{"id":"https://openalex.org/W2157620907","doi":"https://doi.org/10.1152/ajpgi.00415.2004","title":"Role of short-chain fatty acids in colonic HCO3secretion","display_name":"Role of short-chain fatty acids in colonic HCO3secretion","publication_year":2005,"publication_date":"2005-01-28","ids":{"openalex":"https://openalex.org/W2157620907","doi":"https://doi.org/10.1152/ajpgi.00415.2004","mag":"2157620907","pmid":"https://pubmed.ncbi.nlm.nih.gov/15677553"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00415.2004","doi":"https://doi.org/10.1152/ajpgi.00415.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00415.2004","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036720950","display_name":"Sadasivan Vidyasagar","orcid":"https://orcid.org/0000-0003-1535-7259","observed_orcids":["https://orcid.org/0000-0003-1535-7259"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadasivan Vidyasagar","raw_affiliation_strings":["Dept. of Internal Medicine, Yale Univ., PO Box 208019, New Haven, CT 06520, USA. henry.binder@yale.edu","Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine, Yale Univ., PO Box 208019, New Haven, CT 06520, USA. henry.binder@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027957681","display_name":"Christian Barmeyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Barmeyer","raw_affiliation_strings":["","Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065040724","display_name":"John Peter Geibel","orcid":"https://orcid.org/0000-0003-1147-7501","observed_orcids":["https://orcid.org/0000-0003-1147-7501"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Geibel","raw_affiliation_strings":["","Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112387166","display_name":"Henry J. Binder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry J. Binder","raw_affiliation_strings":["","Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056444185","display_name":"Vazhaikkurichi M. Rajendran","orcid":"https://orcid.org/0000-0002-8999-8721","observed_orcids":["https://orcid.org/0000-0002-8999-8721"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vazhaikkurichi M. Rajendran","raw_affiliation_strings":["","Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Internal Medicine, Cellular and Molecular Physiology, and Surgery, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":2.0078,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.85753056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"288","issue":"6","first_page":"G1217","last_page":"G1226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.22709999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.04699999839067459,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":1.0},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.8600000143051147},{"id":"https://openalex.org/keywords/isobutyrate","display_name":"isobutyrate","score":1.0},{"id":"https://openalex.org/keywords/apical-membrane-vesicles","display_name":"apical membrane vesicles","score":0.8330000042915344},{"id":"https://openalex.org/keywords/colonic-crypts","display_name":"colonic crypts","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.9458496570587158},{"id":"https://openalex.org/C2779533339","wikidata":"https://www.wikidata.org/wiki/Q4036893","display_name":"DIDS","level":3,"score":0.8307704925537109},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8078250885009766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6445854902267456},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.6421393156051636},{"id":"https://openalex.org/C2776229602","wikidata":"https://www.wikidata.org/wiki/Q2698455","display_name":"Short-chain fatty acid","level":4,"score":0.596602737903595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43917226791381836},{"id":"https://openalex.org/C3018436504","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Apical membrane","level":3,"score":0.43884649872779846},{"id":"https://openalex.org/C2781217356","wikidata":"https://www.wikidata.org/wiki/Q83426191","display_name":"Monocarboxylate transporter","level":4,"score":0.4267132580280304},{"id":"https://openalex.org/C2779843069","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyric acid","level":2,"score":0.42295822501182556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25355061888694763},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.21249985694885254},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19022789597511292},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1220676600933075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002713","descriptor_name":"Chlorine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005232","descriptor_name":"Fatty Acids, Volatile","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005232","descriptor_name":"Fatty Acids, Volatile","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020148","descriptor_name":"Butyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.00415.2004","doi":"https://doi.org/10.1152/ajpgi.00415.