{"id":"https://openalex.org/W2157441587","doi":"https://doi.org/10.1186/bcr3609","title":"Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer","display_name":"Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer","publication_year":2014,"publication_date":"2014-01-29","ids":{"openalex":"https://openalex.org/W2157441587","doi":"https://doi.org/10.1186/bcr3609","mag":"2157441587","pmid":"https://pubmed.ncbi.nlm.nih.gov/24472707","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3978891"},"language":"en","primary_location":{"id":"doi:10.1186/bcr3609","doi":"https://doi.org/10.1186/bcr3609","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3609","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3609","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3609","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112771700","display_name":"Armina A. Kazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I165556055","display_name":"Loyola University Maryland","ror":"https://ror.org/01by1wp65","country_code":"US","type":"education","lineage":["https://openalex.org/I165556055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armina A Kazi","raw_affiliation_strings":["Department of Biology, Loyola University Maryland, Baltimore, MD, 21210, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","Department of Biology, Loyola University Maryland, Baltimore, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Loyola University Maryland, Baltimore, MD, 21210, USA","institution_ids":["https://openalex.org/I165556055"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Biology, Loyola University Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I165556055"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109405553","display_name":"Rabia Afzal Gilani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rabia A Gilani","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014065158","display_name":"Amanda J. Schech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda J Schech","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052187738","display_name":"Saranya Chumsri","orcid":"https://orcid.org/0000-0001-7117-1446","observed_orcids":["https://orcid.org/0000-0001-7117-1446"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saranya Chumsri","raw_affiliation_strings":["Department of Medicine, University of Maryland, Baltimore, MD, 21201, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","Department of Medicine, University of Maryland, Baltimore, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I4390039317"]},{"raw_affiliation_string":"Department of Medicine, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA","institution_ids":["https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072945710","display_name":"Gauri J. Sabnis","orcid":"https://orcid.org/0000-0001-8703-9394","observed_orcids":["https://orcid.org/0000-0001-8703-9394"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gauri Sabnis","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I4390039317"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA","institution_ids":["https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112906086","display_name":"Preeti Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Preeti Shah","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I4390039317"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA","institution_ids":["https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012068082","display_name":"Olga G. Goloubeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Goloubeva","raw_affiliation_strings":["Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, 21201, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health, University of Maryland, Baltimore, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I4390039317"]},{"raw_affiliation_string":"Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA","institution_ids":["https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112830508","display_name":"Shari S. Kronsberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shari Kronsberg","raw_affiliation_strings":["Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, 21201, USA","Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health, University of Maryland, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Division of Biostatistics and Bioinformatics Department of Epidemiology and Public Health, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113646543","display_name":"Angela Brodie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Angela H Brodie","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Health Science Facilities, Room 580G, 685 West Baltimore Street, Baltimore, MD, 21201, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Health Science Facilities, Baltimore, USA","Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Health Science Facilities, Room 580G, 685 West Baltimore Street, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, USA","institution_ids":["https://openalex.org/I4390039317"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Health Science Facilities, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"School