{"id":"https://openalex.org/W2157662999","doi":"https://doi.org/10.1152/ajpgi.1989.257.3.g470","title":"Erythromycin is a motilin receptor agonist","display_name":"Erythromycin is a motilin receptor agonist","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W2157662999","doi":"https://doi.org/10.1152/ajpgi.1989.257.3.g470","mag":"2157662999","pmid":"https://pubmed.ncbi.nlm.nih.gov/2782416"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.1989.257.3.g470","doi":"https://doi.org/10.1152/ajpgi.1989.257.3.g470","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1989.257.3.g470","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111974666","display_name":"T. L. Peeters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"T. Peeters","raw_affiliation_strings":["Department of Medical Research, Katholieke Universiteit Leuven,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Katholieke Universiteit Leuven,Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015888784","display_name":"Gert Matthijs","orcid":"https://orcid.org/0000-0001-6710-1912","observed_orcids":["https://orcid.org/0000-0001-6710-1912"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"G. Matthijs","raw_affiliation_strings":["Department of Medical Research, Katholieke Universiteit Leuven,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Katholieke Universiteit Leuven,Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048668599","display_name":"Inge Depoortere","orcid":"https://orcid.org/0000-0002-0289-2175","observed_orcids":["https://orcid.org/0000-0002-0289-2175"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"I. Depoortere","raw_affiliation_strings":["Department of Medical Research, Katholieke Universiteit Leuven,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Katholieke Universiteit Leuven,Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035928250","display_name":"Thierry Cachet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"T. Cachet","raw_affiliation_strings":["Department of Medical Research, Katholieke Universiteit Leuven,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Katholieke Universiteit Leuven,Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004798967","display_name":"Jos Hoogmartens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J. Hoogmartens","raw_affiliation_strings":["Department of Medical Research, Katholieke Universiteit Leuven,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Katholieke Universiteit Leuven,Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037216741","display_name":"Gaston R. Vantrappen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"G. Vantrappen","raw_affiliation_strings":["Department of Medical Research, Katholieke Universiteit Leuven,Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Katholieke Universiteit Leuven,Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":15.0957,"has_fulltext":false,"cited_by_count":358,"citation_normalized_percentile":{"value":0.99285343,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"257","issue":"3","first_page":"G470","last_page":"G474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythromycin-a","display_name":"erythromycin A","score":0.9309999942779541},{"id":"https://openalex.org/keywords/motilin-receptor-agonist","display_name":"motilin receptor agonist","score":0.8539999723434448},{"id":"https://openalex.org/keywords/motilin","display_name":"motilin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.8500000238418579},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.6330000162124634},{"id":"https://openalex.org/keywords/human-duodenum","display_name":"human duodenum","score":0.6209999918937683},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C131793682","wikidata":"https://www.wikidata.org/wiki/Q126440","display_name":"Motilin","level":2,"score":0.9785794019699097},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6997070908546448},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.6353925466537476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.619575560092926},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6117992401123047},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5572484731674194},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.5218235850334167},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47060713171958923},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.4579755961894989},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.43982934951782227},{"id":"https://openalex.org/C2777951760","wikidata":"https://www.wikidata.org/wiki/Q5526842","display_name":"Gastrointestinal hormone","level":4,"score":0.4375571012496948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3495405912399292},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3330192565917969},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.18398529291152954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1366559863090515},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011964","descriptor_name":"Receptors, Gastrointestinal Hormone","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011964","descriptor_name":"Receptors, Gastrointestinal Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011964","descriptor_name":"Receptors, Gastrointestinal Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018013","descriptor_name":"Receptors, Neuropeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.1989.257.3.g470","doi":"https://doi.org/10.1152/ajpgi.1989.257.3.g470","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1989.257.3.g470","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:2782416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2782416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2027606442","https://openalex.org/W1856367111","https://openalex.org/W2178854569","https://openalex.org/W2007347926","https://openalex.org/W2084037001","https://openalex.org/W2417728257","https://openalex.org/W2032047716","https://openalex.org/W2159207825","https://openalex.org/W2091942177","https://openalex.org/W1966452363"],"abstract_inverted_index":{"Erythromycin":[0],"A":[1],"(EMA)":[2],"is":[3,207,224],"a":[4,19,82,225],"potent":[5],"stimulator":[6],"of":[7,42,76,85,112,140,147,152,177],"gastrointestinal":[8],"motor":[9,23],"activity.":[10],"In":[11],"vitro":[12,39],"studies":[13],"suggest":[14],"that":[15,21,146,222],"it":[16],"mimics":[17],"motilin,":[18],"peptide":[20],"stimulates":[22],"activity":[24],"in":[25,28,38,117,186,203],"human":[26,187],"and":[27,44,49,94,103,127,149,154,202,215],"rabbit":[29,53],"via":[30],"smooth":[31],"muscle":[32,175],"receptors.":[33],"We":[34,220],"have":[35],"compared":[36],"the":[37,77,113,118,141,150,212],"contractile":[40,79],"effect":[41,173],"EMA":[43,50,104,142,155,161,170,189,209,223],"two":[45],"derivatives,":[46],"8,9-anhydro-EMA-6,9-hemiketal":[47],"(EM201)":[48],"N-oxide,":[51],"on":[52,174,193],"duodenal":[54],"smooth-muscle":[55,67],"strips":[56,176],"with":[57,166],"their":[58],"ability":[59],"to":[60,65,73,81,109,145,164,200],"displace":[61,110],"iodinated":[62],"motilin":[63,115,148,153,201,205,226],"bound":[64],"crude":[66],"membrane":[68],"fractions.":[69],"The":[70,106,137],"concentrations":[71,107],"required":[72,108],"induce":[74,184],"50%":[75,111],"maximum":[78],"response":[80],"supramaximal":[83],"dose":[84],"acetylcholine":[86],"were":[87,134,156,162],"5.0":[88],"x":[89,92,96,122,125,129],"10(-8),":[90,123],"2.0":[91],"10(-6),":[93],"1.0":[95,121],"10(-4)":[97],"M":[98],"for,":[99],"respectively,":[100],"EM201,":[101],"EMA,":[102],"N-oxide.":[105],"labeled":[114],"were,":[116],"same":[119,213],"order,":[120],"1.3":[124],"10(-7),":[126],"4.0":[128],"10(-6)":[130],"M.":[131],"Both":[132],"parameters":[133],"well":[135],"correlated.":[136],"dose-response":[138],"curve":[139],"was":[143,190],"parallel":[144],"effects":[151],"additive.":[157],"Contractions":[158],"induced":[159],"by":[160],"insensitive":[163],"pretreatment":[165],"tetrodotoxin":[167],"or":[168,179],"atropine.":[169],"had":[171],"no":[172],"rat":[178],"dog":[180],"duodenum":[181],"but":[182],"did":[183],"contractions":[185],"strips.":[188],"totally":[191],"ineffective":[192],"ileal":[194],"preparations,":[195],"which":[196,204],"are":[197],"also":[198],"unresponsive":[199],"binding":[206],"absent.":[208],"has":[210],"therefore":[211],"regional":[214],"species":[216],"specificity":[217],"as":[218],"motilin.":[219],"conclude":[221],"receptor":[227],"agonist.":[228]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}