{"id":"https://openalex.org/W2157623482","doi":null,"title":"BASES MOLECULARES DE LAS ACCIONES DE LA INSULINA","display_name":"BASES MOLECULARES DE LAS ACCIONES DE LA INSULINA","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2157623482","mag":"2157623482"},"language":"es","primary_location":{"id":"mag:2157623482","doi":null,"is_oa":false,"landing_page_url":"https://biblat.unam.mx/hevila/REBRevistadeeducacionbioquimica/2008/vol27/no1/3.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306525438","display_name":"REB. Revista de educaci\u00f3n bioqu\u00edmica","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"REB. Revista de educaci\u00f3n bioqu\u00edmica","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jesus A. Reyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]},{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jesus A. Reyes","raw_affiliation_strings":["Instituto Polit\u00e9cnico Nacional , Centro de Investigaci\u00f3n y de Estudios Avanzados, M\u00e9xico, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Polit\u00e9cnico Nacional , Centro de Investigaci\u00f3n y de Estudios Avanzados, M\u00e9xico, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061197781","display_name":"Araceli Arellano-Plancarte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]},{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Araceli Arellano Plancarte","raw_affiliation_strings":["Instituto Polit\u00e9cnico Nacional , Centro de Investigaci\u00f3n y de Estudios Avanzados, M\u00e9xico, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Polit\u00e9cnico Nacional , Centro de Investigaci\u00f3n y de Estudios Avanzados, M\u00e9xico, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.16106487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"1","first_page":"9","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9440000057220459},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7558199167251587},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7253850102424622},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.7044506669044495},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49577435851097107},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.49070727825164795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47696030139923096},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45707637071609497},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4340222477912903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3937658369541168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3517034649848938},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2959229350090027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29502975940704346}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2157623482","doi":null,"is_oa":false,"landing_page_url":"https://biblat.unam.mx/hevila/REBRevistadeeducacionbioquimica/2008/vol27/no1/3.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306525438","display_name":"REB. Revista de educaci\u00f3n bioqu\u00edmica","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"REB. Revista de educaci\u00f3n bioqu\u00edmica","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1521905573","https://openalex.org/W1590273686","https://openalex.org/W1990838637","https://openalex.org/W2006645178","https://openalex.org/W2009886463","https://openalex.org/W2014887370","https://openalex.org/W2015038984","https://openalex.org/W2084521532","https://openalex.org/W2095252238","https://openalex.org/W2122567567","https://openalex.org/W2135896596","https://openalex.org/W2170653092","https://openalex.org/W2172136994"],"related_works":["https://openalex.org/W2905238817","https://openalex.org/W1975732614","https://openalex.org/W80965381","https://openalex.org/W1044248074","https://openalex.org/W2132647577","https://openalex.org/W1987522063","https://openalex.org/W2059286688","https://openalex.org/W2763635492","https://openalex.org/W131243687","https://openalex.org/W3151654797"],"abstract_inverted_index":{"Insulin":[0],"is":[1,73,105],"a":[2,68,74],"hormone":[3],"released":[4],"by":[5],"pancreatic":[6],"beta":[7],"cells":[8,54],"in":[9,16,63,95,118],"response":[10],"to":[11,32,55,57,77,106,128],"elevated":[12],"levels":[13],"of":[14,49,52,61,89,93,101,138],"nutrients":[15],"the":[17,33,37,46,64,78,90,102,108,115,132,136],"blood,":[18],"controlling":[19],"critical":[20],"energy":[21],"functions":[22],"such":[23],"as":[24,71],"glucose":[25],"and":[26,97,114,141],"lipid":[27],"metabolism.":[28],"When":[29],"insulin":[30,34,58,65,112,139],"binds":[31],"receptor":[35,39],"(IR),":[36],"activated":[38],"triggers":[40],"multiple":[41],"signaling":[42,66],"pathways":[43],"that":[44],"mediate":[45],"biological":[47],"actions":[48,113],"insuline.":[50],"Failure":[51],"target":[53],"respond":[56],"presumably":[59],"because":[60],"defects":[62],"pathway,":[67],"state":[69],"known":[70],"insulin-resistance,":[72],"major":[75],"attribute":[76],"pathological":[79],"manifestations":[80],"associated":[81,134],"with":[82,135],"diabetes":[83],"mellitus":[84],"type":[85],"2":[86],"(DM2),":[87],"one":[88],"first":[91],"causes":[92,133],"death":[94],"Mexico":[96],"worldwide.":[98],"The":[99],"objective":[100],"present":[103],"review":[104],"unravel":[107],"molecular":[109],"basis":[110],"for":[111],"mechanisms":[116,124],"involved":[117],"regulating":[119],"its":[120],"effects.":[121],"Understanding":[122],"these":[123],"will":[125],"allow":[126],"us":[127],"understand":[129],"what":[130],"are":[131],"development":[137],"resistance":[140],"DM2.":[142]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}