{"id":"https://openalex.org/W2157446889","doi":"https://doi.org/10.1046/j.1365-2222.1999.00710.x","title":"Effects of ONO\u20101078 (pranlukast) on cytokine production in peripheral blood mononuclear cells of patients with bronchial asthma","display_name":"Effects of ONO\u20101078 (pranlukast) on cytokine production in peripheral blood mononuclear cells of patients with bronchial asthma","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W2157446889","doi":"https://doi.org/10.1046/j.1365-2222.1999.00710.x","mag":"2157446889","pmid":"https://pubmed.ncbi.nlm.nih.gov/10520082"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2222.1999.00710.x","doi":"https://doi.org/10.1046/j.1365-2222.1999.00710.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2222.1999.00710.x","pdf_url":null,"source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical &amp; Experimental Allergy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5096390137","display_name":"Tohda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tohda","raw_affiliation_strings":["Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111974327","display_name":"Nakahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nakahara","raw_affiliation_strings":["Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060426531","display_name":"Kubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kubo","raw_affiliation_strings":["Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haraguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haraguchi","raw_affiliation_strings":["Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038730057","display_name":"Fukuoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fukuoka","raw_affiliation_strings":["Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113685748","display_name":"Nakajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nakajima","raw_affiliation_strings":["Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fourth Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5096390137"],"corresponding_institution_ids":["https://openalex.org/I916559398"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":3.2099,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.92179302,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"11","first_page":"1532","last_page":"1536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pranlukast","display_name":"pranlukast","score":0.9909999966621399},{"id":"https://openalex.org/keywords/leukotriene-receptor-antagonists","display_name":"leukotriene receptor antagonists","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cysteinyl-leukotriene-receptor","display_name":"cysteinyl leukotriene receptor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.9010000228881836},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8650000095367432},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.996999979019165},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mite-allergens","display_name":"mite allergens","score":0.8130000233650208},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.7409999966621399},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.8910089731216431},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.633730411529541},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6285187005996704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5789029598236084},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5522161722183228},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.511639416217804},{"id":"https://openalex.org/C2778166374","wikidata":"https://www.wikidata.org/wiki/Q29938","display_name":"House dust mite","level":4,"score":0.49698880314826965},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4404149651527405},{"id":"https://openalex.org/C2780212800","wikidata":"https://www.wikidata.org/wiki/Q20708039","display_name":"Leukotriene receptor","level":4,"score":0.4395899176597595},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.41924968361854553},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.389908105134964},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.3611176311969757},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.338631808757782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2880699038505554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.277574360370636},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.22565481066703796},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19779619574546814},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10608339309692383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008925","descriptor_name":"Mites","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020024","descriptor_name":"Leukotriene Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2222.1999.00710.x","doi":"https://doi.org/10.1046/j.1365-2222.1999.00710.