{"id":"https://openalex.org/W2157572915","doi":"https://doi.org/10.1369/jhc.2009.953893","title":"Advanced Osteoarthritis in Humans Is Associated With Altered Collagen VI Expression and Upregulation of ER-stress Markers Grp78 and Bag-1","display_name":"Advanced Osteoarthritis in Humans Is Associated With Altered Collagen VI Expression and Upregulation of ER-stress Markers Grp78 and Bag-1","publication_year":2009,"publication_date":"2009-06-22","ids":{"openalex":"https://openalex.org/W2157572915","doi":"https://doi.org/10.1369/jhc.2009.953893","mag":"2157572915","pmid":"https://pubmed.ncbi.nlm.nih.gov/19546472","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2746726"},"language":"en","primary_location":{"id":"doi:10.1369/jhc.2009.953893","doi":"https://doi.org/10.1369/jhc.2009.953893","is_oa":true,"landing_page_url":"https://doi.org/10.1369/jhc.2009.953893","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1369/jhc.2009.953893","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry &amp; Cytochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1369/jhc.2009.953893","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057610123","display_name":"Ashleigh E. Nugent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashleigh E. Nugent","raw_affiliation_strings":["Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066418759","display_name":"Danielle M. Speicher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle M. Speicher","raw_affiliation_strings":["Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057819849","display_name":"Ian M. Gradisar","orcid":"https://orcid.org/0000-0002-8339-7992","observed_orcids":["https://orcid.org/0000-0002-8339-7992"]},"institutions":[{"id":"https://openalex.org/I1294639003","display_name":"Summa Health System","ror":"https://ror.org/03p6fpw74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294639003"]},{"id":"https://openalex.org/I149910238","display_name":"Kent State University","ror":"https://ror.org/049pfb863","country_code":"US","type":"education","lineage":["https://openalex.org/I149910238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Gradisar","raw_affiliation_strings":["Kent State University, Kent, Ohio (AEN, DMS, WEH); and Summa Health Systems, Akron, Ohio (IG)","Summa Health Systems, Akron, Ohio (IG)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kent State University, Kent, Ohio (AEN, DMS, WEH); and Summa Health Systems, Akron, Ohio (IG)","institution_ids":["https://openalex.org/I1294639003","https://openalex.org/I149910238"]},{"raw_affiliation_string":"Summa Health Systems, Akron, Ohio (IG)","institution_ids":["https://openalex.org/I1294639003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111728384","display_name":"Denise L. McBurney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise L. McBurney","raw_affiliation_strings":["Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015358883","display_name":"Anthony Baraga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Baraga","raw_affiliation_strings":["Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109362412","display_name":"Kathleen J. Doane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen J. Doane","raw_affiliation_strings":["Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010132216","display_name":"Walter E. Horton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter E. Horton","raw_affiliation_strings":["Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio (AEN, DMS, DLM, AB, KJD, WEH)","institution_ids":["https://openalex.org/I95240055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057610123"],"corresponding_institution_ids":["https://openalex.org/I95240055"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":2.1209,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.86900627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"57","issue":"10","first_page":"923","last_page":"931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9620000123977661},{"id":"https://openalex.org/keywords/collagen-vi","display_name":"collagen VI","score":0.8309999704360962},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.796999990940094},{"id":"https://openalex.org/keywords/bag-1","display_name":"BAG-1","score":0.953000009059906},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cartilage-matrix-turnover","display_name":"cartilage matrix turnover","score":0.6600000262260437},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.782263457775116},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7624377012252808},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7454586029052734},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6325395107269287},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.5661567449569702},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.524591863155365},{"id":"https://openalex.org/C2778232976","wikidata":"https://www.wikidata.org/wiki/Q15320335","display_name":"Cartilage oligomeric matrix protein","level":4,"score":0.5161558389663696},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46181121468544006},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4613160789012909},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4607788920402527},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4555250108242035},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4446330666542053},{"id":"https://openalex.org/C38008103","wikidata":"https://www.wikidata.org/wiki/Q5145884","display_name":"Collagen, type I, alpha 1","level":3,"score":0.4418080151081085},{"id":"https://openalex.org/C2781013607","wikidata":"https://www.wikidata.org/wiki/Q14877666","display_name":"Type II collagen","level":3,"score":0.4324685335159302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40738752484321594},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3584537208080292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34655576944351196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32032322883605957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2054125964641571},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15509232878684998},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09060162305831909},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099216","descriptor_name":"Chondroitin