{"id":"https://openalex.org/W2157429660","doi":"https://doi.org/10.1093/humrep/det450","title":"Ectopic pregnancy prediction in women with a pregnancy of unknown location: data beyond 48 h are necessary","display_name":"Ectopic pregnancy prediction in women with a pregnancy of unknown location: data beyond 48 h are necessary","publication_year":2013,"publication_date":"2013-12-18","ids":{"openalex":"https://openalex.org/W2157429660","doi":"https://doi.org/10.1093/humrep/det450","mag":"2157429660","pmid":"https://pubmed.ncbi.nlm.nih.gov/24352889","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3923510"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/det450","doi":"https://doi.org/10.1093/humrep/det450","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/det450","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3923510","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039697869","display_name":"Jarcy Zee","orcid":"https://orcid.org/0000-0003-0586-1160","observed_orcids":["https://orcid.org/0000-0003-0586-1160"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Zee","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020692170","display_name":"Mary Dupuis Sammel","orcid":"https://orcid.org/0000-0003-1248-4199","observed_orcids":["https://orcid.org/0000-0003-1248-4199"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. D. Sammel","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005357205","display_name":"Karine Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Chung","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016137378","display_name":"P\u00e9ter Tak\u00e1cs","orcid":"https://orcid.org/0000-0002-0078-5763","observed_orcids":["https://orcid.org/0000-0002-0078-5763"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Takacs","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Miami, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020389365","display_name":"Tom Bourne","orcid":"https://orcid.org/0000-0003-1421-6059","observed_orcids":["https://orcid.org/0000-0003-1421-6059"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"T. Bourne","raw_affiliation_strings":["Department of Cancer and Surgery, Imperial College London, London, UK","Department of Development and Regeneration, KU Leuven, Leuven, Belgium","Department of Obstetrics and Gynaecology, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer and Surgery, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Development and Regeneration, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053242908","display_name":"Kurt Thomas Barnhart","orcid":"https://orcid.org/0000-0002-9499-8144","observed_orcids":["https://orcid.org/0000-0002-9499-8144"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. T. Barnhart","raw_affiliation_strings":["Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA 19104, USA","Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA","Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5053242908"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":0.6143,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.73691437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"3","first_page":"441","last_page":"447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12096","display_name":"Ectopic Pregnancy Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12096","display_name":"Ectopic Pregnancy Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ectopic-pregnancy","display_name":"ectopic pregnancy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pregnancy-of-unknown-location","display_name":"pregnancy of unknown location","score":0.9980000257492065},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/first-trimester","display_name":"first trimester","score":0.5640000104904175},{"id":"https://openalex.org/keywords/early-pregnancy-bleeding","display_name":"early pregnancy bleeding","score":0.46299999952316284},{"id":"https://openalex.org/keywords/prediction-rules","display_name":"prediction rules","score":0.4519999921321869},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6079999804496765},{"id":"https://openalex.org/keywords/emergency-department-evaluation","display_name":"emergency department evaluation","score":0.46700000762939453},{"id":"https://openalex.org/keywords/missed-abortion","display_name":"missed