{"id":"https://openalex.org/W2157516374","doi":"https://doi.org/10.1182/blood-2011-09-377291","title":"Getting to know JAK","display_name":"Getting to know JAK","publication_year":2011,"publication_date":"2011-12-08","ids":{"openalex":"https://openalex.org/W2157516374","doi":"https://doi.org/10.1182/blood-2011-09-377291","mag":"2157516374","pmid":"https://pubmed.ncbi.nlm.nih.gov/22161849"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2011-09-377291","doi":"https://doi.org/10.1182/blood-2011-09-377291","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2011-09-377291","pdf_url":"https://ashpublications.org/blood/article-pdf/118/24/6235/1342867/zh805011006235.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/118/24/6235/1342867/zh805011006235.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hal E. Broxmeyer","raw_affiliation_strings":["INDIANA UNIVERSITY SCHOOL OF MEDICINE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INDIANA UNIVERSITY SCHOOL OF MEDICINE","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038161052"],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.4589,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6654107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"118","issue":"24","first_page":"6235","last_page":"6237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.984000027179718},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/jak-signaling","display_name":"JAK signaling","score":0.7020000219345093},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41004231572151184}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2011-09-377291","doi":"https://doi.org/10.1182/blood-2011-09-377291","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2011-09-377291","pdf_url":"https://ashpublications.org/blood/article-pdf/118/24/6235/1342867/zh805011006235.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:22161849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22161849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2011-09-377291","doi":"https://doi.org/10.1182/blood-2011-09-377291","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2011-09-377291","pdf_url":"https://ashpublications.org/blood/article-pdf/118/24/6235/1342867/zh805011006235.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157516374.pdf","grobid_xml":"https://content.openalex.org/works/W2157516374.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1487246151","https://openalex.org/W1554788037","https://openalex.org/W1978572762","https://openalex.org/W1981541713","https://openalex.org/W1993672020","https://openalex.org/W2016044492","https://openalex.org/W2023869144","https://openalex.org/W2040664937","https://openalex.org/W2068054277","https://openalex.org/W2128045505","https://openalex.org/W2291193566","https://openalex.org/W2499823508"],"related_works":["https://openalex.org/W2040664937","https://openalex.org/W2334791228","https://openalex.org/W2549594786","https://openalex.org/W2979396204","https://openalex.org/W2165542165","https://openalex.org/W2728073471","https://openalex.org/W2577874016","https://openalex.org/W2013781518","https://openalex.org/W2548099047","https://openalex.org/W4224141466"],"abstract_inverted_index":{"Neoplastic":[0],"clone":[1,24],"dominance":[2,25],"is":[3,26],"key":[4],"to":[5,28,33],"disease":[6],"progression.":[7],"In":[8],"this":[9],"issue":[10],"of":[11,36],"Blood":[12],",":[13],"Fleischman":[14],"et":[15],"al":[16],"suggest":[17],"that":[18],"in":[19],"myeloproliferative":[20],"neoplasms":[21],"(MPNs),":[22],"neoplastic":[23],"linked":[27],"JAK2V617F":[29],"effects":[30],"on":[31],"responsiveness":[32],"and":[34],"production":[35],"tumor":[37],"necrosis":[38],"factor":[39],"(TNF)\u2013\u03b1.[1][1]\n\nThis":[40]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}