{"id":"https://openalex.org/W2157443792","doi":"https://doi.org/10.1002/jemt.10192","title":"Regulation of gene expression for neurotransmitters during adaptation to hypoxia in oxygen\u2010sensitive neuroendocrine cells","display_name":"Regulation of gene expression for neurotransmitters during adaptation to hypoxia in oxygen\u2010sensitive neuroendocrine cells","publication_year":2002,"publication_date":"2002-10-16","ids":{"openalex":"https://openalex.org/W2157443792","doi":"https://doi.org/10.1002/jemt.10192","mag":"2157443792","pmid":"https://pubmed.ncbi.nlm.nih.gov/12384962"},"language":"en","primary_location":{"id":"doi:10.1002/jemt.10192","doi":"https://doi.org/10.1002/jemt.10192","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jemt.10192","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jemt.10192","source":{"id":"https://openalex.org/S6191820","display_name":"Microscopy Research and Technique","issn_l":"1059-910X","issn":["1059-910X","1097-0029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy Research and Technique","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jemt.10192","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001040461","display_name":"Waltke R. Paulding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Waltke R. Paulding","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576, USA","Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Phillip O. Schnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip O. Schnell","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063610665","display_name":"Amy L. Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy L. Bauer","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084527167","display_name":"Justin B. Striet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin B. Striet","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James A. Nash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Nash","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017353478","display_name":"Anna Victorovna Kuznetsova","orcid":"https://orcid.org/0000-0002-0297-7013","observed_orcids":["https://orcid.org/0000-0002-0297-7013"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna V. Kuznetsova","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001544425","display_name":"Maria Czyzyk-Krzeska","orcid":"https://orcid.org/0000-0002-0693-8214","observed_orcids":["https://orcid.org/0000-0002-0693-8214"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maria F. Czyzyk\u2010Krzeska","raw_affiliation_strings":["Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001544425"],"corresponding_institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.3152,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.32773109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"59","issue":"3","first_page":"178","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/carotid-body","display_name":"carotid body","score":0.972000002861023},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.8610000014305115},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroendocrine-cells","display_name":"neuroendocrine cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hypoxia-adaptation","display_name":"hypoxia adaptation","score":0.5860000252723694},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/subtractive-cdna-library","display_name":"subtractive cDNA library","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7003387212753296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6648238301277161},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6029505133628845},{"id":"https://openalex.org/C2778113364","wikidata":"https://www.wikidata.org/wiki/Q1532008","display_name":"Carotid body","level":3,"score":0.5387986302375793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5229209661483765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49895286560058594},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.4600076973438263},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.454993337392807},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4356904923915863},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2878127992153168},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2867119312286377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2759549915790558},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.25674736499786377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23330354690551758},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.22229960560798645},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002344","descriptor_name":"Carotid Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002344","descriptor_name":"Carotid Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002344","descriptor_name":"Carotid Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jemt.10192","doi":"https://doi.org/10.1002/jemt.10192","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jemt.10192","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jemt.10192","source":{"id":"https://openalex.org/S6191820","display_name":"Microscopy Research and Technique","issn_l":"1059-910X","issn":["1059-910X","1097-0029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy Research and Technique","raw_type":"journal-article"},{"id":"pmid:12384962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12384962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy research and technique","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jemt.10192","doi":"https://doi.org/10.1002/jemt.10192","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jemt.10192","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jemt.10192","source":{"id":"https://openalex.org/S6191820","display_name":"Microscopy Research and Technique","issn_l":"1059-910X","issn":["1059-910X","1097-0029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy Research and Technique","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1885296625","display_name":null,"funder_award_id":"HL-66312","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2378476752","display_name":null,"funder_award_id":"HL-58687","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2405704844","display_name":"Regulation of Cell Function by Intermittent Hypoxia","funder_award_id":"R01HL066312","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5146823412","display_name":"Regulation Of Gene Expression By Oxygen","funder_award_id":"5r01hl058687-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157443792.pdf","grobid_xml":"https://content.openalex.org/works/W2157443792.