abortion","score":0.4009999930858612},{"id":"https://openalex.org/keywords/miscarriage","display_name":"miscarriage","score":0.6779999732971191},{"id":"https://openalex.org/keywords/intrauterine-pregnancy","display_name":"intrauterine pregnancy","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7817544341087341},{"id":"https://openalex.org/C2776018949","wikidata":"https://www.wikidata.org/wiki/Q207087","display_name":"Ectopic pregnancy","level":3,"score":0.7323966026306152},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6979123950004578},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5653882622718811},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5498769283294678},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.4804779589176178},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47026166319847107},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.46153080463409424},{"id":"https://openalex.org/C3019714739","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"First trimester","level":4,"score":0.45124292373657227},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.43764206767082214},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.26305699348449707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.181221604347229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011261","descriptor_name":"Pregnancy Trimester, First","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011271","descriptor_name":"Pregnancy, Ectopic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011271","descriptor_name":"Pregnancy, Ectopic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016216","descriptor_name":"Ultrasonography, Prenatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/humrep/det450","doi":"https://doi.org/10.1093/humrep/det450","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/det450","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3306328","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3923510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3923510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3923510","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Reprod","raw_type":"Text"},{"id":"pmid:24352889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24352889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1011.1819","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1011.1819","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://humrep.oxfordjournals.org/content/early/2013/12/18/humrep.det450.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1032.9483","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1032.9483","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://humrep.oxfordjournals.org/content/29/3/441.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3306328","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3923510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1043661453","display_name":"Midcareer investigator award in patient oriented research","funder_award_id":"K24HD060687","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4312350252","display_name":"Risk factors as predictors of ectopic pregnancy","funder_award_id":"R01HD036455","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7747718756","display_name":"Development of a serum biosignature for ectopic pregnancy.","funder_award_id":"R01HD076279","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8526135146","display_name":"Mental Health Biostatistics Training Grant","funder_award_id":"T32MH065218","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1968320037","https://openalex.org/W1975773129","https://openalex.org/W1978335116","https://openalex.org/W2012891879","https://openalex.org/W2014266411","https://openalex.org/W2027267404","https://openalex.org/W2042140551","https://openalex.org/W2063434807","https://openalex.org/W2072127724","https://openalex.org/W2078279417","https://openalex.org/W2083791411","https://openalex.org/W2107537280","https://openalex.org/W2110396938","https://openalex.org/W2112316706","https://openalex.org/W2126148303","https://openalex.org/W2136827198","https://openalex.org/W2150428874","https://openalex.org/W2159410320","https://openalex.org/W2301807202","https://openalex.org/W2320008711","https://openalex.org/W2322003018","https://openalex.org/W2340106067","https://openalex.org/W2474746839","https://openalex.org/W4385188159"],"related_works":["https://openalex.org/W2315217629","https://openalex.org/W2111563592","https://openalex.org/W2027267404