of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA","institution_ids":["https://openalex.org/I4390039317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113646543"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.4933,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.80660473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"1","first_page":"R15","last_page":"R15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.19509999454021454,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.16279999911785126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aromatase-inhibitor-resistance","display_name":"aromatase inhibitor resistance","score":0.9760000109672546},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.8610000014305115},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.6840000152587891},{"id":"https://openalex.org/keywords/letrozole","display_name":"letrozole","score":0.7429999709129333},{"id":"https://openalex.org/keywords/exemestane","display_name":"exemestane","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.7570000290870667},{"id":"https://openalex.org/keywords/her2-inhibitors","display_name":"HER2 inhibitors","score":0.5839999914169312},{"id":"https://openalex.org/keywords/hif-1-target-genes","display_name":"HIF-1 target genes","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.7972863912582397},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.7916523814201355},{"id":"https://openalex.org/C2778504769","wikidata":"https://www.wikidata.org/wiki/Q3040305","display_name":"Aromatase inhibitor","level":5,"score":0.7801913022994995},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7414650917053223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6255024075508118},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5158211588859558},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5119034051895142},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.5041862726211548},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4798007309436798},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.479413241147995},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3056151568889618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2054905891418457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17672526836395264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11227288842201233},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08971387147903442},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077289","descriptor_name":"Letrozole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077289","descriptor_name":"Letrozole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077289","descriptor_name":"Letrozole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058539","descriptor_name":"Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058539","descriptor_name":"Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058539","descriptor_name":"Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/bcr3609","doi":"https://doi.org/10.1186/bcr3609","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3609","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3609","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2961347","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3978891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3978891","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3978891","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Res","raw_type":"Text"},{"id":"pmid:24472707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24472707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research : BCR","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/bcr3609","doi":"https://doi.org/10.1186/bcr3609","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3609","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3609","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157441587.pdf","grobid_xml":"https://content.openalex.org/works/W2157441587.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1508497000","https://openalex.org/W1547961512","https://openalex.org/W1756471771","https://openalex.org/W1911110831","https://openalex.org/W1937401270","https://openalex.org/W1965484665","https://openalex.org/W1971877556","https://openalex.org/W1971995358","https://openalex.org/W1972708811","https://openalex.org/W1974024530","https://openalex.org/W1976783896","https://openalex.org/W1987523323","https://openalex.org/W1993220341","https://openalex.org/W1995197723","https://openalex.org/W1996965514","https://openalex.org/W1997971145","https://openalex.org/W1999817838","https://openalex.org/W2002855714","https://openalex.org/W2010959069","https://openalex.org/W2011810742","https://openalex.org/W2011925462","https://openalex.org/W2013064901","https://openalex.org/W2014129554","https://openalex.org/W2015473392","https://openalex.org/W2021381932","https://openalex.org/W2021422667","https://openalex.org/W2023068637","https://openalex.org/W2024788439","https://openalex.org/W2026151244","https://openalex.org/W2031082923","https://openalex.org/W2031423398","https://openalex.org/W2049579456","https://openalex.org/W2054605167","https://openalex.org/W2060668357","https://openalex.org/W2062130939","https://openalex.org/W2067382049","https://openalex.org/W2072839085","https://openalex.org/W2073797382","https://openalex.org/W2074437753","https://openalex.org