{"id":"https://openalex.org/W2157408993","doi":"https://doi.org/10.2147/ijn.s39327","title":"Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique","display_name":"Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2157408993","doi":"https://doi.org/10.2147/ijn.s39327","mag":"2157408993","pmid":"https://pubmed.ncbi.nlm.nih.gov/23737670","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3668958"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s39327","doi":"https://doi.org/10.2147/ijn.s39327","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s39327","pdf_url":"https://www.dovepress.com/getfile.php?fileID=16199","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=16199","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113564595","display_name":"Carolina G\u00f3mez-Gaete","orcid":"https://orcid.org/0000-0003-2080-9870","observed_orcids":["https://orcid.org/0000-0003-2080-9870"]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Carolina G\u00f3mez-Gaete","raw_affiliation_strings":["Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098069329","display_name":"Tobar-Grande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Tobar-Grande","raw_affiliation_strings":["Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036535926","display_name":"Ricardo Godoy","orcid":"https://orcid.org/0000-0002-1951-8120","observed_orcids":["https://orcid.org/0000-0002-1951-8120"]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Ricardo Godoy","raw_affiliation_strings":["Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109275183","display_name":"Bustos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Bustos","raw_affiliation_strings":["Departamento de Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088686239","display_name":"Carlos von Plessing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Carlos von Plessing","raw_affiliation_strings":["Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073174129","display_name":"Elias Fattal","orcid":"https://orcid.org/0000-0002-3194-961X","observed_orcids":["https://orcid.org/0000-0002-3194-961X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210117966","display_name":"Institut Galien Paris-Saclay","ror":"https://ror.org/02mnw9q71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210117966","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elias Fattal","raw_affiliation_strings":["CNRS, UMR 8612, Facult\u00e9 de Pharmacie, Ch\u00e2tenay-Malabry, France","Univ Paris-Sud, Institut Galien Paris-Sud, Facult\u00e9 de Pharmacie, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, UMR 8612, Facult\u00e9 de Pharmacie, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210117966"]},{"raw_affiliation_string":"Univ Paris-Sud, Institut Galien Paris-Sud, Facult\u00e9 de Pharmacie, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I4210117966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058791776","display_name":"Nicolas Tsapis","orcid":"https://orcid.org/0000-0003-2095-2626","observed_orcids":["https://orcid.org/0000-0003-2095-2626"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210117966","display_name":"Institut Galien Paris-Saclay","ror":"https://ror.org/02mnw9q71","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210117966","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Tsapis","raw_affiliation_strings":["CNRS, UMR 8612, Facult\u00e9 de Pharmacie, Ch\u00e2tenay-Malabry, France","Univ Paris-Sud, Institut Galien Paris-Sud, Facult\u00e9 de Pharmacie, Ch\u00e2tenay-Malabry, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, UMR 8612, Facult\u00e9 de Pharmacie, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210117966"]},{"raw_affiliation_string":"Univ Paris-Sud, Institut Galien Paris-Sud, Facult\u00e9 de Pharmacie, Ch\u00e2tenay-Malabry, France","institution_ids":["https://openalex.org/I4210117966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5098374645","display_name":"Olave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172787465","display_name":"University of Concepci\u00f3n","ror":"https://ror.org/0460jpj73","country_code":"CL","type":"education","lineage":["https://openalex.org/I172787465"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Olave","raw_affiliation_strings":["Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile","institution_ids":["https://openalex.org/I172787465"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113564595"],"corresponding_institution_ids":["https://openalex.org/I172787465"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.9453,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.71775976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":null,"first_page":"2065","last_page":"2065"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/biodegradable-microparticles","display_name":"biodegradable