","https://openalex.org/W2066092055","https://openalex.org/W7096794860","https://openalex.org/W7139068043","https://openalex.org/W2027510481","https://openalex.org/W1978335116","https://openalex.org/W2014266411","https://openalex.org/W4310360067"],"abstract_inverted_index":{"STUDY":[0,126,369],"QUESTION:":[1],"Are":[2],"there":[3],"improvements":[4],"in":[5,14,84,102,109,272],"the":[6,31,56,80,103,106,160,183,226,232,311,323,345],"accuracy":[7,227],"of":[8,10,58,64,93,105,185,188,192,228,347,357,398],"prediction":[9,81,104,211,230,255,264,273,346],"ectopic":[11],"pregnancy":[12,19,63,329,356],"(EP)":[13],"women":[15,110,137,350],"with":[16,61,111,138,152,163,169,263,286,351],"early":[17],"symptomatic":[18,353],"using":[20],"human":[21],"chorionic":[22],"gonadotrophin":[23],"(hCG)":[24],"curves":[25],"when":[26],"clinicians":[27],"consider":[28],"visits":[29],"beyond":[30],"first":[32,164,233,267,354],"48":[33,44],"h":[34,45,237],"after":[35,221],"initial":[36,222,229],"presentation?":[37],"SUMMARY":[38],"ANSWER:":[39],"Two":[40],"hCG":[41,95,120,175,216,277],"values,":[42],"measured":[43],"(2":[46],"days)":[47],"apart,":[48,238],"are":[49],"often":[50,123],"not":[51,297,316,326,362],"sufficient":[52],"to":[53,100,159,199,365,378,385,390,400],"accurately":[54],"predict":[55,327],"outcome":[57,115],"a":[59,62,70,112,139,170,178,214,248,352],"woman":[60],"unknown":[65,358],"location":[66],"(PUL),":[67],"but":[68,360],"adding":[69,213],"third":[71,215,249],"visit":[72],"on":[73,118,218,251,266],"Day":[74,219,240,252],"4":[75,220,282],"or":[76,167,239],"7":[77,253],"significantly":[78,224,256],"improved":[79,225,254],"for":[82,344,349],"1":[83],"15":[85],"women.":[86,368],"WHAT":[87],"IS":[88],"KNOWN":[89],"ALREADY:":[90],"The":[91,270,393],"use":[92],"serial":[94],"values":[96,121,176,235,278,288],"is":[97],"commonly":[98],"used":[99],"aid":[101],"final":[107,180],"diagnosis":[108,181],"PUL.":[113],"Initial":[114],"predictions":[116],"based":[117,265],"two":[119,234,268],"may":[122,315,361],"be":[124,363],"incorrect.":[125],"DESIGN,":[127],"SIZE,":[128],"DURATION:":[129],"This":[130,339],"retrospective":[131],"multicenter":[132],"cohort":[133],"study":[134,324,340],"included":[135],"646":[136],"PUL,":[140,171],"recruited":[141,196],"over":[142],"2":[143,174,291],"years.":[144],"Of":[145],"these":[146],"women,":[147],"146":[148],"were":[149,195],"ultimately":[150],"diagnosed":[151],"EP.":[153],"PARTICIPANTS/MATERIALS,":[154],"SETTING,":[155],"METHODS:":[156],"Women":[157],"presenting":[158],"emergency":[161],"room":[162],"trimester":[165,355],"pain":[166],"bleeding,":[168],"at":[172],"least":[173],"and":[177,190,283,292,296,322,330,381,388],"definitive":[179],"from":[182,197,231],"University":[184,187,191],"Pennsylvania,":[186],"Miami":[189],"Southern":[193],"California,":[194],"2007":[198],"2009.":[200],"MAIN":[201],"RESULTS":[202],"AND":[203],"THE":[204,337],"ROLE":[205],"OF":[206,336],"CHANCE:":[207],"Using":[208],"currently":[209],"recommended":[210],"rules,":[212],"evaluation":[217],"presentation":[223],"(48":[236],"2)":[241],"by":[242,257,274,320,373],"9.3%":[243],"(P":[244,259],"=":[245,260],"0.015).":[246],"Adding":[247],"value":[250],"6.7%":[258],"0.031),":[261],"compared":[262,285],"values.":[269],"improvement":[271],"assessing":[275],"four":[276],"(Days":[279,289],"0,":[280,290],"2,":[281],"7)":[284],"three":[287],"4)":[293],"was":[294],"1.3%":[295],"statistically":[298],"significant.":[299],"LIMITATIONS,":[300],"REASONS":[301],"FOR":[302],"CAUTION:":[303],"Missing":[304],"data":[305],"imputation":[306],"likely":[307],"biased":[308],"results":[309],"toward":[310],"null;":[312],"predicted":[313],"outcomes":[314,348],"match":[317],"those":[318],"made":[319],"clinicians;":[321],"does":[325],"intrauterine":[328],"spontaneous":[331],"miscarriage":[332],"separately.":[333],"WIDER":[334],"IMPLICATIONS":[335],"FINDINGS:":[338],"provides":[341],"useful":[342],"information":[343],"location,":[359],"generalizable":[364],"all":[366],"pregnant":[367],"FUNDING/COMPETING":[370],"INTEREST(S):":[371],"Supported":[372],"NIH":[374],"grant":[375],"numbers":[376],"R01-HD036455":[377],"Dr":[379,382,386],"Barnhart":[380],"Sammel,":[383],"K24HD060687":[384],"Barnhart,":[387],"5T32MH065218":[389],"Ms.":[391],"Zee.":[392],"authors":[394],"have":[395],"no":[396],"conflicts":[397],"interest":[399],"declare.":[401]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}