Sulfate Proteoglycan 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002813","descriptor_name":"Chondrosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D024142","descriptor_name":"Collagen Type VI","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1369/jhc.2009.953893","doi":"https://doi.org/10.1369/jhc.2009.953893","is_oa":true,"landing_page_url":"https://doi.org/10.1369/jhc.2009.953893","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1369/jhc.2009.953893","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry &amp; Cytochemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2746726","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2746726","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Histochem Cytochem","raw_type":"Text"},{"id":"pmid:19546472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19546472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1369/jhc.2009.953893","doi":"https://doi.org/10.1369/jhc.2009.953893","is_oa":true,"landing_page_url":"https://doi.org/10.1369/jhc.2009.953893","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1369/jhc.2009.953893","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry &amp; Cytochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6000000238418579}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306237","display_name":"Arthritis Foundation","ror":"https://ror.org/04zk9fe75"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157572915.pdf"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W150569175","https://openalex.org/W1825268336","https://openalex.org/W1975827116","https://openalex.org/W1979972616","https://openalex.org/W1980819818","https://openalex.org/W1990167833","https://openalex.org/W1990750207","https://openalex.org/W1991626074","https://openalex.org/W2000421661","https://openalex.org/W2005394663","https://openalex.org/W2005609015","https://openalex.org/W2006447258","https://openalex.org/W2012120561","https://openalex.org/W2015593138","https://openalex.org/W2017917715","https://openalex.org/W2020437934","https://openalex.org/W2023780451","https://openalex.org/W2024500564","https://openalex.org/W2026314272","https://openalex.org/W2026575610","https://openalex.org/W2029591566","https://openalex.org/W2031116764","https://openalex.org/W2033656654","https://openalex.org/W2034919108","https://openalex.org/W2042319337","https://openalex.org/W2042391634","https://openalex.org/W2042945854","https://openalex.org/W2045558559","https://openalex.org/W2064009495","https://openalex.org/W2068183722","https://openalex.org/W2071497767","https://openalex.org/W2072610101","https://openalex.org/W2073991273","https://openalex.org/W2075438083","https://openalex.org/W2078330227","https://openalex.org/W2079011919","https://openalex.org/W2080889643","https://openalex.org/W2087193732","https://openalex.org/W2088744525","https://openalex.org/W2094637500","https://openalex.org/W2094931111","https://openalex.org/W2095168835","https://openalex.org/W2098013710","https://openalex.org/W2129209927","https://openalex.org/W2138960046","https://openalex.org/W2152398979","https://openalex.org/W2155936356","https://openalex.org/W2158482235","https://openalex.org/W2160765276","https://openalex.org/W2161604602","https://openalex.org/W2162515752","https://openalex.org/W2401560853","https://openalex.org/W2588932223"],"related_works":["https://openalex.org/W2970032074","https://openalex.org/W2029591566","https://openalex.org/W4240654215","https://openalex.org/W2006447258","https://openalex.org/W4391028524","https://openalex.org/W2364563640","https://openalex.org/W2101859918","https://openalex.org/W1964179961","https://openalex.org/W2024500564","https://openalex.org/W2793987623"],"abstract_inverted_index":{"To":[0],"test":[1],"the":[2,15,73],"hypothesis":[3],"that":[4,174],"a":[5,136,186],"perturbation":[6],"of":[7,17,30,36,68,75,97,185],"endoplasmic":[8],"reticulum":[9],"(ER)":[10],"function":[11],"is":[12],"involved":[13,168],"in":[14,99,105,121,132,141,160,181],"pathogenesis":[16],"osteoarthritis":[18],"(OA),":[19],"articular":[20],"cartilage":[21,41,88,109,143,169],"was":[22,84,94,110,118,129,158],"isolated":[23,43],"from":[24,44],"non-OA":[25,133],"patients":[26,45],"secondary":[27],"to":[28,86],"resection":[29],"osteo-":[31],"or":[32],"chondrosarcomas.":[33],"Intra-joint":[34],"samples":[35],"minimal":[37,106],"and":[38,50,58,79,91,102],"advanced":[39,100,161],"osteoarthritic":[40],"were":[42,62],"undergoing":[46],"total":[47],"knee":[48],"arthroplasty":[49],"scored":[51],"for":[52],"disease":[53],"severity.":[54],"Glucose-regulated":[55],"protein-78":[56],"(grp78)":[57],"bcl-2-associated":[59],"athanogene-1":[60],"(bag-1)":[61],"detected":[63],"via":[64],"immunofluorescence":[65],"as":[66],"markers":[67],"non-homeostatic":[69],"ER":[70,177],"function.":[71],"Additionally,":[72],"expression":[74,104],"type":[76,190],"VI":[77,128,152,191],"collagen":[78,151],"its":[80,165],"integrin":[81],"receptor,":[82],"NG2,":[83],"determined":[85],"examine":[87],"matrix":[89],"health":[90],"turnover.":[92],"There":[93],"an":[95],"upregulation":[96,184],"grp78":[98,112],"OA,":[101,180],"variable":[103],"OA.":[107],"Non-OA":[108],"consistently":[111],"negative.":[113],"The":[114,150],"downstream":[115],"regulator":[116],"bag-1":[117],"also":[119],"upregulated":[120],"OA":[122,142,162],"compared":[123,163],"with":[124,135,145,164,183],"normal":[125],"cartilage.":[126],"Collagen":[127],"mainly":[130],"cell-associated":[131],"cartilage,":[134],"more":[137],"widespread":[138],"distribution":[139],"observed":[140],"along":[144],"increased":[146],"intracellular":[147],"staining":[148],"intensity.":[149],"integral":[153],"membrane":[154],"proteoglycan":[155],"receptor":[156],"NG2":[157],"downregulated":[159],"patient-matched":[166],"minimally":[167],"sample.":[170],"These":[171],"results":[172],"suggest":[173],"chondrocytes":[175],"exhibit":[176],"stress":[178],"during":[179],"association":[182],"large":[187],"secreted":[188],"molecule,":[189],"collagen.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