microparticles","score":0.9480000138282776},{"id":"https://openalex.org/keywords/spray-drying","display_name":"spray drying","score":0.8550000190734863},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.9139999747276306},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.7689999938011169},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.640999972820282},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7760000228881836},{"id":"https://openalex.org/keywords/drug-excipient-interaction","display_name":"drug-excipient interaction","score":0.890999972820282},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/articular-pathology","display_name":"articular pathology","score":0.6259999871253967},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.8824087977409363},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.6676576137542725},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.555614173412323},{"id":"https://openalex.org/C2779587474","wikidata":"https://www.wikidata.org/wiki/Q1066303","display_name":"Spray drying","level":2,"score":0.5476996302604675},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.5282757878303528},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.5264414548873901},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5010850429534912},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.47778019309043884},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4541071057319641},{"id":"https://openalex.org/C2909889181","wikidata":"https://www.wikidata.org/wiki/Q27107351","display_name":"Methylprednisolone acetate","level":3,"score":0.4214636981487274},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36983615159988403},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.36417120695114136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33733847737312317},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22570881247520447},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.18836218118667603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1202026903629303},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.11215782165527344},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.10694262385368347},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003890","descriptor_name":"Desiccation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.2147/ijn.s39327","doi":"https://doi.org/10.2147/ijn.s39327","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s39327","pdf_url":"https://www.dovepress.com/getfile.php?fileID=16199","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2670510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3668958","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3668958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3668958","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmid:23737670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23737670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3270592","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3270592","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"INTERNATIONAL JOURNAL OF NANOMEDICINE (ONLINE)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:448de000c23d4209b67604771c19a7cc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/448de000c23d4209b67604771c19a7cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol 2013, Iss default, Pp 2065-2076 (2013)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/13155","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/development-of-biodegradable-methylprednisolone-microparticles-for-tre-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/136869","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/136869","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"INTERNATIONAL JOURNAL OF NANOMEDICINE (ONLINE)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s39327","doi":"https://doi.org/10.2147/ijn.s39327","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s39327","pdf_url":"https://www.dovepress.com/getfile.php?fileID=16199","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3004163614","display_name":null,"funder_award_id":"ANR-10-LABX-33","funder_id":"https://openalex.org/F4320327337","funder_display_name":"Laboratoire d'Excellence en Recherche sur le M\u00e9dicament et l'Innovation Th\u00e9rapeutique"},{"id":"https://openalex.org/G6623444247","display_name":null,"funder_award_id":"10-LABX-33","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G851376201","display_name":null,"funder_award_id":"ANR\u201010\u2010LABX\u201033","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320327337","display_name":"Laboratoire d'Excellence en Recherche sur le M\u00e9dicament et l'Innovation Th\u00e9rapeutique","ror":"https://ror.org/035gq6r08"},{"id":"https://openalex.org/F4320334812","display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/02ap3w078"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157408993.pdf","grobid_xml":"https://content.openalex.org/works/W2157408993.