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2222.1999.00710.x","pdf_url":null,"source":{"id":"https://openalex.org/S17239246","display_name":"Clinical & Experimental Allergy","issn_l":"0954-7894","issn":["0954-7894","1365-2222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical &amp; Experimental Allergy","raw_type":"journal-article"},{"id":"pmid:10520082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10520082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1900718892","https://openalex.org/W1971569966","https://openalex.org/W1996425731","https://openalex.org/W2002196299","https://openalex.org/W2004351423","https://openalex.org/W2028836971","https://openalex.org/W2040813704","https://openalex.org/W2041888971","https://openalex.org/W2045588181","https://openalex.org/W2051656004","https://openalex.org/W2057733959","https://openalex.org/W2092868458","https://openalex.org/W2141574695","https://openalex.org/W2146643436","https://openalex.org/W2151732433","https://openalex.org/W2413693046"],"related_works":["https://openalex.org/W1976504120","https://openalex.org/W2394793141","https://openalex.org/W2039340152","https://openalex.org/W2005438099","https://openalex.org/W2160596532","https://openalex.org/W2404430635","https://openalex.org/W2117925017","https://openalex.org/W2064741078","https://openalex.org/W2120918675","https://openalex.org/W2118378443"],"abstract_inverted_index":{"BACKGROUND:":[0],"ONO-1078":[1,135,174,186,299,340],"(pranlukast)":[2],"is":[3],"a":[4,176,250],"leukotriene":[5,198],"receptor":[6,207],"antagonist":[7,208],"developed":[8],"in":[9,19,42,78,125,238,266,330,344],"Japan.":[10],"This":[11],"drug":[12,36],"has":[13],"been":[14],"shown":[15],"to":[16,30,93,98,147,173,245],"be":[17,342],"useful":[18,343],"oral":[20],"treatment":[21,346],"of":[22,34,40,48,81,88,128,144,153,178,197,216,228,252,289,303,336,347],"bronchial":[23,333,348],"asthma.":[24,268,334,349],"The":[25,86,182,240],"present":[26],"study":[27],"was":[28,91,166],"undertaken":[29],"assess":[31],"the":[32,38,43,79,89,117,126,145,149,205,229,246,301,345],"effects":[33],"this":[35],"on":[37,189,200],"production":[39,302],"cytokines":[41,219],"peripheral":[44,112,190,321],"blood":[45,59,113,191,201,263,322],"mononuclear":[46,60,114,159,192,202,323],"cells":[47,61,115,160,193,203,324],"patients":[49,66,119,331],"with":[50,54,163,327,332],"asthma":[51],"under":[52,161,325],"stimulation":[53,162,326],"specific":[55,328],"antigens.":[56],"METHODS:":[57],"Peripheral":[58],"from":[62,116,291],"mite":[63,82,130,164,236],"antigen-positive":[64],"asthmatic":[65],"(immunoglobulin":[67],"E":[68],"RAST":[69],"score":[70],">":[71],"3)":[72],"were":[73,120,171],"incubated":[74,121],"for":[75,122],"72":[76,123],"h":[77,124],"presence":[80,127],"antigen":[83,131,165],"(10":[84,132],"microg/mL).":[85],"supernatant":[87,146],"culture":[90],"subjected":[92],"enzyme-linked":[94],"immunosorbent":[95],"assay":[96],"(ELISA)":[97],"quantify":[99,148],"interleukin":[100],"(IL)":[101],"-4,":[102],"IL-3,":[103],"IL-5,":[104,155,312],"and":[105,134,156,194,223,256,262,313],"granulocyte":[106],"macrophage-colony":[107],"stimulating":[108],"factor":[109],"(GM-CSF).":[110],"Other":[111],"same":[118],"both":[129],"microg/mL)":[133],"(0.5,":[136],"1,":[137],"or":[138],"10":[139,179],"microg/mL),":[140],"followed":[141],"by":[142,158,204,235,248,320],"ELISA":[143],"cytokines.":[150],"RESULTS:":[151],"Production":[152],"IL-4,":[154,221],"GM-CSF":[157,314],"markedly":[167],"suppressed":[168],"when":[169,233],"they":[170],"exposed":[172],"at":[175],"concentration":[177],"microg/mL.":[180],"CONCLUSION:":[181],"results":[183],"suggest":[184],"that":[185,195,274,283,298,307,316],"acts":[187],"directly":[188],"blockade":[196],"receptors":[199],"cysteinyl-leukotriene":[206],"(LTRA)":[209],"pranlukast":[210],"(ONO-1078)":[211],"can":[212,258],"dose-dependently":[213],"inhibit":[214],"release":[215,288],"immunoreactive":[217],"TH2-type":[218],"(IL-3,":[220],"GM-CSF,":[222],"possibly":[224],"IL-5),":[225],"but":[226],"not":[227],"TH1-type":[230],"cytokine":[231,306],"IL-2,":[232],"stimulated":[234],"allergen":[237],"vitro.":[239],"data":[241],"may":[242,285],"provide":[243],"clues":[244],"mechanism":[247],"which":[249],"number":[251],"LTRA":[253],"including":[254],"zafirulukast":[255],"montelukast":[257],"reduce":[259],"airway,":[260],"sputum":[261],"eosinophil":[264,318],"counts":[265],"clinical":[267],"It":[269],"supports":[270],"animal":[271],"studies":[272],"showing":[273],"anti-IL-5":[275],"antibodies":[276],"partially":[277],"block":[278],"cys-LT-induced":[279],"airway":[280],"eosinophilia,":[281],"suggesting":[282],"cys-LTs":[284],"cause":[286],"secondary":[287],"IL-5":[290],"an":[292],"unknown":[293],"cell-type.":[294],"These":[295],"findings":[296],"indicate":[297],"suppresses":[300],"IL-4":[304],"(a":[305],"affects":[308],"IgG":[309],"antibody":[310],"production),":[311],"(cytokines":[315],"affect":[317],"activation)":[319],"antigens":[329],"Because":[335],"its":[337],"anti-inflammatory":[338],"effects,":[339],"should":[341]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
