[33,183,201],"that":[34,48,202],"may":[35,203],"be":[36],"benefit":[38],"for":[39,143,207,212],"treatment":[41],"infectious":[43],"diarrheal":[44,214],"disease.":[45,215],"METHODS:":[46],"Compounds":[47],"inhibit":[49,121],"STa-induced":[50],"cyclic":[51],"guanosine":[52],"3',5'-monophosphate":[53],"(cGMP)":[54],"production":[55],"were":[56,118,131,139],"selected":[57],"performing":[59],"assays":[61],"on":[62,76,102],"cells":[63],"and":[64,93,96,172,175],"membranes":[65],"containing":[66],"GCC,":[67],"or":[68],"related":[70],"GCA.":[71,144],"The":[72,126],"effect":[73,101],"leads":[75,149],"STa/GCC-dependent":[77],"cystic":[81,156],"fibrosis":[82,157],"transmembrane":[83,158],"conductance":[84,159],"regulator":[85,160],"anion":[86,166,186],"channel":[87],"was":[88,106],"investigated":[89],"in":[90,94,108,112,168,178,188],"T84":[91,146],"cells,":[92],"porcine":[95],"human":[97],"tissue.":[99],"Their":[100],"STa-provoked":[103,165,185],"fluid":[104,173],"transport":[105],"assessed":[107],"ligated":[109],"loops":[111],"piglets.":[113],"RESULTS:":[114],"Four":[115],"N-2-(propylamino)-6-phenylpyrimidin-4-one-substituted":[116],"piperidines":[117],"shown":[119],"GCC-mediated":[122],"cellular":[123],"cGMP":[124,176],"production.":[125],"half":[127],"maximal":[128],"inhibitory":[129],"concentrations":[130],"\u2264":[132],"5":[133],"\u00d7":[134],"10(-7)":[135],"mol/L,":[136],"whereas":[137],"they":[138],">10":[140],"times":[141],"higher":[142],"In":[145],"monolayers,":[147],"these":[148],"blocked":[150,184],"STa/GCC-dependent,":[151],"but":[152],"not":[153],"forskolin/adenylyl":[154],"cyclase-dependent,":[155],"activity.":[161],"inhibition":[163],"reduced":[164],"secretion":[167,187],"pig":[169],"jejunal":[170],"tissue,":[171],"retention":[174],"levels":[177],"STa-exposed":[179],"loops.":[180],"These":[181],"rectal":[189],"biopsy":[190],"specimens.":[191],"CONCLUSIONS:":[192],"have":[194],"identified":[195],"a":[196],"novel":[197],"class":[198],"form":[204],"basis":[206],"development":[208],"future":[210],"therapeutics":[211],"(infectious)":[213]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}