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1237432627","https://openalex.org/W1523374635","https://openalex.org/W1538325952","https://openalex.org/W1543673067","https://openalex.org/W1567708878","https://openalex.org/W1571575178","https://openalex.org/W1573326691","https://openalex.org/W1585324794","https://openalex.org/W1681249975","https://openalex.org/W1749022239","https://openalex.org/W1779005595","https://openalex.org/W1789910835","https://openalex.org/W1927873495","https://openalex.org/W1964037605","https://openalex.org/W1966563762","https://openalex.org/W1967194906","https://openalex.org/W1968768609","https://openalex.org/W1969269984","https://openalex.org/W1970386234","https://openalex.org/W1970587959","https://openalex.org/W1970684904","https://openalex.org/W1975041666","https://openalex.org/W1976081377","https://openalex.org/W1976487077","https://openalex.org/W1978173977","https://openalex.org/W1983652184","https://openalex.org/W1984521310","https://openalex.org/W1986464453","https://openalex.org/W1988935612","https://openalex.org/W1991607763","https://openalex.org/W1993034847","https://openalex.org/W1993528388","https://openalex.org/W1998162485","https://openalex.org/W2002196079","https://openalex.org/W2008552065","https://openalex.org/W2009451093","https://openalex.org/W2010057452","https://openalex.org/W2011135037","https://openalex.org/W2015083014","https://openalex.org/W2019137147","https://openalex.org/W2019646726","https://openalex.org/W2021907907","https://openalex.org/W2022773473","https://openalex.org/W2023113394","https://openalex.org/W2024564719","https://openalex.org/W2025704372","https://openalex.org/W2025974453","https://openalex.org/W2027685228","https://openalex.org/W2028318252","https://openalex.org/W2030165213","https://openalex.org/W2030626909","https://openalex.org/W2033830908","https://openalex.org/W2035204516","https://openalex.org/W2040031153","https://openalex.org/W2046184823","https://openalex.org/W2046407288","https://openalex.org/W2048932314","https://openalex.org/W2051626627","https://openalex.org/W2054864887","https://openalex.org/W2057174409","https://openalex.org/W2057808940","https://openalex.org/W2060449732","https://openalex.org/W2063856939","https://openalex.org/W2071140879","https://openalex.org/W2074358810","https://openalex.org/W2074669923","https://openalex.org/W2075054245","https://openalex.org/W2077868571","https://openalex.org/W2080374319","https://openalex.org/W2083323577","https://openalex.org/W2084419608","https://openalex.org/W2090351704","https://openalex.org/W2091314865","https://openalex.org/W2091579267","https://openalex.org/W2101188502","https://openalex.org/W2102476325","https://openalex.org/W2106805091","https://openalex.org/W2108366666","https://openalex.org/W2110269430","https://openalex.org/W2114168383","https://openalex.org/W2116033894","https://openalex.org/W2137164567","https://openalex.org/W2138905350","https://openalex.org/W2143343444","https://openalex.org/W2144625075","https://openalex.org/W2147718842","https://openalex.org/W2149268957","https://openalex.org/W2153853866","https://openalex.org/W2154683372","https://openalex.org/W2154823420","https://openalex.org/W2154892885","https://openalex.org/W2159310780","https://openalex.org/W2172170481","https://openalex.org/W2182617772","https://openalex.org/W2203057300","https://openalex.org/W2216173657","https://openalex.org/W2267946346","https://openalex.org/W2272744191","https://openalex.org/W2278934279","https://openalex.org/W2326288531","https://openalex.org/W2341489134","https://openalex.org/W2413945329","https://openalex.org/W2600398157"],"related_works":["https://openalex.org/W2045849079","https://openalex.org/W2138662052","https://openalex.org/W1964528955","https://openalex.org/W2026554061","https://openalex.org/W2065224080","https://openalex.org/W2971612552","https://openalex.org/W3108838680","https://openalex.org/W2187399274","https://openalex.org/W2443693435","https://openalex.org/W2008430621"],"abstract_inverted_index":{"Reduced":[0],"oxygen":[1],"tension":[2],"(hypoxia)":[3],"in":[4,10,35,46,70,104,108,160],"the":[5,11,19,36,47,52,56,81,94,105,109,133,161],"environment":[6],"stimulates":[7],"oxygen-sensitive":[8,110],"cells":[9],"carotid":[12],"body":[13],"(CB).":[14],"Upon":[15],"exposure":[16],"to":[17,31,55,76,153],"hypoxia,":[18,137],"CB":[20,40,106],"immediately":[21],"triggers":[22],"a":[23,144],"reflexive":[24],"physiological":[25],"response,":[26],"thereby":[27],"increasing":[28],"respiration.":[29],"Adaptation":[30],"hypoxia":[32,77,103],"involves":[33],"changes":[34],"expression":[37,89,129,159],"of":[38,51,85,90,127,135,143,157],"various":[39],"genes,":[41],"whose":[42],"products":[43],"are":[44,67],"involved":[45],"transduction":[48],"and":[49,65,83,107],"modulation":[50],"hypoxic":[53],"signal":[54],"central":[57],"nervous":[58],"system":[59],"(CNS).":[60],"Genes":[61],"encoding":[62],"neurotransmitter-synthesizing":[63],"enzymes":[64],"receptors":[66],"particularly":[68],"important":[69],"this":[71],"regard.":[72],"The":[73,87],"cellular":[74],"response":[75],"correlates":[78],"closely":[79],"with":[80],"release":[82],"biosynthesis":[84],"catecholamines.":[86],"gene":[88,128,158],"tyrosine":[91],"hydroxylase":[92],"(TH),":[93],"rate-limiting":[95],"enzyme":[96],"for":[97],"catecholamine":[98],"biosynthesis,":[99],"is":[100],"regulated":[101,123],"by":[102,124],"cultured":[111],"PC12":[112],"cell":[113],"line.":[114],"Recently,":[115],"genomic":[116],"microarray":[117],"studies":[118],"have":[119],"identified":[120],"additional":[121],"genes":[122],"hypoxia.":[125],"Patterns":[126],"vary,":[130],"depending":[131],"on":[132],"type":[134],"applied":[136],"e.g.,":[138],"intermittent":[139],"vs.":[140],"chronic.":[141],"Construction":[142],"hypoxia-regulated,":[145],"CB-specific,":[146],"subtractive":[147],"cDNA":[148],"library":[149],"will":[150],"enable":[151],"us":[152],"further":[154],"characterize":[155],"regulation":[156],"CB.":[162]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