/W2075997152","https://openalex.org/W2076174476","https://openalex.org/W2078793320","https://openalex.org/W2081522216","https://openalex.org/W2085921275","https://openalex.org/W2091068407","https://openalex.org/W2093395282","https://openalex.org/W2095180859","https://openalex.org/W2100665415","https://openalex.org/W2103038661","https://openalex.org/W2104711019","https://openalex.org/W2106955083","https://openalex.org/W2111942099","https://openalex.org/W2113761994","https://openalex.org/W2118754663","https://openalex.org/W2120090919","https://openalex.org/W2131638827","https://openalex.org/W2133503038","https://openalex.org/W2136096813","https://openalex.org/W2138935527","https://openalex.org/W2139290609","https://openalex.org/W2140102023","https://openalex.org/W2142786915","https://openalex.org/W2144816570","https://openalex.org/W2147514757","https://openalex.org/W2148194696","https://openalex.org/W2151447010","https://openalex.org/W2152800203","https://openalex.org/W2156453405","https://openalex.org/W2158916045","https://openalex.org/W2164609052","https://openalex.org/W2164895949","https://openalex.org/W2170682201","https://openalex.org/W2264818022"],"related_works":["https://openalex.org/W2048299941","https://openalex.org/W1553670245","https://openalex.org/W2074437753","https://openalex.org/W4234733315","https://openalex.org/W2026151244","https://openalex.org/W2082957731","https://openalex.org/W3090236488","https://openalex.org/W2111586606","https://openalex.org/W2317948341","https://openalex.org/W2001979603"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Although":[1],"aromatase":[2],"inhibitors":[3,202,222,281],"(AIs;":[4],"for":[5,339],"example,":[6],"letrozole)":[7],"are":[8,240],"highly":[9],"effective":[10],"in":[11,102,133,158,194,242,248,258,331],"treating":[12],"estrogen":[13],"receptor":[14],"positive":[15],"(ER+)":[16],"breast":[17,183,292],"cancer,":[18],"a":[19,44,192,343],"significant":[20],"percentage":[21],"of":[22,68,73,94,131,150,213,225,270,289,296,302,312,315,322,345],"patients":[23],"either":[24],"do":[25],"not":[26],"respond":[27],"to":[28,33,41,51,125,143,174,203,209,227],"AIs":[29,42],"or":[30,83,118,223,287],"become":[31],"resistant":[32],"them.":[34],"Previous":[35],"studies":[36,114],"suggest":[37],"that":[38,77,188],"acquired":[39,103],"resistance":[40,185,317],"involves":[43],"switch":[45],"from":[46],"dependence":[47,52],"on":[48,53],"ER":[49],"signaling":[50],"growth":[54,61],"factor-mediated":[55],"pathways,":[56,206],"such":[57,181,327],"as":[58,81,182,274,328,342],"human":[59],"epidermal":[60],"factor":[62,96,99],"receptor-2":[63],"(HER2).":[64],"However,":[65],"the":[66,71,91,127,211,313],"role":[67,93,130,193],"HER2,":[69,152,204],"and":[70,106,120,129,138,146,153,207,215,235,238,244,282,300,346],"identity":[72],"other":[74],"relevant":[75],"factors":[76],"may":[78,189,318],"be":[79,319,336],"used":[80],"biomarkers":[82],"therapeutic":[84,347],"targets":[85],"remain":[86],"unknown.":[87],"This":[88],"study":[89],"investigated":[90],"potential":[92,341],"transcription":[95],"hypoxia":[97],"inducible":[98],"1":[100],"(HIF-1)":[101],"AI":[104,116,134,195,298,316],"resistance,":[105],"its":[107,229,275,340],"regulation":[108,128,212,321],"by":[109,264,279],"HER2.":[110],"METHODS:":[111],"In":[112],"vitro":[113],"using":[115],"(letrozole":[117],"exemestane)-resistant":[119],"AI-sensitive":[121,161],"cells":[122,198,218,246,252,260],"were":[123,141,166,199,219],"conducted":[124,142],"investigate":[126],"HIF-1":[132,156,178,214,324,334],"resistance.":[135,196],"Western":[136],"blot":[137],"RT-PCR":[139],"analyses":[140,165],"compare":[144],"protein":[145,186,234,239],"mRNA":[147,237],"expression,":[148],"respectively,":[149],"ER\u03b1,":[151],"HIF-1\u03b1":[154,226,233,256,290],"(inducible":[155],"subunit)":[157],"AI-resistant":[159,243,259],"versus":[160],"cells.":[162],"Similar":[163],"expression":[164,257,276,295,301],"also":[167,190],"done,":[168],"along":[169],"with":[170,201,221],"chromatin":[171],"immunoprecipitation":[172],"(ChIP),":[173],"identify":[175],"previously":[176],"known":[177],"target":[179,269,325],"genes,":[180,326],"cancer":[184,293,303],"(BCRP),":[187],"play":[191],"Letrozole-resistant":[197],"treated":[200,220],"kinase":[205,267,283],"ER\u03b1":[208],"elucidate":[210],"BCRP.":[216,309],"Lastly,":[217],"inducers":[224],"determine":[228],"importance.":[230],"RESULTS:":[231],"Basal":[232],"BCRP":[236],"higher":[241],"HER2-transfected":[245],"than":[247],"AI-sensitive,":[249],"HER2-":[250],"parental":[251],"under":[253],"nonhypoxic":[254,323],"conditions.":[255],"is":[261],"likely":[262],"regulated":[263],"HER2":[265,280],"activated-phosphatidylinositide-3-kinase/Akt-protein":[266],"B/mammalian":[268],"rapamycin":[271],"(PI3K/Akt/mTOR)":[272],"pathway,":[273],"was":[277],"inhibited":[278],"pathway":[284],"inhibitors.":[285],"Inhibition":[286],"upregulation":[288],"affects":[291],"cell":[294,305],"BCRP;":[297],"responsiveness;":[299],"stem":[304],"characteristics,":[306],"partially":[307],"through":[308,320],"CONCLUSIONS:":[310],"One":[311],"mechanisms":[314],"BCRP,":[329],"implicated":[330],"chemoresistance.":[332],"Thus,":[333],"should":[335],"explored":[337],"further":[338],"biomarker":[344],"target.":[348]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}