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1531651629","https://openalex.org/W1555512291","https://openalex.org/W1972028231","https://openalex.org/W1984044241","https://openalex.org/W1988555521","https://openalex.org/W1992087280","https://openalex.org/W1993348692","https://openalex.org/W1994242917","https://openalex.org/W1995231071","https://openalex.org/W1998045371","https://openalex.org/W1998092723","https://openalex.org/W1999422042","https://openalex.org/W2000291910","https://openalex.org/W2001452970","https://openalex.org/W2001951292","https://openalex.org/W2002714973","https://openalex.org/W2004037624","https://openalex.org/W2011014025","https://openalex.org/W2019238019","https://openalex.org/W2019414770","https://openalex.org/W2019829531","https://openalex.org/W2032006602","https://openalex.org/W2038479023","https://openalex.org/W2038852497","https://openalex.org/W2039917267","https://openalex.org/W2042022412","https://openalex.org/W2043575440","https://openalex.org/W2045359131","https://openalex.org/W2045450260","https://openalex.org/W2047955137","https://openalex.org/W2048713882","https://openalex.org/W2052879067","https://openalex.org/W2053196700","https://openalex.org/W2055319262","https://openalex.org/W2055832646","https://openalex.org/W2056647619","https://openalex.org/W2057627035","https://openalex.org/W2057744497","https://openalex.org/W2070864944","https://openalex.org/W2072361116","https://openalex.org/W2072754176","https://openalex.org/W2076681771","https://openalex.org/W2084536273","https://openalex.org/W2088456951","https://openalex.org/W2089058847","https://openalex.org/W2091853021","https://openalex.org/W2092198330","https://openalex.org/W2112135623","https://openalex.org/W2117076592","https://openalex.org/W2121311539","https://openalex.org/W2122778704","https://openalex.org/W2134234614","https://openalex.org/W2143809776","https://openalex.org/W2146902330","https://openalex.org/W2160554459","https://openalex.org/W2325081315","https://openalex.org/W4256244642","https://openalex.org/W6823124638"],"related_works":["https://openalex.org/W2349337247","https://openalex.org/W2016366406","https://openalex.org/W1999924831","https://openalex.org/W4400429323","https://openalex.org/W2092198330","https://openalex.org/W7071331171","https://openalex.org/W2029138185","https://openalex.org/W1975968668","https://openalex.org/W2131737203","https://openalex.org/W2889013994"],"abstract_inverted_index":{"In":[0,134],"this":[1,179],"work,":[2],"microparticles":[3,37,124,176],"were":[4,38,81],"prepared":[5,147],"by":[6,83],"spray-drying":[7],"using":[8,138],"albumin,":[9],"chondroitin":[10],"sulfate,":[11],"and":[12,67,77,89],"hyaluronic":[13],"acid":[14],"as":[15,29,46,192],"excipients":[16,76],"to":[17,184],"create":[18],"a":[19,60,99,185],"controlled-release":[20],"methylprednisolone":[21,48,56,97,110,120,166],"system":[22],"for":[23,163],"use":[24],"in":[25,50,98,102,114,131,178,188],"inflammatory":[26,150,189],"disorders":[27],"such":[28,191],"arthritis.":[30,193],"Scanning":[31],"electron":[32],"microscopy":[33],"demonstrated":[34],"that":[35,142],"these":[36],"almost":[39],"spherical,":[40],"with":[41],"development":[42],"of":[43,70,96,109,119,144,154],"surface":[44],"wrinkling":[45],"the":[47,51,64,71,78,103,123,127,132,145,164,170],"load":[49,57,130],"formulation":[52,75],"was":[53,111,169],"increased.":[54],"The":[55,106,117,175],"also":[58],"had":[59],"direct":[61],"influence":[62],"on":[63,126,152],"mean":[65],"diameter":[66],"zeta":[68],"potential":[69],"microparticles.":[72,105],"Interactions":[73],"between":[74],"active":[79],"drug":[80,129],"evaluated":[82],"x-ray":[84],"diffraction,":[85],"differential":[86],"scanning":[87],"calorimetry,":[88],"thermal":[90],"gravimetric":[91],"analysis,":[92],"showing":[93],"limited":[94],"amounts":[95],"crystalline":[100],"state":[101],"loaded":[104],"encapsulation":[107],"efficiency":[108],"approximately":[112],"89%":[113],"all":[115],"formulations.":[116],"rate":[118],"release":[121,153],"from":[122],"depended":[125],"initial":[128],"formulation.":[133],"vitro":[135],"cytotoxic":[136],"evaluation":[137],"THP-1":[139],"cells":[140],"showed":[141],"none":[143],"formulations":[146],"triggered":[148],"an":[149],"response":[151],"interleukin-1\u03b2,":[155],"nor":[156],"did":[157],"they":[158],"affect":[159],"cellular":[160],"viability,":[161],"except":[162],"9.1%":[165],"formulation,":[167],"which":[168],"maximum":[171],"test":[172],"concentration":[173],"used.":[174],"developed":[177],"study":[180],"have":[181],"characteristics":[182],"amenable":[183],"therapeutic":[186],"role":[187],"pathology,":[190]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}