{"id":"https://openalex.org/W2157684259","doi":"https://doi.org/10.1186/bcr2119","title":"Continuing trastuzumab beyond disease progression: outcomes analysis in patients with metastatic breast cancer","display_name":"Continuing trastuzumab beyond disease progression: outcomes analysis in patients with metastatic breast cancer","publication_year":2008,"publication_date":"2008-07-16","ids":{"openalex":"https://openalex.org/W2157684259","doi":"https://doi.org/10.1186/bcr2119","mag":"2157684259","pmid":"https://pubmed.ncbi.nlm.nih.gov/18631394","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2575533"},"language":"en","primary_location":{"id":"doi:10.1186/bcr2119","doi":"https://doi.org/10.1186/bcr2119","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr2119","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/bcr2119","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/bcr2119","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072257250","display_name":"Giuseppe Cancello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Cancello","raw_affiliation_strings":["Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131 - Napoli, Italy. giuseppe.cancello@tele2.it","Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131 - Napoli, Italy. giuseppe.cancello@tele2.it","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065889459","display_name":"Emilia Montagna","orcid":"https://orcid.org/0000-0002-0384-0852","observed_orcids":["https://orcid.org/0000-0002-0384-0852"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emilia Montagna","raw_affiliation_strings":["Unit\u00e0 di Ricerca Senologia Medica, Istituto Europeo di Oncologia, via Ripamonti, 435, 20141, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e0 di Ricerca Senologia Medica, Istituto Europeo di Oncologia, via Ripamonti, 435, 20141, Milano, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102245288","display_name":"Diego D\u2019Agostino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego D'Agostino","raw_affiliation_strings":["Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061264992","display_name":"Mario Giuliano","orcid":"https://orcid.org/0000-0003-0835-3153","observed_orcids":["https://orcid.org/0000-0003-0835-3153"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Giuliano","raw_affiliation_strings":["Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024798356","display_name":"Antonio Giordano","orcid":"https://orcid.org/0000-0002-5959-016X","observed_orcids":["https://orcid.org/0000-0002-5959-016X"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Giordano","raw_affiliation_strings":["Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055464636","display_name":"Giuseppe Di Lorenzo","orcid":"https://orcid.org/0000-0001-7414-1568","observed_orcids":["https://orcid.org/0000-0001-7414-1568"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Di Lorenzo","raw_affiliation_strings":["Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025794673","display_name":"Monica Plaitano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Plaitano","raw_affiliation_strings":["Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078562748","display_name":"Sabino De Placido","orcid":"https://orcid.org/0000-0001-5077-6286","observed_orcids":["https://orcid.org/0000-0001-5077-6286"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabino De Placido","raw_affiliation_strings":["Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025684262","display_name":"Michelino De Laurentiis","orcid":"https://orcid.org/0000-0001-9009-1572","observed_orcids":["https://orcid.org/0000-0001-9009-1572"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele De Laurentiis","raw_affiliation_strings":["Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universit\u00e0 'Federico II', via Sergio Pansini, 5, 80131, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025684262"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":4.6191,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95388273,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"4","first_page":"R60","last_page":"R60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.996999979019165},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9120000004768372},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":1.0},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8709999918937683},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.5569999814033508},{"id":"https://openalex.org/keywords/second-line-chemotherapy","display_name":"second-line chemotherapy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.968999981880188},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.7440000176429749},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9808911085128784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9131447672843933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7195712924003601},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.677586555480957},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6609919667243958},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6608562469482422},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5835795402526855},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5387794375419617},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4449140429496765},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.41033071279525757},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4003298580646515},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32314956188201904}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/bcr2119","doi":"https://doi.org/10.1186/bcr2119","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr2119","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/bcr2119","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2575533","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2575533","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Res","raw_type":"Text"},{"id":"pmid:18631394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18631394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research : BCR","raw_type":"Journal Article"},{"id":"pmh:oai:null:20.500.12613/5604","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12613/5604","pdf_url":null,"source":{"id":"https://openalex.org/S4306402624","display_name":"TUScholarShare (Temple University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84392919","host_organization_name":"Temple University","host_organization_lineage":["https://openalex.org/I84392919"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/1129551","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/1129551","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/bcr2119","doi":"https://doi.org/10.1186/bcr2119","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr2119","pdf_url":"https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/bcr2119","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157684259.pdf","grobid_xml":"https://content.openalex.org/works/W2157684259.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1531524380","https://openalex.org/W1898692666","https://openalex.org/W1912896705","https://openalex.org/W1914269090","https://openalex.org/W1974611354","https://openalex.org/W1989456077","https://openalex.org/W2001196910","https://openalex.org/W2019895529","https://openalex.org/W2072292369","https://openalex.org/W2094627540","https://openalex.org/W2095156669","https://openalex.org/W2103836071","https://openalex.org/W2110444464","https://openalex.org/W2115759102","https://openalex.org/W2117115931","https://openalex.org/W2136704455","https://openalex.org/W2141393790","https://openalex.org/W2149997750","https://openalex.org/W2153242757","https://openalex.org/W2158158704","https://openalex.org/W2159459001","https://openalex.org/W2266056862","https://openalex.org/W2318605753","https://openalex.org/W2590038306","https://openalex.org/W4237582555","https://openalex.org/W6811788780"],"related_works":["https://openalex.org/W1988792081","https://openalex.org/W2016360463","https://openalex.org/W2149997750","https://openalex.org/W2103836071","https://openalex.org/W2320224223","https://openalex.org/W2014836885","https://openalex.org/W2563073831","https://openalex.org/W4247911877","https://openalex.org/W2248924803","https://openalex.org/W2136704455"],"abstract_inverted_index":{"INTRODUCTION:":[0],"We":[1,31,49],"performed":[2],"a":[3,117,276],"retrospective":[4,265],"analysis":[5],"of":[6,16,21,35,40,70,93,142,176,224,250],"HER2-overexpressing":[7],"metastatic":[8],"breast":[9],"cancer":[10],"patients":[11,37,52,103,122,190,198,254],"to":[12,98,163,212,240,285],"describe":[13],"clinical":[14],"outcomes":[15,132],"those":[17,41],"who,":[18],"despite":[19],"progression":[20,113,164,274],"the":[22,64,80,125,134,171,201,222,227],"disease":[23],"(PD),":[24],"maintained":[25],"trastuzumab":[26,44,86,110,150,177,193,225,256,272],"for":[27,87,170,189,197,253],"multiple":[28],"chemotherapy":[29,94],"lines.":[30],"also":[32],"compared":[33],"survival":[34,183,252],"these":[36],"with":[38,263,292],"that":[39],"who":[42,104,191,199],"halted":[43,200],"at":[45,111,151],"first":[46,112,138,152,172],"PD.":[47],"METHODS:":[48],"identified":[50],"101":[51],"treated":[53],"between":[54,137],"July":[55],"2000":[56],"and":[57,72,108,139,158,160,167,173,194,231,267],"January":[58],"2007.":[59],"Nineteen":[60],"were":[61,73,114,156,165,186],"still":[62],"receiving":[63],"first-line":[65],"trastuzumab-based":[66],"treatment":[67],"without":[68],"evidence":[69],"PD":[71],"not":[74],"included":[75],"in":[76,261,290],"this":[77],"analysis.":[78],"Of":[79],"remaining":[81],"82":[82],"patients,":[83],"59":[84],"retained":[85,192],"one":[88],"or":[89],"more":[90],"additional":[91],"lines":[92,141,175],"after":[95,273],"PD,":[96],"according":[97],"our":[99],"institution":[100,107],"policy.":[101],"Twenty-three":[102],"changed":[105],"treating":[106],"stopped":[109],"used":[115],"as":[116],"control":[118],"group.":[119],"RESULTS:":[120],"For":[121],"retaining":[123,255],"trastuzumab,":[124],"median":[126,161,181],"follow-up":[127],"was":[128],"39.6":[129],"months.":[130],"Clinical":[131],"showed":[133],"typical":[135],"degradation":[136],"second":[140,174],"therapy":[143],"which":[144],"we":[145,218],"would":[146],"expect":[147],"by":[148],"halting":[149],"progression.":[153],"Response":[154],"rates":[155,185],"35%":[157],"16%":[159],"times":[162],"7.25":[166],"5.25":[168],"months":[169,188,196],"therapy,":[178,226],"respectively.":[179],"The":[180],"overall":[182],"(OS)":[184],"70":[187],"56":[195],"drug":[202],"(hazard":[203],"ratio":[204],"[HR]":[205],"0.87,":[206],"95%":[207,237],"confidence":[208],"interval":[209],"[CI]":[210],"0.51":[211],"1.18;":[213],"P":[214,242],"=":[215,243],"0.52).":[216],"If":[217],"consider":[219],"OS":[220],"from":[221],"start":[223],"figures":[228],"are":[229,283],"53.9":[230],"34.8":[232],"months,":[233],"respectively":[234],"(HR":[235],"0.78,":[236],"CI":[238],"0.58":[239],"1.32;":[241],"0.2).":[244],"CONCLUSION:":[245],"A":[246],"nonstatistically":[247],"significant":[248],"trend":[249],"improved":[251],"is":[257,260,275],"observed.":[258],"This":[259],"line":[262],"most":[264],"analyses":[266],"recent":[268],"randomized":[269,281],"data.":[270],"Retaining":[271],"reasonable":[277],"option,":[278],"but":[279],"further":[280],"data":[282],"warranted":[284],"better":[286],"define":[287],"its":[288],"role":[289],"comparison":[291],"other":[293],"available":[294],"options.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}