{"id":"https://openalex.org/W2157548366","doi":"https://doi.org/10.1002/ijc.2910440428","title":"Effects of cyclosporin a and verapamil on the intracellular daunorubicin accumulation in chinese hamster ovary cells with increasing levels of drug\u2010resistance","display_name":"Effects of cyclosporin a and verapamil on the intracellular daunorubicin accumulation in chinese hamster ovary cells with increasing levels of drug\u2010resistance","publication_year":1989,"publication_date":"1989-10-15","ids":{"openalex":"https://openalex.org/W2157548366","doi":"https://doi.org/10.1002/ijc.2910440428","mag":"2157548366","pmid":"https://pubmed.ncbi.nlm.nih.gov/2477337"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910440428","doi":"https://doi.org/10.1002/ijc.2910440428","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910440428","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112611279","display_name":"Matthijs H. Silbermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. H. Silbermann","raw_affiliation_strings":["Radiobiological Institute TNO, Rijswijk, The Netherlands","Radiobiological Institute TNO, Rijswijk, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiobiological Institute TNO, Rijswijk, The Netherlands","institution_ids":["https://openalex.org/I148297040"]},{"raw_affiliation_string":"Radiobiological Institute TNO, Rijswijk, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111974479","display_name":"Antonius W.M. Boersma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267285","display_name":"Daniel den Hoed Kliniek","ror":"https://ror.org/020rz5h24","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908","https://openalex.org/I4405267285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. W. M. Boersma","raw_affiliation_strings":["Daniel den Hoed Cancer Centre, Rotterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daniel den Hoed Cancer Centre, Rotterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405267285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097804346","display_name":"A. L. W. Jamssen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. L. W. Jamssen","raw_affiliation_strings":["Radiobiological Institute TNO, Rijswijk, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiobiological Institute TNO, Rijswijk, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111739443","display_name":"Rik J. Scheper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. J. Scheper","raw_affiliation_strings":["Department of Pathology of the Free University Hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology of the Free University Hospital, Amsterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030599438","display_name":"Hans Herweijer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267285","display_name":"Daniel den Hoed Kliniek","ror":"https://ror.org/020rz5h24","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908","https://openalex.org/I4405267285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H. Herweijer","raw_affiliation_strings":["Daniel den Hoed Cancer Centre, Rotterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daniel den Hoed Cancer Centre, Rotterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405267285"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108071901","display_name":"Kees Nooter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"K. Nooter","raw_affiliation_strings":["Radiobiological Institute TNO, Rijswijk, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiobiological Institute TNO, Rijswijk, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108071901"],"corresponding_institution_ids":["https://openalex.org/I148297040"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.5564,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.85888657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"44","issue":"4","first_page":"722","last_page":"726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.843999981880188},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":1.0},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9269999861717224},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/drug-efflux-pumps","display_name":"drug efflux pumps","score":0.6930000185966492},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.9126765727996826},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.8361178636550903},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.7838563323020935},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6750125288963318},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.587049126625061},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.5841252207756042},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5662288665771484},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5133227705955505},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5073367953300476},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5027012825012207},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4461211860179901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4433667063713074},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3524000346660614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32936328649520874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.258012056350708},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.22424587607383728},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20462334156036377},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19801419973373413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1897621750831604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1664409637451172},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.060285598039627075},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ijc.2910440428","doi":"https://doi.org/10.1002/ijc.2910440428","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910440428","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:2477337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2477337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Comparative Study"},{"id":"pmh:oai:oai-pmh.tno.nl:71068","doi":null,"is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:1aa7a120-c555-4cee-948a-7869995f875b","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Cancer, 44(4), pp. 722-726.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W101324336","https://openalex.org/W1510707687","https://openalex.org/W1559612378","https://openalex.org/W1595352454","https://openalex.org/W1596954277","https://openalex.org/W1983532335","https://openalex.org/W1990205754","https://openalex.org/W2012306261","https://openalex.org/W2024463580","https://openalex.org/W2028533496","https://openalex.org/W2029185839","https://openalex.org/W2030686317","https://openalex.org/W2034031399","https://openalex.org/W2039790110","https://openalex.org/W2042134248","https://openalex.org/W2059468917","https://openalex.org/W2118069529","https://openalex.org/W2127261170","https://openalex.org/W2131154307","https://openalex.org/W2131283629","https://openalex.org/W2140927361","https://openalex.org/W2152029190","https://openalex.org/W2161663775","https://openalex.org/W2170255900","https://openalex.org/W2223026985","https://openalex.org/W2257345960","https://openalex.org/W2264155967","https://openalex.org/W2415697067","https://openalex.org/W4253385789"],"related_works":["https://openalex.org/W2414672022","https://openalex.org/W2060146469","https://openalex.org/W1974257876","https://openalex.org/W2130613069","https://openalex.org/W1969134786","https://openalex.org/W2045032952","https://openalex.org/W2055830737","https://openalex.org/W2030340955","https://openalex.org/W2095146403","https://openalex.org/W2056755959"],"abstract_inverted_index":{"Multidrug-resistance":[0],"(MDR)":[1],"is":[2,18],"characterized":[3],"by":[4,42],"the":[5,14,50,97],"presence":[6],"of":[7,52,58,71,77,88,99,107,117,122,136,144],"a":[8,82,105],"170":[9],"kDa":[10],"glycoprotein":[11],"(P-glycoprotein)":[12],"in":[13,31,36,61,81,128],"plasma":[15],"membrane.":[16],"P-glycoprotein":[17],"thought":[19],"to":[20,27,110],"act":[21],"as":[22],"an":[23],"efflux":[24],"pump,":[25],"leading":[26],"reduced":[28],"drug":[29,37,93,123],"accumulation":[30,38,79,94],"MDR":[32],"cells.":[33],"This":[34,125],"defect":[35],"can":[39],"be":[40,139],"overcome":[41],"membrane":[43],"transport":[44],"modulating":[45],"agents":[46],"(MTMAs).":[47],"We":[48],"determined":[49],"concentration":[51],"MTMA":[53,89,118],"needed":[54,90,113],"for":[55,91,119,141],"maximal":[56,92,120],"restoration":[57,121],"daunorubicin":[59,78],"content":[60],"4":[62],"Chinese":[63],"hamster":[64],"ovary":[65],"cell":[66],"lines":[67],"with":[68,96],"increasing":[69],"levels":[70],"drug-resistance":[72],"using":[73],"flow":[74],"cytometry.":[75],"Stimulation":[76],"occurred":[80],"dose-dependent":[83],"manner.":[84],"The":[85],"required":[86],"level":[87,98,106],"increased":[95],"drug-resistance.":[100],"CHrA3":[101],"cells,":[102],"which":[103],"have":[104],"resistance":[108],"comparable":[109],"clinical":[111],"samples,":[112],"relatively":[114],"low":[115,134],"concentrations":[116],"accumulation.":[124],"indicates":[126],"that,":[127],"trial":[129],"combining":[130],"drugs":[131],"and":[132],"MTMAs,":[133],"dosages":[135],"MTMAs":[137],"could":[138],"sufficient":[140],"optimal":[142],"potentiation":[143],"cytotoxicity.":[145]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}