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00415.2004","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:15677553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15677553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4460454984","display_name":null,"funder_award_id":"DK 60069","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7299697161","display_name":"Colonic Crypt HCO3 Secretion","funder_award_id":"R01DK060069","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320310246","display_name":"University of Rochester","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W83343953","https://openalex.org/W101807314","https://openalex.org/W766161978","https://openalex.org/W1506819190","https://openalex.org/W1567364863","https://openalex.org/W1579963067","https://openalex.org/W1588926099","https://openalex.org/W1612925887","https://openalex.org/W1778313853","https://openalex.org/W1979117664","https://openalex.org/W2019055319","https://openalex.org/W2048771801","https://openalex.org/W2051477844","https://openalex.org/W2054505873","https://openalex.org/W2067516282","https://openalex.org/W2067665804","https://openalex.org/W2097991034","https://openalex.org/W2116683511","https://openalex.org/W2120509245","https://openalex.org/W2121167265","https://openalex.org/W2122862287","https://openalex.org/W2136199519","https://openalex.org/W2137012287","https://openalex.org/W2138258268","https://openalex.org/W2144603992","https://openalex.org/W2148502095","https://openalex.org/W2159415844","https://openalex.org/W2187950387","https://openalex.org/W2212993917","https://openalex.org/W2252816522","https://openalex.org/W2254207841","https://openalex.org/W2256895485","https://openalex.org/W2277315987","https://openalex.org/W2336230469","https://openalex.org/W2344248648","https://openalex.org/W2395306627","https://openalex.org/W2396172849","https://openalex.org/W2409355753","https://openalex.org/W2412204369","https://openalex.org/W2414241074","https://openalex.org/W2416999119","https://openalex.org/W2419516382","https://openalex.org/W2423928808","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2067516282","https://openalex.org/W2020417319","https://openalex.org/W2395306627","https://openalex.org/W2054505873","https://openalex.org/W2021616307","https://openalex.org/W2138258268","https://openalex.org/W1845744896","https://openalex.org/W2156953072","https://openalex.org/W83343953","https://openalex.org/W2268355757"],"abstract_inverted_index":{"Luminal":[0],"isobutyrate,":[1,66,98],"a":[2,14,123,210,225],"relatively":[3],"poor":[4],"metabolized":[5],"short-chain":[6],"fatty":[7],"acid":[8],"(SCFA),":[9],"induces":[10],"HCO(3)":[11,27,40,91,109,120,132,154,163,197,220,243],"secretion":[12,41,92,121,133,155,198,221,244],"via":[13,209],"Cl-independent,":[15,87],"DIDS-insensitive,":[16],"carrier-mediated":[17],"process":[18],"as":[19,21],"well":[20,38],"inhibiting":[22],"both":[23,101],"Cl-dependent":[24,131,240],"and":[25,56,67,104,113,178,241,254],"cAMP-induced":[26,119,242],"secretion.":[28,110],"The":[29],"mechanism(s)":[30],"responsible":[31],"for":[32,108],"these":[33],"processes":[34],"have":[35],"not":[36,152,171],"been":[37],"characterized.":[39],"was":[42],"measured":[43],"in":[44,49,156,182,233],"isolated":[45,60,78,157],"colonic":[46,61],"mucosa":[47],"mounted":[48],"Lucite":[50],"chambers":[51],"using":[52],"pH":[53],"stat":[54],"technique":[55],"during":[57],"microperfusion":[58],"of":[59,86,202,227,249],"crypts.":[62],"(14)C-labeled":[63,65],"butyrate,":[64],"(36)Cl":[68,180],"uptake":[69,167],"were":[70,184],"also":[71],"determined":[72],"by":[73,97,136,144,168,186,188],"apical":[74,207,229,250],"membrane":[75,208,230,251],"vesicles":[76],"(AMV)":[77],"from":[79],"surface":[80,169,234],"and/or":[81],"crypt":[82,172],"cells.":[83],"Butyrate":[84,150],"stimulation":[85],"DIDS-insensitive":[88],"5-nitro-3-(3-phenylpropyl-amino)benzoic":[89],"acid-insensitive":[90],"is":[93,134,199,222],"greater":[94],"than":[95,143,214],"that":[96,100,194],"suggesting":[99],"SCFA":[102,203,216,238,247],"transport":[103,204],"metabolism":[105],"are":[106],"critical":[107],"Both":[111,175],"lumen":[112,137],"serosal":[114,145],"25":[115,138],"mM":[116,139,190],"butyrate":[117,140,146],"inhibit":[118],"to":[122,246],"comparable":[124],"degree":[125],"(98":[126,147],"vs.":[127,148],"90%).":[128],"In":[129],"contrast,":[130],"downregulated":[135],"considerably":[141],"more":[142,213],"37%).":[149],"did":[151],"induce":[153],"microperfused":[158],"crypts,":[159],"whereas":[160],"an":[161,228],"outward-directed":[162],"gradient-driven":[164],"induced":[165],"(14)C-butyrate":[166],"but":[170],"cell":[173],"AMV.":[174],"(36)Cl/HCO(3)":[176],"exchange":[177,212,232,253],"potential-dependent":[179],"movement":[181],"AMV":[183],"inhibited":[185],"96-98%":[187],"20":[189],"butyrate.":[191],"We":[192],"conclude":[193],"1)":[195],"SCFA-dependent":[196,219],"the":[200,206],"result":[201,226],"across":[205],"SCFA/HCO(3)":[211,231],"intracellular":[215],"metabolism;":[217],"2)":[218],"most":[223],"likely":[224],"epithelial":[235],"cells;":[236],"3)":[237],"downregulates":[239],"secondary":[245],"inhibition":[248],"Cl/HCO(3)":[252],"anion":[255],"channel":[256],"activity,":[257],"respectively.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
